Redbionet Idhs White Paper
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  • 1. WHITE PAPER IDHS Environmental Bioterrorism Detection CONOPS Title: [Regional Environmental Biothreat Detection Network] Period of Performance: 2/2006 – 7/2006 (6 months) Estimated Cost of Task: $150,000 Category that is being bid: [EBD] [December 22, 2005] Technical Point of Contact Contracting Contact Name Mr. Martin Dudziak Mrs. Dannie Marko Mail Address Global InfoTek Inc. Global InfoTek Inc. 1920 Association Drive 1920 Association Drive Suite 200 Suite 200 Reston, VA 20191 Reston, VA 20191 Phone Number (202) 415-7295 (703) 652-1600 x233 Fax Number (703) 652-1697 (703) 652-1697 E-mail Address mdudziak@globalinfotek.com admin@globalinfotek.comCAGE Code: 07AE7 1
  • 2. IDHSEBDA. CONOPS Task Objective and Relevant Mission AreasWest Nile Virus and Avian Flu are among the most well-known high-consequence diseases withcritical vectors involving the natural environment. Association of early warnings and indicatorsthat span large geographic regions is recognized as one of the keys to early interdiction ofpotential outbreaks that could affect millions of inhabitants. Global InfoTek, Inc. (GITI)proposes to coordinate a multi-center program to evaluate and prototype a deployable networkfor detection of bioterrorist and related biothreat outbreaks affecting wildlife populations thatcould be indicative of epidemic or pandemic-proportion dangers to the environment includinghumans.Global InfoTek (GITI) will develop new concepts of operations (CONOPS) for a RegionalEnvironmental Biothreat Detection Network (REDBIONET) that leverages existing biodefensesensing and analysis systems plus emerging new diagnostic tools to enable coordination ofinformation and reporting. The central feature of the GITI approach is the integration of twomajor components – prediction and diagnostic response, in both cases operating in near real-time. The predictive component is based upon the adaptation of the RODS (Regional OutbreakDetection System) that has been developed under BioWatch and NIH support at the Universityof Pittsburgh, Center for Bioinformatics, and which is currently in use by nearly 500 hospitalsand clinics worldwide, collecting data from emergency rooms, clinics, and also analyzingprescription medicine purchases nationwide. This predictive component will be coupled with theknowledge development and dissemination technologies and tools developed by GITI forDARPA and ARDA(DTO) as well as other intelligence and military programs, primarilyaddressing the detection of novel associations, relationships and hypotheses. These resourceswill be integrated with environmental toxicity and microbiotic investigation protocols in currentuse and under development by the Center for Environmental Oncology at the University ofPittsburgh Medical Center.The diagnostic response component is based upon a threefold integration of technology plusmethodology:• software deriving from GITI’s knowledge-based situation awareness and coordinated response technologies, some now in deployment, beyond the R&D phase, with the US Army• regional health information technologies being co-developed by UPMC and IBM• a breakthrough nucleic acid based diagnostic system produced by STMicroelectronics for rapid (15-30 min.) multi-pathogen diagnosis including such pathogens as avian flu virusWith the In-Check system, it is possible to respond to suspicious behaviors and samples withaccurate diagnostic reports that upon completion will be introduced seamlessly and automaticallyinto a response coordination network. In-Check is currently being tested in a large number ofclinical settings within the Americas, Europe and Asia. We regard this PCR-based diagnosticapproach as critical for the realistic success of any EBD solution. Our evaluation and testingcomponents, derived from previous defense and intelligence programs, will enable systematicand rapid review of alternative methods in which sensor placement, data collection, and fielddiagnostics can be optimized to reduce response time and fill in gaps of coverage.Global InfoTek believes that the combination of experienced people and organizationsassembled for this phase I program will pave the way for demonstrable results in the form of 2
  • 3. IDHSEBDenvironmentally portable prototypes by the time the phase I work is completed, with thecapability for widely deployable systems including remote, semi-automated sensing and datacollection, to follow in the course of phase 2 development. The strength of our approach is thatwe are bringing into the picture a deep understanding and expertise, drawing upon internal andexternal specialists, of the entire problem of environmental biothreat and bioterrorist detectionand also response including verification, validation, removal of false positives, and action in theform of medical procedures. Furthermore, we bring into the picture several proven anddemonstrable components including existing versions of intelligent software, integration tools,test platforms, and the MEMS-based microfluidic chips and diagnostic panels for addressingsome of the critical diseases that can be threats to the United States, whether introduced byintentional (terrorist), accidental or natural means.B. Technical Summary and Objectives and Operational DemonstrationOur approach has two elements – prediction and diagnostic response – and we will conduct ourwork on both tracks with an objective of fusing the evaluations and plan-building into a systemthat can serve simultaneously as demonstration, evaluation test bed and a field-ready utility foraddressing interdependent issues:• Integration of military, public health and homeland security networks for surveillance and monitoring of natural and intentionally-introduced anomalies indicative of bio-threats• Mitigation of false positives without the cost of incurring false negatives• Provision of rapid dissemination of information to planners and responders in crisis situations• Rapid distribution of diagnostic and therapeutic measures to prioritized sites of needThe most important first step is to review how current and projected systems, especially thosedeveloped under prior programs at DHS Centers of Excellence and the BioWatch program, canbe integrated into a plan that is extensible to both local and national scope. For this theperformance results of programs such as those at the RODS Laboratory and the Center forEnvironmental Oncology are appropriate and valuable as concrete starting points. It is in ourplan to carefully assess both the data from several experiments as well as the collection andanalysis methodologies. We plan to also work with results from environmental bio-threatactivity conducted by groups at LANL, PNL, Sandia, and companies such as ShawEnvironmental Group and BIOSAFE. We will also be examining alternative and competitivesensor and diagnostic units besides the In-Check platform including technology from IntelCorporation and Ingelhardt Institute (supported by DOE and PNL programs). The motivation forour emphasis upon assessing multiple programs including those that have not been explicitlytargeting the natural environment and wildlife factors is that we believe there are two principalgaps that need to be addressed for an EBD program to be effective in a comprehensive way –pattern discovery and knowledge dissemination.Our prior work in these two topics, addressing similar gaps within military coordination andplanning and within intelligence information sharing, provide us with the actual tools,human/technical resources, and experience to tackle these gaps for EBP planning and prototypearchitectures. We will make particular use of Verona, an intelligent knowledge managementnotebook tool, Command Post of the Future, an agent-enabled system in use for tacticalcoordination among military units in Iraq and in disaster regions, and our current work on CrisisManagement and Disaster Recovery System (CMDRS) Our activity will not (during phase 1) be 3
  • 4. IDHSEBDdirected at technology or tool development but to building a plan and schedule for how tointegrate and assimilate different resources from CDC, DHS, NIAID, and DoD. Figure 1illustrates results from earlier studies on the prediction of contamination progression in an urbanenvironment based upon environmental monitoring (in this case of radiation dosimetry collectedfrom mobile sensor units). Figures 2 and 3 illustrate the conversion path we have alreadyemployed with Verona, a type of tool that we envision to be critical for field workers assessingobservations and validating sensor readings and making determinations for containmentmeasures or other circumventions. Figure 1 – Localization and Progression of Contamination Events Figure 2 – Rapid Transition of Verona Technologies for Incident Assessment and ResponseC. Past Experience (Why GITI?)A successful wide-area multi-sensor, multi-protocol system requires integrated command andcontrol design plus knowledge discovery and situational awareness concepts in order to bestutilize the benefits of sensors and diagnostics such as those offered by PCR microfluids (e.g., In-Check). Global InfoTek has this experience and has been pre-eminent for providing successful,deployable solutions – architecture, components, evaluation, testing, training and installation.GITI possesses the specific expertise – technical, logistic, operational, and cultural – necessary todeliver a comprehensive design and CONOPS for a versatile emergency warning and response 4
  • 5. IDHSEBDnetwork. GITI also brings to the table several potentially applicable technologies developed andtested for past and current DoD and intelligence community programs. Furthermore, as aprovider of design, integration, evaluation and testing capabilities in multiple scientificdisciplines, GITI is expressly capable of leading the planning efforts that necessarily involvespecialists and technologies within biosensing, bioinformatics, clinical diagnostics, andemergency clinical response.D. Deliverables• High-level architecture of REDBIONET service and communication components• Detailed evaluation of bio-informatic analysis models and protocols for interpretation of disparate and distributed sensor readings and statistical reports• HCI design of operator interface components and applications• Preliminary requirements for a REDBIONET prototype and hands-on demonstration• Plan for regional expansion in staged progressionsE. Personnel DataDr. Martin Dudziak, PhD has conducted research in complex nonlinear systems includingpattern recognition and probabilistic reasoning for over two decades. He has been employed inscientific and engineering management for Battelle, Martin Marietta, ST Microelectronics, Intel,Medical College of Virginia, Silicon Dominion and TETRAD Technologies, having received hisdoctorate in theoretical and computational physics from Union Institute and University. Withinthe past 6 years Martin has focused upon the modeling of CBRN emergencies, both terrorist andnatural in origin, counterterrorism with a focus upon biological and nuclear attacks, and earlywarning networks.Mr. Joe Ordia: Before joining GITI, Mr. Ordia served as the lead engineer for the Army’sCommand Post of the Future CoMotion software from 2001-2003. Most recently, Mr. Ordiaserved as GITI’s program manager for the CPOF Pattern Discovery program. In this capacity,Mr. Ordia led a team of machine learning experts in developing solutions to automate the flow ofintelligence information between operators in the Army’s CPOF environment. Mr. Ordia did hisundergraduate studies in Electrical and Computer Engineering at Carnegie Mellon University.Special Advisory Consultants to the Project include:Dr. Dorothy Small, PhD is a senior scientist with Shaw Environmental Group and Ms. Smallhas 20 years experience in a broad array of onsite specific environmental requirements,biohazard emergency response, laboratory analysis, sampling procedures, bioremediation, andconstruction. She was manager of sampling and remediation for the US Post Office AnthraxCleanup in both Trenton, NJ and Washington, DC.Dr. Kristin Omberg, PhD is a Group Leader for the Systems Engineering & Integration Group,Decision Applications Division, Los Alamos National Laboratory and has led a coordination ofmilitary methods and measures for application to public health use with target projects in the SanDiego metropolitan community. She has a background in biosensor integration and the use ofmobile wireless sensor networks in conjunction with alert systems. 5