University of Oklahoma Health Science CenterDocument Transcript
University of Oklahoma Health Science Center
College of Medicine
Microbiology and Immunology
940 Stanton L. Young Blvd.
Oklahoma City, OK 73190
(405) 271- 2133
Visit the Microbiology and Immunology web site at:
John Iandolo, Ph.D., Chair
Rebecca Blackstock, Ph.D., Graduate Liaison
14.1 FACULTY ROSTER
For a complete listing of the departmental graduate faculty visit this web site
14.2 DEGREES OFFERED
Doctor of Philosophy
14.3 AREA OF SPECIALIZATION
Microbial Pathogenesis: Special emphasis on molecular and immunological
mechanisms of diseases caused by bacteria, fungi and viruses.
14.4 PROGRAMS OBJECTIVES
The graduate programs of the department are designed to prepare students for careers
in academic and research areas of microbiology and immunology. The department
offers graduate programs leading to doctoral degrees. Individual programs of study and
research are tailored to student needs by an advisory committee. Programs are based
upon a curriculum designed to provide a solid scientific background with courses
chosen from this department as well as other departments within the University.
Students in other departments may minor in Medical Microbiology and Immunology.
Graduates leave with a sound background in pathogenic bacteriology, mycology,
virology, bacterial metabolism, microbial genetics, immunology, and molecular biology.
14.5 ADMISSION REQUIREMENTS
The department of Microbiology and Immunology is a participant in the interdisciplinary
Graduate Program in Biomedical Sciences (GPiBs), which combines the expertise of
the six programs at the University of Oklahoma Health Sciences Center: Biochemistry &
Molecular Biology, Cell Biology, Microbiology & Immunology, Neuroscience, Pathology
and Physiology. Students wishing to enter the Microbiology and Immunology graduate
program to obtain a Ph.D. degree should apply to GPiBs as described in the GPiBs
section of the Bulletin. An application is filed with the Office of Admissions and is
accompanied by official transcripts and results of the Graduate Record Examination
(GRE), and TOEFL for foreign applicants. Three letters of recommendation, from
individuals who can address the candidate’s research potential and suitability for
graduate school, are also required.
Students who already have a Master’s degree or those who have completed graduate
level coursework equivalent to the GPiBS curriculum and desire to obtain a Ph.D.
should apply directly to the department of Microbiology and Immunology. For admission
to the Department of Microbiology and Immunology applicants who have fulfilled the
undergraduate course requirements for the bachelor's degree in biology or in a related
science will be considered, provided they have an undergraduate grade point average
of at least 3.0 (on a 4.0 point scale). Particular attention is given to grades obtained in
courses in microbiology, biology, chemistry, physics, and mathematics. Applicants must
have met the following undergraduate prerequisites: 20 hours of biology, 4 hours of
which must be in bacteriology or microbiology; 12 hours of chemistry, 4 hours of which
must be organic chemistry; and 8 hours of additional course work selected from the
following: biochemistry, physics, physical chemistry, calculus, genetics, animal
physiology, animal histology, and comparative anatomy. Graduate prerequisites:
Coursework equivalent to the OUHSC GPiBS curriculum with an overall GPA of 3.0 (on
a 4.0 point scale). A student with deficiencies may be admitted with the provision that
the deficiencies be removed as soon as possible after enrollment as a graduate student
by satisfactory performance in a prescribed course or courses This additional course
work may have the effect of increasing the total number of course hours required for the
The general Graduate Record Examination is required and a combined verbal and
quantitative score of 1100 is generally considered a minimum score for applicants. The
subject area examination in biology and molecular biology are optional. In addition three
letters of recommendation are required and a completed department supplemental
application form which includes a statement of career goals.
14.6 DOCTOR OF PHILOSOPHY DEGREE REQUIREMENTS
Students interested in the Ph.D. degree in Microbiology and Immunology are required to
take a minimum of 90 hours of graduate work of which at least 45 hours are MI 6980
(Research for Doctor's Dissertation) and complete a dissertation based on original
research. All Ph.D. students must complete the core courses: The first year integrative
curriculum (GPiBS), Microbial Pathogenesis (MI 6400), Advanced Immunology (MI
6843) and Virology (MI 6303). In addition, all Ph.D. candidates take MI 6980, Research
for the Doctor’s Dissertation. Ph.D. students are required to successfully complete four
hours of MI 5971, Seminar. The remainder of the Ph.D. degree program is completed
with graduate level courses in this or in other departments of the University.
Requirements for any of the individual core courses may be waived by the departmental
orientation committee with sufficient evidence of equivalent prior course completion. A
student may transfer up to 44 hours of graduate course work taken elsewhere
depending upon the decision of the student's advisory committee and the Graduate
College (described elsewhere in Bulletin).
For admission to candidacy for the Ph.D. degree, the student must pass a written and
oral qualifying examination. The examination is offered once a year and should be
completed by the end of the second year. No later than 6 months after completion of the
qualifying examination, each graduate student working toward a Ph.D. degree will be
required to submit a proposal to their advisory committee on their intended dissertation
It is also required that each graduate student obtain teaching experience (laboratory
and lecture) before completion of his/her graduate program. The exact nature and
extent of this experience should take into account the interest, needs, and background
of the student as well as the needs of the department.
Financial support is provided to qualified students entering the program.
14.7 CAREER OPPORTUNITIES
Students who complete a Ph.D. program in Microbiology and Immunology find future
employment in research and/or teaching at academic institutions, research institutes,
biotechnology companies and pharmaceutical companies . In addition, positions are
available in clinical laboratory settings.
14.8 COURSES IN MICROBIOLOGY AND IMMUNOLOGY
MI 5211 Current Literature in Microbiology and Immunology
This course will provide the student with skills necessary for critical review and
interpretation of scientific literature. This will require the student to critique the scientific
paper in terms of hypothesis tested, methods utilized, and conclusions drawn. This
course can be repeated for a maximum of 2 credit hours for the Ph.D. and 2 credit
hours for the M.S. degree.
MI 5243 Molecular Microbiology
A molecular analysis of the cell structure and physiology or bacteria and simple
eukaryotes. The course will focus on genes and genome structure, mutation and
genetic analysis as tools to understand genetic regulation of structure function
interactions and integration of the
organism with its environment.
MI 5354 Medical Mycology
The study of representative agents of some of the superficial and systemic mycoses
and the laboratory diagnoses from clinical specimens. Laboratory included.
MI 5412 Diagnostic Microbiology Laboratory
Preparation for direction of a diagnostic microbiology laboratory. Course content will
include: proper methods of collection of clinical specimens and problem solving
techniques (both administrative and technical) in diagnostic bacteriology, mycology,
virology, parasitology, and serology; interpretation of laboratory results; correlation of
laboratory data with patient's history and clinical findings, with emphasis on the study of
aneroic pathogens and normal microbial flora.
MI 5428 Medical Microbiology and Immunology
The course covers the biological nature of bacteria, viruses, rickettsiae, chyamydie,
fungi and parasites. Emphasis is placed on mechanisms of disease production and the
host response to the infecting agent.
MI 5610 Topics in Infectious Disease
Microbiological aspects of selected areas of infectious diseases will be studied in
depth. Discussion periods of one to four hours duration per week on infectious disease.
Topics will be led by selective graduate faculty members. The course may be repeated
for a maximum total of six hours.
MI 5971 Seminar
May be repeated; Maximum credit toward the M.S. degree two hours, toward Ph.D.
degree four hours.
MI 5990 Special Studies
Topics: Immunology Journal Club
Investigation of some problems in microbiology or immunology. Introduction to research
methods including survey of literature, analysis of data, and preparation of material for
presentation. Minimum enrollment of two hours; Maximum enrollment of six hours per
Additional enrollment for a total of 12 hours.
MI 6101 Immunology Journal Club
This course is designed to teach students to critically evaluate the current literatur ein
Immunology. In addition, they will gain an in depth knowledge of the current state of the
field through their exposure to the most current literature in the field.
MI 6243 Immunology
Fundamental concepts in Immunology will be emphasized. Topics will include cells and
systems that mediate natural and immune resistance; structure and function of
immunoglobulins; T Cell receptors and major histocompatibility complex antigens;
antigen recognition and presentation; cell cooperation in humoral and cell-mediated
immunity; generation of diversity; regulation of the immune response; the complement
system; and applied immunology.
MI 6303 Virology
Animal viruses emphasizing the molecular aspects of viral replication, the cellular
responses following infection, and host-virus interrelationships. The host-parasite
interactions of selected human viruses at the molecular, cellular and organism levels.
MI 6400 Microbial Pathogenesis
The concept of microbial pathogenesis will be taught by first giving an overview of
organismal groups (i.e. bacteria, fungi, rickettsia, protozoa, and viruses) followed by an
in-depth analysis of the pathogenesis of selected model organisms.
MI 6412 Advanced Immunology Laboratory
Experience in animal immunization serology, immunochemistry, cellular immunology
and other current immunological techniques.
MI 6502 Principles of Flow Cytometry
The theory and design of the flow cytometer will be covered. A number of different types
of anaylses that can be accomplished with flow cytometry will be presented and
protocols for these anaylses presented. In addition methods of data analysis will be
MI 6813 Advanced Microbial Physiology and Genetics
Comprehensive studies on the structure and function of the bacterial cell, aerobic and
anaerobic energy metabolism, biosynthetic pathways and their regulation, bacterial and
phage genetics, plasmid biology, recombinant DNA technology, and genetic regulation.
MI 6843 Advanced Immunology
Advanced areas of immunology will be dealt with in the context of contemporary
MI 6980 Research for Doctor's Dissertation
Credit hours may vary.