Administration of a substance to a person with the purpose of preventing a disease Traditionally composed of a killed or weakened micro organism Vaccination works by creating a type of immune response that enables the memory cells to later respond to a similar organism before it can cause disease
31 patients with different ethnicity infected with different subtypes. 30 out of 31 had response towards at least one peptide. 116 of our 185 peptides (62%) did induce a response in at least one patient. 21 of the recognized peptides induced a response in >4 patients (13% of the study subjects).
Neural networks can learn higher order correlations!
What does this mean?
S S => 0 L S => 1 S L => 1 L L => 0 No linear function can learn this (XOR) pattern Say that the peptide needs one and only one large amino acid in the positions P3 and P4 to fill the binding cleft How would you formulate this to test if a peptide can bind?
Mutual information 313 binding peptides 313 random peptides