1. SYLLABUS - CLS 412
INSTRUCTOR: Janice Conway-Klaassen
OFFICE: 342 Bigelow Health Sciences Bldg.
CONTACT: Phone: 895-1315 (24 hour voice mail)
OFFICE HOURS: Tues & Thurs 12:00 - 2:00
or by appointment
COURSE HOURS: Tuesday 9:00 - 11:30
COURSE DESCRIPTION: Discussion of basic and advanced principles of immunology and the
immune response. These principles will be applied to states of health and disease, providing an
understanding of immune function and disease pathology. 3 credits
REQUIRED TEXT & READING:
CLINICAL IMMUNOLOGY - Principles & Laboratory Diagnosis by Sheehan. Lippincott.
Cellular and Molecular Immunology by Abbas, Lichtman, & Pober. WB Saunders.
Immunology by Roitt, Brostoff, and Male 2nd edition
An Introduction to Clinical Immunology and Serology by Widmann & Itatani. FA Davis.
COMPUTER PROGRAM USE POLICY
A supplemental CD Rom tutorial program ("Immunology" by Roitt) is available for student use
during the semester. Before students can check out the tutorial program, they must have signed
the CLS Program form documenting understanding of and compliance with UNLV's policiy
concerning copyright with respect to computer program media. This form is kept in the student's
WEB SITE: This is a great demonstration web site that has animations of the cellular interaction
and the immune response. If you find others - let me know and I will add them to the list.
2. GENERAL OBJECTIVES:
1. List examples of natural barriers against harmful agents.
2. Distinguish specific and non-specific response to foreign materials.
3. Outline and describe the process of B and T cell maturation and proliferation.
4. Compare and contrast the 5 classification of immunoglobulins.
5. List 11 components of complement; describe the 2 complement pathways.
6. List/describe 6 factors which effect antigen-antibody reactions in vivo.
7. Describe the process of cellular immunity
8. Describe the time table of the primary and secondary immune response and correlate the
classifications of immunoglobulins involved at each stage.
9. Compare and contrast the antigen presentation mechanism for T and B cells
10. Describe the interaction of lymphocytes with non-lymphoid effector cells in the immune
11. Describe the various mechanisms of immune response regulation
12. Describe the process for hypersensitivity reactions.
13. Differentiate primary and secondary immunodeficiency disease.
14. Outline 3 mechanisms which have been proposed to explain the etiology of autoimmune
15. Outline and describe the mechanism of immunity to microbes, tumors, and transplantation.
16. Given an organism, develop a schema for immune reaction/response.
3. LECTURE OUTLINE-CLS 412-CLINICAL IMMUNOLOGY:
LEC DATE TOPIC CHAPTER
1 8/26 Introduction to Immunology
Cells/Tissues of Immune System
2 9/2 Major Histocompatibility Complex
Immunoglobulins & Antigens
3 9/9 B/T cell Development
4 9/16 EXAM 1
5 9/23 Immune Activation
Antigen Presentation & Processing
6 9/30 Complement & Inflammation
7 10/7 Infectious Disease Serology
8 10/14 EXAM 2
9 10/21 Hypersensitivity
10 10/28 Immunodeficiency Disease
11 11/4 Immunoproliferative Disease
12 11/11 VETERAN’S DAY – NO CLASS
13 11/18 EXAM 3
14 11/25 Transplantation Immunology
15 12/2 Tumor Immunology
12/9 FINAL EXAM - COMPREHENSIVE
10:10AM - 12:10PM
4. EXAM POLICIES
Exams will be a mixture of objective (multiple choice, true/false, and matching), short answer, and
essay questions. The hourly exams will not be cumulative, i.e they will cover only the topics listed
for each unit. The final exam is cumulative and therefore will cover the entire semester's topics.
Alternative arrangements for exams will be considered when requested prior to the exam date and
time. No exam make-ups are allowed.
The outline above is a tentative schedule of lecture material. Changes may be necessary to cover
the necessary topics. Any changes will be announced in class in advance and will be posted on the
NOTE: The concept behind exams in the CLS Program is different than what most students are
used to. Some questions will involve memorization of facts learned during lecture class or from
reading material. However, a significant portion of exam questions will ask the student to
integrate facts, to apply deductive reasoning and/or generate new ideas. Please use the
objectives to your advantage for studying.
Lecture Exam 1 20%
Lecture Exam 2 20%
Lecture Exam 3 20%
Lecture Exam 4 20%
Lecture Final Exam 20%
A 100-94% C+ 79-78%
A- 93-90% C 77-73%
B+ 89-88% D 72-63%
B 87-84% F Below 63%
Remember: You must receive a final course grade of "C" or better in order to continue enrollment
in the CLS Program. If you receive less than a "C" grade in any CLS course, you may be placed on
Program Academic Probation until such time as you successfully complete the course. If you have
any questions, please see a Program Advisor.
1. This is a professional education program. Attendance is considered mandatory for all
classes. No make-up notes will be provided by the instructor, however, please notify the
instructor directly if you find it necessary to miss a session. DO NOT NOTIFY THE
DEPARTMENT SECRETARY OR ANOTHER FACULTY MEMBER!!
2. Students are expected to come to lecture prepared to participate in the day's activities.
Please be sure to read the chapter sections in the text prior to class.
3. Please see the instructor during the first two weeks of class if you have any conflicts in
5. scheduling due to religious observances.
4. All exams begin promptly at the scheduled course time. They often contain projected slides
for identification, etc., which are shown at the beginning of the exam session. Slides will
not be repeated. DON'T BE LATE FOR EXAMS!!
5. If you have a documented disability that may require assistance, you will need to contact
the Disability Resource Center (DRC) for coordination in your academic accommodations.
The DRC is located in the Reynolds Students Services Complex, Room 137. The DRC
phone number is 895-0866 or TDD 895-0652.
6. The University requires all members of the University community to familiarize themselves
and to follow copyright and fair use requirements. You are individually and solely
responsible for violations of copyright and fair use laws. The University will neither
protect nor defend you nor assume any responsibility for employee or student violations
and fair use laws. Violations of copyright laws could subject you to federal and state civil
penalties and criminal liability as well as disciplinary action under University policies. To
help familiarize yourself with copyright and fair use policies, the University encourages
you to visit its copyright web page at: http://www.unlv.edu.committees/copyright