Mark Lombard Sao Paulo Brazil EniFarMed Aug 2013

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  • 1. North Carolina’s Life Sciences Cluster Impact of the North Carolina Biotechnology Center 21 August 2013 Mark Lombard, MBA Program Director, Bioscience Industrial Development North Carolina Biotechnology Center
  • 2. North Carolina, USA NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 3. Life Sciences in North Carolina • Place – 3 major research universities in a 30 mile radius – Ecosystem of supportive organizations, risk capital, entrepreneurial culture • People – Collaboration among visionary business, academia, gov’t leaders – Attract and retain scientific and business talent • Programs – Company creation, attraction, retention, expansion programs – Innovative workforce development programs • Patience – North Carolina Biotechnology Center: 30 years – Research Triangle Park: 50+ years NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 4. Brazil and North Carolina NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 5. NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 6. Brazil and North Carolina NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 7. Sao Paulo and North Carolina Sao Paulo (2012) North Carolina (2012) • Population: 41,901,219 • Density: 170/km2 • GDP (2010) • Population: 9,752,073 • Density: 83/km2 • GDP (2010) – US$615M – US$15,322 per capita • Machinery, auto and aviation, services, finance, textiles, oranges, sugar cane, coffee, life sciences – $407M – $42,884 per capita • Cotton, tobacco, hogs, chickens, textiles, furniture • Finance, advanced mfg, IT, life sciences NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 8. BIOTECHNOLOGY IN NORTH CAROLINA NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 9. Biotechnology: Heal, Fuel, Feed the World Global Challenges • Human/Animal health • Food availability & security • Energy • Environmental sustainability NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 10. Biotech in NC – Large and Diverse • 3rd Largest Life Science Cluster in the US – Medical Devices & Diagnostics – Contract Research & Manufacturing – Biopharma – Agricultural Biotech 560+ Companies 60,000+ Employees 21% 21% 58% R&D CRO/Testing Mfg/Prod
  • 11. Specialization Biotech in NC – Fastest Growing Growth Rate NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 12. Biotech in NC – High Impact Jobs • Average salary - $78,348 – Nearly double the state’s private sector average • 3.6 additional jobs for each biotech job • 226,000 total jobs NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 13. Biotech in NC – Annual Economic Impact • Direct biotechnology sector revenues $41.2 billion • Employee compensation $12.7 billion • State and local revenues $1.92 billion NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 14. THE NORTH CAROLINA BIOTECHNOLOGY CENTER NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 15. NCBiotech – Mission To provide long-term economic and societal benefits to North Carolina through support of biotech research, business, education and strategic policy statewide. NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 16. NCBiotech – What We Do • State-funded, private, non-profit corporation • Portfolio of programs – Research – Business – Education – Economic Development NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 17. NCBiotech – Programs Research Support Ideas Company Creation and Growth Statewide Econ Devel Products, Companies and Jobs Education, Networking and Other Programs NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 18. NCBiotech – Programs Research Support Ideas Company Creation and Growth Statewide Econ Devel Products, Companies and Jobs Education, Networking and Other Programs NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 19. Research Support • Grant funding for: – New research ideas – Build capacity – equipment/faculty – University/Company research projects • $98 million granted • $4 to $70 leveraged NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 20. NCBiotech – Programs Research Support Ideas Company Creation and Growth Statewide Econ Devel Products, Companies and Jobs Education, Networking and Other Programs NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 21. Company Creation and Growth: NCBiotech Loan Program • $50K - $250K low interest loans • ROI = $117 per $1 loaned
  • 22. Notable Recent Successes $96 million acquisition $25 million IPO BioKier $1.7 million seed financing Up to $1.6 million grant NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 23. Advanced Liquid Logic Microfluidics Lab Instruments • • • • • • • 2003: $50,000 CFG Aug-2004: Company founded May-2005: $15,000 BDL – 1 employee Sep-2005: $72,600 SBR – 3 employees Sep-2006: $160,000 SGL – 6 employees Jun-2009: $220,500 SGL – 24 employees 2011: Launched products for newborn screening, genomic sample prep • 2011-2013: NCBiotech VC events in Palo Alto, Boston, NYC • Aug-2012 : $100,000 IFP • Jul-2013 : $96M acquisition by Illumina – 80 employees – All loans repaid in full + interest and warrants – >$50 million follow-on funding before acquisition • Introductions to bankers and investors, NCBIP, Library, Jobs Board, NCBiotech Partnering 2011-2013, Corporate Communications
  • 24. Heat Biologics Cell-based Cancer Immunotherapy • • • • 2008: Company founded in FL Aug-2011: Recruited to NC 2011-2012: Assistance with investor pitch 2011-2012: NCBiotech VC events in Palo Alto, Boston • Nov-2011: $225,000 SGL - 2 NC employees – Repaid in full with interest + warrants • • • • Apr-2012: Industrial Internship Program Apr-2013: $5 million VC round Jul-2013: $25 million IPO – NASDAQ:HTBX – 5 NC employees Investor introductions, partner introductions, foundation introductions, BATON, Library, Corporate Communications, NCBiotech Partnering 2012, BIO Pavilion
  • 25. BioKier “Medicinalize” Gastric Bypass for Diabetes • • • • • • Nov-2008: Company founded Oct-2010: Emerging Company Preview Oct-2010: $250,000 SRL – 2 employees Oct-2012: Pitch Scrub Nov-2012: SEBIO Presentation Apr-2013: Southeast Venture Philanthropy Summit • May-2013: $250,000 SGL – 3.5 employees • Jul-2013: $1.7 million Broadview Ventures, AHA • Investor introductions, NCBIP, Corporate Communications, Library, NCBiotech Partnering 2011-2013, LSBDP, Biotech Forums
  • 26. Eboo Pharmaceuticals Opioid Modulators for CNS Diseases • • • • • • • • • • • Feb-2012: Company founded May-2012: $30,000 CIL – 2 NC employees Jun-2012: Introduction to Biogen IDEC Jul-2012: SBIR letter of support, recommended MJFF Oct-2012: Introductions to CEO candidates Nov-2012: Advice on business plan, investor pitch Dec-2012: Emerging Company Preview Feb-2013: Facilitated meeting with Eli Lilly Apr-2013: Southeast Venture Philanthropy Summit Jun-2013: Up to $1.6M grant Michael J. Fox Foundation BATON, Corporate Communications, Library
  • 27. NCBiotech – Programs Research Support Ideas Company Creation and Growth Statewide Econ Devel Products, Companies and Jobs Education, Networking and Other Programs NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 28. Statewide Offices – Western (Asheville) – Greater Charlotte – Piedmont Triad (Winston-Salem) – Research Triangle Park – Eastern (Greenville) – Southeastern (Wilmington) NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 29. Economic Development Since July 2010 • 21 projects • 1,754 employees Ripple effects: • 7,803 total jobs • $490 million in payroll • $59 million in state and local revenues • $2.0B in economic activity NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 30. Economic Development Novartis Vaccines • BIO 2004 in San Francisco – Chiron • • • • • • 2006: project announced 2009: plant opens 2012: production begins 2012: $36M expansion 2013: $60M expansion Today: >$1B invested, 700 employees, will grow to 1000 NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 31. Economic Development Medicago • Early 2010: introduced by Canadian Consulate • Mid 2010: DARPA, ARE • Late 2010: construction begins • Mid 2012: 10M flu doses in one month • 2013: Acquired by Mitsubsihi in a $357M deal NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 32. Economic Development Recent Announcements • 2011: Sequenom (molecular diagnostics) – 242 jobs, $19M investment • 2012: Aerocrine (asthma diagnostics) – 45 jobs • 2013: bioMerieux: (in vitro diagnostics) – 44 jobs, $44M investment • 2013: Syngenta (agricultural biotech) – 150 jobs, $94M investment NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 33. NCBiotech – Programs Research Support Ideas Company Creation and Growth Statewide Econ Devel Products, Companies and Jobs Education, Networking and Other Programs NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 34. Workforce and Education • 1900+ teachers trained • 50,000 students reached each year • $7M in grants for lab equipment & new courses • 8,000+ BioWork manuals distributed to colleges NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 35. Biomanufacturing Workforce NCBIOIMPACT • Industry-driven biopharma manufacturing training and education • Emerging and existing labor • BTEC – 82,500 SF; $60M – $12.5M equipment – cGMP pilot plant NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 36. Networking and Community • High-profile conferences • Hamner Conference Center – 30,000 guests annually • Networking groups – More than 3,000 attendees • Biotech Library • NCBiotech Job Network • And much more NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 37. Looking Ahead NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 38. Supportive Ecosystem
  • 39. Life Sciences in North Carolina • Place – 3 major research universities in a 30 mile radius – Ecosystem of supportive organizations, risk capital, entrepreneurial culture • People – Collaboration among visionary business, academia, gov’t leaders – Attract and retain scientific and business talent • Programs – Company creation, attraction, retention, expansion – Innovative workforce development programs • Patience – North Carolina Biotechnology Center: 30 years – Research Triangle Park: 50+ years NORTH CAROLINA BIOTECHNOLOGY CENTER
  • 40. Thank You Mark Lombard Program Director, Bioscience Industrial Development North Carolina Biotechnology Center