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    KING'S COLLEGE LONDON KING'S COLLEGE LONDON Document Transcript

    • CURRICULUM VITAE SECTION A Name: Dr. Ying SUN School: King’s College London School of Medicine (KCLSoM) Department: Asthma, Allergy & Respiratory Science 5th Floor, Tower Wing, Guy’s Hospital, London SE1 9RT Title of present post: Reader in Allergy & Respiratory Medicine e-mail: yin.sun@kcl.ac.uk • SCI search 158 publications • ISI search the cited times more than 9000 by others • More than 80 Original publications (first author in 28), most of which are in prestigious international journals; NEJM 1, JEM 3, 11 in the top journal of Immunological field-J Immunology, 15 in the top journal of Allergy and Clinical Immunology (JACI), more than 10 as Corresponding author and senior authors • Involved in training/supervision of 19 pre- and post- doctoral scientists __________________________________________________________________________________________________ SECTION B – EDUCATION (including academic and other honours) Name of Institution Date Qualification Jilin Medical College, P.R. China 1980 MD Beijing Medical University, P.R. China 1988 MSc Molecular Immunology University of London, National Heart & Lung Institute, UK 1994 PhD Honours 1) Lecturing Professor in Beijing City, P.R. China (2006-) 2) Honorary senior lecturer in Imperial College (2006-) 3) Guest Professor in Jilin University, P.R. China (2005-) 4) Visiting Research Professor in Beihua University, P.R. China (2005-) 5) Visiting Research Professor in the Central South University, P.R. China (2004-) 6) Visiting Research Professor in the Norman Bethune University, Jilin, P. R. China (1998-) Awards and Prizes The Royal Society International Travel Award (2006) British Society of Allergy Clinical Immunology International Travel Award (2004) The Royal Society International Travel Award (1999) American Academy of Allergy International Travel Award (1995) Pharmacia Young Fellowship Prize (1995) American Academy of Allergy International Travel Award (1994) American Academy of Allergy International Travel Award (1993) 1st Medical student prize for Highest 1st Class Honours in Medicine (Jilin Medical College, P.R. China) 1
    • ________________________________________________________________________________________ SECTION C – PREVIOUS APPOINTMENTS WITHIN AND OUTSIDE COLLEGE (with the dates) 2003-2008 Senior Lecturer in King’s College London, UK 2002–2003 Principal Investigator and Head of Immunology, TaiGen Biotech, Taiwan 1996–2001 Lecturer in Imperial College School Medicine, NHLI Division, London, UK 1994–1995 Post-doc Fellow in Imperial College School of Medicine, NHLI Division, London, UK 1988–1989 Lecturer in Beijing Medical University, Division of Immunology, P.R. China 1981–1984 Assistant Professor in Jilin Medical College, Department of Microbiology and Immunology, P.R. China ________________________________________________________________________________________ SECTION D - TEACHING Undergraduate teaching Formal teaching 2006 – to date Immunology for Year 3 Pharmacology students (BM0314 and BM0324), KCL BHS/UG, UK 2006 – to date Biochemical tutor for Year 1 MBBS (MA03, MB03 and MC03), KCLSoM, UK 1985 – 1989 Microbiology and Immunology for medical students, Beijing Medical University, China 1981 – 1984 Microbiology and Immunology for medical students, Jilin Medical College, China Research and Postgraduate training Formal teaching 1994 – to date Teaching of postgraduate clinicians and non-clinicians in national and international programmes (run by KCLSoM; British Society for Allergy and Clinical Immunology; European Academy of Allergy and Clinical Immunology; Postgraduate course on European Respiratory Society; University of London MSc Medical Immunology, Basic and Clinical Allergy etc) 1998 – to date Organizer and teacher for Summer Course of Basic and Clinical Immunology in Jilin University and Capital Medical University, Beijing, P.R. China Postgraduate supervision, and supervising One PhD student (completed within 3 years) two MD students (completed within 2years) 1992 - to date Supervising six PhD students, 7 MD students, 5 post-doc fellows, one visiting lecturer and three visiting professors Teaching material produced Three chapters in international text books aimed variously at students and clinical and non-clinical postgraduates: Human Airway Inflammation (Humana Press Inc., NJ, 2001) Chemokines in Allergic Disease (Marcel Dekker Inc., New York, 1999) Eosinophils in allergy and inflammation (Marcel Dekker, New York, 1993) Teaching and training load Routinely training postgraduates, PhD/MD students, technicians and other visitors within and outside of KCL in molecular immunology, pathology and histology. ________________________________________________________________________________ SECTION E – RESEARCH My research career originally addressed the role of T cell-mediated immunity in the pathogenesis of asthmatic and allergic inflammation. When I commenced working in this field in 1989, under the guidance and inspiration of my supervisor and colleague Professor Barry Kay (National Heart and Lung Institute, London UK), a possible role for T cell-mediated immunity in asthma was regarded generally, and particularly in North America, with a degree of scepticism bordering on derision. Currently, owing in no small part to my careful analysis of the cellular and molecular immunopathology of the T cell component of asthmatic inflammation, the tide has now turned completely, and T cells are now regarded worldwide as playing a fundamental role in asthma pathogenesis. I am recognised internationally as a fundamental contributor to this important work (in fact my work with Barry Kay was highlighted as one of the milestones in asthma research in the past 200 years in the 2
    • official 2nd Centenary publication of the American Thoracic Society, a rare honour). It has had far reaching implications, not least for the clinical management of severe asthmatics, as elaborated below. In 2002, I was invited to join an American modern R&D pharmaceutical industry located in Taiwan. As the principal investigator and director of Section of Immunology, our team focused on mechanisms and target selection of G-protein coupled receptors (GPCR), particularly chemokines and chemokine receptors in allergic inflammation, autoimmune disease and tumour metastasis. Under my direction, our team set up a number of disease models in animals including asthmatic inflammation, rheumatoid arthritis, multiple sclerosis, colitis and skin transplantation rejection. Using these models, my team analysed the toxicology and pharmaceutical kinetics of a number of small molecule compounds which had the potential to be developed into antagonists and agonists for certain GPCRs. Collaboration with industry (grants in category C, E, H below) Together with Professors Kay and Corrigan, I have collaborated successfully with industry in a variety of basic science projects (effects of anti-asthma drugs on T cells, histamine inhibitors on endothelial cells, humanized monoclonal antibodies against IL-5 and IgE in clinical trials and novel targets for therapy of asthma. . In summary I have made fundamental inroads in the investigation of the role of Th-2 cells, Th-2 cytokines, Th-2 attracting chemokines, PGE2 and other mediators in asthma and other allergic inflammation, with tangible clinical consequences, and on the cellular and molecular pathology of severe phenotypes of asthma, including intrinsic asthma, glucocorticoid resistant and aspirin sensitive disease. My contribution to these fields is recognised by my peers worldwide. Future strategy My intention is to continue to develop laboratory-clinical based research in asthma and allergy. I will continue my studies on T cells, cytokines, chemokines and other molecules involved in the mechanisms of various clinical subgroups of asthma and new asthma therapies. I will also embrace existing Departmental and MRC Centre expertise (both basic, since we have an excellent group of molecular and cell biologists, and clinical staff) looking at the relationships between T cell cytokines, chemokines, leukotrienes and airways remodelling. Finally, I will continue to build up my research team and attract high quality research fellows. I will consolidate and further extend my national and international standing. Research funding (Key: PI=principal investigator; Co-A=co-applicant; MP=major participator; letters A-I refer to research categories above) 2008 Guy’s & St Thomas Charity Sum: £261,554 Purpose: The effect of a humanised monoclonal anti-IgE antibody (omalizumab) on disease control and bronchial mucosal inflammation in non-atopic (“intrinsic”) asthma. Co-A (3 year study) (I) 2007 The Friends of Guy’s Hospital Awarded funding (Grant number405) Sum: £3,600 Purpose: Set up the technique of angiogenesis and evaluate the role of human FIZZ-2 in vasscularity in vitro. PI (1 year study) (A) 2007 DANA Foundation (USA) Project Grant Sum: $300,000 Purpose: Cross talk between eosinophils and Th2 memory cells augments allergic lung inflammation. PI (3 year study) (A) 2006 Medical Research Council Project Grant (G0501493) Sum: £396,869 (with FEC) Purpose: The role of FIZZ-2/RELM-beta in airways remodelling in asthma: from mouse to man. PI (3 year study) (A) 2005 Medical Research Council Project Grant (G0400897) Sum: £184,988 Purpose: Functional role of cysteinyl leukotriene and prostaglandin E2 receptors in aspirin sensitive asthma. Co-A (3 year study) (B) 3
    • 2005 Industry funding Sum: £27,809 Purpose: measurement of TSLP in skin biopsies. Co-A (1 year study) (C) 2005Central Research Fund of University of London (AR/CRF/B) Sum: £6,565) Purpose: Regulation of asthmatic inflammation and disease severity by thymic stromal lymphopoietin (TSLP) and chemokines. PI (1 year study) (D) 1999 Industry funding Sum: £389,246 Purpose: Anti IL-5, anti-IgE and anti-histamine reagents in allergic inflammation. MP (3 year studies) (E) 1999 Wellcome Trust Project Grant (004519) Sum: £107,456 Purpose: Eosinophil and basophil recruitment in atopic allergic inflammation. Co-A (2year study) (F) 1994 Medical Research Council Programme Grant (P7705992) Sum: £1,256,769 Purpose: Eosinophils, T cells and Th-2 cytokines in asthma and allergic inflammation. MP (5 year study) (G) 1991 Funds from National Heart & Lung Institute, Department of Allergy & Clinical Immunology and Industry Sum: £ 153,567 Purpose: Eosinophil inflammation in asthma and allergy. MP (3 year) (H) TOTAL FUNDING FOR RESEARCH TO DATE: £2,938,423 Editorial Boards and Scientific Refereeing Editorial Boards: The Open Allergy Journal Reviewing/Refereeing Journals including: Grant giving bodies including: Journal of Allergy and Clinical Immunology MRC American Journal of Respiratory and Critical Care Medicine Wellcome Trust Journal Immunology Royal Society of New Zealand American Journal of Physiology- Lung Cellular and Molecular Physiology Fondation Recherche Mediale J Investigative Dermatology DEFIS DE LA Recherche En Thorax ALLERGOLYIE, French Allergy Clinical and Experimental Allergy Clinical and Experimental Immunology European Respiratory Journal Int Arch Allergy Experimental Cell Research Acta Pharmacology Sinica Invited lectures Numerous seminars/invited lectures in UK, Europe, USA, Taiwan and China Invited seminar, Center for Cancer Immunology Research, Texas USA Huston 2006 Invited seminar, Pulmonary and Critical Care Medicine, Long Island Jewish Medical Center, NY, USA New Hyde Park, New York, 2002 Invited seminar, Aventis, Bridgewater, NJ USA New York 2001 Invited seminar, McGill University, Montreal, Quebec Canada Montreal 1999 Invited seminar, Ophthalmology Institute, University of Illinois, USA Chicago 1993 Invited lecturer, Beijing Capital Medical University, China Beijing 2005, 2006, 2007, 2008 Invited lecturer, Jilin University, China Jilin 2005, 2006, 2007, 2008 Invited lecturer, South Central University, China Changsha 2004 Invited lecturer, Beihua University, China Jilin 2005 4
    • Invited lecture, Beijing United Hospital, China Beijing 1995 Invited speaker, European Academy of Allergology and Clinical Immunology Birmingham 1998 Invited speaker, Royal Society of Medicine London 1997 Invited speaker, European Respiratory Society Berlin, Germany 1997 Invited speaker, British Society for Allergy & Clinical Immunology London 1994 Invited symposium speaker, 5th International cardiovascular disease. Beijing, China Beijing 2004 Invited symposium speaker, The 1st International Symposium on Geriatric Cardiology Beijing China Beijing 2001 Invited speaker, 1st International Conference on Immunopharmacology of Bronchial Asthma. Taiwan 1999 Invited symposium speaker, 2nd International Life Science Symposium in China Shanghai 1995 Activities for Learned Societies American Academy of Asthma, Allergy and Immunology 2005 - to date Member British Society for Allergy and Clinical Immunology 1997 - to date Member ________________________________________________________________________________ SECTION F - ADMINISTRATION Administrative duties include: (1) Personal tutor for Year 1 and Year 2 medical undergraduates in KCLSoM since 2006, twice a month face to face communication and e-mail consultations (2) Departmental Fire Marshal, taking regularly care of fire safety in the department, update of fire safety regulation, checking fire fighting equipment, and report to safety manager of department. Once hearing the fire alarm, fire marshal will wear high visibility jacket, assist in the orderly evacuation of staff from their designated area to a final building exit or place of safety; assist in the dispersal of persons to their assembly areas; assist in crowd control and crowd safety at assembly areas and assist in the safe re-entry into building. 3) Departmental Photographer, taking photos and imagings for departmental gallery and boards for visitors and research purposes ________________________________________________________________________________ SECTION G – KNOWLEDGE TRANSFER With Industry Collaborative basic and clinical research projects (see above); scientific consultant for many major pharmaceutical companies (see above). ________________________________________________________________________________ SECTION H – STANDING IN THE PROFESSION A scientist of international standing in asthma and allergy, particularly in the field of cytokines and chemokines. ________________________________________________________________________________ SECTION I - FURTHER INFORMATION Over the years I have been successful in achieving the goals I have set myself or discussed with my Head of Department at appraisal. I will continue my teaching activities inside and outside the school. I will also continue my research on asthma pathogenesis and try to translate the data from laboratory to clinical care and treatment. ________________________________________________________________________________ SECTION J - FEATURES OF THE APPLICATION I respectfully submit that the following are the most important features in support of my application for conferment of title to Professor: 5
    • I have a past and ongoing record of excellent research addressing fundamental mechanistic processes in the cellular and molecular pathology of asthma. This research has directly influenced patient care and new therapy in asthma. My outstanding research has contributed well beyond the College and will continue to contribute to the standing and esteem of the College, of the KCL School of Medicine and of the University of London. _______________________________________________________________________________ SECTION K - NAMES AND ADDRESSES OF REFEREES Professor Stephen R Durham Head of Allergy and Clinical Immunology National Heart and Lung Institute London SW3 6LY s.durham@imperial.ac.uk Professor Qutayba Hamid Directors: McGill Asthma Center, Respiratory Axis, MUHC Meakins-Christie Laboratories McGill University 3626 St. Urbain Street Montreal , Quebec H2X 2P2 Canada Qutayba.Hamid@McGill.ca Professor M Humbert Professor Marc Humbert, MD, PhD Service de Pneumologie et Réanimation Respiratoire Centre National de Référence des Maladies Vasculaires Pulmonaires Hôpital Antoine Béclère Assistance Publique Hôpitaux de Paris Université Paris-Sud 11 157, rue de la Porte de Trivaux 92140 Clamart France Tel: +33 1 45 37 47 72 Fax: +33 1 46 30 38 24 marc.humbert@abc.aphp.fr Professor Mark Larché Ph.D. Canada Research Chair in Allergy & Immune Tolerance, Dept. Medicine, McMaster University, HSC 4H20, 1200 Main Street West, Hamilton, Ontario L8N 3Z5 Canada tel: +1-905-525-9140 x 21284 fax: +1-905-521-4971 larche@mcmaster.ca 6
    • APPENDIX - LIST OF PUBLICATIONS: DR. Ying SUN Figures in [parentheses, blue] represent total citations of papers (as at 2008) where these exceed 4, according to the ISI citation index. Letters in bold (A-H) refer to research categories in section E above. Corrigan CJ, Jayaratnam A, Wang YH, Liu YJ, de Waal Malefyt R, Meng Q, Kay AB, Phipps S, Lee TH, and Ying S. Early production of thymic stromal lymphopoietin precedes infiltration of dendritic cells expressing its receptor in allergen-induced late phase cutaneous responses in atopic subjects. Allergy 2008 (in press) (ISSN: 0105-4538) (Corresponding author) (C, D) Ying S, O’Connor B, Ratoff J, Meng Q, Fang CL, Cousins D, Zhang G, Gu S, Gao Z, Shamji B, Edwards MJ, Lee TH, and Corrigan CJ. Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease. J Immunol 2008; 181:2790-2798 (ISSN: 0022-1767) (Corresponding author) (C, D) Sheng CH, Di J, Jin Y, Zhang YC, Wu M, Ying S, Zhang GZ. Resistin is expressed in human hepatocytes and induces insulin resistance. Endocrine 2008, 3:135-143 (ISSN: 0969-711X) Wang YH, Angkasekwinai P, Lu N, Voo KS, Arima K, Hanabuchi S, Hippe A, Corrigan CJ, Dong C, Homey B, Yao Z, Ying S, Huston DP, Liu YJ. IL-17E augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated TH2 memory cells. J Exp Med 2007, 204: 1837-47 (ISSN: 0022-1007) [10] (A, D) Ying S, Meng Q, Corrigan CJ, Lee TH. Lack of filaggrin expression in the human bronchial mucosa. J Allergy Clin Immunol 2006, 188:1386-1388 (ISSN: 0091-6749) [16] (B, C) Ying S, Meng Q, Scadding G, Parikh A, Corrigan CJ, Lee TH. Aspirin sensitive rhinosinusitis is associated with reduced E-prostanoid 2 (EP2) receptor expression on nasal mucosal inflammatory cells. J Allergy Clin Immunol 2006, 117: 312-318 (ISSN: 0091-6749) (Corresponding author) [15] (B, C) Loke TK, Mallett KH, Ratoff J, O’Connor B, Ying S, Meng Q, Lee TH, Corrigan CJ. Reduced activation of Activator Protein-1 (AP-1) components in the bronchial mucosa of glucocorticoid sensitive, but not resistant asthmatics in association with systemic glucocorticoid therapy. J Allergy Clin Immunol 2006, 118: 368-375 (ISSN: 0091-6749) [6] (B, C) Ying S, O’Connor B, Ratoff J, Meng Q, Mallett K, Cousins D, Robinson D, Zhang GZ, Zhao JS, Lee TH, Corrigan C. Thymic stromal lymphopoietin (TSLP) expression is increased in asthmatic airways correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 2005, 174: 8183-8190 (ISSN: 0022-1767) (Corresponding author) [71] (C, D) Ong YE, Menzies-Gow A, Barkans J, Benyahia F, Ou TT, Ying S, Kay AB. Anti-IgE (omalizumab) inhibits late phase reactions and inflammatory cells following repeat skin allergen challenge. J Allergy Clin Immunol 2005, 116: 558-562 (ISSN: 0091-6749) [27] (E) Corrigan C, Mallet K, Ying S, Abhi Parikh, Glenis Scadding, Tak Lee. Expression of the cysteinyl leukotriene receptors CysLT1 and CysLT2 on leukocytes and structural cells of the nasal mucosa in patients with chronic rhinosinusitis: influence of aspirin sensitivity. J Allergy Clin Immunol 2005, 115: 316-322 (ISSN: 0091-6749) [23] (B) Alexander C, Ying S, Kay AB, Larche M. Fel d 1-derived T cell peptide therapy induces recruitment of CD4+CD25+; CD4+ interferon-gamma+ T helper type 1 cells to sites of allergen-induced late-phase skin reaction in cat-allergic subjects. Clin Exp Allergy 2005, 35:52-58 (ISSN: 0954-7894) [21] (E) Ying S, O’Connor B, Meng Q, Woodman N, Greenaway S, Wong H, Mallett K, Lee TH, Corrigan C. Expression of prostaglandin E2 receptor subtypes on cells in sputum from asthmatics and controls: effect of allergen inhalational challenge. J Allergy Clin Immunol 2004, 114:1309-1316 (ISSN:0091-6749) (Corresponding author) [6] (B) 7
    • Menzies-Gow A, Ying S, Phipps S, Kay AB. Interactions between eotaxin, histamine and mast cells in early microvascular events associated with eosinophil recruitment to the site of allergic skin reactions in man. Clin Exp Allergy 2004, 34:1276-82 (ISSN: 0954-7894) [8] (E) Ying S, Khan LN, Meng Q, C Bames NC, Kay AB. Inhibition of Late Asthmatic Reactions by Cyclosporin A is associated with enhanced Apoptosis of bronchoalveolar lavage T cells together with decreases in the expression of Bcl-2 and IL-4. Eur Respir J 2003, 22:207-212 (ISSN: 0903-1936) [8] (E) Sehmi R, Dorman S, Baatjes A, Watson R, Foley R, Ying S, Robinson DS, Kay AB, O'Byrne PM, Denburg JA. Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation. Immunology 2003, 109:536-46 (ISSN: 0091-2805) [28] (E) Flood-Page P, Menzies-Gow A, Phipps S, Ying S, Wangoo A, Ludwig MS, Barnes N, Robinson D, Kay AB. Anti-IL-5 treatment (mepolizumab) reduces deposition of extracellular matrix proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics: evidence for a role for eosinophils in airways remodeling. J Clin Invest 2003, 112:1029-1036 (ISSN: 0021-9738) [150] (E) Ying S, Meng Q, Smith S, Larche M, Kay AB. EG2 strong+ and Congo red+ but not EG2 weak+ or MBP+ cells, reliably represent the human eosinophil phenotype in blood and tissues. Allergy and Clin Immunology International 2002, 14:64-69 (ISSN: 0838-1925) [7] (E) Ying S, Meng Q, Kay AB, Robinson DS. Elevated expression of IL-9 mRNA in the bronchial mucosa of atopic asthmatics: relationships to eosinophils, mast cells and T lymphocytes. Clin Exp Allergy 2002, 32:866-71 (ISSN: 0954-7894) [14] (E) Ying S, Yoko Kikuchi, Meng Q, Kay AB, Kaplan AP. Th1/Th2 cytokines and inflammatory cells in skin biopsies from chronic idiopathic urticaria: comparison with the allergen-induced late-phase cutaneous reaction. J Allergy Clin Immunol 2002,109:694-700 (ISSN: 0091-6749) (Corresponding author) [32] (E) Ying S, Q Meng. The effect of levocetirizine on histamine- and cytokine-induced up-regulation of eotaxin by endothelial cells. Allergy 2002, 57:145-146 (ISSN: 0105-4538) (Corresponding author) [5] (E) Menzies-Gow A, Ying S, Sabroe I, Stubbs VL, Soler D, Williams TJ, Kay AB. Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers. J Immunol 2002,169:2712-2718 (ISSN: 0022-1767) [53] (F) Phipps S, Ying S, Wangoo A, Ong YE, Levi-Schaffer F, Kay AB. The relationship between allergen-induced tissue eosinophilia and markers of repair and remodeling in human atopic skin. J Immunol 2002,169:4604-4612 (ISSN: 0022-1767) [50] (E) Granjo E, Lima M, Lopes JM, Doria S, Orfao A, Ying S, Barata LT, Miranda M, Cross NC, Bain BJ. Chronic eosinophilic leukaemia presenting with erythroderma, mild eosinophilia and hyper-IgE: clinical, immunological and cytogenetic features and therapeutic approach. Acta Haematol 2002,107:108-112 (ISSN: 0001-5792) [14] (E) Ying S, Humbert M, Meng Q, Pfister R, Menz G, Could HJ, Kay AB, Durham SR. Local expression of ε germ- line gene transcripts and RNA for the heavy chain of IgE in the bronchial mucosa in atopic and non-atopic asthma. J Allergy Clin Immunol 2001,107:686-692 (ISSN: 0091-6749) [50] (G) Ying S, Meng Q, Barata LT, and Kay AB. Macrophage inflammatory protein-1 (MIP-1) and CCR-1 in allergen- induced skin late phase reactions (LPR): relationship to macrophages, neutrophils, basophils, eosinophils and T lymphocytes. Clin Exp Allergy 2001, 31:1724-1731 (ISSN: 0954-7894) [10] (F) Larche M, Haselden BM, Oldfied WLG, Shirley K, North J, Meng Q, Robinson DS, Ying S, Kay AB. Mechanisms of T cell peptide epitope-dependent late asthmatic reactions. Int Arch Allergy Immunology 2001,124:272-275 (ISSN: 1018-2438) [7] (E) Haselden BM, Larche M, Meng Q, Shirley K, Dworski R, Kaplan AP, Bates C, Robinson DS, Ying S, Kay AB. Late asthmatic reactions provoked by intradermal injection of T cell peptide epitopes are not associated with bronchial mucosal infiltration of eosinophils or TH2-type cells or elevated concentrations of histamine or eicosanoids in bronchoalveolar fluid. J Allergy Clin Immunol 2001, 108:394-401 (ISSN: 0091-6749) [25] (E) 8
    • Nasser SMS, Ying S, Meng Q, Kay AB, Ewan P. Interleukin-10 levels increase in cutaneous biopsies of patients undergoing venom immunotherapy. Eur J Immunol 2001, 31:3704-3713 (ISSN: 0014-2980) [38] (E) Smith SJ, Ying S, Meng Q, Sullivan MHF, Barkans J, Kon OM, Sihra B, Larche M, Levi-Schaffer F, Kay AB. Blood eosinophils from atopic donors mRNA for the α,β, and γ subunits of the high affinity IgE receptor (FcεRI) and intracellular, but not cell surface, α subunit protein. J Allergy Clin Immunol 2000,105:309-317 (ISSN: 0091-6749) [20] (E) Zeibecoglou K, Ying S, Meng Q, Poulter LW, Robinson DS, A.B. Macrophage subpopulations and macrophage-derived cytokines in sputum of atopic, non-atopic asthmatics, atopic and normal controls. J Allergy Clin Immunol 2000, 106:697-704 (ISSN: 0091-6749) [13] (E) Zeibecoglou K, Ying S, Meng Q, Papageorgiou N, Kay A.B, Robinson DS, Papageorgiou N. Expression of Eotaxin in induced sputum of atopic and non-atopic asthmatics. Allergy 2000, 55:1042-1048 (ISSN: 0105-4538) [10] (E) Khan LN, Kon OM, Macfarlane AJ, Meng Q, Ying S, Barnes NC, Kay AB. Attenuation of the allergen induced late asthmatic reaction (LAR) by cyclosporin A (CsA) is associated with inhibition of bronchial eosinophils, IL-5, GM-CSF and eotaxin. Am J Resp Crit Care Med 2000, 162:1377-1382 (ISSN: 1073-449X) [33] (E) Macfarlane AJ, Kon OM, Smith SJ, Zeibecoglou K, Khan LN, Barata LT, McEuen AR, Buckley MG, Walls AF, Meng Q, Humbert M, Barnes NC, Robinson DS, Ying S, Kay AB. Basophils in atopic and non-atopic and late- phase allergic reactions. J Allergy Clin Immunol 2000, 105:99-107 (0091-6749) [59] (E, D) Ying S, Robinson DS, Meng Q, Barata LT, McEuen AR, Buckley MG, Walls A.F, Askenase PW. Kay A.B. C-C chemokines in allergen-induced late phase cutaneous responses in atopic subjects: Association of eotaxin with early 6-hour eosinophils, and eotaxin-2 and MCP-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (MCP-3 and RANTES). J Immunol 1999,163: 3976-3984 (ISSN: 0022-1767) [127] (F) Ying S, Meng Q, Zeibecoglou K, Robinson DS, Macfarlane A, Humbert M, Kay AB. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, MCP-3, and MCP-4) and CCR3 expression in bronchial biopsies from atopic and non-atopic asthmatics. J. Immunol 1999,163:6321-6329 (ISSN: 0022-1767) [202] (F) Zeibecoglou K, Ying S, Yamada T, North J, Burman J, Bungre J, Meng Q, Kay AB, Robinson DS. Increased mature and immature CCR3 messenger RNA+ eosinophils in bone marrow from atopic asthmatics compared to atopic and non-atopic control subjects. J Allergy Clin Immunol 1999,103:99-106 (ISSN: 0091-6749) [26] (F, E) Robinson DS, North J, Zeibecoglou K, Ying S, Meng Q, Rankin S, Hamid Q, Tavernier J, Kay AB. Eosinophil development and bone marrow and tissue eosinophils in atopic asthma. Int Arch Allergy Immunol 1999,118:98-100 (ISSN: 1018-2438) [22] (E) Zeibecoglou K, Macfarlane A, Ying S, Meng Q, Pavord, Barnes NC, Robinson DS, Kay AB. Increases in eotaxin positive cells in induced sputum from atopic asthmatics following inhalational allergen challenge. Allergy 1999, 54:730-735 (ISSN: 0105-4538) [21] (F) Humbert M, Menz G, Ying S, Corrigan CJ, Robinson DS, Durham SR, Kay AB. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences. Immunol Today 1999, 20:528-533 (ISSN: 0167-5699) [131] (G) Menz G, Ying S, Durham SR, Corrigan CJ, Robinson DS, Pfister R, Humbert M, Kay AB. Molecular cocepts of IgE-initiated inflammation in atopic and nonatopic asthma. Allergy 1998, 53:15-21 (ISSN: 0105-4538) [29] (G) Barata LT, Ying S, Meng Q, Barkans J, Rajakulasingam K, Durham SR, Kay AB. Interleukin-4 (IL-4) and IL-5 positive T lymphocytes, eosinophils and mast cells in allergen-induced late-phase cutaneous reactions in atopic subjects. J Allergy Clin Immunol 1998, 101:222-230 (ISSN: 0091-6749) [50] (G) Rajakulasingam K, Till S, Ying S, Humbert M, Barkans J, Sullivan M, Meng Q, Corrigan CJ, Bungre J, Grant JA, Kay AB, Durham SR. Increased expression of high affinity IgE receptor (FcεRI) α chain mRNA and protein bearing eosinophils in human allergen-induced atopic asthma. Am J Respir Crit Care Med 1998, 158:233-240 (ISSN: 1073-449X) [29] (G) Ying S, Barata LT, Meng Q, Grant JA, Barkans J, Durham SR, Kay AB. High affinity IgE receptor (FcεRI)- bearing eosinophils, mast cells, macrophages and Langerhans cells in allergen-induced late-phase cutaneous reactions in atopic subjects. Immunology 1998, 93:281-288 (ISSN: 0019-2805) [33] (G) 9
    • Ying S, Robinson DS, Meng Q, Rottman J, Kennedy R, Ringler DJ, Mackay CR, Daugherty BL, Springer MS, Durham SR, Williams TJ, Kay AB. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma and their association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur J Immunol 1997, 27:3507-3516 (ISSN: 0014-2980) [255] (G) Ying S, Meng Q, Barata LT, Robinson DS, Durham SR, Kay AB. Associations between IL-13 and IL-4 (mRNA and protein), VCAM-1 expression and the infiltration of eosinophils, macrophages and T cells in allergen- induced late-phase cutaneous reactions in atopic subjects. J Immunol 1997, 158:5050-5057 (ISSN: 0022-1767) [75] (G) Ying S, Humbert M, Barkans J, Corrigan CJ, Pfister M, Menz G, Robinson DS, Durham SR, Kay AB. Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and non-atopic (intrinsic) asthmatics. J Immunol 1997, 158: 3539-3544 (ISSN: 0022-1767) [216] (G) Ying S, Meng Q, Taborda-Barata L, Kay AB. Apoptosis of neutrophils and eosinophils and their ingestion by macrophages is associated with resolution of the allergen-induced cutaneous late-phase response in human atopic subjects. Pro Association Am Phy 1997, 109:42-50 (ISSN: 1081-650X) [22] (G) Kay AB, Barata LT, Meng Q, Durham SR, Ying S. Eosinophils and eosinophil-associated cytokines in allergic inflammation. Int Arch Allergy Immunol 1997, 113:196-199 (ISSN: 1018-2438) [72] (G) Barata LT, Ying S, Grant AJ, Humbert M, Barkans J, Meng Q, Durham SR, Kay AB. Allergen-induced recruitment of FcεRI+ eosinophils in human atopic skin. Eur J Immunol 1997, 27:1236-1241 (ISSN: 0014-2980) [12] (G) Meng Q, Ying S, Corrigan CJ, Wakelin M, Assoufi B, Moqbel R, Kay AB. Effects of rapamycin, cyclosporin A, and dexamethasone on interleukin 5-induced eosinophil degranulation and survival. Allergy 1997, 52: 1095-1101 (ISSN: 0105-4538) [24] (G) Humbert M, Ying S, Menz G, Barkans J, Pfister R, Meng Q, Corrigan CJ, Van Damme, Opdenakker G, Durham SR, Kay AB. Bronchial mucosal gene expression of the CC chemokines RANTES and MCP-3 in symptomatic atopic and non-atopic asthmatics: relationship to EG2+ eosinophils and the eosinophil-active cytokines IL-5, GM-CSF and IL-3. Am J Respir Cell Mol Biol 1997,16:1-8 (ISSN: 1044-1549) [108] (G) Iversen PO, Robinson DS, Ying S, Meng Q, Kay AB, Clark-Lewis I, Lopez AF. The GM-CSF analogue E21R induces apoptosis of normal and activated eosinophils. Am J Respir Crit Care Med 1997; 156:1628-1632 [15] (G) Ying S, Meng Q, Taborda-Barata L, Corrigan CJ, Barkans J, Assoufi B, Moqbel R, Durham SR, Kay AB. Human eosinophils express messenger RNA encoding RANTES and store and release biological active RANTES protein. Eur J Immunol 1996, 26:70-76 (ISSN: 0014-2980) [67] (G) Durham SR, Ying S, Varney VA, Jacobson MR, Sudderick RM, Mackay IS, Kay AB, Hamid Q. Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocyte and eosinophils in the nasal mucosa and increses the number of cells expressing messenger RNA for interferon-g. J Allergy Clin. Immunol 1996, 97:1356-65 (ISSN: 0091-6749) [219] (G) Humbert M, Durham SR, Ying S, Kimmitt P, Barkans J, Assoufi B, Pfister B, Menz G, Robinson DS, Kay AB, Corrigan CJ. Bronchial mucosal interleukin-4 (IL-4) and IL-5 expression is a feature of both atopic and non- atopic asthma. Am J Respir Crit Care Med 1996, 154:1497-1504 (ISSN: 1073-449X) [215] (G) Levi-Schaffer F, Karkans J, Newman TM, Ying S, Wakelin M, Hohenstein R, Barak V, Lacy P, Kay AB, Moqbel R. Identification of interleukin-2 in human peripheral blood eosinophils. Immunology 1996, 87:155-161 (ISSN: 0019-2805) [48] (G) Taborda-Barata L, Jacobson M, Walker S, Njuki F, Ying S, Randev P, Durham SR, Kay AB. Effect of cetirizine and prednisolone on cellular infiltration and cytokine mRNA expression during allergen-induced late cutaneous responses. Clin Exp Allergy 1996, 26:68-78 (ISSN: 0954-7894) [23] (G) Humbert M, Grant JA, Taborda-Barata L, Durham SR, Prister R, Menz G, Barkans J, Ying S, Kay AB. High affinity IgE receptor (FcεRI)-bearing cells in bronchial biopsies from atopic and non-atopic asthma. Am J Respir Crit Care Med 1996, 153:931-1937 (ISSN: 1073-449X) [109] (G) 10
    • Ying S, Taborada-Barata L, Meng Q, Humbert M, Kay AB. Allergen-induced transcription of messenger RNA for monocyte chemotactic protein-3 (MCP-3) and RANTES in the skin of human atopic subjects. J Exp Med 1995, 181:2153-2159 (ISSN: 0022-1007) [117] (G) Ying S, Durham SR, Hamid Q, Kay A.B. Phenotype of cells expressing mRNA for TH2-type (IL-4 and IL-5) and TH1-type (IL-2 and IFN-γ) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatics and normal control subjects. Am J Respir Cell Mol Biol 1995, 12:477-487 (ISSN: 1044-1549) [220] (G) Moqbel R, Ying S, Barkans J, Newman TM, Kimmitt P, Wakelin M, Taborda-Barata L, Meng Q, Corrigan CJ, Durham SR, Kay AB. Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product. J Immunol 1995, 155:4939-4947 (ISSN: 0022-1767) [137] (G) Kay AB, Ying S, Durham SR. Phenotype of cells positive for interleukin-4 and interleukin-5 mRNA in allergic tissue reactions. Int Arch Allergy Immunol 1995,107:208-210 (ISSN: 1018-2438) [23] (G) Leng DYM, Martin RJ, Szefler SJ, Sher ER, Ying S, Kay AB, Hamid Q. Dysregulation of interleukin 4, interleukin 5, and interferon c gene expression in steroid resistant asthma. J Exp Med 1995,181:33-40 (ISSN: 0022-1007) [196] (G) Ying S, Durham SR, Musuyama K, Jacobson MR, Kay AB, Hamid Q. T cells are the principal source of interleukin-4 messenger RNA in the nasal mucosa in allergen-induced rhinitis. Immunology 1994, 82:200-206 (ISSN: 0019-2805) [81] (H) Robinson DS, Ying S, Taylor I, Wangoo A, Kay AB, Hamid Q, Shaw RJ. Evidence of TH1-like bronchoalveolar T-cell subset and predominance of IFN-gamma gene activation in pulmonary tuberculosis. Am.J Respir Crit Care Med 1994, 149:989-993 (ISSN: 1073-449X) [78] (H) Ying S, Durham SR, Barkans J, Masuyama K, Jacobson M, Rak R, Lowhagen O, Moqbel R, Kay AB, Hamid Q. T cells are the principal source of interleukin-5 mRNA in allergen-induced allergic rhinitis. Am J Respir Cell Mol Biol 1993, 9:356-360 (ISSN: 1044-1549) [124] (H) Robinson DS, Ying S, Bentley AM, Meng Q, North J, Durham SR, Kay AB, Hamid Q. Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma. J Allergy Clin Immunol 1993, 92:397-403 (ISSN: 0091-6749) [188] (H) Robinson DS, Hamid Q, Ying S, Bentley A, Assoufi B, Durham B, Kay AB. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression. Am Rev Respir Dis 1993, 148:401-406 (ISSN: 0003-0805) [241] (H) Varney V, Hamid Q, Gaga M, Ying S, Jacobson M, Frew AJ, Kay AB, Durham SR. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 1993, 92:644-651 (ISSN: 0021-9738) [341] (H) Robinson DR, Hamid Q, Bentley AM, Ying S, Kay AB, Durham SR. Activation of CD4+ T cells, increased Th2- type cytokine mRNA expression, and eosiniphil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J Allergy Clin Immunol 1993, 92:313-24 (ISSN: 0091-6749) [418] (H) Robinson DS, Hamid Q, Jacobson M, Ying S, Kay AB, Durham SR. Evidence for Th2-type T helper cell control of allergic disease in vivo. Springer Seminars in Immunopathology 1993, 15:17-27 (ISSN: 0344-4325) [20] (H) Durham SR, Ying S, Varney V, Jacobson MR, Sudderick RM, Mackay IS, Kay AB, Hamid Q. Cytokine messenger RNA expression for the IL-3, IL-4, IL-5 and GM-CSF in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia. J Immunology 1992, 148:2390-2394 (ISSN: 0022-1767) [425] (H) Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan CJ, Durham SR, Kay AB. Predominant Th2-type bronchoalveolar lavage T-lymphocyte population in atopic asthma. N Engl J Med 1992, 326:298-304 (ISSN: 0028-4793) [1830] (H) Tsicopoulos A, Hamid Q, Varney V, Ying S, Moqbel R, Durham SR, Kay AB. Preferential mRNA expression of Th1-type cells (IFN-gamma+, IL-2+), in classical delayed-type (tuberculin) hypersensitivity reaction in human skin. J Immunol 1992, 148:2062-2067 (ISSN: 0022-1767) [168] (H) 11
    • Hamid Q, Barkans J, Meng Q, Ying S, Abrams JS, Kay AB, Moqbel R. Human eosinophils synthesize and secrete interleukin-6 in vitro. Blood 1992, 80:1496-1501 (ISSN: 0006-4971) [136] (H) Ying S, Robinson DS, Varney V, Meng Q, Tsicopoulos A, Moqbel R, Durham SR, Kay AB, Hamid Q. TNF- alpha mRNA expression in allergic inflammation. Clin Exp Allergy 1991, 21:745-750 (ISSN: 0954-7894) [125] (H) Kay AB, Ying S, Varney V, Gaga M, Durham SR, Moqbel R, Wardlaw AJ, Hamid Q. Messenger RNA expression of the cytokine gene cluster, IL-3, IL-4, IL-5 and GM-CSF in allergen-induced late-phase cutaneous reaction in atopic subjects. J Exp Med 1991, 173:775-778 (ISSN: 0022-1007) [593] (H) Moqbel R, Hamid Q, Ying S, Barkans J, Hartnell A, Tsicopoulos A, Wardlaw AJ, AB Kay. Expression of mRNA and immunoreactivity for the granulocyte/macrophage-colony stimulating factor (GM-CSF) in activated human eosinophils. J Exp Med 1991, 174:749-752 (ISSN: 0022-1007) [188] (H) Hamid Q, Azzawi M, Ying S, Moqbel R, Wardlaw AJ, Corrigan CJ, Bradley B, Durham SR, Collins JV, Jeffery PK, Quint DJ, Kay AB. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J Clin Invest 1991, 87:1541-1546 (ISSN: 0021-9738) [678] (H) Hamid Q, Azzawi M, Ying S, Moqbel R, Wardlaw AJ, Corrigan CJ, Bradley B, Durham SR, Collins JV, Jeffery PK, Quint DJ, Kay AB. Interleukin-5 mRNA in mucosal bronchial biopsies from asthmatic subjects. Int Arch Allergy Appl Immunol 1991, 94:169 (ISSN: 0020-5915) [33] (H) Other invited reviews Fang CL, Corrigan CJ, Ying S. The treatment targets of asthma: from laboratory to clinic. Inflammation & Allergy-Drug Targets; 2008; 7:119-128 (Corresponding author) Ying S, Zhang GZ, Gu SY, Zhao JS. How much do we know about atopic asthma: where are we now? Cellular Molecular Immunology 2006, 3:321-332 (Corresponding author). Ying S, Corrigan CJ, Lee TH. Mechanisms of aspirin-sensitive asthma. Allergology International 2004, 53:111-119 (Corresponding author) (ISSN: 1323-8930). Ying S. C-C chemokine expression in atopic and nonatopic asthma. Chemical Immunol 2000, 78:178-188 (Corresponding author) (ISSN: 1015-0145). Ying S. The Technique of In Situ Hybridization and its application in respiratory diseases. Pulmonary Critical Care Medicine 2000, 15:58-69 (Corresponding author). Chapters in books Kay A.B., Hamid Q., Robinson D.S., Bentley A.M., Tsicopoulos A., Ying S, Moqbel R.M., Corrigan and Durham S.R., Asthma, Eosinophils, and Interleukin-5. 21:395-406. In “Eosinophils in allergy and inflammation” eds. Gleich G.J., and Kay A.B. Marcel Dekker, New York, 1994 ISBN-0-8247-9121-5 Ying S, Kay AB. In situ hybridization. 21:263-284. In: “Human Airway Inflammation” eds. Forgers DF, Donnelly L. Humana Press Inc., New York 2001 ISBN-0-89603923-4 Ying S, Kay AB. Chemokines in Allergic Asthma. 17:383-402. In: “Chemokines in Allergic Disease” ed. Rothenberg ME. Marcel Dekker Inc., New York, 1999 ISBN-0-8247-0286-7 12