Stem cells background


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Stem cells background

  1. 1. STEM CELL SCAN – Stem Cell Action Network
  2. 2. Stem Cells and Regenerative Biology <ul><li>Major Topics for Discussion : </li></ul><ul><li>What are Stem Cells? </li></ul><ul><li>What are the major types of Stem Cells and where are they found? </li></ul><ul><li>Advantages & Disadvantages to ESCs and ASCs </li></ul><ul><li>Why are Stem Cells so very important? </li></ul><ul><li>The Controversy over Stem Cells? </li></ul>
  3. 3. What Are Stem Cells? <ul><li>Stem cells are the raw material from which all of the body’s mature, differentiated cells are made. Stem cells give rise to brain cells, nerve cells, heart cells, pancreatic cells, etc. </li></ul>
  4. 4. What’s So Special About Stem Cells? <ul><li>They have the potential to replace cell tissue that has been damaged or destroyed by severe illnesses. </li></ul><ul><li>They can replicate themselves over and over for a very long time. </li></ul><ul><li>They can divide and make identical copies of </li></ul><ul><li>themselves over and over again ( Self-Renewal ) </li></ul><ul><li>Understanding how stem cells develop into healthy and diseased cells will assist the search for cures. </li></ul>
  5. 5. The Major Types of Stem Cells <ul><li>Embryonic Stem Cells </li></ul><ul><ul><li>Embryonic (also called “pluripotent”) stem cells are capable of developing into all the cell types of the body. </li></ul></ul><ul><li>B. Adult Stem Cells </li></ul><ul><li>Adult stem cells are less versatile and more difficult to identify, isolate, and purify. </li></ul><ul><ul><li>Stem cells have been found in the blood, bone marrow, liver, kidney, cornea, dental pulp, umbilical cord, brain, skin, muscle, salivary gland . . . . </li></ul></ul>
  6. 6. Advantages and Disadvantages to Embryonic and Adult Stem Cells. Embryonic S.C. Adult S.C. “ Pluripotent” (can become any cell) “ Multipotent” (“can become many but not any”) Stable. Can undergo many cell divisions. Less Stable. Capacity for self-renewal is limited. Easy to obtain but blastocyst is destroyed. Difficult to isolate in adult tissue. Possibility of rejection?? Host rejection minimized
  7. 7. Reprinted with permission of Do No Harm . Click on image for link to website.
  8. 8. Embryonic Stem Cells: SCAN – Stem Cell Action Network Researchers extract stem cells from a 5-7 days old blastocyst . Stem cells can divide in culture to form more of their own kind, thereby creating a stem cell line. The research aims to induce these cells to generate healthy tissue needed by patients.
  9. 9. Reprinted with permission of Do No Harm . Click on image for link to website.
  10. 11. Stem-cell
  11. 12. Why is Stem Cell Research So Important to All of Us? <ul><li>Stem cells allow us to study how organisms grow and develop over time. </li></ul><ul><li>Stem cells can replace diseased or damaged cells that can not heal or renew themselves. </li></ul><ul><li>We can test different substances (drugs and chemicals) on stem cells. </li></ul><ul><li>We can get a better understanding of our “genetic machinery.” </li></ul>
  12. 13. What Human Diseases are Currently Being Treated with Stem Cells? <ul><li>Parkinson’s Disease </li></ul><ul><li>Leukemia (Bone Marrow Transplants) </li></ul><ul><li>Skin Grafts resulting from severe burns </li></ul><ul><li>Stem Cell Therapy has the Potential to : </li></ul><ul><li>Regenerate tissues/organs </li></ul><ul><li>Cure diseases like diabetes, multiple sclerosis, etc. </li></ul>
  13. 14. Click Below for Tutorial Caption: This image depicts a colony of human embryonic stem cells grown over a period of 10 months in the absence of mouse feeder cells. The cell nuclei are stained green; the cell surface in red. Photo Credit: Courtesy Ren-He Xu/University of Wisconsin
  14. 15. Home-learning (4/7 4/8) <ul><li>Use library or internet resources to lean more about stem-cell research, then write a brief report on how the technology will impact the future of medicine. </li></ul>
  15. 16. <ul><li>STEM CELL GUY </li></ul>
  16. 17. Why the Controversy Over Stem cells? <ul><li>Embryonic Stem cells are derived from extra blastocysts that would otherwise be discarded following IVF. </li></ul><ul><li>Extracting stem cells destroys the developing blastocyst (embryo). </li></ul><ul><li>-Questions for Consideration- </li></ul><ul><li>Is an embryo a person? </li></ul><ul><li>Is it morally acceptable to use embryos for research? </li></ul><ul><li>When do we become “human beings?” </li></ul>For further information: