Tricarboxylic acid cycle (krebs cycle)
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Tricarboxylic acid cycle (krebs cycle)

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Tricarboxylic Acid Cycle by Sir Yhong Alderite.

Tricarboxylic Acid Cycle by Sir Yhong Alderite.

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Tricarboxylic acid cycle (krebs cycle) Tricarboxylic acid cycle (krebs cycle) Presentation Transcript

  • TRICARBOXYLICACID CYCLE { Yhong Alderite ,MSERM
  • STEP 1: CITRATE SYNTHASE Enzyme: citrate synthase Process: 1. Formation of citric acid 2. Dehydration
  • Step 2: Aconitase Reaction Enzyme: Aconitase Process : Hydration
  • Step 3: Isocitrate Dehydrogenase Rxn Enzyme: isocitrate dehydrogenase Process: • Dehydrogenation I • Decarboxylation
  • Step 4: a-Ketoglutarate Dehydrogenase Rxn Enzyme: a-ketoglutarate dehydrogenase Process: Oxidative decarboxylation
  • Step 5: Succinyl Co A Synthetase Rxn Enzyme: Succinyl-CoA synthetase Process:Oxidative decarboxylation
  • Step 6 : Succinate Dehydrogenase Rxn Enzyme: succinate dehydrogenase Process: Oxidation
  • Step 7: Fumarase Rxn Enzyme: Fumarase Process: Hydration
  • Step 8: Malate Dehydrogenase Rxn Enzyme: malate dehydrogenase Process: Dehydrogenation
  • Three control points within the cycle– citrate synthase, isocitrate dehydrogenase, and a -ketoglutarate dehydrogenase, are the rate limiting and regulatory enzymes of the citric acid cycle.One control point outside the cycle– The decarboxylation of pyruvate to acetyl-CoA is irreversible.Therefore, it is critical that the reaction be regulated.
  • Summary of Materials and Products: Needed Materials: Products:-Pyruvate - 3 CO2-4NAD - 4NADH-FAD - FADH2-GDP - GTP-Pi - 4H+-2 H2O
  • TCA and Amino Acid Synthesis
  • TCA and Fatty Acid Synthesis
  • TCA and Gluconeogenesis
  • TCA cycle in catabolism