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  • 1. Oral Immunobiology Robert J. Boackle, Ph.D., Course Director Office Room 441 BSB, phone 792-2551 e-mail: boacklrj@musc.edu http://people.musc.edu/~boacklrj/Syllabus_.htm Home Page: http://www.edserv.musc.edu/Oral_Biology MICROBIOLOGY/IMMUNOLOGY (MBIM) - 624 (Dental Students) MICROBIOLOGY/IMMUNOLOGY (MBIM) - 702 (Graduate Students) Credit Hours 3.5 College of Dental Medicine, Medical University of South Carolina Lecture Schedule / Syllabus Spring Semester Room 502, Basic Science Dental Building Textbook: Medical Immunology, Edited by Gabriel Virella, Marcel Dekker Pub., 6th edition. See the sample questions at the end of the Chapters, some of these may appear on the Quizzes. Please purchase your books early, as questions on the examinations may be asked directly from this book. Dental students and medical students use this textbook; therefore you may be able to obtain a used book. Attendance in class, lab demonstrations and small groups is required. Announcements will be sent by e-mail to the entire class. If there are problems with ice on the bridges (or other emergency conditions), please check your e-mail for information about alterations in class times. Please open the link Dental Immunobiology Reports and read very carefully! Students are encouraged to briefly look over the course material in advance of each lecture as illustrated below. http://people.musc.edu/~boacklrj/StudyImmunobiology.ppt Please note that the topic "Library Research-Prepare as a group to meet with instructors" is to provide your small group the needed time to review each other’s manuscript topics and manuscripts, as you begin to prepare for the meetings with instructors (see below). Practice your questions and discussions. We plan to have an upperclassman Teaching Assistant (TA) to help groups get organized. This year the TA is Ms. Mallory Groves groves@musc.edu, phone number 1-803-606-7740. She will need at least a 10 day advanced email notice and also a one-week advanced phone notice of a meeting time with your group (Mallory is a busy senior CDM student). 1/3 Wednesday 8:00 Introduction to Oral Immunobiology Boackle 9:00 Overview of the Immune Response Boackle http://people.musc.edu/~boacklrj/IntroductionImmunology.pdf 1/5 Friday 8:00 Clonal Responses Boackle 9:00 Introduction to Immune Recognition, MHC Boackle 1/10 Wednesday 8:00 Cells and Tissues of the Immune Response L. London 9:00 Ontogeny of Cell Mediated Immunity L. London All groups should have contacted the Teaching Assistant by this time.
  • 2. Extra Credit Take Home Test (Worth up to 2 Extra Points on your final grade) due 1/26 at 8:00 AM 1/12 Friday 8:00 Library Research Prepare as a group to meet with instructors Boackle *9:00 Library Research Prepare as a group to meet with instructors Boackle *Or at 9:00 AM, if extra time is needed, a continuation of the lecture Ontogeny of Cell Mediated Immunity L. London 1/17 Wednesday 8:00 Immunobiology Examination I (90 min) Boackle Students will not be allowed to ask any questions once the exam begins. Multiple choice questions will be the likely format. Please be sure to fill-in nine numbers for your student number on your answer sheet. Any nine digit number is fine, but not your SS# and not your student number. Every blank in the "student number" spaces on the answer sheet must be filled. Also, you must fill-in the entire circle on your answer sheet or the computer will grade your answer as incorrect. 1/19 Friday 8:00 Cell Mediated Immunity CMI-function S. London 9:00 Mediators of Cellular Immunity S. London --(Proinflammatory cytokines) 1/24 Wednesday 8:00 Immunoglobulins - Structure Boackle For additional information on somatic hypermutation select http://people.musc.edu/~boacklrj/Hypermutation-B-clones.pdf 9:00 Antigen-Antibody Reactions Boackle 1/26 Friday 8:00 Complement - Classical Pathway Boackle 9:00 Complement II Boackle 1/31 Wednesday 8:00 Complement and Disease III Boackle 9:00 Complement and Disease IV Boackle 2/02 Friday 8:00 Library Research Prepare as a group to meet with instructors. Boackle 9:00 Mucosal Immunity Lathers http://people.musc.edu/~boacklrj/MucosalImmunity.pdf 2/07 Wednesday 8:00 Immunobiology Examination II Boackle 2/09 Friday 8:00 Immunodeficiency Virella http://people.musc.edu/~boacklrj/VirellaImmunodefDis.pdf 9:00 Immunization/Vaccines Virella http://people.musc.edu/~boacklrj/VirellaVaccines.pdf
  • 3. 2/14 Wednesday 8:00 Hypersensitivity Reactions Virella 9:00 Allergy Virella http://people.musc.edu/~boacklrj/Virella-Allergy.pdf 2/14 Wednesday Wednesday 8:00 Library Research http://people.musc.edu/~boacklrj/Reports_.htm Boackle 9:00 HIV - AIDS - Candida Westwater Please read the following two papers http://people.musc.edu/~boacklrj/HIV-Mucosa.pdf http://people.musc.edu/~boacklrj/ImpairedPhagoHIVMacro.pdf Take Home Test worth 20 extra points on Examination 3 (due at 8:00 am) 2/16 Friday 8:00 Library Research, Prepare as a group to meet with instructors. Boackle 8:00 Tolerance and Autoimmunity Virella http://people.musc.edu/~boacklrj/VirellaTolAutoi.pdf 2/21 Wednesday 8:00 Examination III 2/23 Friday Library Research, Prepare as a group to meet with instructors. Boackle 9:00 Inflammation Virella http://people.musc.edu/~boacklrj/Virella-Inflammation.pdf 2/28 Wednesday Lab Demonstrations SEE SLIDES at http://people.musc.edu/~boacklrj/LabDemonstration.ppt The First Library Report is due when the class attends the Laboratory Demonstrations at 8:00 AM. http://people.musc.edu/~boacklrj/Reports_.htm Please provide all reports as a group-set, and by group #, not individually). Each individual report must have a copy of the respective published article attached (stapled to your report). Remember to make a copy of your report for yourself! [Turn in your reports as a group to Room 502 BSB at 8:00 AM, just before the Lab demonstrations]. Questions on your next exam will include information presented during the lab demonstrations. After the introductory lecture to the entire class at 8:00 AM, Groups 1-6 please stay in the lecture room while groups 7-12 wait in the hall near the elevator for about 15 min before returning to class. Please avoid conversations with other students in the lecture room during the lab demonstrations. 2/28 Wednesday-continued 8:00 Lecture concerning the Lab Demonstrations -All Students must attend (502 BSB) Boackle After the lecture, Groups 1-6 stay in the lecture room while groups 7-12 wait in the hall near the elevator for 15 min before returning to class. Please avoid conversations with other students in the lecture room during the lab demonstrations. 8:45 Lab Demonstrations for Groups 1-6 (502 BSB) Boackle 9:00 Lab Demonstrations or Groups 7-12 (502 BSB) Boackle 3/2 Friday From 8:00 to 9:45 am, Groups I-VI will review Library Reports (with instructors). Meet in Room 502 BSB unless your faculty member has made other arrangements. [Ask your major questions to each other within your group, well before meeting with the instructor]
  • 4. Students should be prepared individually and as a group. I. Albenesius II. Chi III. Westwater IV. L. London V. R. Leite VI. Boackle 3/7 Wednesday From 8:00 am until 9:45 am, Groups VI-XII will review Library Reports (with instructors). Meet in Room 502 BSB [Ask your major questions to each other within your group, well before meeting with the instructor] Students should be prepared individually and as a group. VII. Chi VIII. Albenesius IX. L. London X. R. Leite XI. Westwater XII. Boackle 3/9 Friday 8:00 Dental Caries, Clinical Considerations Albenesius 9:00 Dental Caries, Re-mineralization Barry 3/10 - 3/18 SPRING VACATION 3/21 Wednesday 8:00 Saliva and Host Parasite Relationships Boackle 9:00 Saliva and Host Parasite Relationships Part 2 Boackle http://people.musc.edu/~boacklrj/SalivaSlidesLactoferrin.pdf Take Home Test worth 2 extra points on your final grade, see the syllabus. 3/23 Friday 8:00 Library Research Prepare as a group to meet with instructors. Boackle 9:00 AM Dental Plaque/Dental Caries Lecture Notes SLIDES Boackle http://people.musc.edu/~boacklrj/DentalPlaqueSalivaCaries.pdf See the NOTES for this Lecture from the Preventive Handout Also See Salivary Mutans Tests and see http://people.musc.edu/~boacklrj/BacitracinResistant.pdf 3/28 Wednesday 8:00 Library Research Prepare as a group to meet with instructors. Boackle 9:00 If needed, Dental Plaque/Dental Caries con't Boackle NOTES for this Lecture from the Preventive Handout.pdf Word Version.doc http://people.musc.edu/~boacklrj/PreventiveHandout_.doc 3/30 Friday 8:00 Library Research Prepare as a group to meet with instructors. Boackle 9:00 Dental Caries Immunization Boackle Open the links below: http://people.musc.edu/~boacklrj/Strept-Wall-Assoc-Prot-A.pdf http://people.musc.edu/~boacklrj/Strept-mutans-agglut.pdf
  • 5. http://people.musc.edu/~boacklrj/VirulStrepmutans.pdf 4/04 Wednesday (SECOND LIBRARY REPORTS ARE DUE at 8:00 AM, SUBMIT by GROUP #) 8:00 Periodontal Immunopathology Boackle 9:00 Periodontal Immunopathology II Boackle 4/06 Good Friday 8:00 Osteoclasts, Bone Resorption and Periodontal Disease Lecture Ries 9:00 Tumor Immunology / Cancer Immunotherapy Norris 4/11 Wednesday 8:00 Library Research Prepare as a group to meet with instructors. Boackle 9:00 Library Research Prepare as a group to meet with instructors. Boackle 4/13 Friday 8:00 IMMUNOBIOLOGY EXAMINATION IV (90 min.) (Cumulative) Boackle Students will not be allowed to ask any questions once the exam begins. *Lab Demonstration Material is included 4/18 Wednesday 8:00 Groups I-VI will review Library Reports (with instructors). Room 502 I. R. Leite II. Albenesius III. Lathers IV. Boackle V. L. London VI. Westwater 4/20 Friday 8:00 Groups VII-XII will review Library Reports (with instructors). Room 502 VII. L. London VIII. Lathers IX. Albenesius X. Boackle XI. R. Leite XII. Westwater 4/25 Wednesday (Last day of class) 9:00 AM The College of Dental Medicine requires that all Freshman Dental Students complete a PACE Evaluation for this Course (Oral Immunobiology). Time is provided in Room 502 BSB on this day at 9:00 AM. Check with your class president. ---------------------------------------- All examinations are Cumulative. Library Reports (your written questions, your Discussions of all of the group's questions with instructors) = 25% of the Final Grade in this course. Exam #1 = 20%, Exam #2 = 20%, Exam #3 = 10% Examination #4 = 25% Library Reports and Discussions = 25% (There is no final examination. All examinations are cumulative). Questions by students to the instructors are strongly encouraged. Students should be on time for all lectures so as not to disrupt the class after the lecture begins. Please avoid conversations with
  • 6. other students during the lectures. An excused absence will entitle a student who missed a regular examination or Quiz to take an Oral Exam on the material. A student initiated individual appointment with Dr. Boackle via email is required for any makeup test.