University of Oklahoma Health Science Center
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    University of Oklahoma Health Science Center University of Oklahoma Health Science Center Document Transcript

    • University of Oklahoma Health Science Center College of Medicine Microbiology and Immunology 940 Stanton L. Young Blvd. Oklahoma City, OK 73190 (405) 271- 2133 Visit the Microbiology and Immunology web site at: http://w3.ouhsc.edu/MI/ John Iandolo, Ph.D., Chair Rebecca Blackstock, Ph.D., Graduate Liaison 14.1 FACULTY ROSTER For a complete listing of the departmental graduate faculty visit this web site http://idgweb4.ouhsc.edu/facappt/ 14.2 DEGREES OFFERED Doctor of Philosophy 14.3 AREA OF SPECIALIZATION Microbial Pathogenesis: Special emphasis on molecular and immunological mechanisms of diseases caused by bacteria, fungi and viruses. 14.4 PROGRAMS OBJECTIVES The graduate programs of the department are designed to prepare students for careers in academic and research areas of microbiology and immunology. The department offers graduate programs leading to doctoral degrees. Individual programs of study and research are tailored to student needs by an advisory committee. Programs are based upon a curriculum designed to provide a solid scientific background with courses chosen from this department as well as other departments within the University. Students in other departments may minor in Medical Microbiology and Immunology. Graduates leave with a sound background in pathogenic bacteriology, mycology, virology, bacterial metabolism, microbial genetics, immunology, and molecular biology. 14.5 ADMISSION REQUIREMENTS The department of Microbiology and Immunology is a participant in the interdisciplinary Graduate Program in Biomedical Sciences (GPiBs), which combines the expertise of the six programs at the University of Oklahoma Health Sciences Center: Biochemistry & Molecular Biology, Cell Biology, Microbiology & Immunology, Neuroscience, Pathology and Physiology. Students wishing to enter the Microbiology and Immunology graduate program to obtain a Ph.D. degree should apply to GPiBs as described in the GPiBs section of the Bulletin. An application is filed with the Office of Admissions and is accompanied by official transcripts and results of the Graduate Record Examination (GRE), and TOEFL for foreign applicants. Three letters of recommendation, from
    • individuals who can address the candidate’s research potential and suitability for graduate school, are also required. Students who already have a Master’s degree or those who have completed graduate level coursework equivalent to the GPiBS curriculum and desire to obtain a Ph.D. should apply directly to the department of Microbiology and Immunology. For admission to the Department of Microbiology and Immunology applicants who have fulfilled the undergraduate course requirements for the bachelor's degree in biology or in a related science will be considered, provided they have an undergraduate grade point average of at least 3.0 (on a 4.0 point scale). Particular attention is given to grades obtained in courses in microbiology, biology, chemistry, physics, and mathematics. Applicants must have met the following undergraduate prerequisites: 20 hours of biology, 4 hours of which must be in bacteriology or microbiology; 12 hours of chemistry, 4 hours of which must be organic chemistry; and 8 hours of additional course work selected from the following: biochemistry, physics, physical chemistry, calculus, genetics, animal physiology, animal histology, and comparative anatomy. Graduate prerequisites: Coursework equivalent to the OUHSC GPiBS curriculum with an overall GPA of 3.0 (on a 4.0 point scale). A student with deficiencies may be admitted with the provision that the deficiencies be removed as soon as possible after enrollment as a graduate student by satisfactory performance in a prescribed course or courses This additional course work may have the effect of increasing the total number of course hours required for the advanced degree. The general Graduate Record Examination is required and a combined verbal and quantitative score of 1100 is generally considered a minimum score for applicants. The subject area examination in biology and molecular biology are optional. In addition three letters of recommendation are required and a completed department supplemental application form which includes a statement of career goals. 14.6 DOCTOR OF PHILOSOPHY DEGREE REQUIREMENTS Students interested in the Ph.D. degree in Microbiology and Immunology are required to take a minimum of 90 hours of graduate work of which at least 45 hours are MI 6980 (Research for Doctor's Dissertation) and complete a dissertation based on original research. All Ph.D. students must complete the core courses: The first year integrative curriculum (GPiBS), Microbial Pathogenesis (MI 6400), Advanced Immunology (MI 6843) and Virology (MI 6303). In addition, all Ph.D. candidates take MI 6980, Research for the Doctor’s Dissertation. Ph.D. students are required to successfully complete four hours of MI 5971, Seminar. The remainder of the Ph.D. degree program is completed with graduate level courses in this or in other departments of the University. Requirements for any of the individual core courses may be waived by the departmental orientation committee with sufficient evidence of equivalent prior course completion. A student may transfer up to 44 hours of graduate course work taken elsewhere depending upon the decision of the student's advisory committee and the Graduate College (described elsewhere in Bulletin).
    • For admission to candidacy for the Ph.D. degree, the student must pass a written and oral qualifying examination. The examination is offered once a year and should be completed by the end of the second year. No later than 6 months after completion of the qualifying examination, each graduate student working toward a Ph.D. degree will be required to submit a proposal to their advisory committee on their intended dissertation research project. It is also required that each graduate student obtain teaching experience (laboratory and lecture) before completion of his/her graduate program. The exact nature and extent of this experience should take into account the interest, needs, and background of the student as well as the needs of the department. Financial support is provided to qualified students entering the program. 14.7 CAREER OPPORTUNITIES Students who complete a Ph.D. program in Microbiology and Immunology find future employment in research and/or teaching at academic institutions, research institutes, biotechnology companies and pharmaceutical companies . In addition, positions are available in clinical laboratory settings. 14.8 COURSES IN MICROBIOLOGY AND IMMUNOLOGY MI 5211 Current Literature in Microbiology and Immunology This course will provide the student with skills necessary for critical review and interpretation of scientific literature. This will require the student to critique the scientific paper in terms of hypothesis tested, methods utilized, and conclusions drawn. This course can be repeated for a maximum of 2 credit hours for the Ph.D. and 2 credit hours for the M.S. degree. MI 5243 Molecular Microbiology A molecular analysis of the cell structure and physiology or bacteria and simple eukaryotes. The course will focus on genes and genome structure, mutation and genetic analysis as tools to understand genetic regulation of structure function interactions and integration of the organism with its environment. MI 5354 Medical Mycology The study of representative agents of some of the superficial and systemic mycoses and the laboratory diagnoses from clinical specimens. Laboratory included. MI 5412 Diagnostic Microbiology Laboratory Preparation for direction of a diagnostic microbiology laboratory. Course content will include: proper methods of collection of clinical specimens and problem solving techniques (both administrative and technical) in diagnostic bacteriology, mycology, virology, parasitology, and serology; interpretation of laboratory results; correlation of
    • laboratory data with patient's history and clinical findings, with emphasis on the study of aneroic pathogens and normal microbial flora. MI 5428 Medical Microbiology and Immunology The course covers the biological nature of bacteria, viruses, rickettsiae, chyamydie, fungi and parasites. Emphasis is placed on mechanisms of disease production and the host response to the infecting agent. MI 5610 Topics in Infectious Disease Microbiological aspects of selected areas of infectious diseases will be studied in depth. Discussion periods of one to four hours duration per week on infectious disease. Topics will be led by selective graduate faculty members. The course may be repeated for a maximum total of six hours. MI 5971 Seminar May be repeated; Maximum credit toward the M.S. degree two hours, toward Ph.D. degree four hours. MI 5990 Special Studies Topics: Immunology Journal Club Investigation of some problems in microbiology or immunology. Introduction to research methods including survey of literature, analysis of data, and preparation of material for presentation. Minimum enrollment of two hours; Maximum enrollment of six hours per semester. Additional enrollment for a total of 12 hours. MI 6101 Immunology Journal Club This course is designed to teach students to critically evaluate the current literatur ein Immunology. In addition, they will gain an in depth knowledge of the current state of the field through their exposure to the most current literature in the field. MI 6243 Immunology Fundamental concepts in Immunology will be emphasized. Topics will include cells and systems that mediate natural and immune resistance; structure and function of immunoglobulins; T Cell receptors and major histocompatibility complex antigens; antigen recognition and presentation; cell cooperation in humoral and cell-mediated immunity; generation of diversity; regulation of the immune response; the complement system; and applied immunology. MI 6303 Virology Animal viruses emphasizing the molecular aspects of viral replication, the cellular responses following infection, and host-virus interrelationships. The host-parasite interactions of selected human viruses at the molecular, cellular and organism levels. MI 6400 Microbial Pathogenesis
    • The concept of microbial pathogenesis will be taught by first giving an overview of organismal groups (i.e. bacteria, fungi, rickettsia, protozoa, and viruses) followed by an in-depth analysis of the pathogenesis of selected model organisms. MI 6412 Advanced Immunology Laboratory Experience in animal immunization serology, immunochemistry, cellular immunology and other current immunological techniques. MI 6502 Principles of Flow Cytometry The theory and design of the flow cytometer will be covered. A number of different types of anaylses that can be accomplished with flow cytometry will be presented and protocols for these anaylses presented. In addition methods of data analysis will be taught. MI 6813 Advanced Microbial Physiology and Genetics Comprehensive studies on the structure and function of the bacterial cell, aerobic and anaerobic energy metabolism, biosynthetic pathways and their regulation, bacterial and phage genetics, plasmid biology, recombinant DNA technology, and genetic regulation. MI 6843 Advanced Immunology Advanced areas of immunology will be dealt with in the context of contemporary literature. MI 6980 Research for Doctor's Dissertation Credit hours may vary.