Rethinking Aids Conference - Oakland - November 6-8, 2009   Questioning the Existence of HIV                              ...
Questioning the Existence of HIVAids Rethinkers have different scientific arguments     on the issue of the very existence...
Two radically distinct positions• HIV ‘exists’ but is a “harmless passenger virus”• HIV does not exist                    ...
Two radically distinct positionsNeither of these two positions is fully compatible      with the available scientific evid...
An alternative analysis is therefore suggested                        Questioning the Existence of HIV, E. de Harven
Human Endogenous Retroviruses (HERVs)interfere heavily with findings and interpretation in   AIDS research and may offer a...
Two significant papers on HERVs:1) “The viruses in all of us: characteristics and   biological significance of human endog...
A sizable percentage of the human genome, perhaps as muchas 8%, shows strong analogies to the retroviral genome.Therefore,...
The method used for the determination of                      the alleged“HIV viral load” does not include the isolation o...
"Viral load" means the presence of virus particles      in the peripheral blood, i.e. "viremia"                           ...
In leukaemic mice and chicken, large numbersof retroviral particles can easily bedemonstrated by electron microscopy in sm...
Retroviruses in the blood of leukemic mice                       Questioning the Existence of HIV, E. de Harven
Problems with isolating HIV    Nobody ever succeeded to demonstrateretroviral particles in the blood of AIDS patients,  ev...
Problems with isolating HIV• Non pathogenic viruses are readily visualized  by electron microscopy• Pathogenic and non-pat...
A historic paper was published in Science in 1983 byF. Barré-Sinoussi, Luc Montagnier and their collaborators             ...
The picture, unquestionably, illustrates the assembly ("budding") of     retroviruses on the cell surface of lymphocytes w...
Such electron microscopy evidence is similar to theclassic images of "budding" retrovirus, which I havepublished many year...
Budding of murine Friend leukemia virus                                       Questioning the Existence of HIV, E. de Harv...
However, the retrovirus producing cells in the French      publication are cord blood, placenta derived  lymphocytes. The ...
• Human placenta is loaded with endogenous retroviruses (HERVs)• Pasteur group added HERVs of placental origin to their ce...
HERVs interfere with the interpretation of  clinical studies of AIDS patients ("Viral load") as well as with the analysis ...
So-called "HIV" has never beenneither isolated nor purified directly from             an AIDS patient                     ...
Difficulties to isolate and purify a so-called "HIV" have been initially stressed by Eleni Papadopulos et al. as early as ...
Recognizing the non-existence of so-called   exogenous "HIV”, and the role of HERVs in   clinical and in basic science stu...
Questioning the Existence of HIV, E. de Harven
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Dr. Etienne De harven

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Presentation of Dr. Etienne de Harven at the 2009 Rethinking Aids Conference

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Dr. Etienne De harven

  1. 1. Rethinking Aids Conference - Oakland - November 6-8, 2009 Questioning the Existence of HIV Etienne de Harven, MDFormer Member of the Sloan Kettering Institute, New YorkEmerit. Prof. Pathology, Univ. of TorontoMember of President T. Mbeki AIDS Advisory Panel, SA Questioning the Existence of HIV, E. de Harven
  2. 2. Questioning the Existence of HIVAids Rethinkers have different scientific arguments on the issue of the very existence of HIV Questioning the Existence of HIV, E. de Harven
  3. 3. Two radically distinct positions• HIV ‘exists’ but is a “harmless passenger virus”• HIV does not exist Questioning the Existence of HIV, E. de Harven
  4. 4. Two radically distinct positionsNeither of these two positions is fully compatible with the available scientific evidence Questioning the Existence of HIV, E. de Harven
  5. 5. An alternative analysis is therefore suggested Questioning the Existence of HIV, E. de Harven
  6. 6. Human Endogenous Retroviruses (HERVs)interfere heavily with findings and interpretation in AIDS research and may offer an alternative explanation of the published data Questioning the Existence of HIV, E. de Harven
  7. 7. Two significant papers on HERVs:1) “The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences”, Löwer R. et al., Proc Natl Acad Sci USA, 19962) “Demystified ... Human endogenous retroviruses”, Nelson, P.N. et al., Mol Pathol. 2003 Questioning the Existence of HIV, E. de Harven
  8. 8. A sizable percentage of the human genome, perhaps as muchas 8%, shows strong analogies to the retroviral genome.Therefore, pellets centrifuged from human plasma, with variableamounts of circulating DNA, inevitably contain retroviral-likesequences. Identified and amplified by PCR methodologies,these sequences are possibly misinterpreted as HIV markersand used for the alleged quantification of the hypothetical HIV“viral load”. Questioning the Existence of HIV, E. de Harven
  9. 9. The method used for the determination of the alleged“HIV viral load” does not include the isolation of retroviralparticles and the analyzed pellets have never beencontrolled by electron microscopy to verify thehypothetical presence of such particles Questioning the Existence of HIV, E. de Harven
  10. 10. "Viral load" means the presence of virus particles in the peripheral blood, i.e. "viremia" Questioning the Existence of HIV, E. de Harven
  11. 11. In leukaemic mice and chicken, large numbersof retroviral particles can easily bedemonstrated by electron microscopy in smallsamples of peripheral blood Questioning the Existence of HIV, E. de Harven
  12. 12. Retroviruses in the blood of leukemic mice Questioning the Existence of HIV, E. de Harven
  13. 13. Problems with isolating HIV Nobody ever succeeded to demonstrateretroviral particles in the blood of AIDS patients, even in those patients identified by PCR as presenting with high "viral load" Questioning the Existence of HIV, E. de Harven
  14. 14. Problems with isolating HIV• Non pathogenic viruses are readily visualized by electron microscopy• Pathogenic and non-pathogenic viruses look alike under the electron microscope• Exogenous and endogenous retroviruses look alike under the electron microscope Questioning the Existence of HIV, E. de Harven
  15. 15. A historic paper was published in Science in 1983 byF. Barré-Sinoussi, Luc Montagnier and their collaborators at the Pasteur Institute in Paris Questioning the Existence of HIV, E. de Harven
  16. 16. The picture, unquestionably, illustrates the assembly ("budding") of retroviruses on the cell surface of lymphocytes which had been added to the complex cell cultures studied at the Pasteur Institute. Questioning the Existence of HIV, E. de HarvenBarré-Sinoussi et al. 1983
  17. 17. Such electron microscopy evidence is similar to theclassic images of "budding" retrovirus, which I havepublished many years ago in studies of the murineFriend leukemia virus Questioning the Existence of HIV, E. de Harven
  18. 18. Budding of murine Friend leukemia virus Questioning the Existence of HIV, E. de HarvenExperimental Leukemia, Rich M., 1968
  19. 19. However, the retrovirus producing cells in the French publication are cord blood, placenta derived lymphocytes. The paper fails to demonstrate that theobserved retroviruses originated from a "pre-AIDS" patient. Questioning the Existence of HIV, E. de Harven
  20. 20. • Human placenta is loaded with endogenous retroviruses (HERVs)• Pasteur group added HERVs of placental origin to their cell cultures• Retro-viral particle formation could be shown under these conditions• This was not possible when using peripheral blood lymphocytes instead of cord blood lymphocytes Placenta derived HERVs were essential for observation of retroviruses Questioning the Existence of HIV, E. de Harven
  21. 21. HERVs interfere with the interpretation of clinical studies of AIDS patients ("Viral load") as well as with the analysis of the original 1983 Pasteur Institute paper Questioning the Existence of HIV, E. de Harven
  22. 22. So-called "HIV" has never beenneither isolated nor purified directly from an AIDS patient Questioning the Existence of HIV, E. de Harven
  23. 23. Difficulties to isolate and purify a so-called "HIV" have been initially stressed by Eleni Papadopulos et al. as early as 1993, in the classic Biotechnology paperSuch difficulties are best explained by recognizing the fact that a so-called exogenous "HIV" does not exist, as stated in 1994 by Stefan Lanka Questioning the Existence of HIV, E. de Harven
  24. 24. Recognizing the non-existence of so-called exogenous "HIV”, and the role of HERVs in clinical and in basic science studies should redirect completely AIDS research(see ‘Chemical bases of various AIDS epidemics: recreational drugs, anti-viral chemotherapy and malnutrition’, Duesberg, Köhnlein and Rasnick, 2003) Questioning the Existence of HIV, E. de Harven
  25. 25. Questioning the Existence of HIV, E. de Harven

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