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  • 1. Pathological Basis of Human Disease Course Guide     General information This course was introduced in 1999. It runs for 13 weeks in Semester 2. It consists of up to 12 hours scheduled teaching/learning time per week. An outline timetable of the course is given below but the detailed timetable is also accessible. It is 12 credit points and can be counted towards a major.
  • 2. Academic staff First Point of Contact please direct any enquiries to Lorraine McClinchie in the first instance: [email_address] A/Professor Nick King is the Course Convenor. Subject-specific enquiries should be made of the individual mentor in charge of that section. These are: Assoc Prof Brett Hambly – Cancer & Cardiovascular Prof Nick Hunt - Inflammation Assoc Prof Nick King - Immunology; Respiratory diseases Dr Roger Pamphlett & Assoc Prof Izuru Matsumoto - CNS Dr Bob Bao - Endocrine diseases; Gut disorders.
  • 3. Administrative Staff Any issues to do with the Museum should be raised with the Museum Curator, Dr Murat Kekic. In all cases, email is a very effective method of communication since academic staff may be busy with other duties and therefore not available without a prior arrangement being made.
  • 4. Recommended textbook Kumar, Cotran & Robbins. "Basic Pathology." 7 th Edition. WB Saunders. (Note: new edition may be out soon)
  • 5.
    • Aims of the course
    • To give students an overall understanding of the fundamental biological mechanisms governing disease pathogenesis in human beings
    • To introduce to students basic concepts of the pathogenesis, natural history and complications of common human diseases.
    • To demonstrate and exemplify differences between normality and disease.  
    • To aid students to apply basic concepts of disease processes to their understanding of how different organ systems react to injury.  
    • To explain cellular aspects of certain pathological processes.  
    • To equip students with skills appropriate for careers in the biomedical sciences and for further training in research or professional degrees.
  • 6. Eligibility The course is open to students of the University of Sydney who have completed the appropriate qualifying Units of Study in the 2 nd Year of the Bachelor of Science or Bachelor of Medical Science degrees, or those who have an equivalent qualification from another institution.
  • 7.
    • Practical competencies
    • At the end of the course students will:
    • Have acquired practical skills in the use of a light microscope
    • Have an understanding of basic investigative techniques for disease detection in pathology.
    • Be able to evaluate diseased tissue at the macroscopic and microscopic level.
    • Have the ability to describe and present information on disease pathogenesis in written and verbal form.  
    • Transfer problem-solving skills to novel situations related to disease pathogenesis.
    •  
  • 8. Basic Timetable Note: Varies from week to week - see the full timetable. The types of activities and the locations may vary. Some timetable clashes with other subjects will occur. Note there is some flexibility with respect to the following: Weekly Museum session (Groups MUS1, MUS2, MUS3 and MUS4) Choice of times 1 to 3pm or 3 to 5pm on either Tuesday or Friday may be possible, depending on clashes Weekly Microscope session (Groups MIC1, MIC2 - Rm 559) Choice of times 1 to 3pm or 3 to 5pm on Tuesday may be possible, depending on clashes. Research Project Research manuscript or Clinical Pathogenesis Project (usually 2 tutorials, to be arranged)
  • 9. Lectures: Tuesday 11.00a.m. [Physics Slade Lecture Theatre] Thursday 9.00a.m. [Physics Theatre 2] Friday 11.00a.m. [ Physics Theatre 2 ] *** Web Lecture Notes ***   Practicals: Tuesday 1.00 to 3.00p.m. or 3.00 to 5.00 pm [Blackburn Room 559]   Museum Sessions: Tuesday 1.00 to 3.00p.m or 3.00 to 5.00pm. or Friday 1.00 to 3.00p.m or 3.00 to 5.00pm.* [all sessions in Pathology Museum, Level 5, Blackburn]
  • 10. Project: Wednesday 3.00 to 6.00p.m.* [Various locations, Pathology Department, Level 5, Blackburn]. Students can choose to do a paper-based or pathogenesis project. Details of Projects are available on the web. Students need to choose three preferences and notify the Department (Ms Lorraine McClinchie) via email, as per instructions on the website: www.pathology.usyd.edu.au (follow link in dropdown menu) www.pathology.usyd.edu.au/CPAT3101/cpat_index.html
  • 11.
    • One of two options will be available:
    • Project based on a research manuscript (no attendance at timetabled sessions required, centred on library work and interactions with tutors). The subject areas vary year to year.
    • Pathogenesis Project (no attendance at timetabled sessions required, centred on Pathology museum work and interactions with tutors). The subject areas vary year to year.
    • Hand in at end of the semester (4pm on Monday 18 October)
    • – Attach Assignment Cover Sheet & obtain receipt.
    • To Department of Pathology Main Office (Ms McClinchie or delegate). 
    • - Please see the link on the CPAT3101 website for policies regarding late submissions and illness and misadventure
  • 12. Assessment The course is designed in relation to the learning objectives, and the assessment is an integral part of this. The assessment is designed to test understanding , not regurgitation of "facts". The theory examination will be by MCQ, though not of the "rote learning" variety. There will be an optional "practice" Practical Examination during the course to allow students to familiarize themselves with this form of assessment. Summative assessment: Project Report 20% Theory examination 30% Continuous theory assessment (Stems) 20% Practical examination 30%
  • 13. Learning formats In general, microscopic tutorials tend to have a high practical emphasis and lectures a high theoretical content, in line with the aims of these different forms of learning. Museum sessions will require students to develop their investigative and interpretative skills. You are encouraged to ask questions in tutorials, so no-one need go without any information that they might need to understand the material being covered. Furthermore, a few minutes spent reading the appropriate part of the text-book before lectures or tutorials will reap huge learning benefits.
  • 14. Museum sessions These will vary slightly with the different segments of the course. In general, students will investigate, singly or in groups, microscopic and macroscopic specimens of examples of human diseases. These sessions are expressly self-directed learning sessions. A member of the academic staff and/or a demonstrator with expertise in Pathology will be available in the second half of these sessions which will be held in the Interactive Centre for Human Diseases (Blackburn Building).
  • 15. Microscopic tutorials These will be held in Room 559 Blackburn Building. The features of disease states revealed in microscope slides of processed tissue will be demonstrated and discussed by use of the video microscope. Students also will themselves examine the features of the slides using microscopes.
  • 16.
    • Introductory sessions
    • Note that students with the appropriate skills need not attend these sessions.
    • No microscopy session in first week
    • Intro to Path Museum Friday Week 1. Two sessions starting 12 and 1pm (Dr Kekic)
    • MCQ Stem session Week 2 with Prof King
    • Introduction to searching the biomedical literature using Ovid. Week 3 (to be held in the Medical Library)
  • 17. Resources available to students   The Pathology Museum contains an outstanding collection of macroscopic ("bottle") specimens. These are categorized and catalogued and there is supporting background clinical information. The Museum also contains a number of Macintosh and IBM compatible computers connected to the University network via the Faculty of Medicine GMP network. Students need a password to operate these computers. Through them, students can access Ovid for literature searching and the on-line Pathology Museum.
  • 18. On-line Pathology Museum
    • http://rm555.pathology.usyd.edu.au/museum/
    • OR
    • Link from Pathology Homepage
    • Contains microscopic and macroscopic specimens and some descriptions; the continuous assessment tasks.
  • 19. Museum (continued) The Museum Sessions will be held weekly (except for Weeks 1). The activities will vary for each session. There will be a demonstrator available in the Museum. The microscopic slide preparations relevant to any week of the course will be available in the Museum for revision using the microscopes that are located there.   The Pathology Museum is a real treasure, certainly the best in the Southern Hemisphere. We hope that you will respect it and grow to love it!
  • 20.
    • Museum (continued)
    • The Pathology Museum is open 7.00 am to 7.00 pm Monday to Friday.
    • You need an electronic access card to enter and leave the Pathology Museum. These will be provided during the first 2 weeks of the course (from Security - $30 deposit refundable upon return of card).
    • A computer record of entry and departure from the Museum is kept.
    • In a couple of previous unfortunate incidents of vandalism and theft from the Museum, the police were able to access those records to help them in their enquiries.
  • 21.
    • What do you need to do now?
    • 1. Make sure you sign in on the sign on sheet being passed around the lecture room
    • 2. Check on the web or the Department notice board which group you are in for Microscope Pracs and Museum Pracs (by Friday morning)
    • 3. If you want to change prac groups arrange a swap with a member of the group you wish to swap with. Email the change to the Department.
    • If clashes require a change in Practical Groups then email the Department (cpat3101@pathology.usyd.edu.au) with the following details:
      • Subject that clashes
      • Times that clash occurs
      • Requested change
      • Course convener for clashing subject
    • 5. Research Assignments: email your preferences to the Department (details on how to do this are on the web).