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β- glucan application
      in sepsis
    報告者: intern 陳政光
    指導老師: 韓吟宜醫師
Inflammation pathway in sepsis
醣分類簡圖
β-Glucan
   A fiber-type complex sugar (polysaccharide), derived
    from the cell wall of plants, fungi, and certain bac...
葡聚多醣聚合體
之特性與功能
The application of β-glucan in sepsis
Materials and methods
   Sepsis was induced by cecal ligation and
    puncture (CLP) in Wistar rats.
   The control grou...
Materials and methods
   lung injury evaluation: tissue
    myeloperoxidase (MPO)
    activity, intercellular adhesion mo...
Results
Results
  Effects of β-glucan treatment on lung histopatholog




Representative sections of lung immunohistochemically st...
Conclusion of the paper
   A clinically relevant nonspecific
    immunomodulator
   markedly attenuated the expression o...
Conclusion of the paper
   Down-regulation of ICAM-1 and neutrophil
    accumulation pathways.
   Might be used as a the...
Paper review
   Modulation Of Tissue Toll-Like Receptor 2
    And 4 During The Early Phases Of
    Polymicrobial Sepsis C...
Paper review
   Inhibiting early activation of tissue nuclear
    factor-κB and nuclear factor interleukin 6
    with (1→...
Paper review
   Randomized Phase I/Il Trial of a
    Macrophage-Specific Immunomodulator in
    (PGG-Glucan) in High-Risk...
Take home message
   Glucan :
   動物實驗中有效抑制敗血症的發炎反應
   但是皆術前或術後立刻給予

   未來展望…
   人類臨床試驗?
   萃取方式?
Thank you
for attention
glucan application in sepsis.ppt
glucan application in sepsis.ppt
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glucan application in sepsis.ppt

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Transcript of "glucan application in sepsis.ppt"

  1. 1. β- glucan application in sepsis 報告者: intern 陳政光 指導老師: 韓吟宜醫師
  2. 2. Inflammation pathway in sepsis
  3. 3. 醣分類簡圖
  4. 4. β-Glucan  A fiber-type complex sugar (polysaccharide), derived from the cell wall of plants, fungi, and certain bacteria • 具免疫及生理活化功能,尤以1→3, 1→6 β D glucan功效最佳
  5. 5. 葡聚多醣聚合體 之特性與功能
  6. 6. The application of β-glucan in sepsis
  7. 7. Materials and methods  Sepsis was induced by cecal ligation and puncture (CLP) in Wistar rats.  The control group received saline, and the treatment groups received β-glucan or β- glucan + β-1,3-D-glucanase.  After 5 hours : 測 plasma TNF-α,IL-1, IL-6
  8. 8. Materials and methods  lung injury evaluation: tissue myeloperoxidase (MPO) activity, intercellular adhesion molecule (ICAM) 1 levels, and histopathological examination at 18 h after CLP.  survival rate: monitored for 7 days after CLP.
  9. 9. Results
  10. 10. Results Effects of β-glucan treatment on lung histopatholog Representative sections of lung immunohistochemically stained for ICAM-1.
  11. 11. Conclusion of the paper  A clinically relevant nonspecific immunomodulator  markedly attenuated the expression of proinflammatory cytokines and systemic inflammation in rats with septic peritonitis.  Affect the lethality and the occurrence of acute lung injury as measured through end-organ histological damage in response to sepsis.
  12. 12. Conclusion of the paper  Down-regulation of ICAM-1 and neutrophil accumulation pathways.  Might be used as a therapeutic agent in the treatment of inflammatory lung injury related to sepsis
  13. 13. Paper review  Modulation Of Tissue Toll-Like Receptor 2 And 4 During The Early Phases Of Polymicrobial Sepsis Correlates With Mortality -Crit Care Med 2003 Vol. 31, No. 6  Glucan phosphate attenuates cardiac dysfunction and inhibits cardiac MIF expression and apoptosis in septic mice -Am J Physiol Heart Circ Physiol 291, 2006.
  14. 14. Paper review  Inhibiting early activation of tissue nuclear factor-κB and nuclear factor interleukin 6 with (1→3)-β-D-glucan increases long- term survival in polymicrobial sepsis -Surgery 1999;126:54-65  Protective effect of β-glucan against oxidative organ injury in a rat model of sepsis -International Immunopharmacology 5 (2005) 1387–1396
  15. 15. Paper review  Randomized Phase I/Il Trial of a Macrophage-Specific Immunomodulator in (PGG-Glucan) in High-Risk Surgical Patients -ANNALS OF SURGERY Vol. 220, No. 5, 601-609 K 1994  Effect of PGG-glucan on the Rate of Serious Postoperative Infection or Death Observed After High-Risk Gastrointestinal Operations -Arch Surg. 1999;134:977-983
  16. 16. Take home message  Glucan :  動物實驗中有效抑制敗血症的發炎反應  但是皆術前或術後立刻給予  未來展望…  人類臨床試驗?  萃取方式?
  17. 17. Thank you for attention
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