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  • 1. ©Go Cell International 2010 Hazimi Abd. Hamid
  • 2. ©Go Cell International 2010 Hazimi Abd. Hamid Go Geous - beneficial drink that will definitely awaken even the most weakest of cells. This exquisite product brings to you the secrets of the future so advanced that its formula cannot be compared to any other existing health supplement in the market. Highly efficacious and balanced formulation consist of : PhytoCellTec™ Malus Domestica (Apple Stem Cells), Rousselot Fish Collagen, Acai Berry Extract, Pine Bark Extract, Grape Seed Extract, L-Arginine and Mixed Berries.
  • 3. ©Go Cell International 2010 Hazimi Abd. Hamid Uttwiler Spätlauber (Malus Domestica)- an Apple with an Excellent Storage Ability • Storage ability of apples was an important factor to guarantee fresh fruits over winter in the 18th century • Modern apple cultivars are selected for a sweet flavour and therefore the Uttwiler Spätlauber disappeared • Today the Uttwiler Spätlauber apple is an endangered apple variety with only a few trees left in the world
  • 4. ©Go Cell International 2010 Hazimi Abd. Hamid The Secret of Storage Ability • Longevity of cells • High acid and tannin concentrations • Undiscovered metabolites?
  • 5. ©Go Cell International 2010 Hazimi Abd. Hamid Young and Old
  • 6. ©Go Cell International 2010 Hazimi Abd. Hamid Plant Cell Culture Technology (PCT) • PCT makes it possible to cultivate cells of endangered and rare species • The technology is based on dedifferentiated plant cells • These cells are plant stem cells and can be cultivated in liquid systems
  • 7. ©Go Cell International 2010 Hazimi Abd. Hamid What are Stem Cells? • Stem cells have two properties: Self-renewal - the ability to go through numerous cycles of cell division in an undifferentiated state Differentiation - the capacity to differentiate into other cell types • Toti-, pluri-, multi-, unipotent stem cells
  • 8. ©Go Cell International 2010 Hazimi Abd. Hamid Human: Embryonic Stem Cells (Pluripotent) • Cells derived from the inner cell mass of an early stage embryo • Blastocyst, 4-5 days post fertilization, 50-150 cells • Pluripotent: Differentiate into one of the more than 220 different cell types of an adult body • The use of embryonic stem cells in medicine is discussed controversially
  • 9. ©Go Cell International 2010 Hazimi Abd. Hamid Human: Adult Stem Cells (Multipotent) • Undifferentiated cells among differentiated cells in a tissue or organ • Generate all the cell types of the organ from which they originate — potentially regenerating the entire organ from a few cells • Primary roles: Replenish dying cells and regenerate damaged tissues
  • 10. ©Go Cell International 2010 Hazimi Abd. Hamid Plant Stem Cells Formation of Callus Tissue • If a plant is wounded, a callus tissue is formed (wound healing tissue) • In the callus tissue the normal differentiated cells go back into a dedifferentiated form and become stem cells (not possible in humans) • Mechanism is controlled by different plant hormones (auxins)
  • 11. ©Go Cell International 2010 Hazimi Abd. Hamid PhytoCellTecTM by Mibelle Biochemistry • PhytoCellTecTM utilizes this unique totipotency of plant cells • Only a small quantity of plant material of endangered species is needed • Induction of callus tissue by cutting plant parts • Isolation of stem cells and cultivation on agar plates
  • 12. ©Go Cell International 2010 Hazimi Abd. Hamid From Callus to Plants
  • 13. ©Go Cell International 2010 Hazimi Abd. Hamid PhytoCellTecTM • Complete dedifferentiation of the cells into a homogenous culture (4 -12 months) • Transformation of the cells into liquid suspension (1 - 6 months) • Find optimal conditions for cell cultivation (1 - 6 months)
  • 14. ©Go Cell International 2010 Hazimi Abd. Hamid Stem Cells and Aging • Stem cells are responsible for the rejuvenation • Stem cells are sensitive to environmental threats • Chronological aging leads to the depletion of the number and activity of stem cells  Protection of stem cells and activation of stem cell function is of great importance in our body
  • 15. ©Go Cell International 2010 Hazimi Abd. Hamid Epigenetic Factors in Stem Cells • Normal differentiated cells express only a limited amount of genes (fibroblast: collagen; blood cells: hemoglobin) • Stem cells have the possibility to express the whole DNA • The epigenetic profile regulates the gene expression in stem cells
  • 16. ©Go Cell International 2010 Hazimi Abd. Hamid Activity of PCT Malus Domestica 1. Use of plant stem cells to protect stem cells The components of Malus domestica stem cells are rich in epigenetic factors relevant to protect and maintain the function of skin stem cells. 2. Use of plant metabolites to delay senescence The active ingredients of Malus domestica var. Uttwiler Spätlauber cells contain metabolites which insure longevity of cells.
  • 17. ©Go Cell International 2010 Hazimi Abd. Hamid Study Results Increase in Cell Number (Human Umbilical Cord Stem Cells) 0.1%0.01%Control 0.00E+00 2.00E+04 4.00E+04 6.00E+04 8.00E+04 1.00E+05 1.20E+05 1.40E+05 Cellnumber Malus Domestica stem cell extract
  • 18. ©Go Cell International 2010 Hazimi Abd. Hamid Protection Against UV (Umbilical Cord Stem Cells) 0.01%Control 0.1% -50 -40 -30 -20 -10 0 Decreaseofthelivingcellnumberin% Malus Domestica stem cell extract
  • 19. ©Go Cell International 2010 Hazimi Abd. Hamid Growth of Hair Follicle Hair follicles From human skin fragments (from micro dissection) Test substance PhytoCellTecTM Malus Domestica 0.2% Design Length of hair follicle increases until day 14 → after day 14 induction of senescence → length of hair follicle decreases Day 0 Day 4 Day 7
  • 20. ©Go Cell International 2010 Hazimi Abd. Hamid Length of Hair Follicle -70 -60 -50 -40 -30 -20 -10 0 10 20 Day 16 Day 18 Day 20 Changeinlengthcomparedtoday14in% Control 0.2% Malus Domestica stem cell extract Senescence of hair (stem cells) can be delayed
  • 21. ©Go Cell International 2010 Hazimi Abd. Hamid PhytoCellTecTM Malus Domestica Effect on Gene Expression in Senescent Dermal Fibroblasts Cell line Normal Human Dermal Fibroblasts Design  H2O2 induced senescence (2h) followed by a treatment with 2% PhytoCellTecTM Malus Domestica or not (144 h) Parameters  Gene profile (microarray)
  • 22. ©Go Cell International 2010 Hazimi Abd. Hamid PhytoCellTecTM Malus Domestica Gene Profile (Microarray) ↓ Gen, that is down-regulated by senescence induction (see control) ↑ Gen, that is up-regulated or normalized in senescent cells by PhytoCellTec Malus Domestica Gen After H2O2 Control After H2O2 + 2% Malus Domestica stem cell extract cyclin B1: induces proliferation 73 ↓ 130 ↑ cyclin E1: tumor inducer 78 ↓ 135 ↑ p53: tumor suppressor gene 63 ↓ 137 ↑ insulin-like growth factor II: cell proliferation enhancer 71 ↓ 117 ↑ heme oxigenase 1: antioxidans enzyme 89 ↓ 211 ↑
  • 23. ©Go Cell International 2010 Hazimi Abd. Hamid Summary Product from rare Swiss Malus domestica var. Uttwiler Spätlauber PhytoCellTecTM to produce stem cells from this apple Product activity 1. Activation and protection of stem cells 2. Delay of senescence Results show • Protection of stem cells against UV-radiation • Increase of activity of stem cells • Decrease of senescence markers in fibroblasts • Increase of life span of hair follicles
  • 24. ©Go Cell International 2010 Hazimi Abd. Hamid Claims • Delays senescence of essential cells • Protects longevity of stem cells • Protection of stem cells • Rejuvenation of cells • Maintains the power of regeneration • Combats chronological aging
  • 25. ©Go Cell International 2010 Hazimi Abd. Hamid Properties of PhytoCellTecTM • PhytoCellTecTM is a preparation of plant stem cells • PhytoCellTecTM is produced in Switzerland by a novel plant cell culture technology • PhytoCellTecTM contains plant stem cells to protect and maintain stem cells • The protection of stem cells is a breakthrough approach in anti-aging • Studies showed that PhytoCellTecTM protects human stem cells and rejuvenates them • PhytoCellTecTM delays chronological aging
  • 26. ©Go Cell International 2010 Hazimi Abd. Hamid PhytoCellTec™ Malus Demestica - Benefits • PhytoCellTecTM plant stem cells are a breakthrough in anti-aging therapy • Stem cell treatment is a revolutionary new approach in healthcare industry • Plant stem cells are extremely efficient but also safe to use • PhytoCellTecTM is based on real plant stem cells to trigger the rejuvenation of the body • PhytoCellTecTM delays the natural aging process by maintaining the activity of stem cells
  • 27. ©Go Cell International 2010 Hazimi Abd. Hamid
  • 28. ©Go Cell International 2010 Hazimi Abd. Hamid According to the US edition of Vogue, the First Lady buys a £215 serum which uses an extract from stem cells of the Uttwiller Spattauber apple
  • 29. ©Go Cell International 2010 Hazimi Abd. Hamid Rousselot™ Fish Hydrolyzed Collagen Rousselot™ Hydrolyzed Collagen are natural proteins, derived from the collagen found in fish skins and bones. Some definitions of Collagen Merriam Webster Dictionary “…an insoluble fibrous protein that occurs in vertebrates as the chief constituent of connective tissue fibrils and in bones… Chemistry and Biology of proteins- F.Haurowitz Academic Press, Inc. – New York,1950 “…a structural protein of connective tissues and composes the larger part of the tendons, ligaments…(and)… a portion of the bones, cartilage and skins..”
  • 30. ©Go Cell International 2010 Hazimi Abd. Hamid Rousselot™ Fish Hydrolyzed Collagen Rousselot™ Hydrolyzed Collagen is 92% pure protein made of all essential amino-acids, particularly rich in alanine, arginine, glycine, glutamic acid and proline. Alanine*: Involved in the supply of energy to muscle tissues, brain and central nervous system, alanine plays a role in the metabolism of sugars and organic acids. It strengthens the immune system through its effect on antibody production. Arginine*: Useful for immune system stimulation, arginine is involved in the wound healing process and the secretion of hormones.
  • 31. ©Go Cell International 2010 Hazimi Abd. Hamid Rousselot™ Fish Hydrolyzed Collagen Glutamic Acid*: An important excitatory neurotransmitter, glutamic acid helps speed the healing of ulcers and gives relief from fatigue. Glycine*: Beside its nutrient role for a strong immune system, glycine triggers the release of the oxygen required by the cell-making process. It is also a fast inhibitory neurotransmitter. Proline*: Important for joints and tendons adequate functioning, proline participates in heart muscle strengthening. *Non-essential amino-acid.
  • 32. ©Go Cell International 2010 Hazimi Abd. Hamid Rousselot™ Fish Hydrolyzed Collagen – Clinical Studies Comprehensive clinical studies carried out in Japan and France confirm the effect of taking Rousselot™ Hydrolyzed Collagen on skin health. Background : Fine lines, wrinkles, and loss of elasticity are symptoms commonly associated with aging skin. Accumulated environmental exposure and a natural decrease in cell renewal contribute to other signs less often associated with aging: dull, rough, or dry skin. The latest investigative studies using state-of-the-art technology have challenged the effect of Rousselot™ Hydrolyzed Collagen. Two clinical studies were carried out by global independent skin health research organizations having a well proven approach for verifying product performance claims. Mechanical measurements and volunteers were assessed by certified skin experts.
  • 33. ©Go Cell International 2010 Hazimi Abd. Hamid Rousselot™ Fish Hydrolyzed Collagen – Clinical Studies Conclusion These two clinical studies demonstrated the benefits of Rousselot™ on skin health. Taken daily, up to 12 weeks, the results verify that regular intake of Rousslet™ Hydrolyzed Collagen improves the basic skin condition and structure. Rousslet™ Hydrolyzed Collagen has clinically shown to: Improve skin moisture level Improve skin smoothness by reducing the number of micro-relief furrows Prevent the formation of deep-wrinkles Improve skin suppleness Rousslet™ Hydrolyzed Collagen, a completely characterized and scientifically objectivized natural bioactive ingredient that improves epidermis moisture content and prevents skin aging.
  • 34. ©Go Cell International 2010 Hazimi Abd. Hamid Acai Berry The Acai (ah-sigh-ee) Berry has been around for thousands of years and not until the 1990's was it introduced to the western world. The acai berry was found to possess tremendous health properties. The acai berry was first used by the tribes of the Amazon jungle as a cure for various ailments. The acai berry was discovered to have natural antioxidant properties, as well as being a natural cholesterol controller. When eaten it helps reduce the bad cholesterol in our blood and increases the good cholesterol. The tribes of the Amazon knew of these properties and found out that it helped build the immune system, fight infection, protect the heart, and control prostate enlargement (nature's viagra). It was a great energy food for the tribes-people.
  • 35. ©Go Cell International 2010 Hazimi Abd. Hamid Acai Berry - Benefits • A remarkable concentration of antioxidants that help combat premature aging, with 10 times more antioxidants than red grapes and 10 to 30 times the anthocyanins of red wine. • An almost perfect essential amino acid complex in conjunction with valuable trace minerals, vital to proper muscle contraction and regeneration. • The fatty acid content in açaí resembles that of olive oil, and is rich in monounsaturated oleic acid. Oleic acid is important for a number of reasons: •It helps omega-3 fish oils penetrate the cell membrane; together they help make cell membranes more supple. By keeping the cell membrane supple, all hormones, neurotransmitter and insulin receptors function more efficiently. This is particularly important because high insulin levels create an inflammatory state, and we know, inflammation causes aging. Acai Berry does contain Omega-3 fatty acids, Omega-6 and Omega-9. Each of these can lower the so-called bad cholesterol, or LDL, and each can maintain our HDL, or good cholesterol.
  • 36. ©Go Cell International 2010 Hazimi Abd. Hamid Acai Berry – Other Benefits Healthier Skin- The berry contains many unique properties that work to make your skin look and feel younger. Weight loss - Increases the metabolism in the body, which helps in reducing the unwanted fats from the body. Increases Energy- Our active lifestyles leave us drained of energy. Many of us don’t get enough sleep, and we walk around all day like zombies. This creates serious long-term medical conditions. Thankfully, Acai Berry helps improve your overall energy. You can rest better, and wake up more refreshed in the morning. Improves Blood Flow- Poor circulation can lead to numerous medical conditions (clotting, balding, and heart issues.) Acai Berry supplements work to improve your blood flow, thus staving off many serious ailments. Improved circulation makes you feel better and live longer.
  • 37. ©Go Cell International 2010 Hazimi Abd. Hamid Acai Berry – Other Benefits Stronger Heart- Heart disease is one of the leading causes of death in America. From lack of exercise to poor dietary habits, our hearts endure a lot of stress. Acai Berry supplements give your heart the nutrients it needs to work properly. Better Concentration- Another of the seemingly endless benefits of Acai Berry is the improved mental clarity it produces. In a way, this goes back to the circulation benefits. With better blood flow, your brain is able to operate more efficiently. Reduced Cholesterol- When you think of lowering your cholesterol, you probably recall images of eating healthy foods that taste terrible. Acai Berry supplements save you the trouble of eating tasteless oats. This berry will lower your cholesterol significantly over time. Detoxifies Body- Acai Berry contains several antioxidants that work to eliminate harmful substances from your body. Throughout our life, our body absorbs many damaging substances. Acai Berry works to eradicate them, and to make your immune system stronger than ever before. Enhances Sexual Performance- Known as Viagra of Amazon
  • 38. ©Go Cell International 2010 Hazimi Abd. Hamid Pine Bark Extract Pine bark extract is made from the bark of a European coastal pine tree called the Landes or maritime pine, whose scientific name is Pinus maritima. Researchers have termed the group of antioxidants found in pine bark extract oligomeric proanthocyanidins, or OPCs for short. OPCs (also referred to as PCOs) are some of the most powerful antioxidants available.
  • 39. ©Go Cell International 2010 Hazimi Abd. Hamid Pine Bark Extract Antioxidants play a key role of repairing and protecting cells in the body. They help protect against free radicals, which are damaging byproducts of metabolism and exposure to environmental pollutants. Free radical damage is believed to contribute to aging, as well as too severe conditions including heart disease and cancer. Much research has been conducted on OPCs and on pine bark extract. In France, pine bark extract and OPCs have been rigorously tested for safety and effectiveness, and pine bark extract is a registered drug.
  • 40. ©Go Cell International 2010 Hazimi Abd. Hamid Pine Bark Extract Pine bark extract has been shown to contain a powerful antioxidant that helps protect cells from free radical damage and increases the effectiveness of vitamin C. Pine bark extract has been shown to help lower cholesterol, and to decrease the risk and severity of atherosclerosis, or damage to the arteries. It has been demonstrated to help strengthen and repair tissues made of collagen, a protein that builds blood vessels, skin, and connective tissue. The OPCs in pine bark extract have also been shown to help reduce swelling and inflammation in the body.
  • 41. ©Go Cell International 2010 Hazimi Abd. Hamid Pine Bark Extract - Benefits Pine bark extract is used to reduce the risk and severity of heart disease, strokes, high cholesterol, and circulation problems. It is used in the nutritional treatment of varicose veins and oedema, which is swelling in the body due to fluid retention and leakage of blood vessels. Arthritis and inflammation have also been improved in studies using pine bark extract, as well as the uncomfortable symptoms of PMS and menopause.
  • 42. ©Go Cell International 2010 Hazimi Abd. Hamid Pine Bark Extract - Benefits The OPCs in pine bark extract are recommended for various eye conditions that are caused by blood vessel damage, such as diabetic retinopathy and macular degeneration. Pine bark extract is recommended to improve the health and smoothness of the skin, including damage caused by overexposure to sunlight. Pine bark extract is a supplement used for anti-aging and preventive care as well.
  • 43. ©Go Cell International 2010 Hazimi Abd. Hamid Grape Seed Extract Grape Seed Extract (GSE) is a natural plant constituent (bioflavonoid) which strengthens and protects living tissue. The Oligomeric Proanthocyanidins (OPC) components in GSE are 50 times stronger than Vitamin E and 20 times stronger than Vitamin C. Grape Seed Extract is an antiallergenic, antihistamine, anti-inflammatory, and antioxidant. It strengthens blood vessels, improves skin, and aids in circulation.
  • 44. ©Go Cell International 2010 Hazimi Abd. Hamid Grape Seed Extract is prescribed by doctors in several European countries for the prevention and treatment of a variety of health problems including cardiovascular disease, varicose veins, water retention, collagen damage and arthritis. Because it is used pharmaceutically, it has undergone a tremendous amount of testing. Grape Seed Extract Grape Seed Extract is an extraordinarily safe and effective nutritional supplement.
  • 45. ©Go Cell International 2010 Hazimi Abd. Hamid Grape Seed Extract provides cardiovascular protection by preventing oxidation of lipoproteins (LDL), making them less likely to stick to blood-vessel walls. It also makes the linings of the arteries more resistant to damage and helps control excessive clotting. GSE strengthens the capillaries ensuring a good supply of oxygen and nutrients to the brain and throughout the body. It also affects enzymes that influence blood-fluid balances and therefore may be helpful in lowering blood pressure. Grape Seed Extract
  • 46. ©Go Cell International 2010 Hazimi Abd. Hamid Grape Seed Extract - Benefits Below are some health benefits of grape seed extract: * Grape seed extract is one of the most powerful antioxidants that fights free radicals * Grape seed extract is 20 times more potent than Vitamin C and 50 times stronger than Vitamin E * Grape seed extract helps improve cardiovascular health * It also helps promote brain, skin and eye health * Grape seed extract is also anti-bacterial, anti-viral, and anti-inflammatory
  • 47. ©Go Cell International 2010 Hazimi Abd. Hamid * Grape seed extract is one of the few antioxidants that can penetrate the blood brain barrier to help protect the brain and nerve tissue * Some studies have also shown grape seed extract to prevent the formation of plaque in the arteries * It can also improve mental alertness and help prevent senility Recently, researchers discovered that Grape Seed Extract can help to stimulate healthy hair growth by defeating the hormone dihydrotestosterone (DHT) that stops the hair follicle growth cycle. Grape Seed Extract - Benefits
  • 48. ©Go Cell International 2010 Hazimi Abd. Hamid L - Arginine L-Arginine Could Be A Magic Bullet In Anti-Aging Arsenal Columbia University refers to L-arginine as the "magic bullet" for the cardiovascular system Properties of L-arginine were validated by the 1998 Nobel Prize in Medicine, and since then have created a frenzy of interest in the Pharmaceutical and Nutraceutical fields. Medical researchers have gathered enough clinical evidence to bring L-arginine to the forefront of modern medicine as an accepted treatment for a variety of human ailments. The L-arginine phenomen is changing standard treatment methodologies in heart disease, immune function, adiposity-generated diseases, genetic growth deficiencies, high blood pressure, sexual disfunction, and human aging.
  • 49. ©Go Cell International 2010 Hazimi Abd. Hamid L – Arginine - Benefits The efficacy of L-arginine as a therapeutic agent has been validated by thousands of clinical studies. The benefits and functions attributed to oral ingestion of L-arginine include: • Precursor for the synthesis of Nitric Oxide (NO) • Stimulation of the release of the most important anti-aging hormone in the body; growth hormone. • Improves immune function
  • 50. ©Go Cell International 2010 Hazimi Abd. Hamid • Reduces risk of heart disease • Natural Alternative to Viagra • Increases muscle mass • Reduces adipose tissue body fat • Helps improve insulin sensitivity • Helps decrease blood pressure • Alleviates male infertility, improving sperm production and motility L – Arginine - Benefits
  • 51. ©Go Cell International 2010 Hazimi Abd. Hamid L – Arginine - Obesity Obesity is characterized by increased levels of insulin (high glycemic foods and drinks) and by subnormal growth hormone (GH) release. Insulin promotes fat and carbohydrate storage while GH stimulates lipolysis (fat- burning). The insulin/growth hormone ratio is significantly higher in obese humans than in lean humans. The combination of high insulin and low GH exacerbates the obese condition. L- arginine is the main oral agent responsible for restoration of GH in humans, and administration of L-arginine taken at bedtime on an empty stomach 30 minutes prior to Delta sleep reinstates normal GH levels.
  • 52. ©Go Cell International 2010 Hazimi Abd. Hamid Mixed Berries – Strawberry, Bilberry, Raspberry, Elderberry, Blackcurrant, Red Beet They’re loaded with fiber, which helps you feel full (and eat less).
  • 53. ©Go Cell International 2010 Hazimi Abd. Hamid A recent study even showed that one-half to one cup of mixed berries a day improved cognition and motor performance in animals. Mixed Berries – Strawberry, Bilberry, Raspberry, Elderberry, Blackcurrant, Red Beet Top the charts in antioxidant power, protecting your body against inflammation and free radicals, molecules that can damage cells and organs.
  • 54. ©Go Cell International 2010 Hazimi Abd. Hamid Mixed Berries – Strawberry, Bilberry, Raspberry, Elderberry, Blackcurrant, Red Beet James Joseph, PhD, director of the Neuroscience Lab at the United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, which conducted the study, notes that we become more susceptible to the damaging effects of free radicals and inflammation as we age. Berries help prevent those effects by turning off the inflammation signals triggered by cytokines and COX-2s, making them an ideal part of your diet
  • 55. ©Go Cell International 2010 Hazimi Abd. Hamid THANK YOU

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