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  • 1. UNIVERSITY OF OXFORD Department of Clinical Neurology Oxford Biomedical Research Centre (Brain Theme) and Multiple Sclerosis Society Job Title: Clinical Research Fellow in Multiple Sclerosis Contract Status: This full-time post will be offered on a fixed-term contract for a period of three years. Salary: £30,992 - £44,856, depending on experience (Grade E71) Introduction The University of Oxford seeks applications for a Clinical Research Fellowship to work within the Department of Clinical Neurology on a project relating to basic or clinical aspects of multiple sclerosis. This post has been jointly funded by the Multiple Sclerosis Society and the Oxford Comprehensive Biomedical Research Centre (NIHR). The person appointed will be expected to register for a DPhil with the University of Oxford and may do up to a maximum of two clinical training sessions. The successful candidate may be at any stage in their training, but will usually be an Academic Clinical Fellow or an SpR in clinical neurology or a closely related subject. The work conducted can be in any of the areas described below in the Appendix and can be laboratory or clinically based or a combination of the two, but needs to have a translational element to satisfy both the funders. General Description The person appointed will be planning a career in clinical neurology but may be progressing down either a clinical or academic track. Academic component of the Clinical Research Fellow posts The training will be tailored to individual needs. The successful candidate will on appointment have the opportunity to discuss possible research projects which are currently available with the various PI’s in the Department, described below, who work in the field of MS. A programme of research will then be formulated which it is expected will lead to a DPhil. During their Fellowship they will have access to relevant taught modules. The CRF will also be expected to attend the weekly neuroscience educational meeting and case conference, regular research meetings and other research meetings at the discretion of the supervisor. Mentoring and Supervisory Arrangements for Clinical Research Fellows All PhD students in the Medical Sciences Division have two Research Supervisors.
  • 2. Assessment of Academic/Clinical Competencies and Joint Process Management In addition to the annual RITA, there will be a formal annual academic appraisal of the CRF to monitor progress and expectations. The academic report will also be submitted to and considered by the RITA committee which monitors progress of all SpRs each year. Person Specification: Work Related Essential Desirable Qualifications MBBS or equivalent BSc or equivalent intercalated degree (N.B. NOT essential). and prizes: MRCP Evidence of exceptional academic performance during training. Research/ Demonstrated interest in medical research. Published papers in scientific/medical journals. Publications: Published at least some case reports or review articles under supervision. Presented research abstracts (oral and/or poster) at national/international meetings e.g. ABN annual meeting. Teaching: Demonstrable teaching experience. Clinical Clinically qualified Completed at least ST2 Experience: Skills/Attitudes/kn Strong commitment to a career in clinical Academic commitment will be owledge: neurology. looked on favourably but not essential. Legal/Health/ GMC Registration with a licence to practise Other: Good communication skills and good professional relationships. Satisfactory enhanced disclosure from the Criminal Records Bureau.
  • 3. Because of the nature of the work for which you are applying, this post is exempted from the provisions of Section 4 (2) of the Rehabilitation of Offenders Act 1974 by virtue of the Rehabilitation of Offenders Act 1974 (Exceptions) Order 1975. Applicants are therefore, not entitled to withhold information about convictions, which for other purposes are “spent” under the provisions of the Act, and in the event of employment any failure to disclose such convictions could result in dismissal or disciplinary action by the University. Any information given will be strictly confidential and will be considered only in relation to an application for positions to which the Order applies. Informal enquiries should in the first instance be addressed to Professor Christopher Kennard, Head, Department of Clinical Neurology; tel: 01865 234637 or Email: Please note that applications sent directly to this Email address will not be accepted. Application Procedure Applications for this post must include all of the following: • your curriculum vitae (CV) • a letter explaining how you meet the requirements of this post (these are described in the job description) • completed personal details and equal opportunities monitoring forms, available for download from Alternatively you can request hard copies by emailing marilyn@ or tel. 01865 222729. You should ensure that your CV describes what you have been doing over at least the last 10 years. This may have been employment, education, or you may have taken time away from these activities in order to raise a family, care for a dependent, travel, or for any other reason. Your application will be judged solely on the basis of how your skills and experience match the requirements of the post, and we are happy to consider transferable skills or experience which you may have gained outside the context of paid employment or education. Please send your CV, covering letter and the completed forms to: Deputy Departmental Administrator, Department of Clinical Neurology, FMRIB Centre, John Radcliffe Hospital, Oxford OX3 9DU, or via email to by no later than 29th October 2010. Applications received after this date will not be considered.
  • 4. APPENDIX 1. Background The University of Oxford has an international reputation as a world-class centre of excellence in teaching and research. It employs over 7,800 academic, research and support staff across a wide range of academic disciplines. The University’s mission is to achieve and sustain the highest standards in all of its teaching and research. The Medical Sciences Division includes the pre-clinical departments (Physiology, Anatomy and Genetics, Pathology, Pharmacology) and all the clinical departments of the Medical School, along with the Departments of Experimental Psychology and Biochemistry (see The Division is one of the major centres for clinical and non-clinical research in the UK, having achieved excellent scores in the relevant units of assessment in the 2001 and 2008 HEFCE research assessment exercises. It includes several research Institutes and Units housed in modern buildings. The annual research grant income from external sources for the Medical Sciences Division is over £200 million. A joint initiative between Oxford University and the Oxford Radcliffe Hospital NHS Trust was awarded the status of Biomedical Research Centre (one of only five in the UK) by the National Institute of Health Research (NIHR) in 2007. 2. The Department of Clinical Neurology The Department of Clinical Neurology is one of the clinical departments of the Medical Sciences Division. The academic staff of the Department includes two statutory Professors (Action Research Professor of Neurology, George Ebers; Professor of Neuroimmunology, Lars Fugger); eight titular Professors (Christopher Kennard, Head of Department, Peter Rothwell, Peter Brown, Peter Jezzard, Steve Smith, David Beeson, Margaret Esiri (Emeritus), Angela Vincent (Emeritus)); two Clinical Readers (Michael Donaghy, Kevin Talbot); three Clinical Lecturers and several University Research Lecturers. There are also a large number of young scientists and clinician scientists on independent research fellowships. There are approximately 90 other staff working in the Department, including research support staff, clerical and technical staff, and clinically qualified staff involved in research. There are also a number of visiting researchers from many parts of the world. The average annual expenditure of the Department is approximately £9 million, of which approximately 50% comes from outside sources. The Department is housed in the new West Wing of the John Radcliffe Hospital, which contains all the clinical neurosciences in first-class purpose-built facilities. The Department has major interests in multiple sclerosis (Ebers, Fugger, Palace), stroke and stroke prevention (Rothwell, Schulz), epilepsy (Adcock, Lang), cognitive neuroscience (Butler, Kennard), neurodegeneration (Talbot, Zader, Turner), movement disorders (Brown), peripheral neuropathies (Donaghy), neuromuscular junction disorders (Vincent, Beeson) and neuroimmunology (Vincent, Lang, Buckley). The Functional Magnetic Resonance Imaging of the Brain (FMRIB) Centre (Director, Professor Irene Tracey) is a major internationally recognised focus for imaging of both healthy states and neurological disorders and collaborates widely within the Department, as well as nationally and internationally. Acute stroke and dementia are major interests of the Department of Gerontology (Professor Alastair Buchan, Professor Gordon Wilcock, Professor David Smith) with which Clinical Neurology interacts at many levels. The Thomas Willis Brain Bank was established by Professor
  • 5. Esiri, is now co-directed by her and Dr Olaf Ansorge, and provides an excellent and growing resource which is partly supported by the Alzheimer’s Society and the Alzheimer’s Research Trust. The Department’s web page is The Department has responsibility for teaching neurology to clinical students and provides a variety of teaching to undergraduate preclinical students across a wide range of neuroscience, neuropathology and neuroimmunology. There are around 30 postgraduate students at any one time. The teaching involves both academic non-clinical and clinical staff, as well as NHS staff. 3. The Oxford Comprehensive Biomedical Research Centre BRAIN THEME The Oxford Comprehensive Biomedical Research Centre (OxBRC) is a partnership between the research expertise of the Oxford Radcliffe Hospitals NHS Trust and the University of Oxford. The OxBRC was founded in April 2007 through a competitively awarded grant of £57.5M over five years from the National Institute for Health Research (NIHR), which was established to carry forward the Government's research strategy, "Best Research for Best Health". The goal of the health research strategy is to improve the health and wealth of the nation through research and establish the NHS as an internationally recognised centre of research excellence, by improving research, healthcare education and training. The Brain Theme of the Oxford Comprehensive Biomedical Research Centre was set up 3 years ago to develop translational research in relatively new emerging areas, rather than those well established in the Radcliffe Oxford Hospitals/UoO clinical neurosciences. The strategic aims of the Brain theme are: • To identify scientific advances in the basic neurosciences within the Oxford neuroscience community which offer the potential for translation into new clinical treatments. • To provide the infrastructure in terms of facilities and supporting staff to undertake these translational studies. • To support the appointment of new senior clinician-scientists in the clinical neurosciences, and to provide opportunities for NHS Consultants to undertake clinical research by providing specifically designated research sessions. • To provide a forum for interactions between clinicians and their teams to discuss their programmes and develop new collaborations. The subthemes are • MS and Neuroimmunology • Deep brain stimulation • Chronobiology, sleep and eye disease • Pain The theme has an annual budget of some £600K, which is used to support research fellows (both clinical and non-clinical), consumables and equipment in these areas.
  • 6. 4. Multiple Sclerosis Research in Oxford The Oxford MS research group comprises: a) A clinical and translational research team headed by Dr Jackie Palace who collaborates with all the groups described below. In addition, they are actively involved in clinical trials for new treatments in MS. Recently the group were designated an expert referral centre for Neuromyelitis Optica (NMO) by the NHS’s National Commissioning Group. Projects linked to this will include imaging and laboratory work to identify new antigens which will enhance the specificity of current AQP4 antibody testing. b) An internationally recognised neuroimmunology group led by Prof Lars Fugger has produced novel and spontaneous mouse models of MS and has research interests in the role of inflammation in neurodegeneration, the interaction of infection and immune response genes and functional genetics. Professor Fugger's group seeks to understand the molecular basis for the MHC association in Multiple Sclerosis and how MHC genes interact with environmental factors such as viruses. The group are also investigating how the MHC associated inflammation leads to neurodegeneration, which is responsible for the long-term disability in MS patients. There is a strong focus on translational medicine and both clinicians and non-clinicians are working in the group. The goal is to use the combined knowledge to develop new drugs for the treatment of MS. c) The Functional Magnetic Resonance Imaging of the Brain group (FMRIB) is an internationally recognised imaging research unit which houses researchers consisting of clinicians, physicists, statisticians and mathematical modellers and other neuroscientists. It is involved in translational research across a wide variety of neurological diseases, including multiple sclerosis, and is developing cutting edge imaging protocols. The software produced by FMRIB is used by over 170 sites worldwide. Oxford has been awarded funds by the MRC for a 7T magnet, which will be installed later this year. The MS Imaging programme is led by Dr Valentina Tomassini and Dr Jackie Palace. c) Neuropathology research is led by Professor Margaret Esiri who has an international reputation in MS research and whose interests lie in the study of neurodegenerative aspects of the disease with reference to inflammation, cortical pathology and cross validation with imaging and animal models. d) The Genetics and the natural history of MS group is led by Professor George Ebers, an international leader in this area.The Ebers group has a broad range of foci in MS ranging from natural history (Scalfari et al in press Brain), genomics and epigenetics (Ramagopalan et al submitted, Chao et al in press HMG, Genome Res) genetic epidemiology (Chao et al submitted) and the interphase between pathology and genetics (Deluca et PNAS, Ramagopalan et al submitted) with active collaborations with colleagues at several other universities. At present there are 5 post docs and 3 graduate students and a lab manager. The clinical resources come from the Canadian Collaborative Study which now comprises some 30,000 MS pedigrees and more than 3000 multicase families, 500 pairs of twins among the resources. e) The Neuroimmunology group is led by Professor Angela Vincent who has international recognition as a world leader in antibody associated diseases and its translation into diagnostic assays for clinical use and identification of diseases requiring immunomodulatory therapies. Her research has included the establishment of a aquaporin-4 antibody assay to identify an MS like disease known as Neuromyelitis Optica. By contrasting and comparing this disorder with MS it is hoped to understand better the relationship between inflammation and neurodegeneration in both conditions.
  • 7. Notes for Candidates How will the information on the application forms be used? The information collected on the equal opportunities recruitment monitoring form does not form part of the selection process and will not be circulated to the selection panel. It will be used solely to monitor the effectiveness of the University’s equal opportunities policy. Your CV, covering letter, and personal details form will be circulated to the selection panel. They will use this information to assess your suitability for the post against the selection criteria. If appointed, your application will be retained on your confidential staff file. If you are unsuccessful, your application will be retained for six months and then disposed of securely. At all times the information will be held securely in accordance with the terms of the Data Protection Act 1998. Am I eligible to apply to work for the University? All appointments are made in accordance with the University of Oxford Equal Opportunities Policy and Code of Practice and applications are welcomed from a wide range of candidates. The University undertakes not to discriminate unlawfully against any applicant on the basis of any information revealed. The Immigration, Asylum and Nationality Act 2006 makes it a criminal offence for employers to employ someone who is not entitled to work in the UK. We therefore ask applicants to provide proof of their right to work in the UK before employment can commence. Applicants who would need a work visa if appointed to the post are asked to note that under the UK’s new points-based migration system they will need to demonstrate that they have sufficient points, and in particular that: (i) they have sufficient English language skills (evidenced by having passed a test in basic English, or coming from a majority English-speaking country, or having taken a degree taught in English) and (ii) that they have sufficient funds to maintain themselves and any dependants until they receive their first salary payment. Further information is available at: Will I be asked to provide any other information? Employment with the University is conditional upon satisfying the following requirements: • proof of identity - in the form of a passport, birth certificate, or other acceptable document; • proof of address - in the form of a recent utility bill or bank statement; • proof that you are entitled to work in the UK; • proof of any qualifications required for this post - in the form of certificates or transcripts.
  • 8. Please note that you will need to provide original documents and where any documents are not in English a certified translation will be required. Do not include these documents with your application. You will be sent a request for the relevant information at the appropriate point in the selection process. In addition, if you are selected for this post: • your medical fitness to undertake the duties of the post will be assessed by the University’s Occupational Health Service; • we will take up references to ensure your suitability for appointment. Employment with the University is also subject to satisfactory completion of a probationary period. References Please give the details of two people who have agreed to provide a reference for you. If you have previously been employed, your referees should be people who have direct experience of your work through working closely with you for a considerable period, and at least one of them should be your formal line manager in your most recent job. Otherwise they may be people who know you from recent college, school, or voluntary experience. It is helpful if you can tell us briefly how each referee knows you (e.g. ‘line manager’, ‘work colleague’, ‘college tutor’). Your referees should not be related to you. Your referees will be asked to comment on your suitability for the post and to provide details of the dates of your employment; your attendance during the last 12 months; and of any disciplinary processes which are still considered live. We will assume that we may approach them at any stage unless you tell us otherwise. If you wish us to ask for your permission before approaching a particular referee, or to contact them only under certain circumstances (for example, if you are called to interview) you must state this explicitly alongside the details of the relevant referee(s). General conditions The salary offered for a full-time appointment to this job will be in the range (£30,685 - £44,412 (University Grade: E71), depending on qualifications and experience. If you are appointed at a salary below the top of this range, your salary will automatically be increased each year until you have reached the top point. Increases beyond this point may be available in certain cases. There is also an annual ‘cost-of-living’ salary review, which normally takes place in summer each year. Pay and benefits for part-time appointments are worked out on a ‘pro rata’ basis. For a full-time appointment, the annual holiday entitlement will be 38 days (including 8 public holidays). The appointment will be subject to satisfactory completion of a six-month probationary period. The post is pensionable and the post holder will have the option of becoming or remaining a member of the Universities Superannuation Scheme (USS) or remaining a member of the National Health Service Superannuation Scheme. The University has a generous maternity leave scheme and also offers paternity leave to expectant fathers and partners, and adoption leave. It offers subsidised nursery places, a holiday play-scheme, and tax and National Insurance savings schemes. For further information see
  • 9. Equal Opportunities Policy Statement As an Equal Opportunity employer, we positively encourage applications from people of different backgrounds. All our jobs are filled in line with our equal opportunities code of practice, which helps us make sure that men and women, people of different religions or beliefs, ages, racial groups, and those with disabilities are all treated fairly. POLICY STATEMENT The policy and practice of the University of Oxford require that all staff are afforded equal opportunities within employment. Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job will be the primary consideration. Subject to statutory provisions, no applicant or member of staff will be treated less favourably than another because of his or her gender, marital or civil partnership status, sexual orientation, religion or belief, racial group, age or disability. If you have any questions about equal opportunities at the University of Oxford, please visit our web- site at Data Protection All data supplied by applicants will be used only for the purposes of determining their suitability for the post and will be held in accordance with the principles of the Data Protection Act 1998 and the University’s Data Protection Policy. Further Details Further details about the Department of Clinical Neurology can be found on, and information about Oxford University on