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Skyline College


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  • 1. Skyline College Official Course Outline Date: December 2007 1. TITLE: BIOL 170: Principles of Applied Bioscience 3 Units – three lecture hours per week Prerequisites: none. Recommended: Eligibility for English 836 or English 846 2. COURSE CLASSIFICATION: Credit Course applicable to the Associate Degree 3. COURSE DESCRIPTIONS: Catalog Description: The course is a survey of the principles that govern the living world, from molecules to cells and tissues, to organs and whole organisms, to populations and ecosystems, to the entire biosphere. Special emphasis is placed upon experimental approaches, current issues, and practical application of the scientific method and biological principles to issues affecting public health, agriculture, and socioeconomic change. Current news and developments in relevant areas of biological sciences and biotechnology will be reviewed and discussed. Schedule of Classes Description: The course is a survey of the principles that govern the living world, from molecules to cells and tissues, to organs and whole organisms, to populations and ecosystems, to the entire biosphere. Current news and developments in relevant areas of biological sciences and biotechnology will be reviewed and discussed. 4. COURSE JUSTIFICATION: This course is intended to: A. Fulfill general education credit for the associate degree B. Fulfill general education transfer requirements for CSU area B2 and IGETC area 5 C. Prepare students for further study in biotechnology or life science D. Provide further course offerings for high school students of Biotechnology 5. STUDENT LEARNING OUTCOMES (SLO’S): Upon Completion of this course students should be able to: A. Apply the knowledge of biological science to distinguish between observations, inferences, relationships, and testimonials under investigation. B. Demonstrate the ability to use scientific knowledge to assess personal and environmental health. C. Use the scientific knowledge and skills necessary for active citizenship D. Demonstrate an understanding of how experimental evidence and analysis lead to ongoing pursuits of modern knowledge, theory, and methods of scientific investigation 6. SPECIFIC INSTRUCTIONAL OBJECTIVES: To meet the above learning outcomes the student will need to: A. Describe key characteristics of living organisms and their biological molecules B. Describe essential biological structures and processes that occur at the molecular, cellular, and organismal levels that enable life. C. Explain gene function and the role of genes in inheritance and evolution. Biology 170 – Bioscience - Draft Page 1 of 4 October 19, 2010
  • 2. D. Discuss tools of biotechnology and describe their current and potential uses. E. Explain and practice the scientific method of inquiry. F. Describe ecological interactions that occur within ecosystems, communities, and populations. G. Effectively organize and present scientific information to a group. H. Evaluate biological news and analyze issues in science. 7. COURSE CONTENT: A. Introduction to Biological Sciences and the Scientific Method 1. What is Life? Characteristics that distinguish life from non-life 2. Historical perspective of Biology: 3. The scientific method: observe, question, 4. Scientific Theory and Fact 5. Analyzing, Interpreting, and presenting scientific data B. Biological chemistry 1. Atoms, elements and valence: CHNOPS 2. Energy shells, valence, and the octet rule 3. Chemical bonds, electron affinity/electronegativity, and chemical reactions 4. Properties of water 5. Solutions: Salts, acids, bases, pH 6. Structure and function of Monomers and Polymers/Macromolecules: Carbohydrates, lipids, proteins, nucleic acids C. Cellular structure and function: 1. Foundational Investigations: Pasteur, Urey-Miller 2. Microscopy 3. Cell Theory – Virchow, Schleiden, Schwann, Hooke 4. Prokaryotic cell structures 5. Eukaryotic organelles 6. Biological membranes: fluid mosaic model 7. Concentration gradients and diffusion; equilibrium 8. Membrane transport: passive, active, bulk D. Energy and enzymes 1. Chemical reactions and equilibrium 2. Enzyme structure and function: catalysis & activation energy 3. Enzyme Regulation 4. Enzyme pathways and metabolism 5. Energetic coupling E. Cellular Energetics: Fermentation, Respiration, Photosynthesis 1. (introduce foundational Experiments) – scientific method, process F. Cellular Reproduction: Cell Cycle, Chromosomes, Mitosis and Meiosis 1. Cell cycle regulation 2. Chromosome structure 3. Mitosis 4. Cytokinesis 5. Cells out of control: Cancer 6. Meiosis 7. Recombination 8. Early human development: fertilization, embryology and stem cells Biology 170 – Bioscience - Draft Page 2 of 4 October 19, 2010
  • 3. Mendelian genetics and Chromosomal Inheritance 9. Mendel’s Methods and Laws 10. Non-mendelian inheritance 11. Linkage and chromosome mapping 12. Human Pedigrees G. Molecular Genetics (emphasize foundational Experiments) 1. Structure and function of DNA -- Watson & Crick a. Applications: Hybridization, Restriction, and electrophoresis 2. Central Dogma – Crick, Beadle & Tatum 3. Replication – Meselson and Stahl, Kornberg a. Applications: PCR and Gene sequencing 4. Transcription 5. Genetic Code– Unity of life 6. Translation 7. Mutations, Genetic Disease, and Mutagenesis as a tool 8. Bacteria and viruses as models for study a. Recombination: transformation, conjugation, transduction 9. Bacteria and viruses as tools for Genetic Engineering 10. Gene regulation (emphasize foundational Experiments) 11. Prokaryotes: Operon Model 12. Eukaryotes: levels of gene regulation (transcription to post-translational) 13. Gene regulation in development: communication and control of gene expression; 14. Gene regulation gone wrong: Cancer H. DNA Technology/Genetic engineering (present foundational Experiments) 1. Recombinant DNA Technology a. Applications of DNA Replication – PCR, gene sequencing b. Tools from microorganisms – restriction enzymes, cloning vectors, ligase, Taq, Reverse Transcriptase 2. Genomics and Proteomics 3. Human Gene Therapy – methods, vectors, current applications, limitations 4. Active products of biotechnology: a. Expressing recombinant proteins b. mass-producing proteins for commercial use 5. Genetically engineered plants, transformation techniques 6. a. crops 7. b. drugs 8. Recombinant DNA in animals 9. Animal cloning 10. Tools from the Mammalian Body: The Immune System and Antibodies a. Specific Immunity: B cells and T cells b. Antibody structure and specificity c. Immunological Applications: Diagnosis, Scientific investigation, molecular purification 11. Biotechnology for the Environment: Bioremediation, Detection of contaminants 12. Current Issues: economics, privacy, ethics I. Evolution 1. Microevolution – small changes in a short time Biology 170 – Bioscience - Draft Page 3 of 4 October 19, 2010
  • 4. 2. Darwin’s observations and Natural Selection 3. Genetics and Evolution 4. Macroevolution – changes in populations 5. Hardy-Weinberg and causes of evolution 6. Organisms and adaptations to environment 7. DNA fingerprinting and Genetics – keys to geneaology and evolution a. Evolution – speciation J. Life and the Environment: Ecology 1. Chemical cycling and human impacts: water, N, C 2. Population ecology– tracking speciation and ecological diversity with DNA fingerprints 3. Communities and ecosystems 4. Global impacts: the Biosphere 5. Environmental issues & Human impacts: Biodiversity, Conservation Biology, Bioremediation 8. REPRESENTATIVE METHODS OF INSTRUCTION: Typical methods of instruction may include: A. Lectures with explanations and demonstrations of fundamental concepts of life science. B. Explanation, augmentation and application of concepts presented in text book (25-50 pages readings/week.) C. Presentation and analysis of scientific articles and materials. D. Outside assignments for students to individually engage in analysis of bioscience examples E. Directed Interactive dialogs and consultations amongst students in group study sessions. F. Comparative consideration of readings of the text book and original source materials. G. Written critical examination and analysis of bioscience -- reflective essays, research and term papers H. Assignment, reportage and analysis of field trip activities 9. ASSIGNMENTS: Typical assignments would include: 10. EVALUATION OF STUDENT PERFORMANCE: Typical methods of evaluation may include the following: A. From class exercises and group study results, verification of the understanding of terms and concepts through their proper application and use through exams or other objective means. B. Students engaged in class discussions provide evidence of critical thinking skill in applications of identification, comparisons and formulation of opinions, value judgments and conclusions C. Research papers to find, interpret and integrate factual materials into cohesive and coherent conclusions. D. Mid-term and Final Examinations to ascertain acquisition of factual information and abilities to synthesize deductive answers from that information. 11. RECOMMENDED or REQUIRED TEXT(S): Recommended Textbooks: Starr: Biol. Today & Tomorrow; Campbell: Essential Biology Biology 170 – Bioscience - Draft Page 4 of 4 October 19, 2010