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Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
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Department of Neurology

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  • 1. Department of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of Neurology University of PittsburghUniversity of Pittsburgh School of MedicineSchool of MedicineSchool of MedicineSchool of Medicine September 8, 2008September 8, 2008
  • 2. Departmental OrganizationDepartmental Organizationp gp g Lawrence R. Wechsler, MDLawrence R. Wechsler, MD Interim ChairInterim ChairInterim ChairInterim Chair Department of NeurologyDepartment of Neurology Patrick ConwayPatrick Conway Leslie Dunn, MPHLeslie Dunn, MPH Lawrence Wechsler, MDLawrence Wechsler, MD Vice ChairVice Chair Clinical AffairsClinical Affairs Steven Graham, MD PhD.Steven Graham, MD PhD. Vice ChairVice Chair ResearchResearch Paula Clemens, MDPaula Clemens, MD Vice ChairVice Chair VA AffairsVA Affairs yy Executive AdministratorExecutive Administrator Academic AdministratorAcademic Administrator Tim Greenamyre, MD PhDTim Greenamyre, MD PhD Vice ChairVice Chair Academic AffairsAcademic AffairsVice ChairVice Chair –– Clinical AffairsClinical Affairs Vice ChairVice Chair -- ResearchResearch Vice ChairVice Chair ––VA AffairsVA AffairsVice ChairVice Chair –– Academic AffairsAcademic Affairs
  • 3. Division ChiefsDivision Chiefs
  • 4. Division ChiefsDivision Chiefs Lawrence Wechsler, MDLawrence Wechsler, MD Interim Chairman of NeurologyInterim Chairman of Neurology Chief, Stroke DivisionChief, Stroke Division Director, UPMC Stroke InstituteDirector, UPMC Stroke Institute Anto Bagic, MD, MScAnto Bagic, MD, MSc Chief, Division of EEG and EpilepsyChief, Division of EEG and Epilepsy Director, Center for Advanced Brain Magnetic SourceDirector, Center for Advanced Brain Magnetic Source ImagingImaging Paula Clemens, MDPaula Clemens, MD Chief, VA NeurologyChief, VA Neurology John Doyle, MDJohn Doyle, MD Chief, General NeurologyChief, General Neurology Director, Residency Training ProgramDirector, Residency Training Program Tim Greenamyre MD PhDTim Greenamyre MD PhD Chief Division of Movement DisordersChief Division of Movement DisordersTim Greenamyre, MD PhDTim Greenamyre, MD PhD Chief, Division of Movement DisordersChief, Division of Movement Disorders Director, Pittsburgh Institute of NeurodegenerativeDirector, Pittsburgh Institute of Neurodegenerative Diseases (PIND)Diseases (PIND) Rock Heyman MDRock Heyman MD Chief Division of Neuroimmunology & MultipleChief Division of Neuroimmunology & MultipleRock Heyman, MDRock Heyman, MD Chief, Division of Neuroimmunology & MultipleChief, Division of Neuroimmunology & Multiple SclerosisSclerosis Robert Kaniecki, MDRobert Kaniecki, MD Chief, Headache DivisionChief, Headache Division D id L i MDD id L i MD Chi f Di i i f N l DiChi f Di i i f N l DiDavid Lacomis, MDDavid Lacomis, MD Chief, Division of Neuromuscular DiseasesChief, Division of Neuromuscular Diseases Oscar Lopez, MDOscar Lopez, MD Chief, Cognitive and Behavioral NeurologyChief, Cognitive and Behavioral Neurology
  • 5. Fac lt Dist ib tionFac lt Dist ib tionFaculty DistributionFaculty Distribution Professors 10 Associate Professors 6Associate Professors 6 Assistant Professors 25 R h A i t P f 12Research Assist Profs 12
  • 6. Department of NeurologyDepartment of Neurology Recent Faculty AdditionsRecent Faculty Additions Gena Ghearing, MDGena Ghearing, MD Mayo Clinic; Epilepsy and EEGMayo Clinic; Epilepsy and EEG Eric Hoffmann, PhDEric Hoffmann, PhD Pitt; Molecular genetics of degenerative diseasePitt; Molecular genetics of degenerative disease Samay Jain, MDSamay Jain, MD Columbia; Movement Disorders and early diagnosisColumbia; Movement Disorders and early diagnosis techniquestechniques Angela Lu, MDAngela Lu, MD Pitt; Neuromuscular DiseasesPitt; Neuromuscular Diseases Chith j R MDChith j R MD W St t N l DiW St t N l DiChitharanjan Rao, MDChitharanjan Rao, MD Wayne State; Neuromuscular DiseasesWayne State; Neuromuscular Diseases Asim Roy, MDAsim Roy, MD Tufts University; Neurophysiology and Sleep MedicineTufts University; Neurophysiology and Sleep Medicine M Fi Si fi MDM Fi Si fi MD Pi G l N lPi G l N lM. Firas Sioufi, MDM. Firas Sioufi, MD Pitt; General NeurologyPitt; General Neurology Valerie Suski, DOValerie Suski, DO Duke; Movement Disorders and deep brain stimulationDuke; Movement Disorders and deep brain stimulation Olga Vergun, PhDOlga Vergun, PhD Pitt; The role of mitochondria in regulation & deregulation ofPitt; The role of mitochondria in regulation & deregulation of neuronal ionic homeostasisneuronal ionic homeostasis Barbara Vogler, MDBarbara Vogler, MD Thomas Jefferson; Headache and clinical research trialsThomas Jefferson; Headache and clinical research trials David Wolk, MDDavid Wolk, MD Harvard; Cognitive and Behavioral NeurologyHarvard; Cognitive and Behavioral Neurology Syed Zaidi, MDSyed Zaidi, MD Pitt; Vascular NeurologyPitt; Vascular Neurology
  • 7. Clinical and Research TraineesClinical and Research TraineesClinical and Research TraineesClinical and Research Trainees Neurology ResidentsNeurology Residents 1515 Clinical FellowsClinical Fellows 55 Stroke, Epilepsy, NeuromuscularStroke, Epilepsy, Neuromuscular Movement DisordersMovement Disorders Research AssociateResearch Associate 1717 Post Doc AssocPost Doc Assoc 1212 Post Doc ScholarPost Doc Scholar 22 Graduate StudentsGraduate Students 1111
  • 8. National RankingsNational Rankingsgg NIH Rankings Departments of Neurology U.S. News and World Report Neurology and Neurosurgery 2001 26th 2002 19th 2002 unranked 2003 39th2002 19 2003 14th 2004 17th 2003 39 2004 39th 2005 17th 2005 10th 2006 8th 2007 6th 2006 19th 2007 12th 2008 14th2007 6th 2008 14th
  • 9. Research ThemesResearch ThemesResearch ThemesResearch Themes Neurodegenerative DisordersNeurodegenerative Disorders Diagnosis and Therapeutic Interventions inDiagnosis and Therapeutic Interventions in DementiaDementiaDementiaDementia Mechanisms and interventions in Parkinson’sMechanisms and interventions in Parkinson’s diseasediseasediseasedisease Brain Trauma in humans and animal modelsBrain Trauma in humans and animal models Stroke and ischemiaStroke and ischemia--induced mechanisms ofinduced mechanisms ofStroke and ischemiaStroke and ischemia induced mechanisms ofinduced mechanisms of neuronal deathneuronal death
  • 10. Depa tment DetailsDepa tment DetailsDepartment DetailsDepartment Details Wet laboratory space: BSTWet laboratory space: BST--S; BSTS; BST--3; VA3; VA Clinical research space in KaufmannClinical research space in KaufmannClinical research space in KaufmannClinical research space in Kaufmann Building, UPMC Montefiore, and at theBuilding, UPMC Montefiore, and at the VAMCVAMCVAMCVAMC Led the initiative to launch PittsburghLed the initiative to launch Pittsburgh Institute for Neurodegenerative DiseasesInstitute for Neurodegenerative DiseasesInstitute for Neurodegenerative DiseasesInstitute for Neurodegenerative Diseases
  • 11. Department of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of Neurology Research Funding SourcesResearch Funding Sources $16 000 000 $18,000,000 $20,000,000 g $8 000 000 $10,000,000 $12,000,000 $14,000,000 $16,000,000 alFunding OTHER STATE VA $ $2,000,000 $4,000,000 $6,000,000 $8,000,000 Annu VA NIH $- FY 02 FY 03 FY 04 FY 05 FY 06 FY 07 FY 08 Fiscal Year
  • 12. Department of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of Neurology Extramural FundingExtramural Funding State, 2% R Awards, 20%Industry, 4%Foundation, 9% Fellowships, 3% K Awards, 5%VA/Other Federal, 2% DoD, 3% Training, 1% Center, 24% Program Projects, 27%
  • 13. Department of NeurologyDepartment of Neurology Funding by NIH InstitutesFunding by NIH InstitutesFunding by NIH InstitutesFunding by NIH Institutes Fogarty International Center (FIC), 0.8%National Institute of N ti l I tit t f ChildEnvironmental Health Sciences (NIEHS), 0.1% National Institute of Child Health & Human Development (NICHD), 0.1% National Center for Complementary & Alt ti M di i National Institute of Mental Health (NIMH), 2% Alternative Medicine (NCCAM), 27% National Institute of Aging (NIA), 38% National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS), 2% National Institute of Neurological Disorders & Stroke (NINDS), 30%
  • 14. Centers & Program Project GrantsCenters & Program Project GrantsCenters & Program Project GrantsCenters & Program Project Grants Alzheimer’s Disease Research CenterAlzheimer’s Disease Research Center (P50; O. Lopez, PI; $10,438,440 over 5 years)(P50; O. Lopez, PI; $10,438,440 over 5 years) Morris K. Udall Center of Excellence:Morris K. Udall Center of Excellence: Neuroprotection and Early Detection in PDNeuroprotection and Early Detection in PD (P01; M. Zigmond, PI; $6,453,809 over 5 years )(P01; M. Zigmond, PI; $6,453,809 over 5 years ) GRECC (G i t i R h Ed ti dGRECC (G i t i R h Ed ti dGRECC (Geriatric Research, Education, andGRECC (Geriatric Research, Education, and Clinical Center)Clinical Center) (S. Graham, Director)(S. Graham, Director)(S. Graham, Director)(S. Graham, Director)
  • 15. State Tobacco G antState Tobacco G antState Tobacco GrantState Tobacco Grant This grant focuses onThis grant focuses ons g a t ocuses os g a t ocuses o computer screening techniques for cognitivecomputer screening techniques for cognitive impairment in the communityimpairment in the communityp yp y the use of PET imaging with the amyloid ligandthe use of PET imaging with the amyloid ligand PIB and computer analysis of MR images to aid inPIB and computer analysis of MR images to aid inp y gp y g diagnosisdiagnosis the examination of biological specimens forthe examination of biological specimens forg pg p biomarkers of diagnosis and disease severity usingbiomarkers of diagnosis and disease severity using cuttingcutting--edge techniques to do drug discovery inedge techniques to do drug discovery in novel cellnovel cell--based systems to identify newbased systems to identify newnovel cellnovel cell--based systems to identify newbased systems to identify new treatments for dementia.treatments for dementia.
  • 16. Center on Excellence in Detection, Diagnosis andCenter on Excellence in Detection, Diagnosis and Commonwealth Tobacco Settlement Fund 5/05Commonwealth Tobacco Settlement Fund 5/05--5/09:5/09: Center of Excellence on Research In Neurodegenerative DiseasesCenter of Excellence on Research In Neurodegenerative Diseases Center on Excellence in Detection, Diagnosis andCenter on Excellence in Detection, Diagnosis and Intervention in DementiaIntervention in Dementia DDIDDDID Administrative Core Clinical/Health Basic Research Services Research Basic Research Computerized Screening for Dementia Detection J Saxton, Project Leader Pitt ADRC, SWPA-AAA, PIB-PET for Diagnosis of Dementia W Klunk/D Wolk, Project Leaders University of MRI Diagnostic Analysis J Becker, Project Leader University of Pittsburgh ADRC/Penn State/CMU Tau Metabolism L Taylor, Project Leader University of Pittsburgh ADRC and Cellumen High-Throughput Drug Screening J Lazo, Project Leader University of Pittsburgh Oxidized Neurolipids V Kagan, Project Leader University of Pittsburgh ADRC PST, Theiss Health Center University of Pittsburgh ADRC ADRC/Penn State/CMU ADRC and Cellumen ADRC and Penn State and Univ Pgh GSPH
  • 17. Clinical Trials: NIH and PharmaClinical Trials: NIH and Pharma Ginkgo Biloba Prevention Trial in Older IndividualsGinkgo Biloba Prevention Trial in Older IndividualsG go oba e e t o a O de d dua sG go oba e e t o a O de d dua s (NCCAM and NIA; S. DeKosky, PI; O. Lopez, Co(NCCAM and NIA; S. DeKosky, PI; O. Lopez, Co--PI)PI) 3000 normal elderly in 4 clinical sites around the USA:3000 normal elderly in 4 clinical sites around the USA:yy Pittsburgh, Hopkins, Wake Forest, UC Davis; DataPittsburgh, Hopkins, Wake Forest, UC Davis; Data Mgt/Statistics at Univ. Washington, Lab at U. Vermont,Mgt/Statistics at Univ. Washington, Lab at U. Vermont, Cognitive Diagnostic Center and Imaging Center at U. Pgh.Cognitive Diagnostic Center and Imaging Center at U. Pgh.g g g g gg g g g g Largest grant ever given by NCCAMLargest grant ever given by NCCAM Funded the continuation of the GEM clinical trial forFunded the continuation of the GEM clinical trial for $16 632 639 h h J l 2009$16 632 639 h h J l 2009$16,632,639 through July 2009$16,632,639 through July 2009 Other clinical trials are sponsored by NINDS, NIA andOther clinical trials are sponsored by NINDS, NIA and Pharma in Alzheimer’s Parkinson’s Stroke ALSPharma in Alzheimer’s Parkinson’s Stroke ALSPharma in Alzheimer s, Parkinson s, Stroke, ALS,Pharma in Alzheimer s, Parkinson s, Stroke, ALS, Huntington’s, Multiple SclerosisHuntington’s, Multiple Sclerosis
  • 18. Foundation SupportFoundation Supportpppp Picower FoundationPicower Foundation JT Greenamyre MD PhDJT Greenamyre MD PhD $750 000 per year for 3 years$750 000 per year for 3 yearsJT Greenamyre, MD, PhDJT Greenamyre, MD, PhD, $750,000 per year for 3 years, $750,000 per year for 3 years Pathogenic mechanisms as therapeutic targets in PDPathogenic mechanisms as therapeutic targets in PD Emmerling Fund of the Pittsburgh FoundationEmmerling Fund of the Pittsburgh FoundationEmmerling Fund of the Pittsburgh FoundationEmmerling Fund of the Pittsburgh Foundation Edward Burton, MD, DPhilEdward Burton, MD, DPhil, a two year grant totaling, a two year grant totaling $138,646.$138,646. Development of a biochemical model of Parkinson’s disease inDevelopment of a biochemical model of Parkinson’s disease in zebrafish to enable identification of pathogenic pathways andzebrafish to enable identification of pathogenic pathways and neuroprotective drugs.neuroprotective drugs.p gp g Emmerling Fund of the Pittsburgh FoundationEmmerling Fund of the Pittsburgh Foundation David Hinkle, MD, PhDDavid Hinkle, MD, PhD 3 year grant totaling $166,7603 year grant totaling $166,760, ,, , y g g $ ,y g g $ , The research project will target astrocytes for neuroprotectiveThe research project will target astrocytes for neuroprotective therapies in stroketherapies in stroke
  • 19. Current Career Development AwardsCurrent Career Development Awards Sarah Berman, MD, PhD: K08 Award (NINDS)Sarah Berman, MD, PhD: K08 Award (NINDS) Mitochondrial dynamics in neurodegenerationMitochondrial dynamics in neurodegeneration David Hinkle, MD, PhD: K08 Award (NINDS)David Hinkle, MD, PhD: K08 Award (NINDS) The Potential Role of DJThe Potential Role of DJ--1 in Astrocyte1 in Astrocyte--Mediated NeuroprotectionMediated Neuroprotection Samay Jain, MD: K12 Award (NIH)Samay Jain, MD: K12 Award (NIH) Improving diagnosis and treatment of Parkinson disease with assessments ofImproving diagnosis and treatment of Parkinson disease with assessments of nonnon--motor features by clinical and physiologic measuresmotor features by clinical and physiologic measures Deric Park, MD: K02 award (NINDS)Deric Park, MD: K02 award (NINDS) Determination of growth and differentiation pathways in glioblastoma multiformeDetermination of growth and differentiation pathways in glioblastoma multiforme Amanda Smith, PhD: K01 award (NINDS)Amanda Smith, PhD: K01 award (NINDS) Endogenous neuroprotective agents in Parkinson’s DiseaseEndogenous neuroprotective agents in Parkinson’s Disease David Wolk MD: K23 award (NIA)David Wolk MD: K23 award (NIA)David Wolk, MD: K23 award (NIA)David Wolk, MD: K23 award (NIA) Recollection and Familiarity in AmnesticRecollection and Familiarity in Amnestic--Mild Cognitive ImpairmentMild Cognitive Impairment
  • 20. Training GrantsTraining Grants T32 MH18273 Training in the Neurobiology ofT32 MH18273 Training in the Neurobiology of Neuropsychiatric Disorders (M. Zigmond, PI)Neuropsychiatric Disorders (M. Zigmond, PI)Neuropsychiatric Disorders (M. Zigmond, PI)Neuropsychiatric Disorders (M. Zigmond, PI) U13 NS060553 Training Faculty to Teach Survival SkillsU13 NS060553 Training Faculty to Teach Survival Skills and Ethics (M. Zigmond , PI)and Ethics (M. Zigmond , PI) R25 NS39805 Survival Skills and Ethics Workshops forR25 NS39805 Survival Skills and Ethics Workshops for Neuroscientists (M. Zigmond , PI)Neuroscientists (M. Zigmond , PI) Numerous Neurology faculty serve on other trainingNumerous Neurology faculty serve on other training grants in several basic and clinical departments.grants in several basic and clinical departments.
  • 21. C t f th PINDConcept of the PIND Robert Y. Moore, MD, PhD and Michael Zigmond, PhD conceptualized an Institute for the study ofp f y f Neurodegenerative Diseases, that would build on the significant strengths in research at the university of Pittsburghg Central idea was a dual focus on translational research (to translate ideas from the lab to the clinic)clinic) Laboratories that were open and interactive Clinical translational by clinician researchers AND clinicians who both ran laboratories and did clinical researchwho both ran laboratories and did clinical research Close proximity of laboratories and clinics
  • 22. 1997-2000 Drs. Moore and Zigmond, working with Joanne Beyer, d l d l f th PIND t t t thdeveloped a proposal for the PIND to present to the Scaife Foundation Bob Moore met with Jeff Romoff CEO of UPMC andBob Moore met with Jeff Romoff, CEO of UPMC and secured a promise to match a Scaife Foundation Gift of $10 million with $10 million from UPMC - a promise made goodmade good Drs Moore, Zigmond, and DeKosky met with the Scaife Foundation Board with a proposal to support h PIND l i h P ki ’ Dithe PIND, leveraging the Parkinson’s Disease expertise, Alzheimer’s disease research, emerging ALS research in the Division of Neuropathology, and h d d hother neurodegenerative disease research
  • 23. Th t tThe targets… Dual theme reflected in the unique aspects of the neurodegenerative diseases, and also their common featurestheir common features Neuronal death in specific brain regions Abnormal processing of brain proteinsn rma pr c ng f ra n pr t n Loss of cell-to-cell communication Inflammation O id iOxidative stress
  • 24. Th S if C it t t f ldThe Scaife Commitment: two-fold The PIND gift was $10,800,000 $10 million for the building $800 000 for recruiting equipment seminars education and$800,000 for recruiting, equipment, seminars, education and related activities in the interim before the building was completed Used for PIND symposiums, organizing lectures, recruitment and equipment utilized in labs before the move to the new laboratoriesmove to the new laboratories Allowed PIND to develop its “Center without Walls” presence
  • 25. 2000-2004 Moore took sabbatical in London to study neuroimaging in Parkinson’s disease and then returned to start a new research program DeKosky took Chair of Neurology in 2000; was appointed Director ofDeKosky took Chair of Neurology in 2000; was appointed Director of the PIND Leslie Dunn, MPH, appointed Executive Director of PIND, overseeing PIND activities, grants, seminarsPIND act v t es, grants, sem nars Recruiting for researchers from inside and outside University of Pittsburgh began Zigmond NIH-funded Program Project Grant designated a Morris K.Zigmond NIH funded Program Project Grant designated a Morris K. Udall Parkinson's Disease Research Center of Excellence One of very few to have both basic and clinical research Ed Burton, MD, PhD (movement disorders), David Hinkle, MD, PhD, , ( ), , , (movement disorders) recruited from Queen’s Square and University of Pennsylvania Groundbreaking for the building was held March 6, 2003
  • 26. 2004-present Tim Greenamyre, MD, PhD, recruited from Emory University as Professor and UPMC Chair in MovementUniversity as Professor and UPMC Chair in Movement Disorders, Chief of the Division of Movement Disorders, Department of Neurology, and Director of the PINDthe PIND Additional recruitments in Parkinson’s disease, Alzheimer’s disease, ALS, animal models ofm , L , m m f neurodegeneration Designated as an Advanced Center for Parkinson’s Di R h b th A i P ki DiDisease Research by the American Parkinson Disease Association
  • 27. The Pittsburgh Institute for Neurodegenerative Diseases The Pittsburgh Institute for Neurodegenerative DiseasesNeurodegenerative DiseasesNeurodegenerative Diseases Mission Statement: ByBy virtuevirtue ofof bothboth philosophyphilosophy andand architecture,architecture, thethe PINDPIND isis aa centercenter wherewhere therethere areare nono wallswalls betweenbetween individualindividual scientists,scientists, andand wherewhere therethere areare nono barriersbarriers betweenbetween basicbasic scientificscientific inquiryinquiry andand translationtranslation ofof thethe latestlatest findingsfindings intointo newnewandand translationtranslation ofof thethe latestlatest findingsfindings intointo newnew treatmentstreatments.. AsAs such,such, thethe missionmission ofof thethe PINDPIND isis toto transformtransform cuttingcutting--edgeedge sciencescience intointo novelnovel hh dd dd hh d ld l b fb ftherapiestherapies andand diagnosticsdiagnostics thatthat directlydirectly benefitbenefit individualsindividuals affectedaffected byby neurodegenerativeneurodegenerative diseasesdiseases..diseasesdiseases..
  • 28. The Pittsburgh Institute for Neurodegenerative Diseases The Pittsburgh Institute for Neurodegenerative DiseasesNeurodegenerative DiseasesNeurodegenerative Diseases Administ ti St uctuAdministrative Structure Director: Tim Greenamyre, MD, PhD Executive Committee:Executive Committee: Bob Bowser, PhD Jun Chen, MD St G h MD PhDSteve Graham, MD, PhD Terri Hastings, PhD Peter Strick, PhD
  • 29. Wh t i th PIND?Wh t i th PIND?What is the PIND?What is the PIND? • The 7th floor of BST3
  • 30. Wh t i th PIND?Wh t i th PIND?What is the PIND?What is the PIND? • The 7th floor of BST3 Th i ti t th 7th fl• The investigators on the 7th floor of BST3
  • 31. The Pittsburgh Institute for Neurodegenerative Diseases The Pittsburgh Institute for Neurodegenerative DiseasesNeurodegenerative DiseasesNeurodegenerative Diseases The PeopleThe PeopleThe PeopleThe People Neurology:Neurology: Sarah Berman, MD, PhDSarah Berman, MD, PhD Dave Hinkle, MD, PhDDave Hinkle, MD, PhD Ed Burton, MD, PhDEd Burton, MD, PhD Ruth Perez, PhDRuth Perez, PhD hh h l hh l hTim Greenamyre, MD, PhDTim Greenamyre, MD, PhD Michael Zigmond, PhDMichael Zigmond, PhD Terri Hastings, PhDTerri Hastings, PhD Pharmacology:Pharmacology: Don DeFranco PhDDon DeFranco PhD Michael Palladino PhDMichael Palladino PhDPharmacology:Pharmacology: Don DeFranco, PhDDon DeFranco, PhD Michael Palladino, PhDMichael Palladino, PhD Geriatrics:Geriatrics: Al Fisher, MD, PhDAl Fisher, MD, PhD StructuralStructural Ron Wetzel PhDRon Wetzel PhDStructuralStructural Biology:Biology: Ron Wetzel, PhDRon Wetzel, PhD
  • 32. Sarah Berman, MD, PhD Assistant Professor Sarah Berman, MD, PhD Assistant ProfessorAssistant Professor Neurology Assistant Professor Neurology Mitofusin FUSION OPA Drp1 Fis1 FISSIONFISSION
  • 33. Ed Burton, MD, PhD Assistant Professor Ed Burton, MD, PhD Assistant Professor Genetically tractable models in Zebrafish Assistant Professor Neurology Assistant Professor Neurology in Zebrafish
  • 34. Don DeFranco, PhD Professor Don DeFranco, PhD ProfessorProfessor Pharmacology Professor Pharmacology Oxidative StressOxidative Stress
  • 35. Al Fisher, MD, PhD Assistant Professor Al Fisher, MD, PhD Assistant Professor Geriatric MedicineGeriatric Medicine
  • 36. Tim Greenamyre, MD, PhD Professor Tim Greenamyre, MD, PhD ProfessorProfessor Neurology Professor Neurology
  • 37. Terri Hastings, PhD Associate Professor Terri Hastings, PhD Associate ProfessorAssociate Professor Neurology Associate Professor Neurology
  • 38. David Hinkle, MD, PhD Assistant Professor David Hinkle, MD, PhD Assistant ProfessorAssistant Professor Neurology Assistant Professor Neurology
  • 39. Michael Palladino, PhD Assistant Professor Michael Palladino, PhD Assistant ProfessorAssistant Professor Pharmacology Assistant Professor Pharmacology
  • 40. Ruth Perez, PhD Assistant Professor Ruth Perez, PhD Assistant ProfessorAssistant Professor Neurology Assistant Professor Neurology
  • 41. Ron Wetzel, PhD Professor Ron Wetzel, PhD ProfessorProfessor Structural Biology Professor Structural Biology
  • 42. Michael Zigmond, PhD Professor Michael Zigmond, PhD ProfessorProfessor Neurology Professor Neurology
  • 43. Wh t i th PIND?Wh t i th PIND?What is the PIND?What is the PIND? • The 7th floor of BST3 Th i ti t th 7th fl• The investigators on the 7th floor of BST3 • An inclusive center without walls - b i & li i l i ti tbasic & clinical investigators throughout Pittg
  • 44. How is PIND research funded?How is PIND research funded? Extramural Funding FY-'07 Individual NIH Research Awards 53% Foundations/Associations 21% NIH Program Project or Center Awards 25% $6 031 129 direct$6 031 129 direct$6,031,129 direct $1,476,041 indirect $6,031,129 direct $1,476,041 indirect
  • 45. K-Awards • Sarah Berman, MD, PhD - K08 • Al Fisher, MD, PhD - K08 (Beeson Award) - Division of Geriatrics • Dave Hinkle, MD, PhD - K08 P M b d PhD K99• Pier Mastroberardino, PhD - K99 • Samay Jain, MD - K12y
  • 46. Graduate students • 12 Pitt PhD students (4 MD-PhD) • CNUP Pharmacology MBSB• CNUP, Pharmacology, MBSB • Visiting students from University of Padova, U i it f I b iUniversity of Insubria • Formal exchange agreements with University of Insubria & Mondino Neurological Institute
  • 47. Postdocs • 26 postdocs • PhDs from Pitt Michigan Michigan State• PhDs from Pitt, Michigan, Michigan State, Rome, Padova, Insubria, Navarra 2 RiMED f ll (J i t UPMC Si il )• 2 RiMED fellows - (Joint UPMC-Sicily program)
  • 48. Journal Editors • Molecular Endocrinology, Don DeFranco, editor (IF 5.4)( ) • Neurobiology of Disease, Tim Greenamyre, editor (IF 4.4)(IF 4.4) • Progress in Neurobiology, Michael Zigmond, editor (IF 10 5)(IF 10.5)

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