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Research Overview Research Overview
Research Overview Research Overview
Research Overview Research Overview
Research Overview Research Overview
Research Overview Research Overview
Research Overview Research Overview
Research Overview Research Overview
Research Overview Research Overview
Research Overview Research Overview
Research Overview Research Overview
Research Overview Research Overview
Research Overview Research Overview
Research Overview Research Overview
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Research Overview Research Overview

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  • 1. Research Overview Department of Rheumatic and Immunologic Diseases Carol A. Langford, MD, MHS Vice Chair of Rheumatology Research Department of Rheumatic and Immunologic Diseases Cleveland Clinic
  • 2. Research Activities Department of Rheumatic and Immunologic Diseases Strong past history of research achievements • CCF rheumatologists lead and contributed to advancements in many diseases Stronger present day research portfolio • 41 active IRB approved protocols • 11 Department faculty have IRB approved protocols • 2007 ACR National Meeting – CCF rheumatology had 24 accepted abstracts of original research • Within the Division of Internal Medicine: – Rheumatology had the highest ratio of funded/unfunded research activities
  • 3. Career Development Awards ACR REF Educator Award “Web-based problem-based rheumatology curriculum” Abby Abelson, MD ACR REF Investigator Award “Atherosclerosis and autoimmunity: detecting subclinical coronary artery disease in rheumatoid arthritis patients” Elaine Husni, MD
  • 4. Elaine Husni, MD • PRECISION Pfizer • Long term Study of the Safety of Rituxan® in Patients with Rheumatoid Arthritis After an Inadequate Response to Genentech Previous Anti-TNF Therapy • Registry: Psoriatic Arthritis and Psoriasis Database (PAPD)
  • 5. Center for Metabolic Bone Chad Deal, MD • Open Label Proof of Concept Study of IV Zoledronic Novartis Acid (ZA) 5 mg after Forteo in Postmenopausal Women • Forteo Observational Study Lilly • A Randomized, Double-Blind Study to Compare the Efficacy of Treatment with Denosumab versus Alendronate Sodium in Amgen Postmenopausal Women with low Bone Mineral Density • A Dose-Range Finding Study of SB-751689 in Post-Menopausal GSK Women with Osteoporosis • The effect of teriparatide compared to risedronate on back pain in postmeopausal women with osteoporotic vertebral fracture • Database: Hip Fracture
  • 6. Pediatric Rheumatology Philip Hashkes, MD • Phase 2 Study of IL-1 Trap for Treatment of Familial FDA Mediterranean Fever • Mortality Outcomes in Pediatric Rheumatology Arthritis Foundation • Randomized Clinical Trial in Juvenile Fibromyalgia NIH • Long Term Outcome of Two Cohorts of Children with JIA Long Island Jewish Hosp • A Pilot Multi-center, RDBPC Study of Two Dose Levels of IL-1 Regeneron Trap Administered SC in Pediatric Subjects with Active S JIA • Aggressive Therapy in JIA (TREAT) in early polyarthritis NIH • Phase III Clinical Trials in New Onset Juvenile Dermatomyositis: European consortium Steroids vs Steroids + CyA vs Steroids + MTX • Health Related Quality of Life Measures in Pediatric Lupus • ARCHIVE (A Registry of Children with Vasculitis)
  • 7. RJ Fasenmyer Center of Clinical Immunology Leonard Calabrese, DO • Development of a Web Based Data Management System for the study of Primary Angiitis of the Central Nervous System (PACNS) • Registry: Rheumatic Disorders After HAART • A Phase II Trial of Oxypurinol for the Treatment of Symptomatic Cardiome Hyperuricemic Patients Who are Unable to Tolerate Allopurinol • Oxypurinol in Allopurinol Sensitive Patients (OXY) Cardiome • AIRON-A National Data Bank for Rheumatic Disease Univ. of Kansas
  • 8. • Registry: Pulmonary Arterial Hypertension Quality Enhancement Research Initiative (QuERI) Soumya Chatterjee, MD • Registry: Scleroderma • Clinical profile of diffuse cutaneous systemic sclerosis with Scl-70 antibodies in comparison to those without Scl-70 antibodies William Wilke, MD • A Phase III, RDBPC Study of Retreatment with Rituximab Genentech in Subjects with RA Receiving Background MTX • Frequency of Fibromyalgia Syndrome in Chronic Sarcoidosis
  • 9. Brian Mandell, MD, PhD • Randomized, multicenter, double-blind, placebo-controlled Savient efficacy and safety study of 8 mg PEG-uricase in two dose regimens in hyperuricemic subjects with symptomatic gout Carmen Gota, MD • Cardiovascular Complications of JRA • Certolizumab pegol in RA UCB
  • 10. Center for Vasculitis Care and Research Carol Langford, MD Gary Hoffman, MD • Concurrent Studies of Abatacept in GCA and TAK NIH - NIAMS • Rituximab in ANCA-Associated Vasculitis (RAVE) NIH - NIAID - ITN • VCRC: Abatacept in Mild Relapsing WG NIH - RDCRN • Mechanistic analyses in WG treated with abatacept NIH - RDCRN • VCRC Longitudinal Studies NIH - RDCRN • VCRC: MRI and PET/CT in TAK NIH - NIAMS • WG Etanercept Trial (WGET) Longitudinal Study Johns Hopkins • Short-Term Cyclophosphamide Therapy Vasculitis Foundation / RJ Fasenmyer • Omnibus Blood Draw Rula Hajj-Ali, MD Gary Hoffman, MD Thomas Hamilton, PhD • Gene Expression Profile in Giant Cell Arteritis Vasculitis Foundation
  • 11. Department of Rheumatic and Immunologic Diseases Research Personnel Tiffany Clark, CNP Tara Narby, RN Katy Tuthill, CNP Debora Bork Sonia Crook, RN Research Administrator Geetha Krishnan, RN Louise Kincaid, RN
  • 12. Department of Rheumatic and Immunologic Diseases Fellowship Research Completion of a research project (from design to a written product) is a core requirement of the CCF rheumatology training program Fellowship Research Committee: • Elaine Husni, MD • Gary Hoffman, MD • Abby Abelson, MD • Chad Deal, MD • Philip Hashkes, MD • Carol Langford, MD 8 fellow lead abstracts of original research were presented at the 2007 American College of Rheumatology meeting
  • 13. Department of Rheumatic and Immunologic Diseases Future Goals Infrastructural Goals • Explore avenues to sustain the research infrastructure • Enhance statistical and database support Programmatic Goals • Enhance awareness of active trials and referral for enrollment • Establish a dedicated on-site basic science presence • Pursue a diverse funding portfolio that includes Government, ACR-REF, AF, other private sources, and industry • Continue to expand on areas of known strength • Explore faculty recruitment in areas where new growth is possible

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