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  • 1. External Advisory Committee Indiana University Cancer Center September 25, 2006
  • 2.
    • Overview
  • 3. Overview
    • Continued strong institutional commitment
    • Effective and on-going strategic planning
    • Highly effective and energetic senior and program leadership team
    • Seminal cancer research findings
  • 4. Points of Emphasis
    • Strategic planning, leading to:
      • Key leadership changes
      • Enhanced prevention and control research activity
      • Targeted recruitment
      • New and unique collaborations, including with the Purdue Cancer Center
      • ITRAC is open for business
      • Improved translational research
      • New cores
  • 5.
    • To be a leading, national comprehensive cancer center based on our scientific investigation, health care delivery, and education.
    Vision
  • 6. Mission
    • IUCC seeks to reduce the burden of cancer through innovation and dissemination
  • 7. Goals
        • 1. Foster excellence in interdisciplinary translational research through established and developing research programs.
        • 2. Provide the highest quality patient care through interdisciplinary clinical programs.
        • 3. Develop nationally recognized interdisciplinary graduate and post-graduate education and training programs.
        • 4. Facilitate the development and implementation of a statewide cancer control program.
  • 8. Indiana University Board of Trustees President: Adam Herbert Vice President and Chancellor: Charles Bantz Dean-IU SOM and VP Life Sciences IU: D. Craig Brater IU Cancer Center Director Stephen D. Williams
  • 9.  
  • 10. Senior Leaders
    • Director: Williams
    • Deputy Director: Loehrer
    • AD Basic Research: Kelley
    • AD Clinical Research: Sweeney
    • AD Strategic Planning: Klaunig
    • AD Administration: Darling
    • AD Cancer Programs: Hammoudeh
  • 11. AD Strategic Planning and Partnerships
    • Responsible for coordination of strategic planning activities
    • Interacts with other AD’s
    • External relations
      • Purdue University
      • IU Bloomington including cancer biology
      • IUPUI
      • ISDH,CDC
  • 12. Purdue Cancer Center
    • Monthly meetings (IUPU-L)
    • Two combined retreats, followed by two rounds of pilot projects, of which at least one project led to NCI funding
    • Policies for shared facility use and indirect costs
    • Submission of two complex funding applications, one of which will be funded
      • Clinical Proteomics
      • Interdisciplinary Research Centers (Cancer Care Engineering
  • 13. Programs Established Breast Cancer EDT Hematopoiesis / Microenvironment and Immunology Prevention and Control Developing Molecular Carcinogenesis Tumor Microenvironment
  • 14. Biological Microscopy Biostatistics * Clinical Research Office * Flow Cytometry * Tissue bank* Transgenic and Knockout Mouse * Transplant and Xenograft Mouse Vector Production Cancer Pharmacology/Analytic* New Cores: Angiogenesis / Endothelial Cell Translational Genomics* Chemical Genomics * Administered by IUCC Shared Facilities
  • 15. Essential Characteristics
  • 16. Facilities
  • 17.
    • R3: 125,000 sq ft of new research space that will be assigned by IUCC; completion 1/09
  • 18. “ IU Cancer Center”- cancer hospital and ambulatory care facility; completion 8/08
  • 19. Indiana University Cancer Center Sam Odle Clarian COO Stephen D. Williams MD Director, IUCC Patrick J. Loehrer, Sr. MD Deputy Director, IUCC Medical Director, IUCC FuadHammoudeh Administrator, Clarian Cancer Programs
  • 20.
    • Organizational Capabilities
  • 21. Organizational Capabilities: Strategic Planning
    • Weekly senior leaders meetings
    • Four planning retreats (two,SL’s only; one with program leaders; one cancer hospital)
    • Updating of existing written strategic plan
    • Focused on:
    • - Targeted recruitment and retention
    • -Increasing cancer research funding
    • -Translational clinical research
    • -Core facility development / improvement
  • 22. Organizational Capabilities: Recruitment
    • Sherif Farag, MBBS, PhD (Medicine, H/O)
      • Director of BMT and malignant hematology
      • Recent R21 and current NIH funding
      • Translational cancer research in HMI
    • Yan Xu, PhD (Ob Gyn)
      • Two NCI grants
      • EDT member focusing on ovarian cancer
    • Angelo Cardoso, MD, PhD (Medicine, H/O)
      • HMI member
      • Marrow microenvironment / leukemia and metastasis
  • 23.
    • Nadia Carlesso, MD, PhD(Pediatrics, Wells)
      • HMI member; NIH funding
      • Notch signaling in leukemia
    • Hua Lu, PhD (Biochemistry)
      • Three NCI grants
      • Will hold IUCC endowed chair
      • Basic research with GI focus
    Organizational Capabilities: Recruitment
  • 24. Recruitment (cont)
    • Lindsey Mayo, PhD (Pediatrics, Wells)
      • Basic cancer research
      • NCI R01 funded
    • Prevention and control x 3
    • Biochemistry x 4
  • 25.
    • Interdisciplinary and Trans-disciplinary Coordination and Collaboration
  • 26. Interdisciplinary Collaboration
    • All programs meet or exceed guideline requirements for collaborative publications
    • Multiple examples will be presented
      • Pharmacogenetics of tamoxifen and AI’s
      • JNK Inhibition in AML
      • Parthenolide Analogues
  • 27. Interdisciplinary Collaboration: Prevention and Control
    • Narrowed and refined focus
    • Health services research (several participants)
    • Adolescent medicine
    • Psychology, psychiatry, and clinical epidemiology
    • Meetings and retreat
    • Increased funding and co-publications
    • Funding of NCI R25 training grant: “Training in Research for Behavioral Oncology and Cancer Control?”
    • Noteworthy scientific collaborations and accomplishments
  • 28.
    • David Haggstrom, MD
      • General internist co-recruited with RI HSR
      • GIM and NCI prevention fellowship
      • Focuses on GI cancer screening and QOL
    • Karen Hudmon, DrPh
      • NCI funded researcher
      • Focuses of tobacco control
      • Co-recruited with RI / HSR and Purdue
    • Andrew Saykin, PsyD
      • NCI funded senior investigator
      • Director of IUSM Neuroimaging
      • “ Chemobrain” in breast cancer patients
    Interdisciplinary Collaboration: Prevention and Control
  • 29. Interdisciplinary Collaboration: Prevention and Control
    • With Regenstrief health services resarch group: mid-senior level cancer HSR researcher
    • With Peds adolescent medicine: cancer researcher who focuses on risky behaviors, preferably smoking
    • With Center of Environmental Health and Genetics, epidemiology group
  • 30.
    • Cancer Focus
  • 31. Cancer Focus
    • Increase cancer research funding
      • Recruitment
      • Pilot projects
      • Budget supplements
    • ITRAC
    • Protocol specific research and R21 working group
    • HMI program
      • Translational research meetings
      • Recruitment of Dr. Farag
  • 32.
    • Institutional Commitment
  • 33. Institutional Commitment
    • Top priority: cancer research
    • New buildings and role of the IU Cancer Center
      • R3: 125+k sq ft ($85 m)
      • Cancer hospital: “IU Cancer Center” ($150 m)
    • Annual support of about $1.25 m
    • Additional $4.4m for recruitment
  • 34. Institutional Commitment: Development
    • IUCC development staff increased from two to three FTE’s
    • Development for both hospital and SOM managed by this staff; report to IUCC director
    • 6/03 9/06
    • Endowment $4.1m $12.7m *
    • Non-endowed $1.1m $3.4m
    • *includes 7 chairs and professorships
  • 35. Institutional Commitment: 3D
    • SOM initiative to more equitably allocate resources and indirect costs
    • Departments will receive a significant proportion of indirect costs, but will be responsible for rent
    • Rent for space of investigators occupying IUCC space will be passed through to departments as will indirects
    • Bottom line: IUCC will continue to receive annual support and with departments will allocate space efficiently to most productive investigators
  • 36. Institutional Commitment
    • Center of Environmental Health
      • Director: Jim Klaunig
      • “ Genes, the environment and cancer”
    • IUB cancer biology program
      • Medical sciences program
      • Director and up to eight faculty slots
      • IUCC members and senior leaders lead search
      • Mission is to add to the research capability of the IU Cancer Center
  • 37. Center Director
  • 38. Director
    • Reports to Dean; status similar to chairs
    • Assigns space; allocates budget
    • Membership decisions
    • Appoints senior and program leaders
    • Leads development
    • Represents Indiana University
  • 39. Examples
    • Chair: Radiation Oncology Search
    • School-wide leadership in bio-specimen management and ITRAC
    • IUB cancer biology program and search
    • Identifying and initiating critical core facilities
      • Clinical pharmacology and analytic core
      • Translational genomics
      • Angiogenesis and endothelial cell
  • 40. Summary
    • Diligent strategic planning in the setting of a supportive institution, leading to:
      • Highly interactive programs
      • Novel local and state-wide collaborations
      • Key recruitments
      • Sophisticated new shared facilities
      • Important discoveries for the prevention, detection, and treatment of cancer
  • 41. Future Directions
    • Biospecimen management
      • Informatics
      • Pathology
    • ITRAC
    • Translational research
    • Unique state-wide collaborations
      • Purdue
      • HOG
      • Indiana Cancer Consortium
  • 42. Future Directions
    • Continued targeted recruitment
      • Prevention and control
      • Breast cancer metastasis / genomics
      • Epidemiology
      • Radiation oncology
      • Clinical investigators