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SHIBO JIANG

                                     Laboratory of Viral Immunology
                                The Linds...
9.    Neurath, A.R., Debnath, A.K., Jiang, S., Strick, A., and Dow, G.J. Methods and composition for
      decreasing the ...
Title:           Mechanism of Action of the Anti-HIV Compounds Targeting the gp41 Core Structure.
Award:           ¥400,00...
Role:                   Principle Investigator
Title:                  Antibodies targeting the HIV-1 gp41 Core Structure....
8.Pan, C., Liu, S., and Jiang, S.* (2009). HIV-1 gp41 fusion intermediate: a target for HIV therapeutics
(review). J. Form...
22.Xia, C.L., Jiang, S.B., Liu, S.W. (2009). Research progress on the structure of HIV envelope glycoprotein
and related H...
36.Liu, K., Lu, H., Hou, L., Qi, Z., Teixeira, C., Barbault, F., Jiang, S.*, Xie, L., (2008). Design, Synthesis,
and Biolo...
50.Liu, S., Li, W., Ding, X., Jiang, S. (2008). Microbicides for preventing the sexual transmission of HIV (in
Chinese). C...
64.Su, J., Liu, Y., Zheng, Z.B., Xiao, J.H., Lu, H., Zhong, W., Wangm L.L., Jiang, S.B., Li, S. (2007).
Synthesis of aroma...
79.Du, L., He, Y., Wang, Y., Zhang, H., Ma, S., Wong, C.K., Wu, S.H., Ng, F., Huang, J.D., Yuen, K.Y.,
Jiang, S., Zhou, Y....
94.He, Y., Zhu, Q., Liu, S., Zhou, Y., Yang, B., Li, J., and Jiang, S.* (2005). Identification of a critical
neutralizatio...
109.He, Y., Zhou, Y., Wu, H., Kou, Z, Liu, S., and Jiang, S.* (2004). Mapping of antigenic sites on the
nucleocapsid prote...
124.Liu, S., Wu, Shuguang, and Jiang, S.* (2003). Peptidic HIV fusion inhibitors targeting envelope
glycoprotein transmemb...
139.Zhao, Q., Xu, Z., Yan, Y., Wang, H., Wu, X., Zhang, F., Liu, Y., Bai, W., Luo, W. and Jiang, S.*
(2001). Cloning and e...
155.Neurath, A.R., Strick, N., Lin, K., Li, Y.-Y., Debnath, A.K. and Jiang, S.* (1998). Microbicide B195.
In 12th World AI...
170.Neurath, A.R., Strick, N., Lin, K., and Jiang, S. (1995). The HIV-1 glycoprotein gp41 as a target for
immunoprophylaxi...
185.Luo, K.-X., Wang, L.-P., Nie, J., and Jiang, S.* (1992). Is nonresponsiveness to hepatitis B vaccine due
to latent hep...
199.Neurath, A.R., Strick, N. and Jiang, S. (1991). Recognition of V3 hypervariable loop of HIV-1 gp120 is
not determined ...
215.Jiang, S.* (1986). The changes of thymic structure and functions of Ehrlich ascites carcinoma-bearing
mice. J. Med. Co...
233.Jiang, S., Chen, Z.H., and Li, W.J. (1982). The kinetic change of T lymphocytes in peripheral blood of
tumor-bearing m...
31.Genes and Immunity (ad hoc referee)
32.FEBS Letter (ad hoc referee)
33.Journal of Pharmaceutical Science (ad hoc refere...
2.    Wen Hui Newspaper (Hong Kong). October 10, 1993. A Chinese Scientist Attacks AIDS – Dr. Shibo
      Jiang Discovered...
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  1. 1. SHIBO JIANG Laboratory of Viral Immunology The Lindsley F. Kimball Research Institute New York Blood Center, 310 East 67th Street, New York, N.Y. 10065 Tel: (212) 570-3058, Fax: (212) 570-3099, Email: sjiang@nybloodcenter.org EDUCATION 1978 Graduation from the First Military Medical University, Guangzhou, China. Major: Medicine. 1983 M.S., the First Military Medical University, Guangzhou, China. Major: Immunology. 1995 Ph.D., the Fourth Military Medical University, Xian, China. Major: Microbiology. PROFESSIONAL APPOINTMENTS 1978-80 Teaching Instructor, Microbiology Dept., the First Military Medical University, Guangzhou, China. 1983-85 Lecturer, Immunology Dept., the First Military Medical University, Guangzhou, China. 1985-87 Ph.D. Candidate, the Fourth Military Medical University, Xian, China. 1987-90 Research Fellow, Laboratory of Cellular Physiology and Immunology, the Rockefeller University, New York City, USA. 1990- Assistant Member (1990-1997), Associate Member (1997-2006), Member (2006-), and Lab Head (2002-), Lindsley F. Kimball Research Institute of the New York Blood Center, NYC, USA. 2000- Visiting Professor, Wuhan University; Fudan University, the First Military Medical University; the Fourth Military Medical University; Chinese Academy of Military Medical Sciences, China. 2001- Senior Visiting Scholar, Tsinghua University, Beijing, China 2004-09 Oversea Assessor, Chinese Academy of Sciences, Beijing, China. 2004- Adjunct Professor, the Antiviral Research Center, Southern Medical University, Guangzhou, China. PATENTS 1. Jiang, S., Lin, K., and Neurath, A.R. Synthetic peptides as inhibitors of HIV-1. US Patent 5,444,044. Filed March 26, 1992; Issued August 22, 1995 (exclusively licensed to Trimeris for developing T-20). 2. Neurath, A.R., Strick, N., Haberfield, P., and Jiang, S. Method for the prescreening of drugs targeted to the V3 hypervariable loop of the HIV-1 envelope glycoprotein gp120. US Patent 5,230,998. Issued July 27, 1993. 3. Neurath, A.R., Debnath, A.K., Jiang, S., Li, Y.-Y., and Strick, N. Methods for screening of test compounds for inhibiting binding of a CD4-HIV-1 complex to a chemokine receptor. US Patent 5,798,206. Filed January 10, 1997; Issued August 25, 1998. 4. Jiang, S., Lin, K., and Neurath, A.R. Synthetic peptides as inhibitors of HIV-1 (continuation patent). US Patent 5,840,843. Filed June 7, 1995; Issued on November 24, 1998 (exclusively licensed to Trimeris for developing T-20). 5. Neurath, A.R., Debnath, A.K., and Jiang, S. Beta-Lactoglobulin modified with aromatic anhydride compound for preventing HIV infection. US Patent 5,985,275. Filed August 28, 1996, Issued November 16, 1999. 6. Neurath, A.R., Debnath, A.K., and Jiang, S. Methods for preventing the transmission of or treating patients infected with herpesvirus. US Patent 5,952,009. Filed August 28, 1996; Issued September 14, 1999. 7. Neurath, A.R., Jiang, S. and Debnath, A.K. Methods for preventing HIV-1 or HIV-2 infection. US Patent 6,727,240 B1. Filed Oct. 21, 1994. Issued Apr. 27, 2004. 8. Neurath, A.R., Debnath, A.K., Jiang, S., Strick, A., and Dow, G.J. Methods for decreasing the frequency of transmission of viral infection using cellulose acetate phthalate or hydroxypropyl methylcellulose phthalate excipients. US Patent 5,985,313. Filed July 8, 1998. Issued November 16, 1999.
  2. 2. 9. Neurath, A.R., Debnath, A.K., Jiang, S., Strick, A., and Dow, G.J. Methods and composition for decreasing the frequency of transmission of HIV, herpesvirus and sexually transmitted bacterial infection. US Patent 6,165,493. Filed October 20, 1998. Issued December 26, 2000. 10. Jiang, S., and Debnath, A.K. Screening of antiviral compound targeted to the HIV-1 gp41 core structure. US Patent 6,596,497. Filed March 14, 2000. Issued July 22, 2003 (non-exclusively licensed to Japan Tobacco Company for screening HIV entry inhibitors). 11. Jiang, S., and Debnath, A.K. Compounds for inhibition of HIV infection by blocking HIV entry. US Patent 7,241,803. Filed November 21, 2002. Issued July 10, 2007. 12. Jiang, S., and He, Y. Neutralizing monoclonal antibodies against severe acute respiratory syndrome- associated coronavirus. US Patent 7,629,443. Filed February 7, 2005. Issued December 8, 2009. 13. Jiang, S., He, Y., and Liu, S. SARS vaccines and method to produce highly potent antibodies. Filed June 2, 2004. US Serial No. 60/576,118 (WO/2005/120565). 14. Jiang, S., Debnath, A.K., and Lu, H. Anti-viral compositions comprising heterocyclic substituted phenyl furans and related compounds. Filed June 6, 2006. US Serial No. 60/691,120. (WO/20060/287319) 15. Neurath, A.R., Stone, A., Strick, N., Jiang, S. Rapidly dispersible vaginal tablet that provides a bioadhesive. Filed May 24, 2007. US Serial No. 60/931,548. 16. Jiang, S., Pan, C. Bifunctional molecules for inhibiting HIV entry. Filed May 28, 2008. US Serial No. 61/056,580. 17. Jiang, S., Pan, C. Combination therapy of HIV inhibitors targeting gp41. Filed August 13, 2008. US Serial No. 61/088,571. 18. Jiang, S., Qi, Z., Pan, C. Immunoenhancer-linked oligomeric HIV vaccine. Filed October 17, 2008. US Serial No. 61/106,101. 19. Jiang, S., Qi, Z., Chen, X., Pan, C. Trimeric HIV fusion inhibitors for treating or preventing HIV infection. Filed February 9, 2009. US Serial No. 61/151,110. 20. Jiang, S., Du, L. Immunopotentiator-linked oligomeric influenza immunogenic compositions. Filed October 14, 2009. US Serial No. 61/250,442. GRANTS AWARDED (Peer-reviewed)* Agency: NIH (R01 AI68003-03)(http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen) Role: Principle Investigator Title: SARS-CoV S Protein Receptor-binding Domain-based Vaccines. Award: $1,578,000 Dates: March 2007 – January 2011. Agency: NIH (RO1 AI46221-08)(http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen) Role: Principle Investigator Title: Rational Design of HIV Fusion Inhibitors Targeting gp41. Award: $1,958,250 Dates: February 2006 – January 2011. Agency: NIH (U19 AI076964)(http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen) Role: Program Director and Principle Investigator Title: Anti-HIV Composite Cellulose Acetate Phthalate Film. Award: $6,435,658 Dates: September 2004 – August 2009. Agency: The Outstanding Overseas Chinese Scholars Fund of Chinese Academy of Sciences (2005-2-6) Role: Principle Investigator 2
  3. 3. Title: Mechanism of Action of the Anti-HIV Compounds Targeting the gp41 Core Structure. Award: ¥400,000 Dates: February 2006 – January 2009. Agency: Guangzhou Science and Technology Key Project Foundation (2005Z2-E4041) Role: Principle Investigator Title: Screening and Identification of leading compound of HIV entry inhibitors targeting the gp41. Award: ¥500,000 Dates: July 1, 2005 – June 30, 2008. Agency: MIRC of NYBC (33212146) Role: Principle Investigator Title: Development of anti-HIV drug candidates targeting gp41. Award: $194,000 Dates: August 2005 – July 2007. Agency: NIH (R21 AI62402-05A1) Role: Co-PI (PI: Asim K. Debnath) Title: Rational Design of CCR5 Antagonists as Anti-HIV-1 Drugs. Award: $402,836 Dates: June 2004 – January 2006. Agency: NIH (R21 AI046221-05A1) Role: Principle Investigator Title: Rational design of anti-HIV compounds targeting gp41. Award: $312,176 Dates: July 2004 – June 2005. Agency: NIH (PO1 HD41761) Role: Project Leader of the Project I (Program Director: A. Robert Neurath) Title: In vitro Anti-HIV-1 Activity of CAP (Program title: Anti-HIV Microbicide: Cellulose Acetate Phthalate). Award: $1,035,596 (total program budget: $4,470,356) Dates: September 2001 – July 2005. Agency: NIH (RO1 AI46221-04) Role: Principle Investigator Title: Rational Design of Antiviral Compounds to the gp41 Core. Award: $1,161,334 Dates: April 2000 – March 2004. Agency: NIH (R21 AI54147) Role: Co-PI (PI: Asim K. Debnath) Title: HIV-1 entry inhibitors targeting Phe43 cavity in gp120. Award: $390,000 Dates: September 2002 – August 2004. Agency: National Nature Science Foundation of China (Outstanding Young Scientist Award: 30028021) Role: Principle Investigator Title: Identification of small cyclic anti-HIV peptides using phage display systems. Award: ¥400,000 Dates: December 2000 – November 2003. Agency: NIH (R21 AI42693) 3
  4. 4. Role: Principle Investigator Title: Antibodies targeting the HIV-1 gp41 Core Structure. Award: $389,712 Dates: September 1997 - September 1999. Agency: The New York Community Trust Role: Principle Investigator Title: Peptides from HIV-1 gp41 for Chemotherapy of AIDS. Award: $100,000 Dates: January 1993 - December 1994. Agency: NIH (RO1 CA43315) Role: Co-investigator (PI: A. Robert Neurath) Title: HIV-1 ENV Proteins: Targets for antiviral Chemotherapy Award: $1,211,297 Dates: December 1992 - November 1996. Agency: NIH (RO1 AI29373) Role: Co-investigator (PI: A. Robert Neurath) Title: Epitope Mapping of HIV-1 Enhancing Antibodies Award: $802,563 Dates: August 1990 - July 1994. *Non-peered viewed grants and those from pharmaceutical companies are not listed. PUBLICATIONS (*corresponding author) 1.Du, L., He, Y., Zhou, Y., Liu, S., Zheng, B., Jiang, S.* (2009). Development of vaccines and therapeutics targeting the spike protein of SARS-CoV (invited review). Nature Rev. Microbiol. 7, 226-236. 2.Du, L., Zhao, G., Chan, C., Li, L., Sun, S., Liu, Z., Guo, H., He, Y., Zhou, Y., Zheng, B.J., Jiang, S.* (2009). Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity. Virology. 393, 144-150. 3.Du, L., Zhao, G., Li, L., He, Y., Zhou, Y., Zheng, B.J., Jiang, S.* (2009). Antigenicity and immunogenicity of SARS-CoV S protein receptor-binding domain stably expressed in CHO cells. Biochem. Biophys. Res. Commun. 384, 486-490. 4.Pan, C., Cai, L., Lu, H., Qi, Z., Jiang, S.* (2009). Combinations of first and next generation HIV fusion inhibitors exhibits highly potent synergism against Enfuvirtide-sensitive and resistant HIV-1 strains. J. Virol. 83, 7862-7872. 5.Pan, C., Lu, H., Qi, Z., Jiang, S.* (2009). Synergistic efficacy of combination of enfuvirtide and sifuvirtide, the first- and next-generation HIV-fusion inhibitors. AIDS. 23, 639-641. 6.Pan, C., Wang, G., Liao, M., Zhang, G.H., Jiang, S.* (2009). High genetic and antigenic similarity between a swine H3N2 influenza A virus and a prior human influenza vaccine virus: a possible immune pressure-driven cross-species transmission. Biochem. Biophys. Res. Commun. 385, 402-407. 7.Pan, C., Jiang, S.* (2009). E14-F55 combination in M2 protein: a putative molecular determinant responsible for swine-origin influenza A virus transmission in humans. PLoS Currents: Influenza. Sept 29:RRN1044. 4
  5. 5. 8.Pan, C., Liu, S., and Jiang, S.* (2009). HIV-1 gp41 fusion intermediate: a target for HIV therapeutics (review). J. Formos. Med. Assoc. In press. 9.Wang, H., Qi, Z., Guo, A., Mao, Q., Lu, H., An, X., Xia, C., Li, X., Debnath, A.K., Wu, S., Liu, S., Jiang, S.* (2009). ADS-J1 inhibits HIV-1 entry by interacting with the gp41 pocket region and blocking the fusion- active gp41 core formation. Antimicrob. Agents Chemother. 53, 4987-4998. 10.Katritzky, A. R., Tala, S. R., Lu, H., Vakulenko, A. V., Chen, Q. Y., Sivapackiam, J., Pandya, K., Jiang, S.*, Debnath, A. K. (2009). Design, synthesis, and structure-activity relationship of a novel series of 2-aryl 5-(4- oxo-3-phenethyl-2-thioxothiazolidin-ylidenemethyl) furans as HIV-1 entry inhibitors. J. Med. Chem. Sep 11. [Epub ahead of print]. 11.He, Y., Baker, S.J., MacDonald, A.J., Yu, Y., Cao, L., Li, J., Parhar, R., Heck, S., Hartmann, S., Golenbock, D.T., Jiang, S., Liber, N.A., Semper, A.E., Rosenberg, W.M., Sara Lustigman. (2009). Recombinant Ov-ASP-1, a Th1-biased protein adjuvant derived from the helminth onchocerca volvulus, can directly bind and activate antigen-presenting cells. J. Immunol. 182, 4005-4016. 12.Ma, L., Guo, Y., Yuan, L., Sun, J., Qu, S., Yu, X., Meng, Z., He, X., Jiang, S., Shao, Y. (2009). Phenotypic and genotypic characterization of HIV-1 CRF07_BC circulating in Xinjiang province of China. Retrovirology. 6, 45. 13.Sun, J., Ma, L., Jiang, S., Shao, Y. (2009). HIV-1 B’/C recombinant (CRF07_BC) in virologic non- controllers elicits neutralizing antibodies against heterologous but not autologous viruses. AIDS Res. Hum. Retroviruses. In press. 14.Tian, X., Qin, B., Lu, H., Lai, W, Jiang, S., Lee, K-H., Chen, C.H., Xie, L. (2009). Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorg. Med. Chem. Lett. 19, 5482-5485. 15.Wang, Y., Lu, H., Zhu, Q., Jiang, S.*, Liao, Y. (2009). Structure-based design, synthesis and biological evaluation of new N-carboxyphenylpyrrole derivatives as HIV fusion inhibitors targeting gp41. Bioorg. Med. Chem. Lett. In press. 16.Li, J., Chen, X., Huang, J., Jiang, S.*, Chen, Y.H. (2009). Identification of critical antibody-binding sites in the HIV-1 gp41 six-helix bundle core as potential targets for HIV-1 fusion inhibitors. Immunobiol. 214, 51-60. 17.Zhao, G., Lin, Y., Du, L., Guan, J., Sun, S., Sui, H., Kou, Z., Chan, C., Jiang, S., Zheng, B.J., Zhou, Y. (2009). M2e-based polypeptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses. Virol. J. In press. 18.Li, J., Lu, L., Wu, F., Chen, X., Jiang, S.*, Chen, Y.H. (2009). The interaction between the membrane- proximal external region and the N-trimer region of HIV-1 gp41: involvement in viral fusion. Chinese Sci. Bull. 54, 707-1712. 19.Cai, L., Jiang, S.* (2009). Drug-resistant viruses may repair the impaired fitness by mutations outside the drug target site: implication for developing new drugs with improved resistance profile. Future Microbiol. 4, 507-509. 20.Tan, S., Liu, S., and Jiang, S.* (2009). HIV/AIDS related ocular complication (review). Intern. J. Ophthalmol. 9(2), 203-213. 21.Zhang, R.T., Li, X.J., Li, R.M., Hu, Y.P., Jiang, S.B., Liu, S.W. (2009). VIR576 inhibits antigen-specific T cell activation by binding to the transmembrane domain of T cell receptor (in Chinese). Nan Fang Yi Ke Da Xue Xue Bao. 29(10), 1960-1964. 5
  6. 6. 22.Xia, C.L., Jiang, S.B., Liu, S.W. (2009). Research progress on the structure of HIV envelope glycoprotein and related HIV entry inhibitors (review in Chinese). Chin. Pharm. Bull. 2009, 25(8), 991-994. 23.Chen, M., Jiang, S.B., Liu, S.W. (2009). HIV infection-associated host cellular proteins (review in Chinese). Chen. J. Cell. Mol. Immunol. 25(7), 662-664. 24.Li, L., He, L., Lu, H., Qi, Z., Pan, C., Tan, S., Jiang, S.*, Liu, S. (2009). 3-Hydroxyphthalic Anhydride- modified Chicken Ovalbumin Exhibits Potent and Broad Anti-HIV-1 Activity: a Potential Microbicide for Preventing Sexual Transmission of HIV-1. Antimicrob. Agents Chemother. In revision. 25.Du, L., Zhao, G., Chan, C., He, Y., Zhou, Y., Zheng, B.J., Jiang, S.* (2009). A 219-mer recombinant receptor-binding domain of SARS-CoV spike protein induces highly potent immune responses and protection. Viral. Immunol. In revision. 26.He, Y., Cheng, J., Lu, H., Li, J., Hu, J., Qi, Z., Liu, Z., Jiang, S., Dai, Q. (2008). Potent HIV fusion inhibitors against Enfuvirtide-resistant HIV-1 strains. Proc. Nat. Acad. Sci. USA. 105, 16332-16337. 27.He, Y., Liu, S., Li, J., Lu, H., Qi, Z., Liu, Z., Debnath, A. K., Jiang, S. (2008). Conserved salt-bridge between the N- and C-terminal heptad repeat regions of HIV-1 gp41 core structure is critical for virus entry and inhibition. J. Virol. 82, 11129-11139. 28.He, Y., Chen, J., Li, J., Qi, Z., Lu, H., Dong, M., Jiang, S., and Dai, Q. (2008). Identification of a critical motif for the human immunodeficiency virus type 1 (HIV-1) gp41 core structure: implications for designing novel anti-HIV fusion inhibitors. J. Virol. 82(13), 6349-6358. 29.He, Y., Xiao, Y., Song, H., Liang, Q., Ju, D., Chen, X., Lu, H., Jing, W., Jiang, S.*, Zhang, L. (2008). Design and evaluation of sifuvirtide, a novel HIV-1 fusion inhibitor. J. Biol. Chem. 283 (17), 11126-11134. 30.Qi, Z., Shi, W., Xue, N., Pan, C., Jing, W., Liu, K., Jiang, S.* (2008). Rationally designed anti-HIV peptides containing multi-functional domains as molecule probes for studying the mechanisms of action of the first and second generation HIV fusion inhibitors. J. Biol. Chem. 283, 30376-30384. 31.Huang, J.H., Qi, Z., Wu, F., Kotula, L., Jiang, S.*, Chen, Y.H. (2008). Interaction of HIV-1 gp41 core with NPF motif in Epsin: implication in endocytosis of HIV-1. J. Biol. Chem. 283(22), 14994-5002. 32.Lu, L., Zhu, Y., Huang, J., Chen, X., Yang, H., Jiang, S.*, Chen, Y.H. (2008). Surface exposure of the HIV-1 env cytoplasmic tail LLP2 domain during the membrane fusion process: interaction with gp41 fusion core. J. Biol. Chem. 283(24), 16723-16731. 33.Ma, C., Rong, Y., Radiloff, D.R., Datto, M. B., Centeno, B., Bao, S., Cheng, A.W. M., Lin, F., Jiang, S., Yeatman, T.J., Wang, X.F. (2008). Extracellular matrix protein ßig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. Gene Dev. 22, 308-321. 34.Zhang, M. Y., Vu, B.K., Choudhary, A., Lu, H., Humbert, M., Ong, H., Alam, M., Ruprecht, R., Quinnan, G., Jiang, S., Montefiori, D.C., Mascola, J.R., Broader, C.C., Haynes, B.F., Dimitrov, D.S. (2008). Cross- reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody that recognizes a novel conformational epitope on gp41 and lacks reactivity against self-antigens. J. Virol. 82, 6869-6879. 35.Xie, L., Guo, H., Lu, H., Zhuang, X., Zhang, A., Wu, G., Ruan, J., Zhou, T., Yu, D., Qian, K., Lee, K. H., Jiang, S.*, (2008). Development and preclinical studies of broad-spectrum anti-HIV agent (3'R,4'R)-3- cyanomethyl-3',4'-di-O-(S)-camphanoyl-4-methyl-(+)-cis-khellactone (3-cyanomethyl-DCK). J. Med. Chem. 51, 7689-7696. 6
  7. 7. 36.Liu, K., Lu, H., Hou, L., Qi, Z., Teixeira, C., Barbault, F., Jiang, S.*, Xie, L., (2008). Design, Synthesis, and Biological Evaluation of N-Carboxyphenylpyrrole Derivatives as Potent HIV Fusion Inhibitors Targeting gp41. J. Med. Chem. 51, 7843-7854. 37.Du, L., Zhao, G., Lin, Y., Sui, H., Chan, C., Ma, S., He, Y., Jiang, S., Wu, C., Yuen, K.Y., Jin, D.Y., Zhou, Y., Zheng, B.J. (2008). Intranasal vaccination with recombinant adeno-associated virus encoding coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection against SARS-CoV infection. J. Immunol. 180, 948-956. 38.Du, L., Zhao, G., Lin, Y., Chan, C., He, Y., Jiang, S., Wu, C. Jing, D.Y., Yuen, K.Y., Zhou, Y., Zheng, B.J. (2008). Priming with rAAV encoding RBD of SARS-CoV S protein and boosting with RBD-specific peptides for T cell epitopes elevated humoral and cellular immune responses against SARS-CoV infection. Vaccine. 26, 1644-1651. 39.Du, L., He, Y., Jiang, S., Zheng, B.J. (2008). Development of subunit vaccines against severe acute respiratory syndrome (review). Drugs Today. 44, 63-73. 40.Chien, M.P., Jiang, S., Chang, D.K. (2008). The function of coreceptor as a basis for the kinetic dissection of human immunodeficiency virus type 1 envelope protein mediated cell fusion. FASEB J. 22, 1179-1192. 41.Xiao, W., Du, L., Liang, C., Guan, J., Jiang, S., Lustigman, S., He, Y., Zhou, Y. (2008). Evaluation of recombinant Onchocerca volvulus activation associated protein-1 (ASP-1) as a potent Th1-biased adjuvant with a panel of protein or peptide-based antigens and commercial inactivated vaccines. Vaccine. 26, 5022–5029. 42.Shi, W., Qi, Z., Pan, C., Xue, N., Debnath, A., Qie J, Jiang, S.*, Liu, K. (2008). Novel anti-HIV peptides containing multiple copies of artificially designed heptad repeat motifs. Biochem. Biophys. Res. Commun. 374, 767–772. 43.Li, J., Chen, X., Jiang, S.*, Chen, Y.H. (2008). Deletion of fusion peptide or destabilization of fusion core of HIV gp41 enhances antigenicity and immunogenicity of 4E10 epitope. Biochem. Biophys. Res. Commun. 376, 60-64. 44.Teixeira, C., Barbault, F., Rebehmed, J., Liu, K., Xie, L., Lu, H., Jiang, S., Fan, B., Maurel, F. (2008). Molecular modeling studies of N-substituted pyrrole derivatives--potential HIV-1 gp41 inhibitors. Bioorg. Med. Chem. 16, 3039-3048. 45.Wang, J., Jiang, S., Shi, H., Lin, Y., Wang, J., Wang, X. (2008). Prolongation of corneal xenotransplant survival by T cell vaccination-induced T regulatory cells. Xenotransplantation. 15(3):164-73. 46.Wang, J., Zhang, L., Tang, J., Jiang, S., Wang, X. (2008). Adoptive transfer of transplantation tolerance mediated by CD4+CD25+ and CD8+CD28- regulatory T cells induced by anti-donor specific T cell vaccination. Transplant Proc. 40(5), 1612-1617. 47.Liu, Y., Su, J., Xiao, H.J., Jiang, S.B., Lu, H., Zhong, W., Wang, L.L., Yang, X.H., Li, S. (2008). Synthesis of benzocycloheptene derivatives as CCR5 antagonists with potent anti-HIV activity. Chin. Chem. Lett. 19 (4), 428-430. 48.Sun, W., Wang, H.T., Xia, C.L., Wu, S.G., Jiang, S.B., Jiang, Z.H., Liu, S.W. (2008). 1,2,6-Tri-O-galloyl- β-D-glucopyranose inhibits HIV-induced cell fusion by targeting gp41 (in Chinese). Nan Fang Yi Ke Da Xue Xue Bao. 28(7):1127-1131. 49.Li, L., Jiang, S., Liu, S. (2008). Microbicides in clinical trials for prevention of sexual transmission of HIV (review in Chinese). Chin. J. Prev. Med. 42(9), 1-4. 7
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  18. 18. 199.Neurath, A.R., Strick, N. and Jiang, S. (1991). Recognition of V3 hypervariable loop of HIV-1 gp120 is not determined exclusively by its primary amino acid sequence. In Vaccines 91 (R.M. Chanock, H.S. Ginsberg, F. Brown and R.A. Lerner, eds.), pp15-21. Cold Spring Harbor Laboratory, New York. 200.Ojcius, D.M., Jiang, S. and Young, J.D.-E. (1990). Restriction factors of homologous complement: a new candidate? Immunol. Today 11, 47-49. 201.Jiang, S.B., Ojcius, D.M., Persechini, P.M., and Young, J.D.-E. (1990). Resistance of cytolytic lymphocytes to perforin-mediated killing: inhibition of perforin-binding activity by membrane proteins. J. Immunol. 144, 998-1003. 202.Ojcius, D.M., Jiang, S., Persechini,P.M., Storch,J., and Young,J.D.-E. (1990). Resistance to the pore forming protein of cytotoxic T cells: comparison of target cell membrane rigidity. Mol. Immunol. 27, 839-845. 203.Young, J.D.-E., Jiang, S., Liu, C.-C., and Hasselkus-Light, C.S. (1990). The lymphocyte pore-forming protein perforin and complement components C8 and C9 share domains that are involved in binding to homologous restriction factor as determined by anti-idiotype antibodies. J. Immunol. Methods 128, 133-142. 204.Jiang, S., Ojcius, D.M. and Young, J.D.-E (1990). Perforin-binding to cells and lipid membranes determined by a competition assay. J. Immunol. Methods 126, 29-37. 205.Jiang, S., Hasselkus-Light, C.S., Ojcius, D.M., and Young, J.D.-E. (1990). Purification of a membrane- associated serine esterase from murine cytotoxic T lymphocytes with a single reverse column. Protein Expres. Purif. 1, 77-80. 206.Liu, C.C., Jiang, S., Persechini, P.M., Zychlinsky, A., Clark, W.R., Kaufmann, Y., and Young, J.D.-E. (1989). Resistance of cytolytic lymphocytes to perforin-mediated killing: induction of resistance correlated with increase in cytotoxicity. J. Exp. Med. 169, 2211-2225. 207.Liu, C.C., Detmers, P.A., Jiang, S., and Young, J.D.-E. (1989). A membrane-bound cytotoxin of murine cytolytic lymphocytes related to tumor necrosis factor/cachectin. Proc. Nat. Acad. Sci. USA. 86, 3286-3290. 208.Jiang, S., Persechini, P.M., Perussia, B., and Young, J.D.-E. (1989). Resistance of cytolytic lymphocytes to perforin-mediated killing: Murine CTL and human NK cells do not contain functional soluble homologous restriction factor or other specific soluble protective factors. J. Immunol. 143, 1453-1460. 209.Jiang, S., Persechini, P., Rosse, W.F., Perussia, B., and Young, J.D.-E. (1989). Differential susceptibility of type III erythrocytes of paroxysmal nocturnal hemoglobinuria to lysis mediated by complement and perforin. Biochem. Biophys. Res. Commun. 162, 316-325. 210.Persechini, P.M., Liu, C.-C., Jiang, S., and Young, J.D.-E. (1989). The lymphocyte pore-forming protein perforin is associated with granules by a pH-dependent mechanism. Immunol. Let. 22, 23-27. 211.Jiang, S., Persechini, P.M., Zychlinsky, A., Liu, C.C., Perussia, B., and Young, J.D.-E. (1988). Resistance of cytolytic lymphocytes to perforin-mediated killing: lack of correlation with complement- associated homologous species restriction. J. Exp. Med. 168, 2207-2219. 212.Jiang, S.*, and Li, W.J. (1987). Influence of Ehrlich ascitic carcinoma on immune system: inhibition of host response to thymus-dependent antigen. J. Med. Colleges PLA (in English) 2, 36-39. 213.Jiang, S.* (1987). Advance in neuroendocrinoimmunology (review in Chinese). Shanghai J. Immunol. 7, 165-170. 214.Jiang, S.* (1987). Neuroendocrinoimmunology (review in Chinese). Immunol. J. 2, 140-143. 18
  19. 19. 215.Jiang, S.* (1986). The changes of thymic structure and functions of Ehrlich ascites carcinoma-bearing mice. J. Med. Colleges PLA (in English) 1, 311-326. 216.Jiang, S., Xiao, J.G., and Li, W.J. (1985). Mechanism of delayed-type hypersensitive change in Ehrlich ascites carcinoma-bearing mice (in Chinese). Chin. J. Clin. Oncol. 12, 238-241. 217.Jiang, S., Chen, Z.H., and Li, W.J. (1985). Histological change of immune organs of tumor-bearing mice (in Chinese). Cancer Res. Prev. Treat. 12, 9-12. 218.Jiang, S., Chen, Z.H., and Li, W.J. (1985). The distribution of T lymphocytes in immune organs of tumor-bearing mice (in Chinese). Cancer Res. Prev. Treat. 12, 187-191. 219.Jiang, S., Zhang, L., and Li, W.J. (1985). The antigen-binding cells in spleen of tumor-bearing mouse (in Chinese). Chin. J. Cancer 1, 14-20. 220.Jiang, S., Chen, Z.H., and Li, W.J. (1985). Influence of malnutrition on immune system (in Chinese). J. First Mil. Med. Univ. 5, 189-191. 221.Jiang, S., and Li, W.J. (1985). Influence of Ehrlich ascites carcinoma on cell subpopulations in host thymus (in Chinese). Prog. Biochem. Biophys. 6, 38-40. 222.Jiang, S., and Li, W.J. (1985). Surface morphological change of thymocytes in Ehrlich ascites carcinoma-bearing mice (in Chinese). Chin. J. Oncol. 7, 342-345. 223.Jiang, S., Chen, Z.H., and Li, W.J. (1984). The change of synthesis of DNA and RNA in the thymus of tumor-bearing mice (in Chinese). J. First Mil. Med. Univ. 4, 13-16. 224.Jiang, S., Zhang, L., and Li, W.J. (1984). The reaction of Ehrlich ascites carcinoma-bearing host to thymus-independent antigen (in Chinese). Shanghai J. Immun. 4, 283-286. 225.Jiang,S. (1984). The possible relationship between tumor and thymic atrophy (review in Chinese). Medicine and Philosophy 8, 14-20. 226.Jiang, S., and Li, W.J. (1984). Thymic atrophy and its effects on immune system (review in Chinese). Foreign Med. Sect. Immunol. 1, 18-22. 227.Jiang, S. (1984). Tumor missile therapy (review in Chinese). Chin. J. Cancer 1, 72. 228.Jiang, S., Chen, Z.H., and Li, W.J. (1983). Innovation in identification method of T lymphocyte esterase activity (in Chinese). Shanghai J. Immunol. 3, 254-260. 229.Jiang, S., Chen, Z.H., and Li, W.J. (1983). Complex contrast stain of T lymphocyte esterase (in Chinese). Chin. J. Lab. Med. 6, 234-235. 230.Jiang, S., Chen, Z.H., and Li, W.J. (1983). Effect of acute thymus atrophy on number of T lymphocytes in peripheral blood of Ehrlich ascites carcinoma-bearing mice (in Chinese). Shanghai J. Immunol. 2, 8-10. 231.Jiang, S., Chen, Z.H., and Li, W.J. (1983). Influence of Ehrlich ascites carcinoma on immune system: IV. Distribution of T lymphocytes in the immune organs of tumor-bearing mice (in Chinese). J. First Mil. Med. Univ. 4, 9-14. 232.Jiang, S., and Li, W.J. (1983). Influence of Ehrlich ascites carcinoma on immune system: III. Histological changes of the immune organs of tumor-bearing mice (in Chinese). J. First Mil. Med. Univ. 4, 3-8. 19
  20. 20. 233.Jiang, S., Chen, Z.H., and Li, W.J. (1982). The kinetic change of T lymphocytes in peripheral blood of tumor-bearing mice with acute thymic atrophy (in Chinese). Cancer Res. Prev. Treat. 9, 127-142. 234.Jiang, S., and Li, W.J. (1980). Ultrastructural change of cytotoxic T lymphocytes after interaction with target cells (review in Chinese). Int. J. Immunol. 1, 34-38. PROFESSIONAL ACTIVITY Institutional Service: 1999-08 Member, the Internal Review Board (IRB) of the NYBC. 2002- Member, the Patent Committee of the NYBC. 2004-07 Member, the Core Facility Review Committee of the LFKRI. 2002-03 Member, the Space Committee of the LFKRI. 2001-02 Chair, the Research Committee of the LFKRI. 1990-02 Member, Ad hoc peer review committees the LFKRI (for faculty promotion). 1996-97 Chair, the Seminar Committee of the LFKRI. 1991-99 Member, the P3 Committee of the LFKRI. Service to Professional Publications: 1. Editorial Consultant, The Lancet, 2005.3.14- (http://www.thelancet.com) 2. Executive Guest Editor, Current Pharmaceutical Design, 2002.11.12-2008.12.31 3. Member of Editorial Board, International Journal of Virology, 2005.9.2-2009.1 (http://www.academicjournals.net/2/eb.php?id=2&theme=2&jid=ijv) 4. Member of Editorial Board, Electronic Journal of Biology (eJBio), 2005.2.2-2008.2.1 5. Member of Editorial Board, The Open AIDS Journal, 2008.12.3- (http://www.bentham.org/open/toaidj/EBM.htm) 6. Member of International Editorial Board, International Journal of Ophthalmology (IJO), 2006.8.24- (http://www.world-eye.cn/xsnews/News_View.asp?NewsID=5420) 7. Member of Editorial Board, Journal of Medical Universities of PLA (in English)(1986-1990). 8. Nature Medicine (ad hoc referee) 9. Nature Technology (ad hoc referee) 10.Journal of Experimental Medicine (ad hoc referee) 11.PNAS (ad hoc referee) 12.Journal of Immunology (ad hoc referee) 13.Journal of Virology (ad hoc referee) 14.AIDS (ad hoc referee) 15.Journal of Pathology (ad hoc referee) 16.Journal of Molecular Biology (ad hoc referee) 17.Plos Med (ad hoc referee) 18.Plos Pathogen (ad hoc referee) 19.Plos One (ad hoc referee) 20.Journal of Biochemistry (ad hoc referee) 21.Antiviral therapy (ad hoc referee) 22.JAIDS (ad hoc referee) 23.Virology (ad hoc referee) 24.Viruses (ad hoc referee) 25.Virus Journal (ad hoc referee) 26.Retrovirology (ad hoc referee) 27.Journal of General Virology (ad hoc referee) 28.Journal of Infectious Diseases (ad hoc referee) 29.Journal of Virology Methods (ad hoc referee) 30.Virus Immunology (ad hoc referee) 20
  21. 21. 31.Genes and Immunity (ad hoc referee) 32.FEBS Letter (ad hoc referee) 33.Journal of Pharmaceutical Science (ad hoc referee) 34.Peptides (ad hoc referee) 35.Vaccines (ad hoc referee) 36.Gene Therapy (ad hoc referee) 37.BBA-General Subjects (ad hoc referee) 38.Clinical Chemistry (ad hoc referee) 39.Current Medicinal Chemistry (ad hoc referee) 40.Virus Research (ad hoc referee) 41.AIDS Research and Human Retroviruses (ad hoc referee) 42.IUBMB Life (ad hoc referee) 43.Cell Physiology and Biochemistry (ad hoc referee) 44.Clinical Microbiology Review (ad hoc referee) 45.Applied and Environmental Microbiology (ad hoc referee) 46.Medical Research Review (ad hoc referee) 47.Clinical and Vaccine Immunology (ad hoc referee) 48.Journal of Orthopedic Research (ad hoc referee) 49.ChemBioChem (ad hoc referee) 50.Future Microbiology (ad hoc referee) 51.Journal of Formosan Medical Association (ad hoc referee) 52.Protein & Cell (ad hoc referee) Other Professional Service: • Ad hoc Member, grant review study section on Innovative AIDS Vaccines, Center for Scientific Review Special Emphasis Panel, NIH (1998). • Ad hoc Member, grant review study section on In vitro Test Systems for Evaluating Chemotherapies against AIDS, Center for Scientific Review Special Emphasis Panel, NIH (2002). • Member of Abstract Review Committee for the XIV International AIDS Conference at Barcelona, Spain (2002). • Member of Abstract Review Committee for the XV International AIDS Conference at Bangkok, Thailand (2004). • Member, the Scientific Advisory Committee of the International Virology Workshop, Wuhan, China (2004). • Ad hoc Member, grant review study section on Innovative Research Topic in Virology, Center for Scientific Review Special Emphasis Panel, NIH (2004). • Member, Overseas Assessor Board for Chinese Academy of Sciences (CAS) (2004 - ). • External Reviewer for Canadian Institutes of Health Research (CIHR) (2004). • External Reviewer for Chinese National Sciences Foundation (CNSF) (2005 - ). • Member, the Scientific Advisory Committees of IDDST-2006, World AIDS Day-2006, IDDST-2007, IDDST-2008, WSA-2008, 2008 Vaccine Summit (2006-2008), IDDST-2009. • Regular Member, AIDS Discovery and Development of Therapeutics (ADDT) Study Section, NIH (2007-2009)(http://www.csr.nih.gov/Roster_proto/meeting_roster.asp?stdate=3/5/2008&enddate= 3/5/2008&grcode=&srg=ADDT&SRGDISPLAY=ADDT&agsqnum=197706). • External Reviewer for Hong Kong Research Grant Council (RGC)(2008 - ). SELECTED NEWS REPORTS 1. China Daily, September 26, 1993. A Chinese Scientist Discovered a Peptidic Anti-HIV Drug in the United States (in Chinese). 21
  22. 22. 2. Wen Hui Newspaper (Hong Kong). October 10, 1993. A Chinese Scientist Attacks AIDS – Dr. Shibo Jiang Discovered a New Anti-HIV Drug (in Chinese). 3. PR Newswire - 30 Jan 1996. Lab Tests Show New Milk-Based Compound Prevents HIV Transmission By Blocking Body's HIV Receptor Sites: Inexpensive Compound Holds Potential for Reducing Sexual Transmission of AIDS on A Worldwide Scale. http://www.aegis.com/news/pr/1996/pr960146.html 4. AIDSWeekly Plus, December 7, 1998. AIDS Immunity: MAb Binds HIV's Coiled Coil. http://www.aegis.com/pubs/aidswkly/1998/aw981202.html. 5. AIDSWeekly Plus, March 8, 2004. HIV/AIDS Pathogenesis: Conformation of HIV gp41 during cell entry determined. http://www.aegis.com/default.asp? req=http://www.aegis.com/pubs/aidswkly/2004/AW040305.html 6. U.S. Newswire – March 19, 2004. Scientists from N.Y. Blood Center's Research Institute Identify Peptide with Potential to Inhibit SARS Virus Infection. http://releases.usnewswire.com/GetRelease.asp? id=104-03192004. 7. Yahoo! News. March 19, 2004. Scientists from N.Y. Blood Center's Research Institute Identify Peptide with Potential to Inhibit SARS Virus Infection. http://story.news.yahoo.com/news? tmpl=story&cid=669&ncid=669&e=1&u=/usnw/20040319/pl_usnw/scientists_from_n_y__blood_cente r_s_research_institute_identify_peptide_with_potential_to_inhibit_sars_virus_infection104_xml. 8. World Journal, March 24, 2004 (volume 1039). Chinese research team discovered anti-SARS agents (in Chinese). http://www.worldjournal.com/wj-chinese-news.php?nt_seq_id=937487&sc_seq_id=120 9. ABC Newsletter. March 26, 2004. Researchers at New York Blood Center’s Lindesley F. Kimball Research Institute use common strategies to combat emerging infectious diseases. Volume 12, p8, 2004. http://www.americasblood.org. 10. Pearson H. News@Nature, May 10, 2004. SARS linked to sweat - Could you catch the disease from a handshake? http://www.nature.com/news/2004/040503/pf/040503-13_pf.html. 11. ABC News Online, May 7, 2004. SARS may spread through sweat. http://www.abc.net.au/news/newsitems/s1103670.htm. 12. Yahoo! News, May 7, 2004. SARS Could Spread Via Coughs, Sweat, Urine. http://story.news.yahoo.com/news? tmpl=story&cid=571&ncid=751&e=4&u=/nm/20040507/hl_nm/health_sars_research_dc. 13. The Mirror Post, May 1, 2007. Prevention of Sexual Transmission of HIV Is Urgently Needed. Mrs. Li Ya Mo, Reporter of The Mirror Post in New York. 22

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