KEITH MOSTOV


RECENT PROFESSIONAL SCHOOL TEACHING
Teaching Hours

           COURSE               LECTURE       LAB      ...
3.    James Casanova, 1988-91           Supported by ACS and Cystic Fibrosis Foundation.
                                 ...
27.   Arlinet Kierbel-2001-              Supported by NIH (Joint with Joanne Engel)
28.   Lucy O’Brien 2001-05            ...
1. Leonard Katz, UC Santa Cruz, 1994-95
2. Elena Kleiman, UC Berkeley, 1995-96
3. Ellen Katz, UC Berkeley, 1999-

Student ...
DEPARTMENTAL, UNIVERSITY, AND PROFESSIONAL SERVICE
Member, Department of Biochemistry and Biophysics (joint appointment)
M...
1993-1994
Executive Committee, Biomedical Sciences Graduate Program
Curriculum Committee, Biomedical Sciences Graduate Pro...
1998-1999
Vice-chairman, Department of Anatomy
Executive Committee, Department of Anatomy
Research Evaluation and Allocati...
2003-2004
Executive Committee, Liver Center
Joint Information Technology Governance Committee
Faculty Search Committee, BM...
Scientific Advisory Board, NIH Research Center for Minority Institutions, Cell and Molecular Biology
        Center, Unive...
Golden Gate Heights Neighborhood Association, Neighborhood Emergency Response Team, 1996-present
National Yiddish Book Cen...
$162,000 Total Direct Costs

Cancer Research Institute Investigator Award
Membrane protein sorting
7/1/90—6/30/94
$200,000...
$201,534 Total Direct Costs




Current (All Mostov P.I.)

NIH R01 AI25144
Transport of immunoglobulins across epithelial ...
6/1/01-5/31/06
$630,000 Total Direct Cost

NIH P01 AI053194
I am PI on this Program Project Grant, as well as leader of Pr...
7/87  Gordon Conference: Membrane Molecular Biology
7/87  Gordon Conference: Membrane Transport
9/87  International Germin...
11/95      American Society for Nephrology, San Diego
2/96       Keystone Symposium: Cell Polarity
7/96       FEBS Meeting...
4/05  FASEB Symposium on Cell Polarity, San Diego, CA
5/05  EMBO/IRCC Meeting on Invasive Growth, Torino, Italy
6/06  Japa...
12/85      McGill University, Department of Molecular Biology
5/86       Cornell University, Department of Cell Biology an...
11/90      Stanford University, Department of Pharmacology
2/91       Lawrence Berkeley Laboratory
2/91       University o...
10/98      Washington University, St. Louis, Keynote Speaker, Mallinckrodt Symposium
1/99       California Institute of Te...
02/07      Memorial Sloan Ketterin Cancer Center, NY, NY
04/07      Fox Chase Cancer Center, Distinguished Lecturer, Phila...
RESEARCH PROGRAM: Epithelial polarity and morphogenesis

The most fundamental type of organization of cells in metazoa is ...
Selected publications.


van IJzendoorn, S.C.D., Tuvim, M.J., Weimbs, T., Dickey, B.F., and Mostov, K.E. Direct interactio...
10/19/10   23
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Tenure Package

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  1. 1. KEITH MOSTOV RECENT PROFESSIONAL SCHOOL TEACHING Teaching Hours COURSE LECTURE LAB CONFERENCE EXAM YEARS Med. School Curriculum 2 40 6 04 Med. School Curriculum 42 6 01, 02, 03 IDS 100 2 48 4 25 97, 98, 00, Biochemistry 110 2 1 97, 98 Biochemistry 112 2 1 97, 98 PH292 (UCB) 2 01 RECENT GRADUATE SCHOOL TEACHING Teaching hours GRADUATE LECTURE CONFERENCE EXAM YEARS COURSES BMS 260 8 6 01, 02, 03, 04 Cell Biology 245 10 2 97, 98, 05 Cell Biology 245 2 6 02, 04 Cell Biology 245 15 6 99, 00, 03, Oral Biology 225 2 97, 98, 99, 00, 01, 02 Gene Therapy 170.23 2 00 Teaching Award Nomination Nominated for “An Outstanding Lecture Award” by first-year medical students for IDS 100, 1999. Post-doctoral Fellows 1. Neil Simister, 1985-89 Supported by EMBO and Cancer Research Institute. Currently Associate Professor, Brandeis University. 2. Phil Breitfeld, 1986-89 Supported by NIH Physician-Scientist Award. Currently Professor and Chief of Pediatric Hematology/Oncology, University of Indiana Medical Center. 10/19/10 1
  2. 2. 3. James Casanova, 1988-91 Supported by ACS and Cystic Fibrosis Foundation. Currently Professor, University of Virginia Health Sciences Center. 4. Gerard Apodaca, 1989-95 Supported by Cancer Research Institute and American Heart Association. Currently Professor, University of Pittsburgh. 5. Curtis Okamoto, 1990-94 Supported by Damon Runyon-Walter Winchell. Currently Professor, University of Southern California. 6. Benjamin Aroeti, 1990-94 Supported by Human Frontiers of Science Program Organization and American Heart Association. Currently Professor, and Chairman, Program of Cell and Developmental Biology Hebrew University, Jerusalem. 7. Morgane Bomsel, 1990-92 Supported by CNRS. Currently at Institut Cochin, Paris. 8. Wenxia Song, 1992-94 Supported by American Heart Association. Currently Assistant Professor, Dept. of Immunology and Microbiology, University of Maryland, College Park, MD. 9. Steven Chapin, 1992-2000 Supported by ACS. Currently Senior Research Scientist, Arizeke Pharmaceuticals. 10. Yoram Altschuler, 1993-2000 Supported by Cancer Research Institute. Assistant Professor, Hadassah Medical School, Jerusalem (9/00) 11. Karen Singer, 1994-97 Supported by Cystic Fibrosis Foundation. Currently Senior Scientist, Metabolex, Inc. Hayward, CA. 12. Janice Richman-Eisenstat, 1994-98 Supported by Parker B. Francis Foundation. Currently Assistant Professor, Dept. of Medicine (Pulmonary), University of Mannitoba, Winnipeg, Mannitoba, Canada 13. Thomas Weimbs, 1994-99 Supported by Alexander von Humbolt Foundation. Currently Assistant Professor, Cleveland Clinic 14. Seng-Hui Low, 1994-99 Supported by Irvington Institute. Currently Assistant Professor, Cleveland Clinic 15. Frederic Luton, 1994-99 Supported by CNRS. Currently Assistant Professor, INSERM, Valbonne, France 16. Daniel Balkovetz, 1995-96 Supported by NIH. Currently Assistant Professor, University of Alabama at Birmingham. 17. Marcel Verges, 1995-2004 Supported by Spanish Government. Currently Asst Prof, Univ. Valencia, Spain 18. Joshua Lipschutz, 1997-2001 Currently Assistant Professor, University of Pennsylvania. Supported by NIH K08. 19 Steen Hansen, 1997-2000 Supported by Weimann Foundation. Currently Assistant Professor, Boston Biomedical Research Institute. 20. Barbara Kazmierczak, 1997-2001 Supported by Howard Hughes Physician-Scientist (joint with Joanne Engel). Currently Assistant Professor, Yale University. 21. Mirjam Zegers, 1998- Supported by American Cancer Society. Currently Assistant Prof., Univ. Chicago 22. Martin ter Beest, 1998- Supported by Cystic Fibrosis Foundation. Currently Assistant Prof., Univ. Chicago. 23. Sven van IJzendoorn, 1999-2001 Supported by HFSPO. Currently Assoc. Prof., Univ. Groningen, 24. Wei Yu, 2000- Supported by American Heart Association Fellowship 25. Anirban Datta, 2001- Supported by Susan G. Komen Breast Cancer Foundation 26. Tao Su, 2001- Supported by NIH 10/19/10 2
  3. 3. 27. Arlinet Kierbel-2001- Supported by NIH (Joint with Joanne Engel) 28. Lucy O’Brien 2001-05 Currently scientist, UC Berkeley 29. Paul Brakeman 2002-05 Currently Asst Prof, UCSF Dept Pediatriatrics 30. Fernando Martin 2003- Supported by HFSPO. 31. Kathleen Liu 2003-05 Currently Instructor, UCSF Division of Nephrology 32. Minji Kim 2003- Supported by California Tobacco-Related Disease Fellowship 33. Toshiyuki Yamaji 2003-06 Currently Asst Prof., RIKEN, Japan 34. Max Levin 2003-05 Currently Assistant Professor, University of Goteborg, Sweden 35. Naoki Tanimizu 2004 Supported by Japanese Government 36. Leonid Katz 2004-06 Currently Principal Scientist, Merck. 37. Dennis Eastburn 2005 Supported by Ruth Kirschstein NRSA (NIH F32). 38. David Bryant, 2006 Supported by Australian Government 39. Catherine Jacobson, 2006 Supported by NIH Training Grant 40. Annette Shewan, 2006 Supported by C.J. Martin Fellowship (Australia) Visiting Professors 1. Jeanine Wiener-Kronish, 1991-92 Vice-chair, Dept of Anesthesia, UCSF 2. Carlos Enrich, 1993-94 Professor, University of Barcelona, Spain. 3. Suzanne Fleiszig, 1994-96 Professor, UC Berkeley 4. Ama Gassama, 2002-2006 Senior Researcher, INSERM, Toulouse, France 5. Pascale Leroy, 2003- Senior Researcher, CNRS, Marseille, France Graduate Students Full-time students 1. Michael Cardone, Department of Anatomy, 1989-95. Currently Postdoctoral Fellow, MIT. 2. James Arden, Department of Pharmaceutical Chemistry, 1989-90. Currently Associate Professor, Cornell University Medical College. 3. Anne Pollack, Department of Anatomy, 1991-96. Currently Postdoctoral Fellow, University of Arizona, Tucson. 4. Lucy O’Brien, Biomedical Sciences Program, 1995-2001, Currently Postdoctoral Fellow, UCSF Laboratory rotations 1. Anne de Bruyn Kops, Whitehead Institute, 1985-1986. 2. Michael Cardone, Department of Anatomy, Spring 1989 3. Anne Pollack, Department of Anatomy, Winter 1991 4. Iris Roth, Biomedical Sciences Program, Summer 1992 5. Lucy O’Brien, Biomedical Sciences Program, Spring 1994 6. Michael Penn, MSTP, Autumn 1994 7. Lani Keller, PIBS Tetrad, Winter 2004 8. Clara Dey, PIBS Tetrad, Spring 2004 9. Isla Cheung, PIBS Tetrad, Spring 2005 10. Teddy Lam, PSPG, Summer 2005 Visiting Graduate Students 1. Nina Do, UC Berkeley, 1995-96 2. Cindy Jun, UC Berkeley, 1995-96 3. Leo Mok, UC Berkeley, 1995-96 4. Sven van IJzendoorn, University of Groningen, Netherlands, 1996-97 Visiting Undergraduate Students 10/19/10 3
  4. 4. 1. Leonard Katz, UC Santa Cruz, 1994-95 2. Elena Kleiman, UC Berkeley, 1995-96 3. Ellen Katz, UC Berkeley, 1999- Student Qualifying Committees Angela Porter, Department of Anatomy Darren Wong, Department of Pharmaceutical Chemistry James Arden, Department of Pharmaceutical Chemistry Iris Roth, Biomedical Sciences Program Chris van Ooij, Biomedical Sciences Program Jennifer Zamanian, PIBS Tetrad Jessica Blumstein, PIBS Tetrad Dianne Wakeham, Department of Pharmaceutical Chemistry David Sanchez, BMS Marla Abodeely, BMS Robert Gage, PSPG Kelly DuBois, BMS Ben Laufer, PSPG Jeremy Wilbur, PIBS Biophysics Clara Dey, PIBS Tetrad Lani Keller, PIBS Tetrad Isla Cheung, PIBS Tetrad Student Thesis Committees Thesis Committee, Eric Grote, PIBS Tetrad Thesis Committee, Vivian Wong, Department of Physiology Thesis Committee, James Arden, Department of Pharmaceutical Chemistry Thesis Examiner, Seng-Hui Low, National University of Singapore Thesis Committee, Chris van Ooij, Biomedical Sciences Program Thesis Examiner, Sven van IJzendorn, Univeristy of Groningen Thesis Committee, Shoumita Dasgupta, PIBS Tetrad Thesis Committee, Jessica Blumstein, PIBS Tetrad Thesis Examiner, Tao Su, University of Sidney Thesis Committee, Marla Abodeely, Biomedical Sciences Program Thesis Committee, Chantilly Munson, PIBS Tetrad Thesis Committee, Isla Cheung, PIBS Tetrad Thesis Examiner, Purnima Bhat, University of Melbourne Mentoring and other Educational Activities Gave workshop at Meharry Medical College on “How to Write and Publish Scientific Papers”, 1988 Judge, British Society for Cell Biology Student Poster Competition, 1993 Mentor, K21 Scientist Development Award, Mark von Zastrow, Assistant Professor, Department of Psychiatry, UCSF, 1994 Organized High School Program, American Society for Cell Biology, San Francisco, CA, 1994 Judge, Vienna Institute of Molecular Pathology, Spring Meeting Student Poster Competition, 1998 Scientific Advisory Board, NIH Research Center for Minority Institutions, Universidad Central del Caribe, Puerto Rico, 2001-present American Society for Cell Biology, Women in Cell Biology Career Lunch, Table Leader, 2001, 03, 05 Ernest E. Just Symposium, Medical University of South Carolina, 2006 10/19/10 4
  5. 5. DEPARTMENTAL, UNIVERSITY, AND PROFESSIONAL SERVICE Member, Department of Biochemistry and Biophysics (joint appointment) Member, Cell Biology Program, Program in Biological Sciences Member, Biomedical Sciences Program Member, Liver Center Member, Cardiovascular Research Institute Member, UCSF Comprehensive Cancer Center Member, Program in Pharmaceutical Sciences and Pharmacogenetics Member, Program in Host-Pathogen Interactions University Committee Service 1989-1990 Seminar Committee, Department of Anatomy (organized 20 very well attended seminars.) Ad hoc committees for faculty appointments. MSO Search Committee, Department of Anatomy 1990-1991 Committee on Minicourses, Department of Biochemistry Committee on MD with Thesis, School of Medicine Co-organizer, Membrane Traffic Journal Club Ad hoc committees for faculty appointments Faculty Search Committee, Proctor Foundation 1991-1992 Seminar Committee, Cardiovascular Research Institute Committee on MD with Thesis, School of Medicine Library Committee, Academic Senate Organizer, Biweekly Membrane Traffic Meeting Co-organizer, Membrane Traffic Journal Club Glass Facility Committee, Department of Anatomy Graduate Admissions Committee, PIBS Seminar Committee, Seminars in Biology Faculty Search, Department of Anatomy Search Committee, University Library, Director of Information Resources and Services 1992-1993 Executive Committee, Biomedical Services Graduate Program Curriculum Committee, Biomedical Services Graduate Program Ad hoc Committee for Faculty Appointments Seminar Committee, Seminars in Biology Committee on MD with Thesis, School of Medicine Glassware Facility Committee, Department of Anatomy Co-organizer, Membrane Traffic Journal Club Library Committee, Academic Senate Committee on Mini-courses, Department of Biochemistry Graduate Admissions Committee, PIBS Committee on UCSF Fellows Program 10/19/10 5
  6. 6. 1993-1994 Executive Committee, Biomedical Sciences Graduate Program Curriculum Committee, Biomedical Sciences Graduate Program Committee on MD with Thesis, School of Medicine Co-organizer, Membrane Traffic Journal Club Seminar Committee, Seminars in Biology Glassware Facility Committee, Department of Anatomy Library Committee, Academic Senate Appointments and Promotions Committee, CVRI Graduate Admissions Committee, PIBS Ad hoc Committee for Faculty Appointments Curriculum Development and Program Enrichment Committee, Graduate Program in Oral Biology Committee on UCSF Fellows Program 1994-1995 Curriculum Committee, Biomedical Sciences Graduate Program Co-organizer, Membrane Traffic Journal Club Seminar Committee, Seminars in Biology Graduate Admissions Committee, PIBS Ad Hoc Committee for Faculty Appointments and Promotions Committee on UCSF Fellows Program Advisory Committee, Graduate Program in Oral Biology 1995-1996 Research Evaluation and Allocation Committee Curriculum Committee, Biomedical Sciences Graduate Program Co-organizer, Membrane Traffic Journal Club Graduate Admissions Committee, PIBS Ad Hoc Committee for Faculty Promotions Advisory Committee, Graduate Program in Oral Biology 1996-1997 Research Evaluation and Allocation Committee Co-organizer, Membrane Traffic Journal Club Graduate Admissions Committee, PIBS Chairman, Selection Committee for Culpeper Foundation Medical Scholar Chairman, Department of Anatomy DNA Sequencer Committee Committee for the Review of Appointments and Advancements to the Academic Administrator/Academic Coordinator Series 1997-1998 Vice-chairman, Department of Anatomy Executive Committee, Department of Anatomy Research Evaluation and Allocation Committee Co-organizer, Membrane Traffic Journal Club Graduate Admissions Committee, PIBS Chairman, Selection Committee for Culpeper Foundation Medical Scholar Chairman, Department of Anatomy DNA Sequencer Committee Committee for the Review of Appointments and Advancements to the Academic Administrator/Academic Coordinator Series 10/19/10 6
  7. 7. 1998-1999 Vice-chairman, Department of Anatomy Executive Committee, Department of Anatomy Research Evaluation and Allocation Committee Co-organizer, Membrane Traffic Journal Club Graduate Admissions Committee, PIBS Chairman, Selection Committee for Culpeper Foundation Medical Scholar Chairman, Department of Anatomy DNA Sequencer Committee Committee for the Review of Appointments and Advancements to the Academic Administrator/Academic Coordinator Series Molecular Medicine Training Program Selection Committee 1999-2000 (On sabbatical autumn, 1999) Co-Chair, PIBS Journal Club Research Evaluation and Allocation Committee Co-organizer, Membrane Traffic Journal Club Admissions interviewer, PIBS, BMS, MSTP Ad hoc Committees for Faculty Promotions Curriculum Development Committee, BMS Selection Committee, Phi Beta Kappa Graduate Scholarship 2000-2001 Joint Information Technology Governance Committee Research Evaluation and Allocation Committee Co-organizer, Membrane Traffic Journal Club Admissions interviewer, PIBS, BMS, MSTP Ad hoc Committees for Faculty Promotions BMS Cell Biology Course committee Co-Director, Sandler Family Facility for Live Cell Confocal Microscopy 2001-2002 Executive Committee, Liver Center Joint Information Technology Governance Committee Research Evaluation and Allocation Committee Co-organizer, Membrane Traffic Journal Club Admissions interviewer, PIBS, BMS, MSTP Ad hoc Committees for Faculty Promotions BMS Cell Biology Course committee Co-Director, Sandler Family Facility for Live Cell Confocal amd MultiphotonMicroscopy Postdoctoral Training Grant Selection committee, Department of Biochemistry and Biophysics UCSF Selection Committee, Culpeper Scholar in Medical Sciences UCSF Selection Committee, Searle Scholar 2002-2003 Executive Committee, Liver Center Joint Information Technology Governance Committee Research Evaluation and Allocation Committee Co-organizer, Membrane Traffic Journal Club Admissions interviewer, PIBS, BMS, MSTP Ad hoc Committees for Faculty Promotions BMS Cell Biology Course committee Co-Director, Sandler Family Facility for Live Cell Confocal amd MultiphotonMicroscopy, Parnassus Director, Sandler Family Facility for Live Cell Confocal and Multiphoton Microscopy, Mission Bay Postdoctoral Training Grant Selection committee, Department of Biochemistry and Biophysics UCSF Selection Committee, Culpeper Scholar in Medical Sciences Search Committee, Chief Division of Nephrology 10/19/10 7
  8. 8. 2003-2004 Executive Committee, Liver Center Joint Information Technology Governance Committee Faculty Search Committee, BMS/PIBS Ophthalmology Faculty Search Committee, BMS/PIBS Nephrology Research Evaluation and Allocation Committee Admissions interviewer, PIBS, BMS, MSTP, Molecular Medicine Ad hoc Committees for Faculty Promotions BMS Cell Biology Course committee Director, Sandler Family Facility for Live Cell Confocal and Multiphoton Microscopy, Mission Bay Postdoctoral Training Grant Selection committee, Department of Biochemistry and Biophysics UCSF Selection Committee, Searle Scholar Meetings Organized and Chaired Workshop on Immunoglobulin Transport, FASEB, Saxtons River, VT, 1988 Session on Transcytosis at FASEB meeting on Fc Receptors, Copper Mountain, CO, 1990 Bay Area Membrane Molecular Biology Meeting, 1991 Session on Targeting in Epithelial Cells at UCLA Keystone Meeting on Cell Polarity, Tamarron, CO, 1993 Co-Chair, Mini-symposium on Cell Polarity, ASCB Meeting, San Francisco, CA 1994 Chair, Keystone Meeting on Cell Polarity, Lake Tahoe, CA 1996 Co-Chair, Mini-symposium on Cell Polarity, ASCB Meeting, San Francisco, CA 1998 Co-Chair, Mini-symposium on Cell Polarity, ASCB Meeting, Washington, DC 2001 Co-chair, Special interest subgroup on small GTPases, ASCB Meeting, San Francisco, CA 2002 Co-Organizer, EMBO Meeting on Epithelial Polarity in Development and Disease, Carry Le Rouet, France, 2004 Keystone Symposia, Cell Biology Advisory Council, 2004- Advisory Committees at Other Universities Membrane Traffic Center, Johns Hopkins University Renal Division, Epithelial Cell Biology Center, University of Pittsburgh Polycystic Kidney Disease Center, Mt. Sinai School of Medicine, New York. Society Service American Society for Cell Biology, Local Arrangements Committee, 1994. Organized High School Teachers and Students Program American Society for Cell Biology, Congressional Liaison Committee, 1999- American Society for Cell Biology, Pre-doctoral Travel Award Committee, 1998 American Society for Cell Biology, Women in Cell Biology Career Lunch, Table Leader, 2001- Society for Mucosal Immunology, Publication Committee. 1999-present American Cancer Society, Council for Extramural Grants, 2004-. Keystone Symposia, Cell Biology Advisory Council, 2004- American Society for Cell Biology, National Award Selection Committee International Service World Health Organization—International Union of Immunoglogical Societies, Nomenclature Committee, Subcommittee on Fc Receptor Nomenclature, 1992-present U.S. Civilian Research Development Foundation for the Independent States of the Former Soviet Union, 2001-present Advisor to U.S. Defense Threat Reduction Agency Consultant to International Science and Technology Center, St Petersburg, Russia. 10/19/10 8
  9. 9. Scientific Advisory Board, NIH Research Center for Minority Institutions, Cell and Molecular Biology Center, Universidad Central del Caribe, Puerto Rico, 2001-present Scientific Advisor, Cancer Stem Cell Research Center, Torino, Italy, 2005- . Editorial Boards Molecular Biology of the Cell, Editorial Board1997-2001, Associate Editor 2002- In 2003 I made decisions on 66 manuscripts for Molecular Biology of the Cell. International Review of Cytology, 1987-Present Guest Editor, Seminars in Cell Biology, 1991 Traffic, 1999-Present BioMed Central Cell Biology, 2000-present Guest Editor, METHODS, 2003 Reviewer Activities In 2003 I reviewed 75 manuscripts for Science, Cell, Molecular Cell, Developmental Cell, Neuron, Immunity, Nature, Nature Cell Biology, Nature Biotechnology, Nature Reviews Molecular Cell Biology, EMBO Journal, Journal of Cell Biology, Molecular Biology of the Cell, PNAS, Journal of Biological Chemistry, Traffic, Journal of Cell Science, Journal of Clinical Investigation, Journal of Immunology, and other journals. As Associate Editor of Molecular Biology of the Cell, I handle approximately 6-8 manuscripts per month. I am an ad hoc reviewer of an average of two grants per month, primarily for NSF, and also for the VA, and agencies in England, Switzerland, Ireland, Italy, Israel, HFSP, and Wellcome Trust. Member, American Cancer Society, Council on Extramural Grants, 2004-. This Council oversees the entire extramural research budget of the ACS and makes policy recommendations for the extramural program. NIH, CMBK Study Section, 2004- NCI, External oversight of intramural program, 2004. Regular Member: Cell Biology Study Section (Cellular Organization Panel), NSF, 1995-2002 Member: Special Study Sections, National Cancer Institute, 1992, 1993 Member: Special Study Sections, NIAID, 1996, 1997, 2000 American Cancer Society, Cell Biology Study Section, Ad Hoc, 1994 National Institute of Allergy and Infectious Diseases, Special Emphasis Panel, 1996, 2000 National Institute of Diabetes and Digestive and Kidney Disease, Special Emphasis Panel, 2000, 2003 Ad hoc Member, Telethon Career Project, Italian Telethon, 1999. National Institute of Child Health and Human Development, External oversight of intramural program, 2002; Professional Societies American Society for Cell Biology American Association for Advancement of Science Society for Mucosal Immunology (Member since inception) American Society for Microbiology Other Community Service Parents Committee, Room Parent, Jewish Community Center, Rosenberg Preschool, 1995-98 10/19/10 9
  10. 10. Golden Gate Heights Neighborhood Association, Neighborhood Emergency Response Team, 1996-present National Yiddish Book Center, member, 1988-present Beyt Tikkun (synagogue), member, 1996-98 Congregation Beth Sholom, member 1998-1999 Congregation Bnai Emmunah, member 2000-present San Francisco Youth Synchronized Skating Team, fundraising, 1999-2000 Patents (all assigned to UC Regents) U.S. Patent 6855810, issued February 15, 2005, “Ligands directed to the non-secretory component, non- stalk region of the pIgR and methods of use thereof US Patent 6,808,709, issued October 26, 2004, “Immunoglobulins containing protection proteins and their use.” US Patent 6,340,743, issued January 22, 2002, “Antibodies to pIgR Stalk” US Patent 8,856,383, issued March, 2000, “Cellular Internalization of pIgR Stalk and Associated Ligands” US Patent 6,046,037, issued April 4, 2000, “Method for producing immunoglobulins containing protection proteins in plants and their use.” US Patent 6,303,341, issued October 16, 2001, “Method for producing immunoglobulins containing protection proteins in plants and their use.” U.S. Patent Application 09/292,274, "Protein Transport Assays" U.S. Patent Application 60/192,198, “Anti-pIgR antibodies with improved transcytosis.” EXTRAMURAL RESEARCH SUPPORT Past NIH New Investigator Award R23 AI 21752 Transepithelial transport of immunoglobulins (At Whitehead Institute) 10/1/84—6/30/87 $105,000 Total Direct Costs Hood Foundation Transport of immunoglobulins across intestinal cells (At Whitehead Institute) 1/1/88—12/31/87 $35,000 Total Direct Costs Searle Scholar Award Polarized traffic in epithelial cells 7/1/89—6/30/92 10/19/10 10
  11. 11. $162,000 Total Direct Costs Cancer Research Institute Investigator Award Membrane protein sorting 7/1/90—6/30/94 $200,000 Total Direct Costs Charles E. Culpeper Foundation Scholar in Medical Science Protein sorting in polarized cells 7/1/92—6/30/95 $300,000 Total Direct Costs Edward Mallinckrodt Foundation Medical Scholar Epithelial Membrane Traffic 10/1/92—9/30/95 $175,000 Total Direct Costs NIH Gene Therapy Center, Pilot Project Apical Uptake of DNA 7/l/93-6/30/95 $100,000 Total Direct Costs American Heart Association Established Investigator 7/1/93-6/30/98 $255,000 Total Direct Costs American Cancer Society Regulation of transcytosis IM-78977 7/1/95—6/30/98 $321,000 Total Direct Costs NIH R01 AI39161 A novel method for intestinal absorption of antibodies 9/1/95-8/31/00 $513,003 Total Direct Costs NIH R21DK55722 A novel method for mucosal gene delivery 4/1/99-3/31/01 $200,000 Total Direct Costs NIH R44AI41895 (SBIR Phase 2) (P.I. Kerry Petersen at LI-COR Corp.) Detecting biomolecules with near-infrared fluorescence 10/1/99-9/30/01 $291,000 Total Direct Costs DOD/US Army Breast Cancer Membrane traffic alterations in epithelial cancer 9/30/97-10/29/00 10/19/10 11
  12. 12. $201,534 Total Direct Costs Current (All Mostov P.I.) NIH R01 AI25144 Transport of immunoglobulins across epithelial cells (Grant originated at Whitehead Institute and moved to UCSF) 7/1/87—6/30/92 $771, 938 Total Direct Costs Competitive Renewal Funded 8/1/92-7/31/97 $930,575 Total Direct Costs Competitive Renewal Funded 8/1/97-7/31/02 $1,083,640 Total Direct Costs Competitive Renewal Funded (MERIT Award, 10 years) 8/1/02-7/31/12 $2,500,000 Total Direct Costs NIH RO1 DK067153-01 Control of orientation of epithelial polarity 4/1/04-3/31/09 $1,250,000 Total Direct Costs NIH R01 HL55980 Host cell determinants in Pseudomonas pneumonia 12/1/95—11/30/98 $439,644 Total Direct Costs Competitive Renewal Funded 4/1/99-3/31/04 $1,170,244 Total Direct Costs NIH R01 AI36953 Regulation of transcytosis of immunoglobulins 10/1/95-9/30/00 $761,651 Total Direct Costs Competitive Renewal Funded 10/1/00/-8/31/05 $750,000 Total Direct Cost NIH RO1DK58061 Novel method for mucosal transport of protein drugs 10/19/10 12
  13. 13. 6/1/01-5/31/06 $630,000 Total Direct Cost NIH P01 AI053194 I am PI on this Program Project Grant, as well as leader of Project 1 and Director of Cores A and C. Project 1 Molecular control of epithelial wound healing 09/30/02-03/31/07 $708,223 Total Direct Cost Core A Administrative Core 09/30/02-03/31/07 $211,759 Total Direct Cost Core C Mulitiphoton and confocal live cell imaging 09/30/02-03/31/07 $284,509 Total Direct Cost NIH S10 RR017973 4/1/03-3/31/04 Multiphoton Microscope Facility for UCSF Mission Bay $496,002 Total Direct Costs. INVITED TALKS AT MEETINGS 7/81 Gordon Conference: Red Blood Cells 5/82 New York Academy of Science, Mucosal Immunology Meeting 7/82 Gordon Conference: Lysosomes 9/84 World Congress on Cell Biology, Tokyo, Symposium: Membrane Traffic 9/84 Satellite Meeting on Membrane Recycling, Kyoto, Japan 11/84 Cold Spring Harbor, Banbury Meeting on Membrane Traffic 5/85 French Society for Immunology, Annual Meeting, Keynote Speaker 9/85 European Molecular Biology Laboratory, Membrane Traffic Course 11/85 ASCB Annual Meeting, Mini-symposium on Cell Polarity 7/86 Gordon Conference: Lysosomes 8/86 FASEB Summer Conference: Receptors 12/86 ASCB: Mini-symposium: Cell Polarity 1/87 Salk Institute Symposium 3/87 Recombinant DNA Congress, San Francisco 4/87 FASEB: Mini-symposium on Epithelial Polarity 6/87 FASEB Summer Meeting: Fc Receptors 10/19/10 13
  14. 14. 7/87 Gordon Conference: Membrane Molecular Biology 7/87 Gordon Conference: Membrane Transport 9/87 International Germinal Center Congress, Oslo, Norway 10/87 EMBO Meeting on Cell Polarity, Bandol, France 11/87 Upjohn Meeting on Advanced Drug Delivery 5/88 FASEB: Mini-symposium on Epithelial Polarity 7/88 Gordon Conference: Lysosomes 8/88 FASEB Summer Conference: Receptors 9/88 Joint ASCB/EMBO Meeting on Intracellular Traffic, Pitlochry, Scotland 10/88 UCSF Laurel Heights Biotechnology Conference 1/89 ASCB Mini-symposium: Endocytosis 5/89 American Gastroenterological Association Meeting 7/89 Gordon Conference: Membrane Molecular Biology 7/89 Gordon Conference: Membrane Transport 6/90 Gordon Conference: Lysosomes 6/90 FASEB Summer Conference: Fc Receptors 7/90 International Congress on Mucosal Immunology, Tokyo, Plenary Lecture 8/90 World Congress on Gastroenterology, Satellite Meeting on Mucosal Immunology, Sydney 12/90 ASCB Mini Symposium: Cell Polarity 2/91 Gordon Conference: Angiotensin 6/91 IRBM Symposium on Gene Expression During Liver Differentiation and Disease, Sorrento, Italy 6/91 International Falk Symposium on Hepatic Endocytosis, Hamburg, Germany (Keynote Speaker) 8/91 FASEB Summer Conference: Gastrointestinal Tract 6/92 Gordon Conference: Lysosomes 7/92 International Congress on Cell Biology, Madrid, Symposium: Endocytosis 2/93 Keystone Symposium on Epithelial and Neuronal Polarity 2/93 Keystone Symposium on Genetic and In Vitro Analysis of Cell Compartmentalization. 2/93 Keystone Symposium on Emerging Principles for Vaccine Development: Antigen Processing and Presentation 3/93 Gordon Conference: Molecular Pharmacology 3/93 Society for Inherited Metabolic Disorders Annual Meeting, Asilomar 4/93 British Society for Cell Biology, Norwich, England 7/93 FASEB Summer conference: Protein Kinases 11/93 American Gastroenterological Association Winter Conference: Gastrointestinal Transport 7/94 Gordon Conference: Lysosomes 12/94 ASCB Mini-symposium: Cell Polarity 6/95 Cold Spring Harbor Symposium 7/95 FASEB Meeting: Gastrointestinal Tract 8/95 Danish Cancer Society, Copenhagen 10/19/10 14
  15. 15. 11/95 American Society for Nephrology, San Diego 2/96 Keystone Symposium: Cell Polarity 7/96 FEBS Meeting, Barcelona, Spain 8/96 Society for Industrial Microbiology, Raleigh-Durham, North Carolina 9/97 European Science Foundation, Endocytosis Meeting, Barcelona, Spain 4/98 R.R. Bensley Award Lecture, FASEB Meeting, San Francisco 5/98 Institute of Molecular Pathology Cancer Symposium, Vienna, Austria 10/98 American Society of Nephrology, Philadelphia 12/98 American Society of Cell Biology, Minisymposium on Cell Polarity, San Francisco (session co- chair) 3/99 Rockefeller University/Cornell Medical College MD/PhD Program Anniversary Symposium 8/00 BioCity Symposium, University of Turku, Finland 3/01 ASCB Keith Porter Symposium, Airlie, Virginia 5/01 Symposium in honor of Gunter Blobel, 65th Birthday, Max Planck Institute, Dresden, Germany 5/01 Rockefeller University Centennial Symposium, New York City 7/01 Keystone Symposium on Drug Delivery, Breckenridge, Colorado 7/01 British Society for Pharmacology, Dublin, Ireland 8/01 International Workshop on Developmental Nephrology, Victoria, British Columbia 9/01 INSERM Laudat Conference on Epithelial Polarity, Aix-les-Bains, France 9/01 Jacques Monod/EMBO Conference on Microfilament Function, Giese, France 11/01 ColdSpring Harbor/Banbury Conference on Tubulogenesis, Huntington, NY 12/01 American Society of Cell Biology, Minisymposium on Cell Polarity, Washington, DC (session co- chair) 6/02 Institute of Biopreparations, Conference on Cytokines, Inflammation and Immunity, St. Petersburg, Russia. 9/02 International Society for Differentiation, Lyon, France 12/02 American Society of Cell Biology, Session on monomeric GTPases. San Francisco. 5/03 American Society for Microbiology, Session on Epithelia-Pathogen Interactions, Washington, DC. 5/03 Digestive Diseases Week, Orlando, FL 6/03 Gordon Conference on Small GTPases, Ventura, CA. 7/03 FASEB Meeting on GI System, Tucson, AZ 9/03 European Science Foundation, Endocytosis Meeting, Naples, Italy 11/03 American Society for Nephrology, San Diego, CA 11/03 Bay Area Membrane Traffic Meeting. 1/04 Keystone Symposium on Rab GTPases, Breckenridge, CO 1/04 Timberline Meeting on Cell Polarity, Mt. Hood, Oregon 3/04 EMBO Meeting on Epithelial Polarity in Development and Disease, Carry Le Rouet, France, 2004 4/04 FASEB Symposium on Epithelial Polarity, Washington, D.C. 9/04 Welcome Meeting on Cell Organization, Singapore 3/05 Keystone Meeting on Cell Polarity, Coeur d'Alene, Idaho 10/19/10 15
  16. 16. 4/05 FASEB Symposium on Cell Polarity, San Diego, CA 5/05 EMBO/IRCC Meeting on Invasive Growth, Torino, Italy 6/06 Japanese Society of Developmental Biology Symposium, Sendai, Japan 8/05 FASEB Meeting on Polycystic Kidney Disease, Keynote Speaker, Saxtons River, VT 9/05 American Liver Foundation Symposium, Boston, MA 10/05 Cooperative Biological Research Review, St. Petersburg, Russia 12/05 Society for Basic Urologic Research/Eur. Soc. for Urological Research, Miami, FL 2/06 Developmental Vascular Biology Workshop, Pacific Grove, CA 2/06 Ernest Just Symposium, Medical University of South Carolina, Charleston, SC 5/06 Max-Delbrueck Center Meeting on Epithelial Organization and Organ Development, Berlin, Germany 6/06 Lunenfeld Institute Symposium on Cell Polarity, Toronto, Canada 6/06 Novartis Foundation Symposium on Vascular Development, London, UK. 6/06 Royal Society of Medicine/Physiological Society meeting on Angiogenesis, London, UK. 12/06 ASCB Meeting on Lipid Signaling, San Diego, CA 12/06 ASCB Meeting on Epithelial Systems Biology, San Diego, CA 4/07 Experimental Biology, Plenary Session. Washington, D.C. INVITED RESEARCH SEMINARS 10/80 European Molecular Biology Laboratory 10/80 University of Milan, Italy, Institute of Pharmacology 10/80 University of Lausanne, Switzerland, Department of Biochemistry 10/80 University of Naples, Italy, Department of Biochemistry 11/81 Rockefeller University, Laboratory of Cell Physiology 4/82 New York University, Department of Pathology 2/83 New York Blood Center 10/83 Yale University, Department of Cell Biology 10/83 NIH, Laboratory of Pathology 2/84 MIT, Department of Biology 2/84 SUNY Downstate Medical Center, Department of Pathology 10/84 Harvard University, Department of Cell and Developmental Biology 12/84 Harvard University, Department of Biochemistry and Molecular Biology 12/84 Tufts University, Department of Cell Biology 5/85 Pasteur Institute, Paris, Department of Molecular Biology 8/85 Collaborative Research Co., Lexington, MA 9/85 University of Lausanne, Switzerland, Department of Biochemistry 10/85 Harvard University, Department of Cellular Biology and Anatomy 10/85 Yale University, Department of Cell Biology 10/19/10 16
  17. 17. 12/85 McGill University, Department of Molecular Biology 5/86 Cornell University, Department of Cell Biology and Anatomy 5/86 Biogen, Cambridge, MA 5/86 New York University, Department of Cell Biology 9/86 Harvard Medical School, Joslin Diabetes Center 11/86 Massachusetts General Hospital, Laboratory of Gastroenterology 11/86 SUNY Downstate Medical Center, Department of Cell Biology 12/86 NIH Laboratory of Cell Biology 1/87 Columbia University, Department of Physiology 2/87 Princeton University, Department of Molecular Biology 3/87 Stanford University, Department of Biochemistry 3/87 Genentech 3/87 UCSF, Department of Biochemistry and Biophysics 4/87 Brandeis, Department of Biology 5/87 Rockefeller University 7/87 University of Pennsylvania, Department of Pathology 7/87 Cambridge Neuroscience Research Company 9/87 Norwegian Cancer Research Institute 9/87 University of Bergen, Norway, Department of Immunology 10/87 Weslyan University, Department of Molecular Biology 2/88 Dartmouth Medical College, Department of Biochemistry 5/88 Alkermees Research Co. 10/88 University of Massachusetts, Amherst, Department of Biochemistry 10/88 Yale Medical School, Section on Immunology 10/88 Mehary Medical College, Department of Biochemistry 10/88 University of Illinois Medical College, Chicago, Department of Immunology 10/88 Fox Chase Cancer Center 9/89 Stanford University, Immunology Program 9/89 Athena Neurosciences Co. 10/89 UCSF, Department of Anatomy 10/89 UCSF, CVRI 11/89 UCSF, Department of Microbiology and Immunology 2/90 Cornell Medical College, Department of Cell Biology 2/90 Annual NOVO Lecture, Danish Biological Society 2/90 European Molecular Biology Laboratory, Heidelberg 2/90 Academy of Sciences, Department of Molecular Biology, East Berlin 7/90 Kyushu University, Fukuota, Japan, Department of Molecular Biology 8/90 University of Melbourne, Australia, Department of Pathology 8/90 Heart Research Institute, Sydney 10/19/10 17
  18. 18. 11/90 Stanford University, Department of Pharmacology 2/91 Lawrence Berkeley Laboratory 2/91 University of California, Berkeley, Department of Molecular and Cell Biology 3/91 University of Colorado, Department of Cellular and Structural Biology 6/91 Princeton University, Department of Molecular Biology 6/91 University of Basel, Biocenter 6/91 Cornell University Medical College, Department of Cell Biology 6/91 Albert Einstein College of Medicine, Department of Anatomy and Structural Biology 8/91 Whitehead Institute 1/92 Stanford University, Department of Microbiology and Immunology 3/92 Vanderbilt University, Department of Pharmacology 4/92 Monsanto Corporation 4/92 Washington University, St. Louis, Program in Immunology 7/92 Tel Aviv University, Department of Biochemistry 7/92 Hebrew University, Lautenberg Center for Immunology 7/92 Weizmann Institute, Department of Chemical Immunology 4/93 Memorial Sloan Kettering Cancer Research Institute, Laboratory of Cellular Biophysics 4/93 Guys and St. Thomas’ Medical School, London, Department of Immunology 10/93 University of Kentucky, Department of Microbiology and Immunology 1/94 UCSF, Cardiovascular Research Institute 2/94 Vollum Institute, Oregon Health Sciences University 3/94 University of Utah, Department of Pathology 4/94 University of Arizona, Department of Cell Biology and Anatomy 7/94 Mount Desert Island, Biological Laboratory, Bar Harbor, Maine 8/94 Alza Corporation, Palo Alto, California 1/95 University of Alabama, Birmingham, Department of Physiology 5/95 Mayo Medical Center, Rochester, MN, Department of Biochemistry 9/95 University of Wisconsin, Madison, WI, Department of Biochemistry 1/96 Chiron Corp., Emeryville, California 8/96 LI-COR Corp., Lincoln, Nebraska 9/96 Case-Western Reserve University, Cleveland, Ohio 1/97 Inhale Therapeutic Systems, Palo Alto, CA 3/97 Stanford University, Department of Biochemistry, Palo Alto, CA 4/97 University of Chicago, Department of Physiological and Pharmacological Sciences, Chicago, IL 5/97 Cornell University Medical College, Department of Biochemistry, New York, NY 8/97 LI-COR Corp., Lincoln, Nebraska 10/97 Immunex Corp., Seattle, WA 5/98 Cornell Univeristy, Department of Physiology, NY. 9/98 UCSF, Department of Pediatrics 10/19/10 18
  19. 19. 10/98 Washington University, St. Louis, Keynote Speaker, Mallinckrodt Symposium 1/99 California Institute of Technology, Pasadena, CA, Department of Biology. 3/99 Cornell University, Department of Cell Biology 5/99 New York University School of Medicine, Department of Cell Biology 8/99 UCSF, Division of Nephrology 9/99 Indiana University School of Medicine, Division of Nephrology 11/99 Yale University School of Medicine, Department of Cell Biology 12/99 University of Alabama at Birmingham, Department of Cell Biology 4/00 Columbia University College of Physicians and Surgeons, Department of Physiology 4/00 Mt. Sinai School of Medicine, Department of Biochemistry 7/00 University of North Carolina, Chapel Hill, Department of Pharmacology 8/00 Baylor University, Houston, TX, Department of Biochemistry 9/00 NIH, National Institute of Child Health and Human Development 10/00 St. Jude Children’s Research Hospital, Memphis, TN 11/00 Albert Einstein Medical College, New York, NY, Department of Molecular Pharmacology 1/01 University of Southern California, Department of Pharmaceutical Sciences 1/01 Princeton University, Princeton NJ, Department of Molecular Biology 2/01 School of Medicine, University of Southern California 9/01 Institut Curie, Paris, France 2/02 Emory University, Atlanta, GA, Department of Pathology 3/02 Vanderbilt University, Nashville, TN, Department of Microbiology 4/02 University of Pittsburgh, Pennsylvania, Department of Cell Biology 5/02 Northwestern University, Evanston IL. Department of Molecular Biology 10/02 Protein Design Labs, Freemont, CA. 1/03 Scripps Research Insitute, La Jolla, CA, Department of Cell Biology 3/03 Harvard Medical School, Boston MA, Digestive Diseases Center. 4/03 University of California, San Francisco, CA, Liver Center 4/03 Universidad Central del Caribe, Puerto Rico, Center for Neurobiology 4/03 Cornell University, Department of Cell Biology, New York 4/03 Rutgers University, Department of Molecular Biology, New Jersey 4/04 UCSF, Division of Nephrology 10/04 University of Illinois, Department of Pharmacology, Chicago, Illinois 2/05 Oregon Health and Science University, Department of Developmental and Cell Biology, Portland, OR 3/05 University of Pennsylvania, Department of Biology, Philadelphia, Pennsylvania 5/06 EMBL, Heidelberg, Germany 5/06 University of Iowa, Department of Anatomy and Cell Biology, Iowa City, Iowa 6/06 San Raffaele Scientific Institute, Milan, Italy 6/06 Ludwig Institute, London, UK 10/19/10 19
  20. 20. 02/07 Memorial Sloan Ketterin Cancer Center, NY, NY 04/07 Fox Chase Cancer Center, Distinguished Lecturer, Philadelphia, PA 04/07 Max Planck Institute for Cell Biology and Genetics, Dresden, Germany 05/07 University of Illinois at Chicago, Department of Biological Sciences, Chicago, IL 10/19/10 20
  21. 21. RESEARCH PROGRAM: Epithelial polarity and morphogenesis The most fundamental type of organization of cells in metazoa is that of epithelia. Epithelial cells form sheets of cells that line surfaces and internal cavities. The simplest metazoa, such as hydra, consist largely of two concentric cylinders of epithelial cell sheets. Most internal organs in higher animals, such as the respiratory, digestive, genito-urinary and vascular systems are lined by a single layer of epithelial cells. We are studying both the structure of individual epithelial cells and how they are organized into multicellular tissues and organs. We are focused on three basic questions: 1. How is the polarization of epithelial cells determined? Epithelial cells are highly polarized, with an apical surface facing the lumen of the cavity and a basolateral surface facing other cells and extracellular matrix. Epithelial cells have a conserved set of protein complexes, such as the Par3/Par6 complex, which are needed to become polarized. Upstream of these complexes, we have discovered a new pathway that determines the orientation of polarization, that is which way the cell points. Alterations in this pathway can cause cells to reverse polarity, so that the apical surface now points away from the central lumen. We have found that this pathway starts with assembly of the laminin-rich extracellular matrix around the cells, followed by integrin signaling at the basolateral surface. The signal for orientation of polarity must then move across the cells; this may be mediated by transcellular movement of the small GTPase, Cdc42. Finally, Cdc42 apparently promotes the organization of the Par3/Par6 and other complexes at the apical surface of the cell. 2. Once the initial orientation of polarity is determined, how does the cell execute this program to become fully polarized? The apical and basolateral surfaces of the cell have completely different protein and lipid compositions, and so the cell has mechanisms to specifically sort these components to one surface or the other. The lipid phosphatidyl inositol 3,4,5-P3 (PIP3) is a crucial determinant of this process. Normally PIP3 is found only at the basolateral surface. Ectopic localization of PIP3 to the apical surface can transform this apical surface into basolateral surface, by causing the relocalization of normally basolateral proteins to the apical surface, as well as removal of apical proteins from this transformed surface. Proteins and lipids are transported to the apical or basolateral surfaces by vesicular carriers. The fusion of these carriers with the surface involves syntaxin proteins, which are found on the target membrane. We have found that syntaxin 4 is exclusively basolateral, while syntaxin 3 is exclusively apical. Ectopic localization of syntaxin 3 to the basolateral surface causes misdelivery of apical proteins to the basolateral surface. This data indicate that PIP3 and syntaxins specify where vesicles are delivered to in the cell. 3. The basic building block of most epithelial organs are tubes, lined by epithelial cells. How do epithelial cells organize themselves into tubes? We have found that when epithelia cells remodel to form tubes, they start by partially dedifferentiating, losing their epithelial polarity and taking on many of the properties of migrating fibroblasts. The cells then migrate to positions where they will form the new tube. The cells then re-differentiate, reacquiring epithelial polarity and creating new lumens between the cells. Tubulogenesis can thus be conceptualized as occurring in two stages, dedifferentiation and re- differentiation. 10/19/10 21
  22. 22. Selected publications. van IJzendoorn, S.C.D., Tuvim, M.J., Weimbs, T., Dickey, B.F., and Mostov, K.E. Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells. Develop. Cell, 2:219-228, 2002 I conceived, directed and interpreted this work. Van IJzendoorn was a post-doc in my lab who performed all the experiments. The middle authors contributed reagents. O’Brien, L.E., Zegers, M.M.P., and Mostov, K.E. Opinion: Building epithelial architecture: insights from three- dimensional culture models. Nat. Rev. Mol. Cell Biol. 3:531-537, 2002 This Opinion piece proposed several novel concepts and has been highly influential in the field. For instance, new computer modeling studies have been done based on ideas proposed in this paper. I conceived of the ideas. Much of the writing was done by O’Brien in close collaboration with me. Zegers did the drawings. Yu, W., O’Brien, L.E., Wang, F., Bourne, H., Mostov, K.E., and Zegers, M.M.P. Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures. Mol. Biol. Cell, 14:748-763, 2003. I conceived, directed and interpreted this work. Yu and Zegers were post-docs in my lab who did the work. The other authors provided reagents. O'Brien, L.E., Tang., K., Kats E.S., Schutz-Geschwender, A., Lipschutz, J.A., Mostov, K.E., ERK and MMPs Sequentially regulate distinct stages of epithelial tubule development. Developmental Cell. In press. 2004. I conceived, directed and interpreted this work. O’Brien was a student and then post-doc in my lab who did the work, assisted by Tang (a technician) and Katz (a summer student). Schutz-Geschwender and Lipschutz contributed to methodological development. Vergés, M., Luton, F., Gruber, C., Tiemann, F., Reinders, L., Huang, L., Burlingame, A., Haft, C., Mostov. K.E. The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. Nat. Cell Biol. In press. August 2004. I conceived, directed and interpreted this work. Vergés was a post-doc in my lab who did the work, with help from Luton, another post-doc in my lab and Gruber, a technician in my lab. Tiemann was a collaborator at a company who supplied reagents. Reinders and Huang were technicians in Burlingame’s lab who provided mass spectroscopy analysis. Haft was a collaborator at NIH who supplied reagents. 10/19/10 22
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