Your SlideShare is downloading. ×
0
Osteoarthritis
Osteoarthritis
Osteoarthritis
Osteoarthritis
Osteoarthritis
Osteoarthritis
Osteoarthritis
Osteoarthritis
Osteoarthritis
Osteoarthritis
Osteoarthritis
Osteoarthritis
Osteoarthritis
Osteoarthritis
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×
Saving this for later? Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime – even offline.
Text the download link to your phone
Standard text messaging rates apply

Osteoarthritis

748

Published on

osteoarthritis

osteoarthritis

Published in: Health & Medicine, Technology
0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
748
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
50
Comments
0
Likes
1
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
No notes for slide
  • We will focus on adaptive responses. All these feature of an adaptive response require very specific interactions of molecules. Will describe B and T cells and their roles. Immunological memory - vaccination
  • The important difference between B and T cells is how they can recognize antigens.
  • • Antibody producing, have membrane bound antibodies, proliferation......., memory – plasma, point out the molecular interactions.
  • • Has a T-cell receptor – only recognition of antigens together with MHC molecules. Explain how this work and the difference between class I and class II molecules. Point out the importance of molecular interaction. Explain how Th cells can help B cells - drawing
  • Draw the pictures!!!!
  • Transcript

    • 1. SECONDARY OA: Appears at any age in apreviously damaged or congenitally abnormaljoint . OA is a “wear and tear” phenomenon.Indeed the vertebrae , hips and knees are mostaffected . OA can be superimposed uponRHEUMATOID ARTHRITIS.
    • 2. Two main theories:1)BIOMECHANICAL THEORY2)BIOCHEMICAL THEORY
    • 3.  This maintains the wear and tear leads to deranged function,focal death, and reactive proliferation of chondrocytes. Collagen breakdown , fissuring and flaking and osteophyte formation occurs.
    • 4. maintains that aging leads to lessenedmatrix maintenance and excess oflytic enzymes , which in turns lead tosynovitis . Synovitis further results ina release of inflammatory mediatorsand cytokines(especially IL-1) ,degradative enzymes and freeradicals and eventually chondrocytedeath.
    • 5.  Primary abnormality is thinning and fragmentation of the articular cartilage. Loss of articular cartilage leads to exposure of subchondral bone , which appears as shiny foci on the articular surface( enburnation ). New bone formation , usually in the form of nodules (spurs). Formation of osteocartilagenous loose bodies (“joint mice”). Inflammation is absent.
    • 6. CLINICAL FEATURES:Although OA may be asymptomatic,most patients experience morning stiffness in affected joints . There is usually no local heat or tenderness , but affected joints often show restricted range of motion , small efusions and crepitus. A slowly progressive disease characterized by joint disability.It is associated with ALKAPTONUREA and FOOTBALL PLAYERS.
    • 7. OSTEOARTHRITIS IN KNEE JOINT.
    • 8. OSTEOARTHRITIS.

    ×