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Department of Neurology Department of Neurology Presentation Transcript

  • Department of Neurology University of Pittsburgh School of Medicine September 8, 2008
  • Departmental Organization p g Lawrence R. Wechsler, MD Interim Chair Department of Neurology Patrick Conwayy Leslie Dunn, MPH Executive Administrator Academic Administrator Lawrence Wechsler, MD Tim Greenamyre, MD PhD Steven Graham, MD PhD. Paula Clemens, MDVice Chair – Clinical Affairs Vice Chair – Academic Affairs Vice Chair - Research Vice Chair –VA Affairs
  • Division Chiefs
  • Division ChiefsLawrence Wechsler, MD Interim Chairman of Neurology Chief, Stroke Division Director, UPMC Stroke InstituteAnto Bagic, MD, MSc Chief, Division of EEG and Epilepsy Director, Center for Advanced Brain Magnetic Source ImagingPaula Clemens, MD Chief, VA NeurologyJohn Doyle, MD Chief, General Neurology Director, Residency Training ProgramTim Greenamyre MD PhD Greenamyre, Chief, Chief Division of Movement Disorders Director, Pittsburgh Institute of Neurodegenerative Diseases (PIND)Rock Heyman, MD Heyman Chief, Chief Division of Neuroimmunology & Multiple SclerosisRobert Kaniecki, MD Chief, Headache DivisionDavid Lacomis, MDD id L i Chief, Di i i Chi f Division of Neuromuscular Diseases fN l DiOscar Lopez, MD Chief, Cognitive and Behavioral Neurology
  • Faculty Dist ib tion Fac lt DistributionProfessors 10Associate Professors 6Assistant Professors 25Research Assist ProfsR hA i tP f 12
  • Department of Neurology Recent Faculty AdditionsGena Ghearing, MD Mayo Clinic; Epilepsy and EEGEric Hoffmann, PhD Pitt; Molecular genetics of degenerative diseaseSamay Jain, MD Columbia; Movement Disorders and early diagnosis techniquesAngela Lu, MD Pitt; Neuromuscular DiseasesChitharanjan Rao, MDChith j R Wayne State; N W St t Neuromuscular Di l DiseasesAsim Roy, MD Tufts University; Neurophysiology and Sleep MedicineM. Firas Sioufi, MDM Fi Si fi Pitt; G Pi General Neurology lN lValerie Suski, DO Duke; Movement Disorders and deep brain stimulationOlga Vergun, PhD Pitt; The role of mitochondria in regulation & deregulation of neuronal ionic homeostasisBarbara Vogler, MD Thomas Jefferson; Headache and clinical research trialsDavid Wolk, MD Harvard; Cognitive and Behavioral NeurologySyed Zaidi, MD Pitt; Vascular Neurology
  • Clinical and Research Trainees Neurology Residents 15 Clinical Fellows 5 Stroke, Epilepsy, Neuromuscular Movement Disorders Research Associate 17 Post Doc Assoc 12 Post Doc Scholar 2 Graduate Students 11
  • National Rankings gNIH Rankings U.S. News and World ReportDepartments of Neurology Neurology and Neurosurgery 2001 26th 2002 unranked 2002 19th 2003 39th 2003 14th 2004 39th 2004 17th 2005 17th 2005 10th 2006 19th 2006 8th 2007 12th 2007 6th 2008 14th
  • Research ThemesNeurodegenerative DisordersDiagnosis and Therapeutic Interventions inDementiaMechanisms and interventions in Parkinson’sdiseaseBrain Trauma in humans and animal modelsStroke and ischemia-induced mechanisms of ischemia-neuronal death
  • Department Depa tment DetailsWet laboratory space: BST-S; BST-3; VA BST- BST-Clinical research space in KaufmannBuilding, UPMC Montefiore, and at theVAMCLed the initiative to launch PittsburghInstitute for Neurodegenerative Diseases
  • Department of Neurology Research Funding Sources $20,000,000 $18,000,000 $16,000,000 $16 000 000Annual Funding g $14,000,000 OTHER $12,000,000 STATE $10,000,000 $8,000,000 $8 000 000 VA $6,000,000 NIH $4,000,000 $2,000,000 $- $ FY 02 FY 03 FY 04 FY 05 FY 06 FY 07 FY 08 Fiscal Year
  • Department of Neurology Extramural Funding Foundation, 9% Industry, 4% R Awards, 20% State, 2% DoD, 3%VA/Other Federal, 2% K Awards, 5%Fellowships, 3% Training, 1% Program Projects, Center, 24% 27%
  • Department of Neurology Funding by NIH Institutes Fogarty International National Institute of Center (FIC), 0.8% Environmental Health National I tit t of Child N ti l Institute f Sciences (NIEHS), 0.1% Health & Human Development (NICHD), 0.1% National Center for Complementary & Alternative Medicine Alt ti M di i National Institute of Aging (NCCAM), 27% (NIA), 38%National Institute of Mental Health (NIMH), 2% National Institute of National Institute of Arthritis & Musculoskeletal Neurological Disorders & & Skin Diseases (NIAMS), Stroke (NINDS), 30% 2%
  • Centers & Program Project Grants Alzheimer’s Disease Research Center (P50; O. Lopez, PI; $10,438,440 over 5 years) Morris K. Udall Center of Excellence: Neuroprotection and Early Detection in PD (P01; M. Zigmond, PI; $6,453,809 over 5 years ) GRECC (Geriatric Research, Education, and (G i t i R h Ed ti d Clinical Center) (S. Graham, Director)
  • State Tobacco G ant GrantThis g a t focuses o s grant ocuses on computer screening techniques for cognitive impairment in the community p y the use of PET imaging with the amyloid ligand PIB and computer analysis of MR images to aid in p y g diagnosis the examination of biological specimens for g p biomarkers of diagnosis and disease severity using cutting- cutting-edge techniques to do drug discovery in novel cell-based systems to identify new cell- treatments for dementia.
  • Commonwealth Tobacco Settlement Fund 5/05-5/09: 5/05- Center of Excellence on Research In Neurodegenerative Diseases Center on Excellence in Detection, Diagnosis and Intervention in Dementia DDID Administrative Core Clinical/Health Basic Research Services Research Computerized PIB-PET for MRI Diagnostic Screening for High-Throughput Oxidized Neurolipids Diagnosis of Analysis Tau MetabolismDementia Detection Drug Screening V Kagan, Dementia J Becker, L Taylor, J Saxton, J Lazo, Project Leader W Klunk/D Wolk, Project Leader Project Leader Project Leader Project Leader University of Pittsburgh Project Leaders University of Pittsburgh University of PittsburghPitt ADRC, SWPA-AAA, University of Pittsburgh ADRC University of ADRC/Penn State/CMU ADRC and Cellumen PST, Theiss Health ADRC and Penn State and Univ Pgh GSPH Pittsburgh ADRC Center
  • Clinical Trials: NIH and PharmaG go oba e e t oGinkgo Biloba Prevention Trial in O de Individuals a Older d dua s (NCCAM and NIA; S. DeKosky, PI; O. Lopez, Co-PI) Co- 3000 normal elderly in 4 clinical sites around the USA: y Pittsburgh, Hopkins, Wake Forest, UC Davis; Data Mgt/Statistics at Univ. Washington, Lab at U. Vermont, Cognitive Diagnostic Center and Imaging Center at U. Pgh. g g g g g Largest grant ever given by NCCAM Funded the continuation of the GEM clinical trial for $16,632,639 h $16 632 639 through July 2009 hJ lOther clinical trials are sponsored by NINDS, NIA andPharma in Alzheimer s, Parkinson’s Stroke ALS Alzheimer’s Parkinson s, Stroke, ALS,Huntington’s, Multiple Sclerosis
  • Foundation Support ppPicower Foundation JT Greenamyre MD PhD, $750 000 per year for 3 years Greenamyre, MD, PhD, $750,000 Pathogenic mechanisms as therapeutic targets in PDEmmerling Fund of the Pittsburgh Foundation Edward Burton, MD, DPhil, a two year grant totaling DPhil, $138,646. Development of a biochemical model of Parkinson’s disease in zebrafish to enable identification of pathogenic pathways and neuroprotective drugs. p gEmmerling Fund of the Pittsburgh Foundation David Hinkle, MD, PhD 3 year g , , y grant totaling $166,760 g$ , The research project will target astrocytes for neuroprotective therapies in stroke
  • Current Career Development AwardsSarah Berman, MD, PhD: K08 Award (NINDS) Mitochondrial dynamics in neurodegenerationDavid Hinkle, MD, PhD: K08 Award (NINDS) The Potential Role of DJ-1 in Astrocyte-Mediated Neuroprotection DJ- Astrocyte-Samay Jain, MD: K12 Award (NIH) Improving diagnosis and treatment of Parkinson disease with assessments of non- non-motor features by clinical and physiologic measuresDeric Park, MD: K02 award (NINDS) Determination of growth and differentiation pathways in glioblastoma multiformeAmanda Smith, PhD: K01 award (NINDS) Endogenous neuroprotective agents in Parkinson’s DiseaseDavid Wolk MD: K23 award (NIA) Wolk, Recollection and Familiarity in Amnestic-Mild Cognitive Impairment Amnestic-
  • Training GrantsT32 MH18273 Training in the Neurobiology ofNeuropsychiatric Disorders (M. Zigmond, PI)U13 NS060553 Training Faculty to Teach Survival Skillsand Ethics (M. Zigmond , PI)R25 NS39805 Survival Skills and Ethics Workshops forNeuroscientists (M. Zigmond , PI) Numerous Neurology faculty serve on other training grants in several basic and clinical departments.
  • Concept of the PINDC t f th Robert Y. Moore, MD, PhD and Michael Zigmond, PhD conceptualized an Institute for the study of p f y f Neurodegenerative Diseases, that would build on the significant strengths in research at the university of g Pittsburgh Central idea was a dual focus on translational research (to translate ideas from the lab to the clinic) Laboratories that were open and interactive Clinical translational by clinician researchers AND clinicians who both ran laboratories and did clinical research Close proximity of laboratories and clinics
  • 1997-2000 Drs. Moore and Zigmond, working with Joanne Beyer, developed a proposal f th PIND t present t th d l d l for the to t to the Scaife Foundation Bob Moore met with Jeff Romoff, CEO of UPMC and Romoff secured a promise to match a Scaife Foundation Gift of $10 million with $10 million from UPMC - a promise made good Drs Moore, Zigmond, and DeKosky met with the Scaife Foundation Board with a proposal to support the PIND, leveraging the Parkinson’s Disease h PIND l i h P ki ’ Di expertise, Alzheimer’s disease research, emerging ALS research in the Division of Neuropathology, and other neurodegenerative disease research h d d h
  • The tTh targets… t Dual theme reflected in the unique aspects of the neurodegenerative diseases, and also their common features Neuronal death in specific brain regions Abnormal pr c n rma processing of brain pr t n ng f ra n proteins Loss of cell-to-cell communication Inflammation Oxidative O id i stress
  • The S if CTh Scaife Commitment: two-fold it t t f ld The PIND gift was $10,800,000 $10 million for the building $800,000 $800 000 for recruiting equipment seminars education and recruiting, equipment, seminars, related activities in the interim before the building was completed Used for PIND symposiums, organizing lectures, recruitment and equipment utilized in labs before the move to the new laboratories Allowed PIND to develop its “Center without Walls” presence
  • 2000-2004 Moore took sabbatical in London to study neuroimaging in Parkinson’s disease and then returned to start a new research program DeKosky took Chair of Neurology in 2000; was appointed Director of the PIND Leslie Dunn, MPH, appointed Executive Director of PIND, overseeing PIND act v t es, grants, seminars activities, sem nars Recruiting for researchers from inside and outside University of Pittsburgh began Zigmond NIH-funded Program Project Grant designated a Morris K. NIH funded Udall Parkinsons Disease Research Center of Excellence One of very few to have both basic and clinical research Ed Burton, MD, PhD (movement disorders), David Hinkle, MD, PhD , , ( ), , , (movement disorders) recruited from Queen’s Square and University of Pennsylvania Groundbreaking for the building was held March 6, 2003
  • 2004-present Tim Greenamyre, MD, PhD, recruited from Emory University as Professor and UPMC Chair in Movement Disorders, Chief of the Division of Movement Disorders, Department of Neurology, and Director of the PIND Additional recruitments in Parkinson’s disease, Alzheimer’s disease, ALS, animal models of m , L , m m f neurodegeneration Designated as an Advanced Center for Parkinson’s Disease R Di Research by th A h b the American P ki i Parkinson Di Disease Association
  • The Pittsburgh Institute forNeurodegenerative DiseasesMission Statement:By virtue of both philosophy and architecture,the PIND is a center where there are no wallsbetween individual scientists, and where thereare no barriers between basic scientific inquiryand translation of the latest findings into newtreatments.treatments. As such, the mission of the PIND isto transform cutting-edge science into novel cutting-therapies and d h d diagnostics that d h directly b l benefit findividuals affected by neurodegenerativediseases.diseases.
  • The Pittsburgh Institute forNeurodegenerative Diseases Administrative Structure Administ ti St uctu Director: Tim Greenamyre, MD, PhD Executive Committee: Bob Bowser, PhD Jun Chen, MD Steve G h St Graham, MD, PhD MD Terri Hastings, PhD Peter Strick, PhD
  • What i th Wh t is the PIND?• The 7th floor of BST3
  • What i th Wh t is the PIND?• The 7th floor of BST3• Th investigators on the 7th floor The i ti t th fl of BST3
  • The Pittsburgh Institute forNeurodegenerative Diseases The PeopleNeurology: Sarah Berman, MD, PhD Dave Hinkle, MD, PhD Ed Burton, MD, PhD Ruth Perez, PhD Tim Greenamyre, MD, PhD h Michael Zigmond, PhD h l h Terri Hastings, PhDPharmacology: Don DeFranco, PhD DeFranco Michael Palladino, PhD PalladinoGeriatrics: Al Fisher, MD, PhDStructural Ron Wetzel PhD Wetzel,Biology:
  • Sarah Berman, MD, PhDAssistant ProfessorNeurology FUSION Mitofusin OPA Drp1 Fis1 FISSION
  • Ed Burton, MD, PhDAssistant ProfessorNeurology tractable models Genetically in Zebrafish
  • Don DeFranco, PhDProfessorPharmacology Oxidative Stress
  • Al Fisher, MD, PhDAssistant ProfessorGeriatric Medicine
  • Tim Greenamyre, MD, PhDProfessorNeurology
  • Terri Hastings, PhDAssociate ProfessorNeurology
  • David Hinkle, MD, PhDAssistant ProfessorNeurology
  • Michael Palladino, PhDAssistant ProfessorPharmacology
  • Ruth Perez, PhDAssistant ProfessorNeurology
  • Ron Wetzel, PhDProfessorStructural Biology
  • Michael Zigmond, PhDProfessorNeurology
  • What i th Wh t is the PIND?• The 7th floor of BST3• Th investigators on the 7th floor The i ti t th fl of BST3• An inclusive center without walls - basic b i & clinical i li i l investigators ti t throughout Pitt g
  • How is PIND research funded? Extramural Funding FY-07 Individual NIH Foundations/Associations Research 21% Awards 53% NIH Program Project or Center Awards 25% $6,031,129 $6 031 129 direct $1,476,041 indirect
  • K-Awards• Sarah Berman, MD, PhD - K08• Al Fisher, MD, PhD - K08 (Beeson Award) - Division of Geriatrics• Dave Hinkle, MD, PhD - K08•P Pier Mastroberardino, PhD - K99 M b d• Samay Jain, MD - K12 y
  • Graduate students• 12 Pitt PhD students (4 MD-PhD)• CNUP Pharmacology, MBSB CNUP, Pharmacology• Visiting students from University of Padova, University of I U i it f Insubria b i• Formal exchange agreements with University of Insubria & Mondino Neurological Institute
  • Postdocs• 26 postdocs• PhDs from Pitt Michigan Michigan State, Pitt, Michigan, State Rome, Padova, Insubria, Navarra• 2 RiMED f ll fellows - (J i t UPMC Si il program) (Joint UPMC-Sicily )
  • Journal Editors• Molecular Endocrinology, Don DeFranco, editor ( (IF 5.4) )• Neurobiology of Disease, Tim Greenamyre, editor (IF 4.4)• Progress in Neurobiology, Michael Zigmond, editor (IF 10.5) 10 5)