Hofer - PowerPoint Presentation

654 views
566 views

Published on

Published in: Health & Medicine, Technology
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
654
On SlideShare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
3
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Hofer - PowerPoint Presentation

  1. 1. The Sackler InstituteThe Sackler Institute ForFor Developmental PsychobiologyDevelopmental Psychobiology Columbia UniversityColumbia University NY State Psychiatric InstituteNY State Psychiatric Institute Established April, 2001Established April, 2001
  2. 2. Sackler Institute at ColumbiaSackler Institute at Columbia D I V I S I O N SD I V I S I O N S ClinicalClinical Behavioral NeuroscienceBehavioral Neuroscience Basic ScienceBasic Science Research on Developmental ProcessesResearch on Developmental Processes Department of PsychiatryDepartment of Psychiatry School of Public HealthSchool of Public Health Pediatrics/NeonatologyPediatrics/Neonatology Obstetrics and GynecologyObstetrics and Gynecology Biochemistry andBiochemistry and Molecular BiophysicsMolecular Biophysics Psychoanalytic CenterPsychoanalytic Center Parent/Infant ProgramParent/Infant Program Behavioral MedicineBehavioral Medicine Neurobiology andNeurobiology and BehaviorBehavior
  3. 3. Sackler Institute at ColumbiaSackler Institute at Columbia D I V I S I O N SD I V I S I O N S ClinicalClinical Myrna WeissmanMyrna Weissman Behavioral NeuroscienceBehavioral Neuroscience Myron A Hofer, DirectorMyron A Hofer, Director Jennifer Knowles, AdministratorJennifer Knowles, Administrator Michael MyersMichael Myers Jonathan PolanJonathan Polan Jay GingrichJay Gingrich Basic ScienceBasic Science Thomas JessellThomas Jessell Developmental NeuroimagingDevelopmental Neuroimaging Bradley PetersonBradley Peterson William Fifer, Assistant DirectorWilliam Fifer, Assistant Director Sackler Award and NIMH Research FellowshipsSackler Award and NIMH Research Fellowships
  4. 4. • What are the risk factors for mood and anxietyWhat are the risk factors for mood and anxiety disorders across generations?disorders across generations? • 3 Generations of Depression:3 Generations of Depression: – Anxiety in childhoodAnxiety in childhood – Depression in adolescence and adulthoodDepression in adolescence and adulthood • Current study on serotonin transporter geneCurrent study on serotonin transporter gene – Genetic variants, EEG responses and MRIGenetic variants, EEG responses and MRI Clinical DivisionClinical Division Myrna Weissman, PhDMyrna Weissman, PhD Genetic EpidemiologyGenetic Epidemiology
  5. 5. • Formation of attachmentFormation of attachment • Mechanisms of separation effectsMechanisms of separation effects • Regulation of developmentRegulation of development Behavioral NeuroscienceBehavioral Neuroscience Myron Hofer, MD, DirectorMyron Hofer, MD, Director Developmental Role of Parent/Infant InteractionsDevelopmental Role of Parent/Infant Interactions Early Development of SocialEarly Development of Social Cognition in Transgenic ModelsCognition in Transgenic Models of Autismof Autism
  6. 6. • Infant feeding experiences: role in shapingInfant feeding experiences: role in shaping autonomic nervous system developmentautonomic nervous system development • Intrauterine and neonatal nutrition:Intrauterine and neonatal nutrition: programming of metabolic and neurobehavioralprogramming of metabolic and neurobehavioral disordersdisorders • Epigenetic mechanisms and underlying effectsEpigenetic mechanisms and underlying effects Behavioral NeuroscienceBehavioral Neuroscience Michael Myers, PhDMichael Myers, PhD Long-term Effects of Early ExperienceLong-term Effects of Early Experience
  7. 7. • Reversibly increased levels in striatumReversibly increased levels in striatum – Limited to prenatal periodLimited to prenatal period • Specific defect in working memorySpecific defect in working memory • Models cognitive deficit in schizophreniaModels cognitive deficit in schizophrenia Behavioral NeuroscienceBehavioral Neuroscience Jonathan Polan, MDJonathan Polan, MD Maternal-Infant NeurobiologyMaternal-Infant Neurobiology Transgenic model: Dopamine type 2 receptor geneTransgenic model: Dopamine type 2 receptor gene
  8. 8. • How do neurons first establish their identity?How do neurons first establish their identity? • What cues guide them to their targets?What cues guide them to their targets? • How do neuronal circuits forms and function?How do neuronal circuits forms and function? Basic ScienceBasic Science Thomas Jessell, PhDThomas Jessell, PhD Developmental Neurobiology: Genes, Molecules and CellsDevelopmental Neurobiology: Genes, Molecules and Cells
  9. 9. Sackler Institute at ColumbiaSackler Institute at Columbia D I V I S I O N SD I V I S I O N S ClinicalClinical Myrna WeissmanMyrna Weissman Behavioral NeuroscienceBehavioral Neuroscience Myron A Hofer, DirectorMyron A Hofer, Director Jennifer Knowles, AdministratorJennifer Knowles, Administrator Michael MyersMichael Myers Jonathan PolanJonathan Polan Jay GingrichJay Gingrich Basic ScienceBasic Science Thomas JessellThomas Jessell Developmental NeuroimagingDevelopmental Neuroimaging Bradley PetersonBradley Peterson William Fifer, Assistant DirectorWilliam Fifer, Assistant Director Sackler Award and NIMH Research FellowshipsSackler Award and NIMH Research Fellowships
  10. 10. • Exposure to nicotine, alcohol and SSRI’sExposure to nicotine, alcohol and SSRI’s – Link to SIDSLink to SIDS • Effects of Maternal Anxiety and DepressionEffects of Maternal Anxiety and Depression on fetal behavior and autonomic systemon fetal behavior and autonomic system Behavioral NeuroscienceBehavioral Neuroscience William Fifer, PhD, Assistant DirectorWilliam Fifer, PhD, Assistant Director Fetal/Infant Neurobehavioral DevelopmentFetal/Infant Neurobehavioral Development
  11. 11. • Formation of attachmentFormation of attachment • Mechanisms of separation effectsMechanisms of separation effects • Regulation of developmentRegulation of development Behavioral NeuroscienceBehavioral Neuroscience Myron Hofer, MD, DirectorMyron Hofer, MD, Director Developmental Role of Parent/Infant InteractionsDevelopmental Role of Parent/Infant Interactions Early Development of SocialEarly Development of Social Cognition in Transgenic ModelsCognition in Transgenic Models of Autismof Autism
  12. 12. • Formation of attachmentFormation of attachment • Mechanisms of separation effectsMechanisms of separation effects • Regulation of developmentRegulation of development Behavioral NeuroscienceBehavioral Neuroscience Myron Hofer, MD, DirectorMyron Hofer, MD, Director Developmental Role of Parent/Infant InteractionsDevelopmental Role of Parent/Infant Interactions The Evolution of DevelopmentThe Evolution of Development
  13. 13. • Virtual reality paradigmsVirtual reality paradigms • Diffusion tensor imagingDiffusion tensor imaging Developmental NeuroimagingDevelopmental Neuroimaging Bradley Peterson, MDBradley Peterson, MD Long-term effects of premature birthLong-term effects of premature birth 3 generations at risk for depression3 generations at risk for depression
  14. 14. • Neuroligin genes and cognitive deficits ofNeuroligin genes and cognitive deficits of schizophreniaschizophrenia • Serotonin 2A receptors necessary for responsesSerotonin 2A receptors necessary for responses to hallucinogenic drugsto hallucinogenic drugs • Serotonin transporter gene knockout revealsSerotonin transporter gene knockout reveals unique early developmental role for serotonin inunique early developmental role for serotonin in depressiondepression Behavioral NeuroscienceBehavioral Neuroscience Jay Gingrich MD, PhDJay Gingrich MD, PhD Transgenic Models of Schizophrenia and DepressionTransgenic Models of Schizophrenia and Depression
  15. 15. Myrna WeissmanMyrna Weissman William FiferWilliam Fifer Bradley PetersonBradley Peterson Catherine MonkCatherine Monk 3 generation study3 generation study – Genetic VarientsGenetic Varients – EEG startedEEG started – MRIMRI
  16. 16. Novel Role for Serotonin inNovel Role for Serotonin in Early DevelopmentEarly Development • Transporter gene under-expression increasesTransporter gene under-expression increases vulnerabilityvulnerability – Clinical: short form of gene linked to adult depressionClinical: short form of gene linked to adult depression – Knockout mice show adult depressive phenotypeKnockout mice show adult depressive phenotype • SSRI: paradoxical effectsSSRI: paradoxical effects – Pregnant women: neonatal syndromePregnant women: neonatal syndrome – Children and Adolescents: ineffective and/or activatingChildren and Adolescents: ineffective and/or activating – Pre-weaning mice show adult “depressive” phenotypePre-weaning mice show adult “depressive” phenotype

×