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Microsoft Word - Clinical Immunology
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Microsoft Word - Clinical Immunology



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  • 1. Clinical Immunology Course Number: 140435 Credit hours: 2 Department: Microbiology and Immunology Course Level: Third Year Faculty: Medicine Course Description / Objectives / Plans: This is a 2 credit hour course provided to medical students in the 2nd semester in the 3rd year of their medical education. It is designed to provide the more common clinical disease categories that are related to malfunction or dysfunction of the immune system. It is considered as the clinical application of the basic immunology that was provided to the medical students in the first semester of the third year. Lectures are provided on power point series of lectures. Word version is available as well. Main Objectives: 1- Discuss the pathogenesis of different immune mediated diseases, taking Gell and Coomb’s classification hyper sensitivity diseases as the prototype. Discuss examples of each type. 2- Discuss primary immune deficiency syndromes. 3- Discuss secondary immune deficiency syndromes, emphasizing on HIV disease. 4- Discuss immune reconstitution. 5- Auto immunity and HLA relation. 6- Discuss auto inflammatory syndromes as a new classification system of old diseases and newly described illnesses. 7- Tumor immunology/ relation of the immune system to the development of different tumors. 8- Vaccinations: different types of vaccinations and how they stimulate the immune system. 9- Infections with different microorganisms and how these microorganisms evade the immune system and how does the immune system respond to the evading mechanisms. 10- Slide show of several clinical cases with pointing out the pathogenesis of each lesion. 11- Clinical scenarios: case presentation, relations of signs and symptoms to the disease process and pathogenesis. The following is a detailed description of the course objectives. 1- Mechanisms of immunologic diseases type I: Objectives a- Understand the variety of pathological processes whereby immune system function or dysfunction can cause disease, and appreciate the basic pathogenic mechanisms involved in development of immunologic diseases. Faculty of Medicine – An-Najah National University - Palestine Page 1
  • 2. b- Understand the unique features of IgE mediated diseases. c- Review the chemistry of IgE and its relation to allergic diseases. d- Understand the T cell regulation of IgE production e- Understand the central role of Mast cells in allergic reactions 2- Mechanisms of Immunologic diseases type II and III. Objectives a- Understand the differences in the mechanisms behind Type II and Type III. b- Become acquainted with prototypic diseases mediated by antibodies and immune complexes c- Understand the approaches used to diagnose these types of diseases. 3- Mechanisms of immunologic diseases type IV Objectives: Review of all of the above. a- Focus on T cells mediated diseases using contact dermatitis as a prototype. b- Understand that T cell responses to certain viral infections can lead to secondary T cell mediated disease. c- Introduce experimental allergic encephalomyelitis and multiple sclerosis as examples of autoimmune T cell mediated diseases. 4- Primary immune deficiencies. Objectives. a- Define immune deficiency and note its frequency and inheritance pattern. b- Understand the genetic basis for primary immune deficiency c- Enumerate and define the more common forms of B lymphocyte deficiency. d- Enumerate and defined the more common forms of T cell deficiency. e- Explain the current knowledge of defects in phagocytic cells f- Explain how complement components produce defects in host responses. g- Delineate the age order of appearance of the immune deficiencies h- Enumerate the tests of human immune function to diagnose disease states. 5- Primary immune deficiencies/ Continue. Objectives. a- To understand the clinical and laboratory findings of phagocytic cell disorders b- To understand how to make the diagnosis of a phagocytic cell disorder c- To understand the fundamentals for management of a phagocytic cell disorder. Faculty of Medicine – An-Najah National University - Palestine Page 2
  • 3. 6- Primary immune deficiency/ continue Objectives a- Introduce more rare cases of primary immune deficiency syndromes b- Present these cases to promote or challenge the students with difficult cases to promote the interest in clinical research and related pathogenesis of illnesses. These cases are rare and of interest only for academic and research purposes. 7- Secondary immune deficiencies. Objectives a- Define a secondary state of Immune deficiency. b- Learn the major categories of secondary immune deficiency. c- Focus on HIV disease as the most illustrative example of a state of secondary immune deficiency. d- Define the importance of immune reconstitution in treatment of HIV. 8- Immune reconstitution Objectives: a- Define the therapeutic need for immunoglobulin replacement therapy in immune deficiency. b- Review the use of interferon gamma in chronic granulomatous disease. c- Review cellular immune reconstitution d- Enzyme replacement therapy, PEG-ADA. e- Gene replacement f- Immune suppressant therapy. 9- Auto immunity, HLA and diseases. Objectives. a- Define autoimmune disease. b- Review factors which contribute to autoimmunity. c- Note important HLA- disease association. d- Discuss mechanisms underlying autoimmunity: How is tolerance to “self” broken? 10- Auto inflammatory disorders. Objectives. a- Introduce the concept of auto inflammatory disorders, pathogenesis of these illnesses. b- Point out the differences between auto immune diseases and auto inflammatory diseases. c- Present some of the auto inflammatory disorders d- Present treatment principles of these disorders. Faculty of Medicine – An-Najah National University - Palestine Page 3
  • 4. 11- Tumor Immunology Objectives. a- Introduce lymphoid malignancies b- Explain how host and viral oncogenes interact to cause cancer. c- Describe the different types of tumor antigens and explain how tumors evade the immune response d- List several approaches to cancer immunotherapy. 12- Infections and vaccines. Objectives. a- Describe three different types of vaccine currently in use and how they vary in their safety and efficacy. b- Describe two different types of whooping cough vaccine and why they are used in different countries. c- Explain why influenza vaccine may need to be given every year. d- Describe two newer approaches to vaccination. 13- Slide show: showing photos of nearly all of the above mentioned illnesses with correlation between the signs and symptoms and the pathogenesis of the disease. Objectives: a- To show actual picture of the diseases that we presented b- Try to correlate the basic sciences in medicine with clinical sign. 14- Clinical scenarios/ discussion. The medical students will present several clinical scenarios in allergic and immunologic medicine with clinical history/ physical examination findings and related laboratory issues and radiologic findings. Also the main objectives of these cases is to correlate between the learned information gained from basic immunology course with actual disease process/ and more importantly strategies of treatment options for the patients whose clinical presentation was discussed. Course Assessment: 1- Exam I 25% of the Final Grade 2- Exam II 25% of the Final Grade 3- Exam III (Final Exam) 50% of the Final Grade 100% 0f the Final Grade Faculty of Medicine – An-Najah National University - Palestine Page 4
  • 5. References: 1- Jane way immune biology 2- Immunology for medical students. 3- Nelson text book of pediatrics. 4- Immunology / Stein. Faculty of Medicine – An-Najah National University - Palestine Page 5