Syllabus: Neurological Sciences
Block Director: Cynthia Standley, Ph.D. cstand@email.arizona.edu
(602) 827-2148
Room 322 A...
Readings:
Recommended Textbooks:
• The Human Brain - An Introduction to its Functional Anatomy, 6th edition, Elsevier, by ...
Essentials of Radiology (Mettler) (2005) (MD Consult)
Functional Neuroanatomy : Text & Atlas (2005) (STAT!Ref)
Gabbard's T...
• Cranial nerve pathways:
http://www.meddean.luc.edu/lumen/MedEd/GrossAnatomy/h_n/cn/cn1/mainframe.htm
• Neurohistology: h...
The block director will work with Dr. Chadwick’s office to make any arrangements necessary
during the capstone week to acc...
Ron Hammer, PhD Ron.Hammer@arizona.edu
Mark Haussler, PhD Haussler@u.arizona.edu
Barry Hendin, MD bhendin@pnal.net
Peter J...
2:00pm
Neurochemical
Systems and
Neuropharmacology
R. Hammer
CNS Injury
and Repair
J. Abbas
WEEK 2 TOPIC/THEME: THE PATIENT WITH WEAKNESS
OCTOBER 26-30,2009
Monday Tuesday Wednesday Thursday Friday
9:00 am
CBI 2
OP...
Development
S. Ghosh
R. Hammer of the ANS
R. Gonzales
10:00am
Motor
Learning and
Recovery
E. Vu
Ventricular
System,
Edema,...
WEEK4 TOPIC/THEME: NEUROENDOCRINOLOGY
NOVEMBER 9-13,2009
Monday Tuesday Wednesday Thursday Friday
9:00 am
CBI 4
OPEN Clini...
WEEK5 TOPIC/THEME: FINISH NEUROENDOCRINOLOGY/THE PATIENT WITH HEADACHE/HEADTRAUMA
NOVEMBER 16-20,2009
Monday Tuesday Wedne...
WEEK 6 TOPIC/THEME: INTRO TO COGNITIVE FUNCTION AND DYSFUNCTION
NOVEMBER 23-27,2009
Monday Tuesday Wednesday Thursday Frid...
WEEK7 TOPIC/THEME: MOVEMENT DISORDERS
NOVEMBER 30-DECEMBER 4,2009
Monday Tuesday Wednesday Thursday Friday
9:00 am
CBI 6
O...
WEEK 8 TOPIC/THEME: COGNITIVE FUNCTION AND DYSFUNCTION
DECEMBER 7-11,2009
Monday Tuesday Wednesday Thursday Friday
9:00 am...
WEEK 9 TOPIC/THEME: SENSORY SYSTEMS: EYE AND EAR
JANUARY 4-8,2010
Monday Tuesday Wednesday Thursday Friday
9:00 am
CBI 8
O...
WEEK 10 TOPIC/THEME: SENSORY SYSTEMS; VESTIBULAR AND PAIN; SUBSTANCE ABUSE AND ADDICTION
JANUARY 11-15,2010
Monday Tuesday...
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  1. 1. Syllabus: Neurological Sciences Block Director: Cynthia Standley, Ph.D. cstand@email.arizona.edu (602) 827-2148 Room 322 ABC1 Academic Coordinator: Natalie Melchiorre nmelchio@email.arizona.edu Dates: October 19th , 2009 – January 15, 2010 Location: Lectures in ASU Mercado C240 CBIs in COM-Phoenix Bldg 3 unless otherwise noted Principal Mission: The Neurological Sciences Block is designed to provide instruction in the basic science and clinical foundation required for examination and treatment of disorders of the nervous system and the five senses. Emphasis will be on a comprehensive overview of the neurological sciences including topics such as neuroanatomy, neurophysiology, neuropharmacology, neurochemistry, neuroendocrinology, neuroimmunology, neuropathology, neurobiology and neurology. Clinical topics focused on in this Block include weakness, movement disorders, head trauma, stroke, gait disturbance, cognitive dysfunction (such as schizophrenia, bipolar disorder, anxiety, etc.), seizures, visual disturbances, and neuroendocrinological signaling in visceral functions such as hunger, satiety, energy, growth and sexual function. Teaching and Learning Objectives: 1) Describe the structure and function, from the molecular to the systems level, of a healthy central nervous system and contrast that with the abnormal manifestation in neurological and psychiatric disorders. 2) Integrate neuroanatomical information with neuropathology, neuropharmacology, and neurophysiology to better understand sensory, motor, cognitive, affective and behavioral disorders. 3) Identify the cellular and molecular processes of neuroadaptation resulting in growth & development, learning & memory, and recovery of brain function after injury. 4) Characterize the major neuroendocrine signaling pathways that regulate feeding behavior, growth, reproduction, metabolism, and the stress response using examples of the feedback loops, hormone and receptor biology, as well as signal transduction pathways which govern the respective physiologic responses. 5) Explore differential diagnoses of neurological, psychiatric and neuroendocrine disorders using critical thinking skills through case-based learning. Practice patient evaluation and presentation of history, physical exam and relevant laboratory results, and consider public health issues, and ethical and privacy concerns in these cases. 6) Elucidate public health aspects of addiction and mental health and the biostatistical tools used in surveillance and research on these topics.
  2. 2. Readings: Recommended Textbooks: • The Human Brain - An Introduction to its Functional Anatomy, 6th edition, Elsevier, by John Nolte, 2009 • Neuroanatomy through Clinical Cases, Sinauer, by Hal Blumenfeld, 2002. • Neuroanatomy: An Atlas of Structures, Sections and Systems, 7th edition, LWW, by Duane Haines, 2008. • Greenspan's Basic & Clinical Endocrinology, 8th edition, Lange Medical Books, by David G. Gardner and Dolores M. Shoback, 2007. (used in subsequent blocks, and available on-line (see below)) Other additional textbooks of interest: • Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 2nd edition, by Golan, 2008. • Robbins and Cotran Pathologic Basis of Disease 8th edition, Saunders/Elsevier, by Kumar et al, 2009 (available on-line, see below). • Wheater’s Functional Histology: A Text and Colour Atlas, Churchill Livingstone/Elsevier, 5th edition, by Young et al, 2006. • Physiology, 3rd edition, by Costanzo, 2008 • Human Embryology and Developmental Biology, 4th edition, by Carlson, 2008. • Basic Medical Endocrinology, 4th edition, Academic Press, Goodman, 2009. • Clinical Neuroanatomy, 6th edition, by Snell, 2010. Other resources available ELECTRONICALLY through our library portal: Adams and Victor's Principles of Neurology (2009) (STAT!Ref) American Psychiatic Publishing Textbook of Geriatric Psychiatry (4th ed. 2009) (APPI) American Psychiatric Association Practice Guidelines (APPI) American Psychiatric Publishing Textbook of Psychiatry (2008) (APPI) American Psychiatric Publishing Textbook of Psychopharmacology (2009) (APPI) Diagnostic and Statistical Manual of Mental Disorders : DSM-IV-TR (2000) (STAT!Ref) Basic Histology : Text & Atlas (2005) (STAT!Ref) Clinical Neurology (2009) (STAT!Ref) Endocrinology: An Integrated Approach (2001) (NCBI)
  3. 3. Essentials of Radiology (Mettler) (2005) (MD Consult) Functional Neuroanatomy : Text & Atlas (2005) (STAT!Ref) Gabbard's Treatments of Psychiatric Disorders (2007) (APPI) Goodman and Gilman's The Pharmacologic Basis of Therapeutics (2006) (STAT!Ref) Grainger & Allison's Diagnostic Radiology (2008) (MD Consult) Greenspan's Basic & Clinical Endocrinology (2007) (STAT!Ref) Manual of Clinical Psychopharmacology (2007) (APPI) Neuroscience (2001) (NCBI) Pathophysiology of Disease : An Introduction to Clinical Medicine (2006) (STAT!Ref) Review of Medical Physiology (2005) (STAT!Ref) Robbins and Cotran: Pathologic Basis of Disease (2010) (MD Consult) Textbook of Clinical Neurology (Goetz) (2007) (MD Consult) Williams Textbook of Endocrinology (2008) (MD Consult) Websites that you might find helpful: • Neurology exam: http://www.neuroexam.com/ • Neuroradiology: http://www.med.harvard.edu/AANLIB/home.html • Nervous system (developed by Jack Nolte at UA COM-Tucson): Stalking the Wild Asparagyrus! http://neuro825.medicine.arizona.edu/signin/ • Interactive Neurology: http://webcampus.drexelmed.edu/interactive/neurology/ • Neuropathology: http://neuropathology.neoucom.edu/index.html • The Human Brain Atlas: https://www.msu.edu/~brains/brains/human/index.html • Neuroscience Tutorial: http://thalamus.wustl.edu/course/
  4. 4. • Cranial nerve pathways: http://www.meddean.luc.edu/lumen/MedEd/GrossAnatomy/h_n/cn/cn1/mainframe.htm • Neurohistology: http://education.vetmed.vt.edu/Curriculum/VM8054/Labs/Lab9/Lab9.htm • Interactive Brain Atlas: http://www9.biostr.washington.edu/da.html • Virtual Histology & Histopathology: http://www.path.uiowa.edu/virtualslidebox/ • Clinical Endocrinology: http://www.endotext.org/ • The Hormone Foundation: http://www.hormone.org/ • Medical Matrix Endocrinology: http://www.medmatrix.org/_SPages/Endocrinology.asp • Rural Nurse Endocrine http://ruralnurseorganization- dl.slis.ua.edu/clinical/endocrinology/index.htm Please note: All faculty are encouraged to provide a key reference in the lesson plan for every session. Such a reference is one that faculty deem to be the most appropriate in covering the required depth and breadth of the session presented. When possible, faculty will suggest readings from texts that are on the official inter-block textbook list. The academic coordinator and library staff have been advised regarding all readings and will strive to make these reading available electronically and/or in hard copy. Since session presenters distill a large amount of available material to a manageable set of session objectives, it is crucial that students access these readings for the most complete coverage of the material presented in class. AZMed Dashboard On a daily basis, all students should consult the AZMed dashboard for the most current announcements, schedule of classes learning materials. As might be expected, last minute changes in scheduling, etc. are sometimes necessary, and this type of information will be shared with all students via the AZMed dashboard. In addition, important information may also be shared with students and faculty via e-mail, using the University e-mail system. Therefore, daily surveillance of student e-mail accounts is strongly suggested. Assessment Exam Dates/Times: Exam 1 – October 30, 2009 Exam 2 – November 20, 2009 Exam 3 – December 11, 2009 Exam 4 – January 15, 2010 Exam Format: USMLE-style multiple choice questions Grading/Weights of Exams: Exam grades will be determined based on the percentage of questions answered correctly. Students must correctly answer 70% of the total number of questions administered over all four exams. CBI Surveys: Your performance in CBIs will be assessed through faculty surveys. You will be assessed on the following competencies: Medical knowledge, Patient care, Interpersonal and communication, Professionalism, Systems-based practice, Practice based learning and improvement. To pass a block or course the following criteria must be met: • 70% or greater in Medical Knowledge as assessed by exams. This will be calculated as total number of correct responses divided by the total number of questions on all exams combined throughout the block o If this is not achieved by the end of the block, a supplemental assessment or re-examination will occur on January 22, 2010 to cover the material on the tests that were not passed at the 70% level during the block. A score of 70% or higher on the supplemental assessment will result in a pass.
  5. 5. The block director will work with Dr. Chadwick’s office to make any arrangements necessary during the capstone week to accommodate the student, should a re-examination be necessary. o If the supplemental assessment exam score is also <70% the block is failed. o If a block or course is failed, it must be remediated in the summer or retaken next year. Possibilities for remediation will need to be discussed with and approved by the block director. • Satisfactory performance in each competency, including Medical Knowledge as evaluated by facilitator surveys. An unsatisfactory in a competency in a block will lead to an incomplete grade. If a satisfactory is achieved in this competency in the next block, the unsatisfactory will be considered remediated and the incomplete will be changed to a pass. Block Failure A failure of the block will require students to remediate the entire block over the summer session. If a block remediation is required students will be notified by the Office of Learning Resources and arrangements will be made with the block director. Course Evaluation by Students Students will be asked periodically to complete course and faculty evaluations. The results from these are used to assess the curriculum and faculty teaching. Code of Scholastic Conduct Students are reminded that the Code of Scholastic Conduct (http://studentaffairs.medicine.arizona.edu/) requires that all medical students act honorably in all phases of their academic work. Should you have questions or concerns, please contact the instructor or the Dean of Students. Americans with Disabilities Act If you anticipate issues related to the format or requirements of this course, please meet with the block director to discuss ways to ensure your full participation in the course. If you determine that formal, disability-related accommodations are necessary, you must be registered with Disability Resources (520-621-3268; drc.arizona.edu) and notify the block director of your eligibility for reasonable accommodations. Faculty Contact Information: Name Email James Abbas, PhD Jimmy.Abbas@asu.edu Leslie Baxter, PhD Leslie.Baxter@chw.edu Doug Campos-Outcalt, MD dougco@u.arizona.edu Carlos Carrera, MD Carlos.carrera2@va.gov Stephen Coons, MD Stephen.Coons@chw.edu Steven Curry, MD Steven.curry@bannerhealth.com Mindy Fain, MD mjfain@email.arizona.edu Mark Fischione, MD mfischione@aol.com Terry Fife, MD tfife@email.arizona.edu Amelia Gallitano-Mendel, MD, PhD amelia@email.arizona.edu Rayna Gonzales, PhD rjgonzal@email.arizona.edu Georgia Hall, PhD georgiah@email.arizona.edu
  6. 6. Ron Hammer, PhD Ron.Hammer@arizona.edu Mark Haussler, PhD Haussler@u.arizona.edu Barry Hendin, MD bhendin@pnal.net Peter Jurutka, PhD Peter.Jurutka@asu.edu Kenro Kusumi, PhD kenro@asu.edu Julie Liss, Ph.D. Julie.liss@asu.edu Scott Leischow, PhD sleischow@azcc.arizona.edu Kara Lewis, MD k3lewis@chw.edu Jianming Liang, Ph.D. Jianming.Liang@asu.edu Phil Malan, MD, PhD malan@u.arizona.edu Brian McKay, PhD bsmckay@eyes.arizona.edu David Mendelson, DO Dmendelson1@yahoo.com Anne Morrison, PhD Morrison@aging.arizona.edu Shahram Partovi, MD spartovi@partovi.net Diana Petitti, PhD diana.petitti@asu.edu J. Michael Powers, MD Jmpowers1@cox.net Hal Rekate, MD Harold.Rekate@bnaneuro.net Kenneth Root, DO keroot@cox.net Andrew Shetter, MD c/o Diane.dorsey@bnaneuro.net Cynthia Standley, PhD cstand@email.arizona.edu Stuart Stein, MD sstein118@comcast.net Eric Vu, PhD Eric.Vu@chw.edu Andrea Waxman, MD Andrea.Waman@bannerhealth.com Jei Wu, MD, PhD Jie.Wu@chw.edu Block Calendar: WEEK1TOPIC/THEME: INTRODUCTION/: ORGANIZATION, CELLULAR COMPONENTS, TOPOGRAPHY OF THE CNS OCTOBER 19-23,2009 Monday Tuesday Wednesday Thursday Friday 9:00 am CBI 1 OPEN Clinical Anatom y Histology of the Nervous System M. Fischione Clinical Anatomy CBI 1 CLOSE 10:00am Neuron and Brain Structure R. Hammer 11:00am Intro to CNS C.Standley/R. Hammer Spinal Cord Organization and Pathways I R. Hammer Noon Lunch 1:00pm Synaptic Transmission C. Standley Doctoring: Neuro Exam Spinal Cord Organization and Pathways II R. Hammer
  7. 7. 2:00pm Neurochemical Systems and Neuropharmacology R. Hammer CNS Injury and Repair J. Abbas
  8. 8. WEEK 2 TOPIC/THEME: THE PATIENT WITH WEAKNESS OCTOBER 26-30,2009 Monday Tuesday Wednesday Thursday Friday 9:00 am CBI 2 OPEN/CLOSE Clinical Anatom y MS as a Model of Neuroimmunological Disease B. Hendin Clinical Anatomy SPLC I J. Robert 10:00am Clinical Biostatistics III D. Petitti Neuroimaging and Informatics J. Liang 11:00am Systemic Anatomy of the Brainstem R. Hammer The Patient with Weakness K. Root Noon Lunch 1:00pm Introduction to Neuropathology S. Coons LCE NLS Exam 1 2:00pm WEEK3 TOPIC/THEME: STROKE/INTRO TO NEUROENDOCRINOLOGY NOVEMBER 2-6,2009 Monday Tuesday Wednesday Thursday Friday 9:00 am CBI 3 OPEN/CLOSE Clinical Anatom y CNS Patterning and Neuroanatomy of the Hypothalamus Physiology and Pharmacology
  9. 9. Development S. Ghosh R. Hammer of the ANS R. Gonzales 10:00am Motor Learning and Recovery E. Vu Ventricular System, Edema, Hydrocephalus S. Stein Thalamus A. Shetter 11:00am SPLC II J. Robert Neuroimaging S. Partovi Biopac GSR and ANS function C. Standley Noon Lunch 1:00pm Neurovascular Disease S. Coons Doctoring: Weakness Clinical Anatomy Exam2:00pm
  10. 10. WEEK4 TOPIC/THEME: NEUROENDOCRINOLOGY NOVEMBER 9-13,2009 Monday Tuesday Wednesday Thursday Friday 9:00 am CBI 4 OPEN Clinical Anatom y Veteran’s Day Clinical Anatomy CBI 4 CLOSE10:00am 11:00am Principles of Neuroendocrinology P. Jurutka Pharmacology Glucocorticoids S. Curry Noon Lunch 1:00pm CRH, Stress, Analgesia Axis M. Haussler LCE Neuroendocrine Signaling in Satiety and Hunger M. Haussler 2:00pm Psychophysiology of Stress/How the Environment gets under our Skin J. Robert Psychophysiology of Feeding
  11. 11. WEEK5 TOPIC/THEME: FINISH NEUROENDOCRINOLOGY/THE PATIENT WITH HEADACHE/HEADTRAUMA NOVEMBER 16-20,2009 Monday Tuesday Wednesday Thursday Friday 9:00 am Neuroendocrine Signaling in Energy Expenditure P. Jurutka Clinical Anatomy: Spinal cord, Brain, Meninges, Blood Supply Cerebral Blood Flow and Obstruction C. Standley Clinical Anatomy: Cranial Nerves: Face and Scalp SPLC 3 J. Robert 10:00am Neuroendocrine Signaling in Growth P. Jurutka Intracranial Pressure H. Rekate SPLC 4 J. Robert 11:00am Neuroendocrine Signaling: Reproductive Axis M. Haussler Brain Herniation M. Fischione The patient with Head Trauma K. Root Noon Lunch 1:00pm Lactation and Behavior M. Haussler Doctoring: Headache Neuro Exam 2 2:00pm OPEN
  12. 12. WEEK 6 TOPIC/THEME: INTRO TO COGNITIVE FUNCTION AND DYSFUNCTION NOVEMBER 23-27,2009 Monday Tuesday Wednesday Thursday Friday 9:00 am CBI 5 OPEN/CLOSE Clinical Anatomy : Cranial Nerves: Oral Cavity Depression, Dementia and Delirium M. Fain Thanksgiving Fall Break 10:00am 11:00am Competency to Consent in a Clinical Setting J. Robert Noon Lunch 1:00pm Cerebral Cortex R. Hammer LCE Fall Break 2:00pm
  13. 13. WEEK7 TOPIC/THEME: MOVEMENT DISORDERS NOVEMBER 30-DECEMBER 4,2009 Monday Tuesday Wednesday Thursday Friday 9:00 am CBI 6 OPEN Clinical Anatomy : Cranial Nerves: Nasal Cavity, Ear Cortical Representation Language L. Baxter Clinical Anatomy: Cranial Nerves; Orbit CBI 6 CLOSE 10:00am Dysarthrias, Dysphonias J. Liss 11:00am Basal Ganglia R. Hammer Cerebellum R. Hammer Degenerative Disorders S. Coons Noon Lunch 1:00pm Motor Control and Reflexes C. Standley Doctoring: Tremor Clinical Anatomy Exam 2:00pm Movement Disorders in the Clinic J. Samanta
  14. 14. WEEK 8 TOPIC/THEME: COGNITIVE FUNCTION AND DYSFUNCTION DECEMBER 7-11,2009 Monday Tuesday Wednesday Thursday Friday 9:00 am CBI 7 OPEN/CLOSE Limbic System R. Hammer Clinical Biostatistics IV D. Petitti Seizures and Anticonvulsants J. Wu Anxiety and Anxiolytics 10:00am Hippocampus Learning and Memory R. Hammer Somatoform Disorders A. Gallitano Schizophrenia A. Gallitano Bipolar Disorder 11:00am Sleep and Sleep Disorders C. Standley Personality and Personality Disorders A. Waxman Antipsychotics A. Gallitano Arizona Behavioral Health System D. Campos- Occult Noon Lunch 1:00pm CNS Tumors S. Coons LCE Neuro Exam 3 2:00pm Winter Break for the Next 3 weeks December 14-18, 2009 December 21-25, 2009 December 28, 2009-January 1, 2010
  15. 15. WEEK 9 TOPIC/THEME: SENSORY SYSTEMS: EYE AND EAR JANUARY 4-8,2010 Monday Tuesday Wednesday Thursday Friday 9:00 am CBI 8 OPEN Neural Development K. Kusimi Functional Anatomy Retina B. McKay Sensory System Development K. Kusimi CBI 8 CLOSE 10:00am Neural Crest K. Kusimi Neuroanatomy and Neurology of Eye Movement J.M. Powers Common ENT Disorders D. Mendelson 11:00am Regional Anatomy of the Brainstem R. Hammer Brainstem Function R. Hammer Neurology of Visual Pathways J.M. Powers Congenital Disorders; Deafness, Blindness K. Kusimi, K. Lewis Noon Lunch 1:00pm Regional Anatomy of the Brainstem R. Hammer Doctoring: Double Vision Clinical Biostatistics V part A D. Petitti 2:00pm Clinical Localization of Brainstem Lesions T. Fife Clinical Biostatistics V part B D. Petitti
  16. 16. WEEK 10 TOPIC/THEME: SENSORY SYSTEMS; VESTIBULAR AND PAIN; SUBSTANCE ABUSE AND ADDICTION JANUARY 11-15,2010 Monday Tuesday Wednesday Thursday Friday 9:00 am OPEN Therapeutic Uses of Opiates and Psychostimulants (Pain pathways) R. Hammer Pathophysiology of Addiction R. Hammer Neurobiology of Alcoholism C. Carrera OPEN 10:00a m Vestibular System and Balance T. Fife General Anesthetics P. Malan Prevention and Treatment of Substance Abuse and Addiction S. Leischow Responsible Conduct in Research J. Robert OPEN 11:00a m Patient with Ataxia/Vertigo T. Fife Eicosonoids M. Haussler OPEN Noon Lunch 1:00pm Empathic Aging- Experiential Approach G. Hall, A. Morrison Truth Telling J. Robert LCE Neuro Exam 4 2:00pm Truth Telling J. Robert Empathic Aging- Experiential Approach G. Hall, A. Morrison

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