Breakthroughs in Bioscience From NIH-Funded Basic Research to Improved Health New Hampshire
National Institutes of Health (NIH) <ul><li>Nation’s medical research agency </li></ul><ul><li>Funds the science that lead...
Research Enterprise Is Critical to New Hampshire’s Economy <ul><li>The state’s biotechnology industry employed 3,884 worke...
  NIH Funding Supports Many Programs at Dartmouth <ul><li>The Center for Molecular, Cellular, and Translational Immunologi...
NIH: Saving Lives Through Science <ul><li>Current annual budget of around $29.3 billion </li></ul><ul><li>Greater than 80%...
How NIH Makes Science Happen… <ul><li>Researchers working at local universities, hospitals and research institutions are d...
Basic Research: From Bench to Bedside <ul><li>Much of NIH funding goes to  basic or fundamental research </li></ul><ul><li...
What about medical breakthroughs? <ul><li>Medical  breakthroughs  often come from unrelated areas of science or medicine <...
Evolution of Research to Healthcare Selected modern examples…
Cardiovascular disease <ul><li>Information on the biochemical structure & synthesis of cholesterol led to the development ...
Cardiovascular disease 60 70 30-year Investment per American ~$110.00 Total Economic return of improved treatment & preven...
HIV / AIDS <ul><li>Fundamental knowledge of how viruses replicate gave scientists targets for therapy. Researchers looking...
HIV / AIDS Survival rates for those infected with HIV has increased by 10 years Deaths from AIDS dropped nearly 70% betwee...
Cancer <ul><li>Basic research into the shape and characteristics of the estrogen receptor gave us  tamoxifen , which can r...
Cancer 30-year Investment per American ~$260.00 Total Millions of People 1971 1986 1990 2003 9 6 3 Increase in Cancer Surv...
Infant mortality <ul><li>Studies on lung function led to the discovery of  surfactant . This protein-lipid mixture is cruc...
NIH-Funded Discoveries at Dartmouth <ul><li>Researchers have shown that women with higher levels of an antibody called hum...
The Bottom Line… <ul><li>People are living  longer, healthier lives  because of NIH funded medical research </li></ul><ul>...
The Challenge… <ul><li>NIH funding is entirely dependent on  Congressional support </li></ul><ul><li>In recent years, Cong...
New Hampshire’s Congressmen Need to Advocate for NIH Funding <ul><li>Nothing should surpass improving our health as a nati...
We Need your Help: Working Together for NIH <ul><li>Contact Senators Gregg and Shaheen and your Congressional Representati...
Want to know more?? Please visit  http:// opa.faseb.org   Federation of American Societies for Experimental Biology (FASEB)
Upcoming SlideShare
Loading in...5
×

New Hampshire

159

Published on

Published in: Health & Medicine, Technology
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
159
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
2
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide
  • June 1 st , 569, 778,408 mil --- last year 407,258,114 This report provides a summary, by school, of awarded dollars posted to the ogca system, by the date and the report title (6-1-2004). The totals reflect the awarded dollars for all grant and contract funding periods active on the day of the report. Funding periods may vary from partial to multiple years, depending on the type of grant or contract and may reflect the total awarded for each year the funding period is active. Prior totals are based on the awarded dollars for the funding periods that were active on the first day of the month for the date indicated. 2359 count of the project as of june 1 Shelby mixed in.. In a nutshell Sercab – 15.7 mil NINDS Go live with reports oct 1
  • New Hampshire

    1. 1. Breakthroughs in Bioscience From NIH-Funded Basic Research to Improved Health New Hampshire
    2. 2. National Institutes of Health (NIH) <ul><li>Nation’s medical research agency </li></ul><ul><li>Funds the science that leads to medical advancement </li></ul><ul><li>Campus in Bethesda, MD – but most funding is distributed to university researchers throughout the United States </li></ul><ul><ul><li>Dartmouth College received more than $80 million in NIH awards for FY08; University of New Hampshire received more than $2.1 million </li></ul></ul>
    3. 3. Research Enterprise Is Critical to New Hampshire’s Economy <ul><li>The state’s biotechnology industry employed 3,884 workers in 2002 </li></ul><ul><li>One of the largest biotech companies in the world, Lonza Biologics, with more than 500 employees, is based in Portsmouth, NH </li></ul><ul><li>New Hampshire receives more NIH funding on a per capita basis than the national average </li></ul><ul><li>Dartmouth College ranks in top 100 for total R&D expenditures </li></ul><ul><li>High tech jobs employ more than 35,000 workers in the state </li></ul>
    4. 4. NIH Funding Supports Many Programs at Dartmouth <ul><li>The Center for Molecular, Cellular, and Translational Immunological Research at Dartmouth Medical School received nearly $12 million from NIH to promote multidisciplinary work in immunology/cancer </li></ul><ul><li>Studies at the Lung Biology Center of Dartmouth focus on cystic fibrosis, one of the most common genetic diseases in the U.S., and research of environmental factors that contribute to lung cancer </li></ul><ul><li>Federal grants to the Medical School increased 4% from FY04-FY05, while funding for grants increased 63% overall since 2001 </li></ul>
    5. 5. NIH: Saving Lives Through Science <ul><li>Current annual budget of around $29.3 billion </li></ul><ul><li>Greater than 80% distributed throughout the country </li></ul><ul><ul><li>More than 50,000 grants </li></ul></ul><ul><ul><li>212,000 scientists </li></ul></ul><ul><ul><li>2,800 universities </li></ul></ul><ul><li>Portfolio of basic, translational, and clinical research </li></ul>NIH has been involved in nearly all the medical & health related discoveries of the past century
    6. 6. How NIH Makes Science Happen… <ul><li>Researchers working at local universities, hospitals and research institutions are dependent on federal support to fund their research, hire lab personnel and train young scientists </li></ul><ul><li>They write research grant proposals to compete for funding </li></ul><ul><ul><li>Must explain why they think it’s a good idea, how they’re going to do the experiments, and what impact it will have on science & medicine </li></ul></ul><ul><li>Proposals are reviewed in a two-tiered system </li></ul><ul><ul><li>Peer-reviewed by scientists to ensure highest quality science </li></ul></ul><ul><ul><li>Reviewed again for applicability to scientific or health priorities by NIH officials and other stakeholders, including public members </li></ul></ul><ul><ul><li>NIH review system is the envy of the world! </li></ul></ul><ul><li>Very competitive!!! </li></ul><ul><ul><li>Before - 1 in 3 proposals funded; now closer to 1 in 6 </li></ul></ul><ul><ul><li>High quality research is not being done for lack of funding </li></ul></ul>
    7. 7. Basic Research: From Bench to Bedside <ul><li>Much of NIH funding goes to basic or fundamental research </li></ul><ul><li>Basic research is driven by interest in a scientific question </li></ul><ul><li>The main motivation is to expand knowledge and understanding , not to create or invent something </li></ul><ul><li>However, the insight into how the human body works and understanding of how diseases and disorders operate provides the foundation for medical progress </li></ul>&quot;People cannot foresee the future well enough to predict what's going to develop from basic research. If we only did applied research, we would still be making better spears.&quot; Dr. George Smoot, Berkeley National Lab
    8. 8. What about medical breakthroughs? <ul><li>Medical breakthroughs often come from unrelated areas of science or medicine </li></ul><ul><ul><li>Research on cancer biology has led to drugs for: heart disease; viral diseases like influenza, Herpes & AIDS; and osteoporosis </li></ul></ul><ul><ul><li>Physicists studying the effects of magnets on atomic particles made the discovery that gave us MRI </li></ul></ul><ul><li>Usually based on years or decades of fundamental knowledge </li></ul><ul><ul><li>Over time, scientists solve or find different pieces of the puzzle </li></ul></ul><ul><li>This makes it difficult to predict where the next breakthrough will come from </li></ul><ul><ul><li>Makes it imperative to support a broad range of scientific research </li></ul></ul><ul><ul><li>Much of this research is too basic for the private sector </li></ul></ul><ul><ul><ul><li>The federal investment often lays the foundation for advances in healthcare </li></ul></ul></ul>
    9. 9. Evolution of Research to Healthcare Selected modern examples…
    10. 10. Cardiovascular disease <ul><li>Information on the biochemical structure & synthesis of cholesterol led to the development of statins </li></ul><ul><li>Discoveries in basic kidney biology and blood pressure regulation converged with an unexpected finding involving snake venom to yield ACE inhibitors , one of our most effective hypertension medications </li></ul><ul><li>Understanding how the blood clots, together with a new cancer treatment and the first commercial use of recombinant technologies, resulted in rtPA, a clot-busting drug that can prevent death from heart attack or stroke </li></ul>RESULTS?? 63% REDUCTION IN DEATHS FROM HEART DISEASE AND A 70% REDUCTION IN DEATHS DUE TO STROKE; MORE THAN 1 MILLION LIVES SAVED IN 2006 ALONE
    11. 11. Cardiovascular disease 60 70 30-year Investment per American ~$110.00 Total Economic return of improved treatment & prevention $2.6 TRILLION 95 75 500 400 300 200 100 50 55 65 80 85 90 00 Deaths per 100,000 Year ~ 514,000 Actual Deaths in 2000 ~ 1,329,000 Projected Deaths in 2000
    12. 12. HIV / AIDS <ul><li>Fundamental knowledge of how viruses replicate gave scientists targets for therapy. Researchers looking for a new cancer drug hit one of those targets when they discovered a way to block replication, resulting in the development of AZT . </li></ul><ul><li>Increased understanding of how HIV operates at the cellular and molecular level identified more targets, and eventually led to the combination of drugs knows as the ‘triple cocktail.’ </li></ul>RESULTS?? AIDS HAS BEEN TRANSFORMED FROM AN ACUTE FATAL ILLNESS TO A CHRONIC CONDITION; THE PROPHYLACTIC USE OF ANTI-VIRALS PREVENTED ALMOST 350,000 DEATHS WORLDWIDE IN 2005
    13. 13. HIV / AIDS Survival rates for those infected with HIV has increased by 10 years Deaths from AIDS dropped nearly 70% between 1995 and 2000
    14. 14. Cancer <ul><li>Basic research into the shape and characteristics of the estrogen receptor gave us tamoxifen , which can reduce breast cancer incidence among women at risk by over 45%. </li></ul><ul><li>The breakthrough finding that human papillomavirus (HPV) could cause cervical cancer has led to a new vaccine that NIH estimated could reduce cervical cancer incidence by as much as 90%. </li></ul><ul><li>While investigating the cellular machinery controlling cell growth, scientists developed bortezomib - now used to treat patients with multiple myeloma. </li></ul>RESULTS?? FROM 1993-2002, CANCER DEATH RATES DROPPED 1.1% PER YEAR; MORE THAN 2/3 OF PEOPLE DIAGNOSED WITH CANCER CAN EXPECT TO LIVE 5+ YEARS
    15. 15. Cancer 30-year Investment per American ~$260.00 Total Millions of People 1971 1986 1990 2003 9 6 3 Increase in Cancer Survivors
    16. 16. Infant mortality <ul><li>Studies on lung function led to the discovery of surfactant . This protein-lipid mixture is crucial for the survival of premature infants, decreasing the number of infant deaths from respiratory distress from 15,000 per year to less than 1,000. </li></ul><ul><li>The use of anti-virals to prevent mother to child HIV transmission has reduced the rate from 25% to about 1% in the U.S. </li></ul><ul><li>Studies on a metabolite of progesterone, known as progesterone 17P , have led to the finding that injections of this compound can reduce pre-term deliveries by as much as 30%, a particularly important result for African American women. </li></ul>RESULTS?? IN LESS THAN A CENTURY, INFANT MORTALITY IN THE U.S. HAS BEEN REDUCED BY 90%, TRANSLATING TO ALMOST 500,000 BABIES SAVED PER YEAR
    17. 17. NIH-Funded Discoveries at Dartmouth <ul><li>Researchers have shown that women with higher levels of an antibody called human mucin, or MUC1, are less likely to develop ovarian cancer. The findings may lead to a vaccine to prevent ovarian cancer </li></ul><ul><li>First gene for the enzyme involved in cholesterol storage cloned </li></ul><ul><li>Discovered that a specific genetic variation in ODC gene affects aspirin’s effectiveness in preventing colon cancer </li></ul><ul><li>Recently, researchers using Near Infrared Spectroscopy found areas in the brain that indicate bilingualism </li></ul>
    18. 18. The Bottom Line… <ul><li>People are living longer, healthier lives because of NIH funded medical research </li></ul><ul><li>What were once swiftly fatal illnesses have become treatable or manageable conditions </li></ul><ul><li>For those suffering from diseases that have no current treatment or cure, medical research provides hope – which has a major impact on quality of life </li></ul>
    19. 19. The Challenge… <ul><li>NIH funding is entirely dependent on Congressional support </li></ul><ul><li>In recent years, Congressional support has diminished , and the NIH budget is slowly eroding from lack of funding and inflation </li></ul><ul><li>Lack of understanding in Congress about the importance of medical research and the treatments and hope it provides </li></ul><ul><li>As the NIH budget falls, success rate also falls </li></ul>Diminished investment in NIH = loss of talented researchers = missed opportunities = delays in medical progress
    20. 20. New Hampshire’s Congressmen Need to Advocate for NIH Funding <ul><li>Nothing should surpass improving our health as a national priority </li></ul><ul><li>Opportunities for discoveries that translate to improved health for our citizens have never been greater </li></ul><ul><li>Every increase in the NIH budget means additional funding for research in the state and new jobs </li></ul>
    21. 21. We Need your Help: Working Together for NIH <ul><li>Contact Senators Gregg and Shaheen and your Congressional Representative </li></ul><ul><ul><li>Let them know that medical research is important to you and what a bargain it is </li></ul></ul><ul><li>Write a letter to the newspaper and talk to your friends </li></ul><ul><ul><li>Help educate policymakers and neighbors about the important work NIH is doing </li></ul></ul><ul><li>Nothing is more important than our health </li></ul><ul><ul><li>The National Institutes of Health (NIH) should be an American priority </li></ul></ul>
    22. 22. Want to know more?? Please visit http:// opa.faseb.org Federation of American Societies for Experimental Biology (FASEB)
    1. A particular slide catching your eye?

      Clipping is a handy way to collect important slides you want to go back to later.

    ×