Laboratory of Mycobacterial Diseases and Cellular Immunology <ul><li>Lab structure and personnel </li></ul><ul><li>Researc...
Research Sections of the Laboratory of Mycobacterial Diseases and Cellular Immunology <ul><li>Molecular Vaccines </li></ul...
LMDCI – Molecular Vaccines Section <ul><li>Current staff </li></ul><ul><li>Sheldon Morris, P.I. </li></ul><ul><li>Steven D...
LMDCI Research – Molecular Vaccines Section <ul><li>Development of novel TB DNA vaccines </li></ul><ul><li>Characterizatio...
LMDCI – Mycopathogenesis Section <ul><li>Current Staff </li></ul><ul><li>Michael Brennan, P.I. </li></ul><ul><li>Thames Pi...
LMDCI Research – Mycopathogenesis Section <ul><li>Characterization of the HBHA adhesin </li></ul><ul><li>Characterization ...
LMDCI – Immune Mechanisms Section <ul><li>Current staff </li></ul><ul><li>Karen Elkins, P.I. </li></ul><ul><li>Siobhan Cow...
LMDCI Research – Immune Mechanisms Section <ul><li>Determine the basis of innate immune responses to LVS </li></ul><ul><li...
LMDCI – Regulatory Duties <ul><li>Provide pre-clinical guidance </li></ul><ul><li>Review IND submissions </li></ul><ul><li...
LMDCI – Regulated Products <ul><li>VACCINES </li></ul><ul><li>TB, malaria, tularemia, Lyme disease,  </li></ul><ul><li>Q f...
Involvement with the  Public Health Community <ul><li>WHO GAVI committee </li></ul><ul><li>WHO TB Vaccine Initiative Advis...
Involvement with the  Public Health Community <ul><li>NIH Study Sections </li></ul><ul><li>NIH TB Vaccine Review Committee...
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Laboratory of Mycobacterial Diseases and Cellular Immunology

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Laboratory of Mycobacterial Diseases and Cellular Immunology

  1. 1. Laboratory of Mycobacterial Diseases and Cellular Immunology <ul><li>Lab structure and personnel </li></ul><ul><li>Research interests </li></ul><ul><li>Regulatory responsibilities </li></ul><ul><li>Involvement with the public health community </li></ul>
  2. 2. Research Sections of the Laboratory of Mycobacterial Diseases and Cellular Immunology <ul><li>Molecular Vaccines </li></ul><ul><li>Mycopathogenesis </li></ul><ul><li>Immune Mechanisms </li></ul>
  3. 3. LMDCI – Molecular Vaccines Section <ul><li>Current staff </li></ul><ul><li>Sheldon Morris, P.I. </li></ul><ul><li>Steven Derrick, Ph.D. </li></ul><ul><li>C. Goter Robinson, Ph.D. </li></ul><ul><li>Amy Li Yang, M.S. </li></ul><ul><li>Collaborators </li></ul><ul><li>FDA/CDRH </li></ul><ul><li>NIH/VRC </li></ul><ul><li>NIH/NICHD </li></ul><ul><li>Albert Einstein </li></ul><ul><li>SRI </li></ul>
  4. 4. LMDCI Research – Molecular Vaccines Section <ul><li>Development of novel TB DNA vaccines </li></ul><ul><li>Characterization of attenuated Mtb strains </li></ul><ul><li>Identification of drug resistance mechanisms </li></ul>
  5. 5. LMDCI – Mycopathogenesis Section <ul><li>Current Staff </li></ul><ul><li>Michael Brennan, P.I. </li></ul><ul><li>Thames Pickett, Ph.D. </li></ul><ul><li>D. Veerabadran, Ph.D. </li></ul><ul><li>Marcela Parra, Ph.D. </li></ul><ul><li>Collaborators </li></ul><ul><li>Institut Pasteur </li></ul><ul><li>Johns Hopkins </li></ul><ul><li>CDC </li></ul><ul><li>Corixa </li></ul><ul><li>Albert Einstein </li></ul><ul><li>University of Sassari </li></ul>
  6. 6. LMDCI Research – Mycopathogenesis Section <ul><li>Characterization of the HBHA adhesin </li></ul><ul><li>Characterization of the novel PE gene family of Mycobacterium tuberculosis </li></ul>
  7. 7. LMDCI – Immune Mechanisms Section <ul><li>Current staff </li></ul><ul><li>Karen Elkins, P.I. </li></ul><ul><li>Siobhan Cowley, Ph.D. </li></ul><ul><li>Ellen Fernandez, Ph.D. </li></ul><ul><li>Carmen Collazo, Ph.D. </li></ul><ul><li>Susan Colombini </li></ul><ul><li>Elizabeth Hamilton </li></ul><ul><li>Anda Meierovics </li></ul><ul><li>Collaborators </li></ul><ul><li>NIH/NIAID </li></ul><ul><li>NIH/NCI </li></ul><ul><li>UMD – Baltimore </li></ul><ul><li>Univ. of Victoria </li></ul><ul><li>Oregon Health and Science </li></ul><ul><li>UCLA </li></ul><ul><li>Harvard </li></ul><ul><li>CDC </li></ul>
  8. 8. LMDCI Research – Immune Mechanisms Section <ul><li>Determine the basis of innate immune responses to LVS </li></ul><ul><li>Determine the role of B cells in immunity to LVS and Mtb </li></ul><ul><li>Elucidate protective T cell-mediated immune responses to LVS and Mtb </li></ul>
  9. 9. LMDCI – Regulatory Duties <ul><li>Provide pre-clinical guidance </li></ul><ul><li>Review IND submissions </li></ul><ul><li>Review BLAs </li></ul><ul><li>Inspect manufacturing facilities </li></ul><ul><li>Review product labeling and advertising </li></ul><ul><li>Review product lot release documents </li></ul><ul><li>Assist in developing regulatory policy </li></ul>
  10. 10. LMDCI – Regulated Products <ul><li>VACCINES </li></ul><ul><li>TB, malaria, tularemia, Lyme disease, </li></ul><ul><li>Q fever, leishmania </li></ul><ul><li>IMMUNOTHERAPEUTICS </li></ul><ul><li>BCG, M. vaccae </li></ul><ul><li>DIAGNOSTICS </li></ul><ul><ul><li>Skin test reagents, devices </li></ul></ul>
  11. 11. Involvement with the Public Health Community <ul><li>WHO GAVI committee </li></ul><ul><li>WHO TB Vaccine Initiative Advisory Board </li></ul><ul><li>WHO TB Clinical Trials Working Group </li></ul><ul><li>Standard reagents for the WHO </li></ul><ul><li>CDC skin test studies </li></ul><ul><li>BTEP program </li></ul>
  12. 12. Involvement with the Public Health Community <ul><li>NIH Study Sections </li></ul><ul><li>NIH TB Vaccine Review Committee </li></ul><ul><li>NIH Blue Ribbon Panels </li></ul><ul><li>Advisory Committee for the Elimination of Tuberculosis </li></ul><ul><li>Federal TB Task Force </li></ul><ul><li>Editorial Boards for scientific journals </li></ul>

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