roundtable     FRAMEWORKS & CHALLENGES ASSOCIATED WITHBIO-PROSPECTING & TECHNOLOGICAL DEVELOPMENT IN THE         BRAZILIAN...
OBJECTIVES Provide an overview of the genetic & human assets, theongoing bio-prospecting and technological development    ...
AUDIENCE About 80 attendees Countries represented   – Brazil, Canada, United States, United Kingdom,     Sweden, Switzer...
AUDIENCE Institutions represented    – ABDI - Brazilian Agency for Industrial      Development; ANPROTEC; Biotechnology I...
Opportunites & ChallengesBy Stakeholder GroupDISCUSSION HIGHLIGHTS
INVESTORS & COLLABORATORS                    OPPORTUNITIES                                                    CHALLENGES1....
INSTITUTES OF SCIENCE & TECHNOLOGY                     OPPORTUNITIES                                                      ...
STARTUPS                   OPPORTUNITIES                                                 CHALLENGES1. Accelerate the growt...
Prof. Dr. Carlos Gustavo Nunes, M.Sc., Ph.D.UFAM, Manaus, AM, Brazilcgustavo@ufam.edu.br | cgustavo@biotechamazonia.comPRE...
A BRIEF MESSAGE Brazil will grant 75,000 scholarships over the next four-year period, five  times the current number.    ...
Over 55% Brazil’s land
Amazon river holds about  17% of all fresh waterIt pours millions cubic feet of water into the Atlantic      EVERY SECOND
The most extraordinary  attribute of life is its       diversity…The Amazon rain forest  is the pinnacle of it.
THE BIODIVERSITY IN              NUMBERS Plants    – 300 different species in one ha. Animals    – ~3,000 different fish...
CONVENTIONAL USE OF TROPICAL FORESTS–Agriculture–Pasture–Extraction  •Minerals, gas and petroleum  •Wood
RATIONAL USES OF TROPICAL FORESTS Establishment of Research & Innovation Parks   –   Bio-prospecting /discovery   –   Bio...
A NEW GEOGRAPHY OF SCIENTIFIC COLLABORATIONS      Brazilian Amazon: the yet unknown profile                               ...
PROTEAM                                          Biodiversity, Conservation & Guarana (Paullinia cupana)                  ...
SCIENCE AND TECHNOLOGY PARK    FOR SOCIAL INCLUSIONFEDERAL UNIVERSITY OF AMAZONAS            UFAM
PCTIS: A NEW APROACH     FOR SUSTAINABILITY Modern concept:  Innovation Network  ~500 researchers in    networking  ~100 ...
BIOTECHNOLOGY IN THE PCTIS Biocentro focus  – Biotechnology development  – Working on Amazon biodiversity  – Innovation  ...
BIOCENTRO: R&D New enzymes Antibiotics Anti-cancer molecules Pigments, dyes Biocides (pesticides,  fungicides) Diagn...
 Challenges   – Million compounds and     molecules waiting for     characterization   – Incipient bio-industry   – Scarc...
PCTIS proposal                                 Management         Innovation                       Social inclusion       ...
Partnering Institutions(Technology development, technical, material & financial support, consulting)                      ...
Roundtable Bioprospecting at Brazilian Amazon, Boston, June18, 2012 - Discussion highlights & presentation
Roundtable Bioprospecting at Brazilian Amazon, Boston, June18, 2012 - Discussion highlights & presentation
Roundtable Bioprospecting at Brazilian Amazon, Boston, June18, 2012 - Discussion highlights & presentation
Roundtable Bioprospecting at Brazilian Amazon, Boston, June18, 2012 - Discussion highlights & presentation
Roundtable Bioprospecting at Brazilian Amazon, Boston, June18, 2012 - Discussion highlights & presentation
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Roundtable Bioprospecting at Brazilian Amazon, Boston, June18, 2012 - Discussion highlights & presentation

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An initiative of EXCEED AMERICAS, with the support of BIO International Convention and the Licensing Executives Society (LES) – Brazil Chapter, the roundtable “Frameworks & Challenges Associated with Bio-Prospecting & Technological Development in the Brazilian Amazon & Similar Regions” was held on June 18, 2012, at the Westin Boston Waterfront Hotel. The roundtable objectives were:

a. Provide an overview of the genetic & human assets, the ongoing bio-prospecting and technological development in the Brazilian Amazon;

b. Stimulate cross-pollination of best practices in the Amazon and other similar regions;

c. Develop a framework to minimize bio-prospecting challenges;

d. Discuss bio-prospecting as a key strategy towards technological development and the sustainable growth of the global economy.

This document highlights the opportunities and challenges discussed during the roundtable and includes the 15-minute presentation of Prof. Dr. Carlos Gustavo Nunes da Silva, DSc, PhD, Professor of Molecular Biology and Genetic Engineering of UFAM-Federal University of Amazonas.

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Roundtable Bioprospecting at Brazilian Amazon, Boston, June18, 2012 - Discussion highlights & presentation

  1. 1. roundtable FRAMEWORKS & CHALLENGES ASSOCIATED WITHBIO-PROSPECTING & TECHNOLOGICAL DEVELOPMENT IN THE BRAZILIAN AMAZON & SIMILAR REGIONS Boston, June 18, 2012 Sponsorship & Organization Promotional Support
  2. 2. OBJECTIVES Provide an overview of the genetic & human assets, theongoing bio-prospecting and technological development in the Brazilian AmazonStimulate cross-pollination of best practices in the Amazon and other similar regions Develop a framework to minimize bio-prospecting challenges Discuss bio-prospecting as a key strategy towardstechnological development and the sustainable growth of the global economy.
  3. 3. AUDIENCE About 80 attendees Countries represented – Brazil, Canada, United States, United Kingdom, Sweden, Switzerland Companies represented – Abbott; AstraZeneca R&D Lund; Bioamber, Inc.; Bristol-Myers Squibb; Burrill & Company; Debiopharm AS; DuPont; Eli Lilly & Company; FIOCRUZ; FKBiotec; GlaxoSmithkline; INCT (National Institute of Science & Technology) Nanobiotecnologia; Johnson & Johnson; Keller and Heckman LLP; Leonardos & Licks Advogados; MedStar Cleveland Clinic Innovation Alliance; Merck-Serono; Monsanto Company; Nanodynamics; Pfizer, Inc.; Sanofi; SinoVeda Canada; Synthetic Genomics, Inc.; TransLegal, LLC; UBS Financial Services
  4. 4. AUDIENCE Institutions represented – ABDI - Brazilian Agency for Industrial Development; ANPROTEC; Biotechnology Industry Organization; BrBIOTEC; BIO-RIO Foundation; MPEG - Museu Paraense Emílio Goeldi; National Research Council Canada; IP Network of the Minas Gerais State; René Rachou Research Center - CPqRR – Fiocruz, Minas Gerais; SENAI Innovation Institute CETEC-SENAI; State Secretariat of Science, Technology & Higher Education, Government of Minas Gerais; State Secretariat of Science, Technology and Innovation, Government of Pará; UFAM - Universidade Federal do Amazonas; UFMG - Universidade Federal de Minas Gerais; UNB - Universidade de Brasília.
  5. 5. Opportunites & ChallengesBy Stakeholder GroupDISCUSSION HIGHLIGHTS
  6. 6. INVESTORS & COLLABORATORS OPPORTUNITIES CHALLENGES1. Early access to matchless molecules and compounds in 1. Complexity of accessvarious sectors a. The extract collections are spread in several storagea. Massive collections of extracts to be screened; areas, which reduces the efficiency of access andb. Natural compounds with biological activity already scalability; identified. b. Need to boost the screening / characterization of Amazon molecular wealth and compounds; c. Platform fragmentation – a centralized, automated and controlled lab will require large investments.2. Capitalize on the biotech momentum 2. Investment risksa. Bring technology and funds to create a unique, a. Must establish clearer policies and priorities towards centralized and automated storage and research lab in investment in biotechnology innovation; the Amazon region; b. Regulations must be harmonized / streamlined in orderb. Boost the screening of extracts through technology to make the country competitive; transfer and collaborative partnerships; c. Bureaucracy - lengthy timelines to import researchc. The sprouting bio-industry in Brazil and the untapped materials, to obtain patents, registration and licenses R&D potential offer vast opportunity to the for both research and clinical trials, to register products, establishment of new, innovative enterprises. to access the bio assets; d. The establishment of biotechnology university spinoffs is embryonic which makes it challenging to identify those of attractive investment grade.
  7. 7. INSTITUTES OF SCIENCE & TECHNOLOGY OPPORTUNITIES CHALLENGES1. Increase R&D activities 1. Legal frameworka. Characterize million compounds and molecules; a. Unclear policies to access Brazilian biodiversity;b. Bring thousands of compounds in early stages of b. Increased risk to investors: massive fines and litigation for development to clinical. an unclear regulatory system; c. Patent Office genetic resource patent filing requirements greatly increase risk of investment: i. Compliance mechanisms should not be in the Patent Office as genetic resource is not yet invention. d. A new regulatory framework is under discussion: i. Regulations must be harmonized / streamlined in order to attract R&D private investments.2. Boost R&D partnerships 2. Infrastructure & Bureaucracya. Benefit from the increased demand of national a. Lengthy timelines to import research materials; corporations for new technologies; b. Complex and lengthy clinical trials approval process;b. Capitalize on the current interest of transnational c. Risks to invest due to current policies and bureaucracy organizations to build or increase presence in Brazil; (refer to topic I. Investors & Collaborators);c. The larger share of biodiversity assets are in the Brazilian d. Although the Brazilian Amazon region is the core of the Amazon region: biodiversity in the planet, its characteristics make it a i. This may confer the region the status of a challenging place to develop a biotech cluster. potential biotechnology ST&I valley in the globe.3. Fuel the establishment of university spinoffs 3. Scarce private / venture capitala. New regulatory framework in place to register biological a. Mechanisms to encourage the creation of new spinoffs products and stimulate startup creation. need to be further expanded or even created in some states: i. Boston biotechnology cluster is an example.
  8. 8. STARTUPS OPPORTUNITIES CHALLENGES1. Accelerate the growth of startups 1. Infrastructure & Bureaucracya. The developing bio-industry, and the number of a. Need to further improve the approval process of bio- compounds and molecules to be characterized embody based projects; vast opportunity to the establishment of new b. Current infrastructure of public agencies do not support businesses. the growing demand for new projects and start-ups approvals; c. Not enough auditors and consultants specialized in the assessment of bio-based projects: d. Dedicated educational programs have been recently launched.2. Partner with tech-based local and international 2. Lack of resources for internationalizationorganizations and institutions, to combine knowledge, a. International expertise in early stages:resources and fill technology gaps. i. The Triple Helix innovation model locally adopted in some states of Brazil needs to be further stimulated in other regions; ii. And further stimulated at the international scope.
  9. 9. Prof. Dr. Carlos Gustavo Nunes, M.Sc., Ph.D.UFAM, Manaus, AM, Brazilcgustavo@ufam.edu.br | cgustavo@biotechamazonia.comPRESENTATION
  10. 10. A BRIEF MESSAGE Brazil will grant 75,000 scholarships over the next four-year period, five times the current number. – Goal: to promote the consolidation and expansion of ST&I in Brazil by means of international exchange and mobility. The strategy aims to: – Increase the presence of students, scientists and industry personnel from Brazil in international institutions of excellence; – Encourage young talents and highly qualified researchers from abroad to work with local investigators in joint projects; – Induce the internationalization of Brazilian universities and research centers.
  11. 11. Over 55% Brazil’s land
  12. 12. Amazon river holds about 17% of all fresh waterIt pours millions cubic feet of water into the Atlantic EVERY SECOND
  13. 13. The most extraordinary attribute of life is its diversity…The Amazon rain forest is the pinnacle of it.
  14. 14. THE BIODIVERSITY IN NUMBERS Plants – 300 different species in one ha. Animals – ~3,000 different fish species – 30% of the birds in the world – Most of the small poisonous amphibians – New insects species being discovered every day Microorganisms – Beyond reasonable assessment Unique ecological relationships – Physiology – Behavior – Biochemistry
  15. 15. CONVENTIONAL USE OF TROPICAL FORESTS–Agriculture–Pasture–Extraction •Minerals, gas and petroleum •Wood
  16. 16. RATIONAL USES OF TROPICAL FORESTS Establishment of Research & Innovation Parks – Bio-prospecting /discovery – Bio and nanotechnologies – Bio and environmental engineering – Technology transfer Management and sustainability – Forest-based management – Non wood materials – Agro energy – Ecotourism – Social inclusion
  17. 17. A NEW GEOGRAPHY OF SCIENTIFIC COLLABORATIONS Brazilian Amazon: the yet unknown profile UFAP UFRR EMBRAPA UFAM EMBRAPA UFAM UFOPA UFAM UFMA UFAM UFAM UEMA UFAM UFPA PETROBRAS INPA UFRA EMBRAPA VALE MEG FIOCRUZ UFAM EMBRAPA UFAC UEA PCTG EMBRAPA SUFRAMA UNIR HEMOAM UFTO IPEPATRO PCTIS EMBRAPA FIOCRUZ EMBRAPA UFMT UEMTCollections Petro/mining Tech Industry R&D Inst. Universities R&D in Health
  18. 18. PROTEAM Biodiversity, Conservation & Guarana (Paullinia cupana) Biotechnology networkChromobacterium violaceum 22 institutions 20 Projects (ongoing) Doctoral Program with 100 projects (begining) www.bionorte.org.br REALGENE Amazonian Genome and Transcriptome network REDEBIO Guarana transciptome + 10 other genomes/transcriptome Dermatology & Cosmetic About 120 researchers from Development several institutions of all Amazon States
  19. 19. SCIENCE AND TECHNOLOGY PARK FOR SOCIAL INCLUSIONFEDERAL UNIVERSITY OF AMAZONAS UFAM
  20. 20. PCTIS: A NEW APROACH FOR SUSTAINABILITY Modern concept: Innovation Network ~500 researchers in networking ~100 projects – Over 100 partners • Government • Companies • NGOs – Traditional communities (over 1,000)
  21. 21. BIOTECHNOLOGY IN THE PCTIS Biocentro focus – Biotechnology development – Working on Amazon biodiversity – Innovation – Sustainability – Training of traditional communities, researchers, graduates and postgraduate
  22. 22. BIOCENTRO: R&D New enzymes Antibiotics Anti-cancer molecules Pigments, dyes Biocides (pesticides, fungicides) Diagnosis and tests
  23. 23.  Challenges – Million compounds and molecules waiting for characterization – Incipient bio-industry – Scarce private / venture capital Tackling it – Develop and attract key expertise – Accelerate the creation of startups – Attract bio-industry – Encourage private investment and partnerships
  24. 24. PCTIS proposal Management Innovation Social inclusion Technology transfer Government Environmental protection Industry People EDUCATION
  25. 25. Partnering Institutions(Technology development, technical, material & financial support, consulting) Rede NIT Amazônia Oriental Rede NIT Amazônia Ocidental FIOCRUZ

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