Universitat de les
UIB Illes Balears
Master in Microbiology
2006-2007 Academic Year
Course title: Mechanisms of Microbial Pathogenicity
Course code: a cumplimentar por el Centro de Tecnologías de la Información
Type of course: Optional
Level of course: Postgraduate
Year of study: First
Timetable: See the timetable for the Master in Microbiology programme
Language of instruction: Spanish/Catalan, reading comprehension skills in
Name: Dr. Sebastián Albertí Contact: firstname.lastname@example.org
A solid background (at the bachelor’s degree level) in biochemistry, molecular biology,
genetics, cellular biology, microbiology, plant-animal physiology and chemistry
Number of ECTS credits 5
Number of classroom hours: 40
Independent study hours: 85
Integrated immune system responses to infectious agents. Therapeutic applications.
E2- Become familiar with and adept at handling various immunological techniques
E4- Apply methodological procedures to the study of antimicrobials
E5- Grasp the strategies (pathogenicity mechanisms) used by microorganisms to escape
the immune system and cause infection and the therapeutic applications involved
G1- Acquire an integrated view of microorganisms, their biological properties and their
roles and applications in the fields of ecology, health, industry, agriculture and
G2- To enhance prior knowledge of microbiology and the elements involved in
developing and/or applying ideas at the research level as well as in other areas
1. Bacteria-host interactions. Types of interactions. Normal microbiota. Parasite
interactions: the concepts of pathogenicity and virulence. Stages in infectious
2. Epidemiology of infectious disease. Principles and methods. Transmission and
control. Principles of chemoprophylaxis and immunoprophylaxis
3. Immunity to viruses
4. Immunity to bacteria
5. Immunity to fungi
6. Factors in microbial virulence. Identification of virulence factors. Adhesins. Invasins.
Toxins. Immune system resistance factors. Other factors in virulence.
7. Infectious diseases, their etiologic agents and virulence factors: Gram-positive
microorganisms (Staphylococcus aureus, Staphylococcus epidermidis and other
coagulase-negatives, Streptococcus Beta-haemolytic, Streptococcus pneumoniae,
Listeria monocytogenes and Bacillus anthracis)
8. Infectious diseases, their etiologic agents and virulence factors: Gram-negative
microorganisms (Neisseria meningitidis, Neisseria gonorrhoeae, Vibrio cholerae,
Enterobacteria, Pseudomonas aeruginosa, Haemophilus influenzae, Brucella,
9. Infectious diseases, their etiologic agents and virulence factors: Other
microorganisms (Clostridium, Bacteroides, Mycobacterium tuberculosis, Fungi)
10. Main clinical systems and their correlation with virulence factors
1. In vitro study of innate and specific immune effect mechanisms. Bacterial factors of
resistance. The complement system. Opsonization. Antimicrobial peptides.
Phagocytosis. The effect of antibodies.
2. Integrated study of the immune system response against bacterial infection. Animal
models in studying infections.
Methodology and student workload
1. Teaching method: Classroom sessions
Classroom/independent work: 10/50
Type of group: whole group
2. Teaching method: Laboratory
Classroom/independent work: 25/10
Type of group: pairs
3. Teaching method: Tutorials
Classroom/independent work: 2/0
Type of group: groups of four
4. Teaching method: Theoretical study
Classroom/independent work: 0/25
Type of group: individual
5. Teaching method: Evaluation
Classroom/independent work: 3/0
Type of group: individual
Assessment instruments, criteria and learning agreement
Knowledge of microorganism strategies (pathogenicity mechanisms) to escape the
immune system. Familiar with the different methodologies involved in studying
antimicrobials and skill at handling various immunological techniques. Students must
attend practical sessions and pass the final exam to earn a passing grade in the course.
A written exam on the course’s theoretical and practical content
A written exam on theoretical and practical course content: 75%
On-going assessment of laboratory notebook: 20%
On-going assessment of lecture classes: 5%
Assessment based on a learning agreement: No
Independent study material and recommended reading
Bibliography, resources and annexes
ABBAS, K.A., POBER, J.S. and LICHTMAN, AH. 2003. Cellular and molecular
immunology. McGrawHill. New York.
AYOUB, E.M., CASSELL, G.H., BRANCHE, W.C. and HENRY, T.J. 1990. Microbial
Determination of Virulence and Host Response. ASM. Washington.
DAVIS, B.D., DULBECCO, R., EISEN, H.N. and GINSBERG, H.S. 1997. Tratado de
Microbiology. Salvat SA. Barcelona.
DORMAN, C.J. 1994. Genetics of bacterial virulence. Blackwell Scientific
EVANS, A.S. and FELDMAN, H. 1991. Bacterial Infections of Humans. Epidemiology
and Control. Plenium Press. London.
ISENBERG, H.D. 2004. Clinical microbiology. Procedures Handbook. ASM.
KREIER, J.P. and MORTENSEN, R.F. 2001. Infection, Resistance and Immunity.
MANDELL, G.L., BENNETT, J.E. and DOLIN, R. 2000. Principles and practice of
infectious diseases. Churchill-Livingstone. NW.
MIMS, C.A., PLAYFAIR, J.H.L., ROITT, I.M., WAKELIN, D. and WILLIAMS, R.
1993. Vaccination. Mosby. London.
MISS, C., IMMOCK, N., NASH, A. and STEPHEN, J. 1995. (4ª ed). Mims'
Pathogenesis of Infectious Diseases. Academic Press. London.
MURRAY, P.R. 2002. Microbiology médica. Mosby España. Madrid.
PUMAROLA, A., RODRÍGUEZ TORRES, A., GARCÍA RODRÍGUEZ, J.A. y
PIEDROLA ANGULO, G. 1999. Microbiology y parasitología médicas. Masson.
ROITT, I.M. 2001. Essential Immunology. Blackwell scientific. Oxford.
ROTH, J.A. 1995. Virulence Mechanisms of Bacterial Pathogens. ASM. Washington.
SALYERS, A. A. andWHITT, D.D. 2001. Bacterial pathogenesis. A molecular
approach. ASM. Washington.
RYAN, K.J.and RAY, C.G. 2004. Sherris medical microbiology. An introduction to
infectious diseases. Elsevier. New York.
SUSSMAN, M. 1997. Escherichia coli: Mechanisms of virulence. Cambridge
University Press. Cambridge.
TORTORA, G.J., FUNKE, B.R. and CASE, C.L. 2004. Microbiology: An introduction.
Pearson Education Inc. Benjamin Cummings. Menlo Park. CA.
JOURNALS (available on-line at the UIB library)
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASES. Elsevier Science
Publishers. New York.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTIOUS
DISEASES. Vieweg Sohn Verlag. Wiesbaden.
INFECTION AND IMMUNITY. American Society for Microbiology. Washington.
INVESTIGACION Y CIENCIA. Prensa Científica, S.A. Barcelona.
JOURNAL OF CLINICAL MICROBIOLOGY. American Society for Microbiology.
JOURNAL OF INFECTIOUS DISEASES. University Chicago Press. Chicago.
JOURNAL OF MEDICAL MICROBIOLOGY. Churchill Livingstone. Edinburgh.
LA RECHERCHE. Societé des Éditions Scientifiques. Paris.
MOLECULAR MICROBIOLOGY. Blackwell Scientific Publications. Oxford.
MUNDO CIENTIFICO.Ed.Fontalba, S.A. Barcelona.
NATURE. McMillan Co., Hampshire.
SCIENCE. American Association for the Advancement of Science, Washington.
SCIENTIFIC AMERICAN. Science American Inc., New York.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES.National
Academy of Sciences of USA. Washington.
Link to the course teaching guide