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Osteoarthritis
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osteoarthritis

osteoarthritis

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  • We will focus on adaptive responses. All these feature of an adaptive response require very specific interactions of molecules. Will describe B and T cells and their roles. Immunological memory - vaccination
  • The important difference between B and T cells is how they can recognize antigens.
  • • Antibody producing, have membrane bound antibodies, proliferation......., memory – plasma, point out the molecular interactions.
  • • Has a T-cell receptor – only recognition of antigens together with MHC molecules. Explain how this work and the difference between class I and class II molecules. Point out the importance of molecular interaction. Explain how Th cells can help B cells - drawing
  • Draw the pictures!!!!

Transcript

  • 1. SECONDARY OA: Appears at any age in apreviously damaged or congenitally abnormaljoint . OA is a “wear and tear” phenomenon.Indeed the vertebrae , hips and knees are mostaffected . OA can be superimposed uponRHEUMATOID ARTHRITIS.
  • 2. Two main theories:1)BIOMECHANICAL THEORY2)BIOCHEMICAL THEORY
  • 3.  This maintains the wear and tear leads to deranged function,focal death, and reactive proliferation of chondrocytes. Collagen breakdown , fissuring and flaking and osteophyte formation occurs.
  • 4. maintains that aging leads to lessenedmatrix maintenance and excess oflytic enzymes , which in turns lead tosynovitis . Synovitis further results ina release of inflammatory mediatorsand cytokines(especially IL-1) ,degradative enzymes and freeradicals and eventually chondrocytedeath.
  • 5.  Primary abnormality is thinning and fragmentation of the articular cartilage. Loss of articular cartilage leads to exposure of subchondral bone , which appears as shiny foci on the articular surface( enburnation ). New bone formation , usually in the form of nodules (spurs). Formation of osteocartilagenous loose bodies (“joint mice”). Inflammation is absent.
  • 6. CLINICAL FEATURES:Although OA may be asymptomatic,most patients experience morning stiffness in affected joints . There is usually no local heat or tenderness , but affected joints often show restricted range of motion , small efusions and crepitus. A slowly progressive disease characterized by joint disability.It is associated with ALKAPTONUREA and FOOTBALL PLAYERS.
  • 7. OSTEOARTHRITIS IN KNEE JOINT.
  • 8. OSTEOARTHRITIS.