PTG-E Congress 2008 Microbe Hunters GI Lecture


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This is a short summary of year 2008 knowledge concerning the role of gut microbiota in human disease.

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  • Figure 1. Tickling Toll-like Receptors (TLRs). Commensal bacteria secrete TLR ligands such as lipopolysaccharide and lipoteichoic acid, which interact in the normal intestine with a population of surface TLRs. The resultant basal signaling, which is normally ongoing, enhances the ability of the epithelial surface to withstand injury while also priming the surface for enhanced repair responses. Because many types of cells on the surface of the intestine -- epithelial cells, lymphocytes between the epithelial cells, subepithelial mesenchymal cells, macrophages, and dendritic cells -- express TLRs, it is not known whether this critical homeostatic mechanism is maintained by the cell populations that also respond by means of TLRs when the surface is breached. Either the disruption of TLR signaling or the removal of TLR ligands compromises the ability of the intestinal surface to withstand insult and effect repair.
  • PTG-E Congress 2008 Microbe Hunters GI Lecture

    1. 1. ŁOWCY MIKROBÓW 2008 w poszukiwaniu teorii wszystkiego Wojciech Marlicz Klinika Gastroenterologii PAM, Szczecin Kongres PTG-E Gdańsk 13-15 czerwiec 2008
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    4. 4. Jama ustna Żołądek Dwunastnica Jelito czcze Jelito kręte Jelito grube Odbyt Lactobacilli 1-100/g Lactobacilli 1x10 2 /g Streptococci 1x10 4 /g Lactobacilli Streptococci Enterobacteria Bifidobacteria Yeasts 1x10 5 /g 1x10 6 /g Bifidobacteria Lactobacilli Streptococci Bacteroides Enterobacteria 1x10 5 /g 1x10 8 /g Bacteroides Eubacteria Bifidobacteria Anaerobic cocci Clostridia Lactobacilli Enterobacteria Streptococci 1x10 10 /g 1x10 11 /g
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