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    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae BIOGRAPHICAL Name Mohamed Labib Salem Date of Birth December 28, 1962 Place of Birth Zifta, Gharbia, Egypt Citizenship Egyptian Marital Status Married with 3 kids Home address 1551 Sam Rittenburg Blvd, Apartment 116, Charleston, SC 29407, USA Phones: +1-843-766-0898 (Home) +1-843-817-3426 (Cell) FAX +1-843-792-2556 Permanent Position Professor of Immunology Zoology Department Faculty of Science Tanta University Egypt Current Position Assistant Research Professor Cancer Immunology Director, Vaccine Projects, Surgical Oncology Department of Surgery Medical University of South Carolina, Charleston, SC 29425, Phone: +1- 843-792-7576 (Office) Phone: +1- 843-792-8504 (lab.) Fax: +1-843-792-2556 e-mails: salemm@musc.edu; mohamedlabibsalem@yahoo.com EDUCATION ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 1
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae High School Diploma 10/1977- 6/1980 Kish Military High School, Zifta, Egypt B.S., Biology (Major); General Zoology (Minor) 10/1980-5/1984 Faculty of Science, Tanta University, Egypt Post-graduate Diploma, Comparative Anatomy 9/1985-12/1986 Faculty of Science, Tanta University, Egypt M.S., Biology (Major); Comparative Anatomy (Minor) 9/1986-9/1989 Faculty of Science, Tanta University, Egypt Ph.D., ImmunoEndocrinology 9/1991-12/1995 The research project was accomplished in the Department of Immunology, Kyushu University, Japan (27 months),Oct. 1992 to Dec. 31, 1995). The research project was funded by a pre-doctoral fellowship from the Cultural Affairs and Missions Sector, Ministry of Higher Education, Egypt. PhD Graduation was from Tanta University, Egypt. PhD courses in Pathological Sciences 04/1999-3/2001 Completed 2 years out of 3 years required for Ph.D. in Pathological Sciences, Department of Immunology, Medical Institute of Bioregulation, Kyushu University, Japan ACADEMIC POSITIONS Demonstrator, General Zoology 10/1984-9/1989 Zoology Department, Tanta University, Egypt Assistant Lecturer, General Zoology 10/1989-9/1992 Zoology Department, Tanta University, Egypt Visiting Researcher, Immunology 10/1992-12/1994 Department of Immunology, Kyushu University, Japan Assistant Lecturer, Zoology 1/1995-1/1996 Faculty of Science, Tanta University, Egypt Assistant Professor, Immunology 2/1997-8/2001 Faculty of Science, Tanta University, Egypt Research Associate, Cancer Immunology 10/1997-3/2001 Department of Immunology Kyushu University, Japan Associate Professor, Immunology 9/2001-11/2005 Department of Zoology, Faculty of Science, Tanta University, Egypt Post Doctoral Fellow, Immunology 6/2001-6/2002 Department of Surgery, Medical University of South Carolina, USA Professor of Immunology 12/2006-present Department of Zoology, Faculty of Science, Tanta University, Egypt Assistant Research Professor, Cancer Immunology 7/2002-present Department of Surgery, Medical University of South Carolina, USA Director, Vaccine Laboratories 2005-present Section of Surgical Oncology, Hollings Cancer Center, Medical University of South Carolina. Charleston, SC, USA ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 2
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae MEMBERSHIP IN PROFESSIONAL SOCIETES American Association of Cancer Research (AACR) American Association of Immunologist (AAI) International Society of Biological Therapy (SBT) International Society of Cytokine (ISC) International Immunopharmacology European Society of Cancer Immunology Committee of Hollings Cancer Center Association of Egyptian-American Scholars The American Association of Yemeni Scientists and Professionals The Association of African Biomedical Scientists Egyptian Society of Immunology German-Egyptian Society of Zoology Arab Union Society of Biology Tumor Host Interaction Program, Medical University of South, South Carolina, Charleston, SC Tumor Vaccine and Cell Therapy Working Group International Society of Poets COMMITTEE Advisory committee for Flow Cytometry Facility, Hollings Cancer Center, Medical University of South Carolina. Charleston, SC, USA. PhD committee for Iris Moralez (PhD student). Cancer Immunology and Immunotherapy committee for the annual retreat. TEACHING EXPERIENCE: LECTURE Tumor Immunology 2005-now Postgraduate Students, Medical University of South Carolina, USA Immunology 1996-1997 Undergraduate Students at Faculty of Science, Tanta University, Egypt Tumor Immunology 1996-1997 Postgraduate Students at Faculty of Science, Tanta University, Egypt Molecular Biology 1996-1997 Undergraduate Students at Faculty of Science, Tanta University, Egypt LABORATORY TEACHING EXPERIENCE Practical Animal Physiology (1984~1992) Undergraduate students, Faculty of Science, Faculty of Pharmacy, and Faculty of Dentistry and Faculty of Education, Tanta University, Egypt Vertebrate Anatomy (1984~1992) ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 3
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae Undergraduate students, Faculties of Sciences and Faculty of Education, Tanta University, Egypt Histology (1984~1992) Undergraduate students, Faculty of Science, Faculty of Pharmacy, and Faculty of Dentistry and Faculty of Education, Tanta University, Egypt Histochemistry (1989~1992) Undergraduate students, Faculty of Sciences, Tanta University, Egypt Comparative Anatomy (1984~1992) Undergraduate students, Faculty of Sciences, Tanta University Egypt Embryology (1984~1992) Undergraduate students, Faculty of Sciences, Tanta University, Egypt Immunology (1995~1996) Postgraduate students, Faculty of Sciences, Tanta University, Egypt ACADEMIC SUPERVISION A- At the Medical University of South Carolina Wessam Hassan Elnemr (PhD student, Al-Azhar University) 2007~ James Kuhlen (MD student, 2-month rotation) 2007 Elizabeth C. Little (PhD student); (2-month rotation) 2007~ Dr. Ahmed Khafagy (3-month fellowship, Suez Canal University) 2007 Osama Naga, (Research Specialist I) 2007~ Haley Brimmer (Middle School Student, Shadowing Day) 2007 Amir A. AL-Khami (PhD student) 2006~ Ginny Williams (PhD student); (2-month rotation) 2006 Elizabeth C. Little (PhD student); (2-month rotation) 2006 Maria-Anna Alicia (PhD/MD Fellow); (2-month rotation) 2006 Marcela C. Diaz-Montero (Instructor) 2005~ Sabry El Naggar (PhD student) 2004~2006 Andre Kadima (Post-doctoral fellow) 2001~2007 Yuehua Zhou (Research specialist) 2001-2003 Carolina Velez ((Research specialist) 2003-2004 Eben Pariser (Undergraduate College student), (3-month rotation) 2002 Alyson Browning, (Ph.D. student); (3-month rotation) 2002 Jarrett E. Walsh (MD student); (3-month rotation) 2003 Rufei Lu (high school student); (3-month rotation) 2003 B- At Tanta University, Egypt Nahla A. AL Said, B.Sc., M.Sc., (Ph.D. work) 1997-2000 “Interference of anti-inflammatory drugs with Schistosomiasis infection” Iman M. Yoness, B.Sc., (M.Sc. work) 1997-2001 “Interference of anti-inflammatory drugs with azoxymethane-induced colon cancer” ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 4
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae Heba M. Al Ashry, B,Sc., (M.Sc. work) 1996-2003 “Interference of inflammatory and anti-inflammatory drugs with Trichnella spiralis infection” Asmaa L. Mohamed, B.Sc., (M.Sc. work) 1999-now “Interference of histamine and its antagonists with mammary adenocarcinoma” LANGUAGE SKILLS Arabic: Native English: Fluent, reading, writing and speaking Japanese: Good speaking, fair writing and reading. EDITORIAL REVIEW Grant Reviews Broad Medical Research Program, USA Swiss National Science Foundation, (Berne, Switzerland) Journal and Grant Reviews Journal of Cellular and Molecular Medicine J. Neuroimmunology Immunology Letter Methods and Findings in Experimental and Clinical Pharmacology Medical Science Monitor International Immunopharmacology Vaccine Human Immunology Cancer Immunology and Immunotherapy Planta Medica Journal of Food Composition and Analysis Turkish Journal of Veterinary and Animal Sciences EDITORIAL BORAD American Journal of Immunology (Science Publication), Regional Editor TheScientificWorld’s Editorial Network (Immunology and Inflammation) RESEARCH INTERESTS My preclinical research is focuses on improving cancer-based vaccination through different approaches, including: 1) optimizing in vivo-based dendritic cell vaccination; 2) utilizing cytokines to improve peptide-based vaccination; 3) utilizing novel compounds with cytokine-like effects (Toll-like receptor ligands) to augment peptide-based vaccination; and 4) combination of chemotherapy with adoptive therapy and peptide-based vaccination. I use different preclinical models, including colon cancer, lymphoma, and melanoma cancer models, as well as different type of transgenic and knockout mice. ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 5
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae My clinical research focuses on characterization of the immunoregulatory cells that associate with advanced stage of cancers. I focus my studies on the immature myeloid- derived suppressive cells (MDSC) and CD4+CD25+FoxP3+ T regulatory (Treg). A great interest is to develop efficacious strategies that can interfere with regulatory function of these cells or approaches that induce the differentiation of these cells into immunopotentiating population. HONORS/AWARDS Incentive (Encouraging) National Award in Biology; Academy of Scientific Research and Technology-Egypt, July 16 2004. Phase VII Award, Hollings cancer Center, Department of Defense, 11/01/2004- 10/31/226 Selective Poem award: “Title: We All Shall Die”, International Society of Poets, 2006 Selective Poem award: “Painless Pain”, International Society of Poets, 2006. Selective Poem award: “I Feel Like None”, International Society of Poets, 2007. Research Excellence Award from Marine Polymer Technologies, Inc. Awarded a Junior Research Scholarship by the Ministry of Higher Education, Egypt, for the period October 1992 through December 1994 while pursuing graduate degree studies. INVITED LECTURES Immunomodulatory and immunotherapeutic potentials of Nigella sativa, the black seed. The 1st International Conference on Prophetic Medicine, Abha Private Hospital, Abha, Saudi Arabia, King Saudi Arabia, February, 2008. Lymphodepletion: A bad for good immunotherapy. Internal Speaker, Cancer Immunology and Immunotherapy Lecture Series, Hollings Cancer Center, Medical University of South Carolina, Charleston, USA. February 2008. Development of Molecular Cancer Therapies: From Bench to Bedside of Cancer Vaccines. A graduate student course at Department of Microbiology and Immunology, Medical University of South Carolina. Optimizing Cancer Immunotherapy By Creating Beneficial Host Microenvironments, Department of Surgery, Medical University of South Carolina, USA; June 11, 2007. Novel Adjuvant Approaches for Optimization of Peptide-based Cancer Vaccines. Faculty of Medicine and Health Sciences, United Arab Emirates University, United Arab Emirates, Al-Ain, 30 May, 2004 Optimization of T cell responses to vaccination: Applications for cancer immunotherapy. Presented to the Permanent Committee for Professorship Promotion, Ministry of Higher Education, Ain Shams University, Egypt, November 15, 2006. Influence of Female Sex Hormones on Immune Responses. Center for Biomedical Physics, Temple University School of Medicine, Philadelphia, Pennsylvania, USA. 24 November, 2000. RESEARCH SUPPORT Pending grants Source: Tanta University, Egypt Role: Principle Investigator Title: Establishing “Animal research vivarium” at Tanta University. ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 6
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae Goal: Establishing a state-of-art VIVARIUM as a core animal facility at Tanta University will pave the road to its full accreditation by the AAALAC Int. Source: National Cancer Institute (R01) Period: Submitted in June 2007 Cycle, Pending Role: Principle Investigator Title: Maximizing memory T cell responses by matured post chemotherapy dendritic cells. Goal: The major goal of this project is to manipulate dendritic cells expanded after treatment of the recipient host with cyclophosphamide before adoptive T cell therapy to enhance the overall anti-tumor immunity. Ongoing Research Grants Source: National Cancer Institute (R01) Period: 07/04/01–06/30/2009 Title: Altering post vaccination T cell contraction Goal: The major goal of this project is to define the cytokines (IL-2, IL-12, IL-7, type IFNs) and danger signal) that modulate programmed T cell contraction the in vivo response to peptide-based cancer vaccine. Role: Co-Principle Investigator; Principle Investigator, Dr. David J Cole Completed Research Grants Source: Phase VII Award, Department of Defense Period: 11/01/2004-10/31/226 Role: Principle Investigator Title: Preclinical assessment of the novel peptide-based cancer vaccine F2 gel/CEA/IL-12 Goal: The major goal of this project is to develop novel cancer therapeutics vaccine to colon carcinoma utilizing a novel IL-12 delivery system designated F2 gel matrix. Source: Hollings Cancer Center, Medical University of South Carolina Period: 01/01/2005-12/13/2007 Role: Principle Investigator Title: Immature myeloid immunosuppressor cells in breast cancer patients: Implications for anti-tumor vaccination. Goal: The major goal of this grant is to explore how expansion of certain immune cells called immature myeloid cells suppresses the immune response in breast cancer patients. Source: Marine Polymer Technologies Inc., Danvers, Massachusetts, USA Period: 06/01/2004-12/31/2006 Role: Principle Investigator Title: Evaluation of F2 gel/IL-12-based vaccination on hepatic fibrosis and protection after Schistosoma mansoni infection. Goal: The major goal of this project is to develop F2 gel/IL-12 as a novel strategy for schistosoma vaccine. ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 7
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae Source: Chain Reaction for a Cure a Breast Cancer Period: 01/01/05–21/31/2009 Title: Circulating myeloid suppressor cells in breast cancer patients: Implications for future vaccine development Goal: The primary goal of this project is to characterize the phenotype of immature myeloid cells in peripheral blood of early breast cancer patients. The secondary goal is to induce differentiation of these immunosuppressive cells into immunopotentiating cells. Role: Principle Investigator Source: National Cancer Institute (R01) Period: 07/01/01–06/30/2004 Title: In Vivo Effector T Cell Response to Peptide Vaccination Goal: The major goal of this project was to define the in vivo response of antigen- specific T cells to a novel peptide-based cancer vaccine and cytokines. Role: Co-Principle Investigator Source: Marine Polymer Technology, Boston, USA Period: 07/01/01–06/30/2004 Title: Characterization of p-GlcNAc (F2 gel matrix) as an immune adjuvant and a delivery system for cytokines Goal: The main goal of this project was to define the optimal conditions for the delivery of cytokines by F2 gel matrix Role: Co-Principle Investigator; Principle Investigator, Dr. William Gillanders, M.D. Source: Tanta University, Egypt Period: 01/01/97–12/31/2003 Title: New Technology for control of the intermediate host of schistosomiasis in Egypt, Laboratory and semi field application. Goal: The main goal of this grant is to develop new technology to enhance the efficacy, lower toxicity of the chemical that are used in field to kill the snail that serve as the intermediate host harboring the infective stage of Schistosoma mansoni, a worm that case a global liver disease. Role: Co-Principle Investigator; Principle Investigator, Dr. Mohamed Mona, PhD Source: Section of Missions, Ministry of Higher Education, Egypt Period: 10/13/1992- 12/311994 Title: Interrelationship between estrogen and immune responses Goal: The major goal of this fellowship was to explore the role of endogenous cytokines in the interrelationship between female sex steroids and inflammatory immune responses Role: Fellow (Pre-doctoral fellowship) ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 8
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae WORKSHOPS 1- Head and Neck Multidisciplinary research Workshop. Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA, April 19 th, 2007. 2- Hematological Malignancies Symposium. February 13, 2007. Riviera Theatre & Conference Centre, Charleston, SC, USA. 3- Tenure Mentoring Workshop, Cosponsored by Office of the provost and the Faculty Senate, Medical University of South Carolina, SC, USA. Friday, May 12, 2006. 4- Immunotherapy of Cancer X: Tumor Vaccine and Cell Therapy Working Group (TVACT). Washington, DC, Convention Center USA, April, 2006. 5- Cancer Chemoprevention: Bridging Statewide Partnerships: The Science Driving The Latest Cancer Chemoprevention Strategies. The Citadel Holliday Alumni Center, March 16-17, 2006. 6- Immunotherapy of Cancer X: Tumor Vaccine and Cell Therapy Working Group (TVACT). Washington, DC, Convention Center USA, April, 2005. 7- Translational Therapeutics Spring Symposium, Hollings Cancer Center, Citadel Alumni House, Charleston, SC, USA, March. 11, 2005. 8- Hematological Malignancies Symposia. Medical University of South Carolina, Charleston, SC, USA, Feb. 24, 2005. 9- The Translational Therapeutics Spring Seminar, Citadel Holliday Alumni Center, Charleston, SC, USA, March 11, 2005. 10- Immunotherapy of Cancer X: Tumor Vaccine and Cell Therapy Working Group (TVACT). Orlando, Florida, USA, March 26, 2004. 11- Gene Regulation in Cancer. Hollings Cancer Center, Medical University of South Carolina, March 12, 2004. 12- Grantsmanship workshop. Organized by National Institute of Health with Dr. Ronald Geller, Health Research Associates. Medical University of South Carolina, Charleston, SC. Part 1, March 11, 2003; Part 2: April 29, 2003; and Part 3: May 20, 2003. 13- Modulation of Angiogenesis and Apoptosis in Cancer Therapy. Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA, March 14, 2003. 14- Tumor Immunology Primer, organized by Society for Biological Therapy. Hilton La Jolla Torrey Pines, San Diego, CA, USA, November 7, 2002. 15- OSHA Requirements: Hazard Community/Hazardous waste disposal, Blood borne pathogen standard, Tuberculosis, Fire safety and Ergonomics. On line workshop at Local network, Medical University of South Carolina, Charleston, SC, USA, Dec. 13th, 2001. 16- Human Subject Assurance Online Training Modules. Intranet work, Medical University of South Carolina, Charkeston, SC, USA. August 19, 2002. 17- Developing Skills in Molecular Pathology. Faculty of Medicine, Zagazig University, Egypt, April 2-3, 1997. ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 9
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae 18- Mollecular Pathology, Flow Cytometry, Immage Cytometry, In Situ hyperidization, PCR and ELISA Techniques. Pathology Dept., Faculty of Medicine, Zagazig Univ, Egypt, May 6-7, 1997. 19- Environmental Variability of Natural Wildlife. Faculty of Science, Tanta Univ., Under Cure of Ministry of Environmental affairs, Egypt, May 10, 1997. 20- English Course for Graduate studies. Faculty of Education, Tanta University, Egypt, Nov. ~ Dec., 1994. 21- Molluscicidal Evaluation from the Plant Origin in the Control of Schistosoma mansoni Snails. Theodor Bilharz Institute, Cairo, Egypt, May 27, 1996. 22- Educational Program for Teaching. Graduate studies, Faculty of Education, Tanta Univ., Egypt, June 1995. 23- Cultivation and Molluscicidal Application of Ambrosia Martima Plant. Building of Gharbia Governorate, December 23, 1995. 24- The Winter Advanced Course for Immunology & Infectious Diseases (WACIID)'1994. Tokyo, Japan, Feb. 13-16, 1994. 25- HLA and Tumors. Tumori Instituti Pascali, Napoli, Italy, Dec. 2-6, 1996. 26- Immunosuppressive Drugs & the Immune System. Tumori Instituti Pascali, Napoli, Italy, 2-11 Nov., 1994. 27- International English Language Testing System (IELTS) course, Center number EG002, Writing Examiner Number EG002/02/89, Speaking Examiner Number EG002/02/89, August 24, 1992. British Council, Alexandria, Egypt. CONFERENCES: ORAL PRESENTATION 1- Mohamed L. Salem, Ismail M. AL-Sharkawy, and Abdelfattah A Sadakah. Faculty Research Development Project (FRDP) to support life sciences in Egypt. Annual American-Egyptian Association Scholars (AEAS) conference, Dec. 25-27, 2006, National research Center, Cairo, Egypt. 2- Mohamed L. Salem, Andre Kadima, Sabry EL-Naggar, and William E. Gillanders, David J. Cole. Cyclophosphamide Preconditioning Enhances The Antigen-specific CD8 T Cell Responses to Peptide Vaccination: Evidence of Enhanced Innate Immunity and Induction of A Beneficial Cytokine Milieu. Tumor vaccine & Cell Therapy (TVACT) Working Group: Immunotherapy of Cancer XI, April 15, 2005, Garden Grove, California, USA. 3- Mohamed L. Salem, Andre Kadima, David J. Cole, and William E. Gillanders. Mediation of the adjuvant effect of the toll-like receptor 3 (TLR3) agonist by induction of a rapid beneficial inflammatory cytokine milieu. 7th International Conference of Anticancer Research. 25-30 October 2004, Corfu, Greece. 4- Walid A. Osta, Yian Chen, Joshua Glenn, Kaidi Mikhitarian, Mohamed L. Salem, David J. Cole, Michael Mitas, and William E. Gillanders. Defining the Mechanisms underlying Inhibition of breast cancer carcinogenesis by EpCAM gene silencing. 7th International Conference of Anticancer Research. 25-30 October 2004, Corfu, Greece. 5- Mohamed L Salem, Yuehua Zhou, Andre N Kadima, Christophe L Nguyen, Mark P Rubinstein, Marina Demcheva, John N Vournakis, David J Cole, William E Gillanders. Sustained release of interleukin-12 from a novel delivery system using a poly-N-acetyly ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 10
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae glucoseamine-based polymer matrix enhances peptide-based cancer vaccine. Tumor Vaccine & Cell Therapy (TVACT) Working Group: Immunotherapy of Cancer X. Orlando, Florida, USA, March 26, 2004. 6- Mohamed L Salem, Andre N Kadima, David J Cole, William E Gillanders. Double- stranded RNA (dsRNA) danger motif is potent adjuvant for accentuating peptide-based vaccine by bridging innate and adaptive immunity. 3rd Annual Research Retreat, Wild Dunes, Charleston, SC, USA, December 23rd, 2003. 7- Mohamed L Salem, Yuehua Zhou, Andre N Kadima, Christophe L Nguyen, Mark P Rubinstein, Marina Demcheva, John N Vournakis, David J Cole, William E Gillanders. Sustained release of interleukin-12 from a novel delivery system using a poly-N-acetyly glucoseamine-based polymer matrix enhances peptide-based cancer vaccine. Recent concepts in cancer management. Helnal Paletine Hotel, Montaza Palace, Alexanderia, Egypt, 22-24 Oct, 2003. 8- Mohamed L Salem, Andre Kadima, Mark P Rubinstein, Marina Demcheva, John N Vournakis, David J Cole, William E Gillanders. Mechanisms of enhanced antigen-specific T cell response following vaccination with a novel peptide-based cancer vaccine and systemic interleukin-2 (IL-2). J. Immunother., 25(6):S35, 2002. 17th annual Scientific Meeting of the Society for Biological Therapy, November 7-10, La Jolla, California, USA. 9- Mark P Rubinstein, Andre Kadima, Mohamed L Salem, Christophe L Nguyen, William E Gillanders, David J Cole. Systemic administration of IL-15 augments the antigen-specific primary CD8+ T cell response following vaccination. J. Immunotherapy, 25(6):S18, 2002. 17th annual Scientific Meeting of the Society for Biological Therapy, November 7- 10, La Jolla, California, USA. 10- Mohamed L. Salem, Kenji Kishihara, Matsuzaki G. and Nomoto K. Subcutaneous treatment with linoleic acid suppresses the growth of EL4 thymoma in mice through augmentation of Cytolysis of CD8 and production of IFN- . The Autumn Conference of Immunology, 19-21 Nov., 2000, Abstract no. 48, Page: 25Chicago, USA. 11- Mohamed L. Salem, Wael Attia Y., Wageh Awara A., Al Mehallawy A. Immunotoxicity of cadmium chloride in mice: Time course study. "HLA and Tumours", Italy, Naples, Dec. 2-6, 1996. 12- Mohamed L. Salem. Increase of the bacteriostatic function against early infection of mice with Listeria monocytogenes after treatment with beta-estradiol. J. Egypt German Society of Zoology, Vol.23(A), Comp. Physiol, 347-378, Feb. 1997. 13- Mohamed L. Salem, Wael Attia Y., Wageh Awara A., Al Mehallawy A. Immunotoxicity of cadmium chloride in mice. J. Union Arab Biology, Vol. 6 (A) Zoology, 531-554, Nov. 1996. 14- Mohamed L. Salem, Matsuzaki G. and Nomoto K. Immunoregulatory influence of - estradiol on Macrophage Functions. Proc. Jap. Soc. Immunol., Kyoto, Japan Nov. 1994. CONFERENCES: POSTER PRESENTATION & ABSTRACTS 1- Mohamed L. Salem, Sabry EL-Naggar, Andre Kadima, Marcela Diaz, Amir A. AL-Khami, Wiiliam E. Gillanders, Marina Demcheva, John N Vournakis, and David Cole. Poly-N- ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 11
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae acetyl glucosamine gel (F2 gel) matrix is a novel non-viral delivery system that augments the efficacy of CD8+ T cells responses to vaccination with naked DNA plasmid encoding HIV-1 p37. Cancer Drug Discovery and Development: Bridging Academic and Industry Partenrships; Spring Symposium. Kiawah Island, SC, USA; Marc 23-24, 2007. 2- Mohamed L. Salem, Amir A. Al-Khami, Hany. Al-Wahsh, Wael Attia, Yousry Al-Bolkiny, Hala Hussain, Sabry A. EL-Naggar, Marina Demcheva, John Vournakis, and David J. Cole , and Ismail M. Al-Sharkawy: Paracrine delivery of low non-toxic levels of IL-12 from poly-N-acetyl glucosamine gel (F2 gel) matrix lowered the liver and lung fibrosis induced by Schistosoma mansoni eggs. 13th International Congress of Immunology, Rio De Janeiro, Brazil-August 21-25, 2007 3- Mohamed L. Salem, C. Marcela Diaz-Montero, Yian Chen, Sabry A. EL-Naggar, Andre N. Kadima, William E. Gillanders and David J. Cole: The TLR3 agonist poly (I:C) acted directly on mouse CD8 T cells and augmented their antigen-specific responses upon adoptive transfer into naïve recipient mice. 96th Annual Meeting of American Association of Immunologists (AAI), May 18-22, 2007, Miami Beach Convention Center, Miami, Florida, USA. 4- Amir A. Al-Khami, Alberto Monetro, Marcela Diaz, David J. Cole, and Mohamed L. Salem: Circulating Levels of CD4+ CD25+ T cells Correlate with Clinical Cancer Stage and Inversely Correlate with CD8+ T cells. 96th Annual Meeting of American Association of Immunologists (AAI), May 18-22, 2007, Miami Beach Convention Center, Miami, Florida, USA 5- Alberto Monetro, Amir A. Al-Khami, Marcela Diaz, David J. Cole, and Mohamed L. Salem: Circulating Immature Myeloid Cells (ImC) Levels Correlate with Clinical Cancer Stage and Cyclophosphamide (CTX) Treatment. 96th Annual Meeting of American Association of Immunologists (AAI), May 18-22, 2007, Miami Beach Convention Center, Miami, Florida, USA. 6- Mohamed L. Salem, Sabry EL-Naggar, Andre Kadima, Marcela Diaz, Narender Nath, Amir A. AL-Khami, and David Cole. Cyclophosphamide treatment leads to striking expansion of functional dendritic cells in vivo: Implications for cancer immunotherapy. 98th Annual Meeting for American Association of Cancer Research (AACR). April 14-18, 2007. Los Angeles, CA. 7- Kristi Vissage, Alberto Montero, Mohamed L. Salem, David Cole, and Marcela Díaz- Montero. Increased Levels of Circulating Immature Myeloid Cells (ImC) Correlates with Advanced Cancer Stage and Doxorubicin/Cyclophosphamide Treatment. 6th Annual Research Retreat. Citadel, Charleston, SC, USA. November 17th, 2006. 8- Mohamed L. Salem, Sabry EL-Naggar, Andre Kadima, Marcela Diaz, and David J.Cole. Cyclophosphamide treatment leads to striking expansion of functional dendritic cells in vivo: Implications for therapeutic tumor-specific adoptive immunotherapy. 6th Annual Research Retreat. Citadel, Charleston, SC, USA. November 17th, 2006. 9- Mohamed L. Salem, Sabry A. EL-Naggar, Andre Kadima, Marcela Diaz-Montero, William E. Gillanders, and David J. Cole. Vaccination using Toll-like receptor ligand (TLRL)-primed dendritic cells and TLR3L poly I:C administration leads to an augmentation of antigen-specific memory CD8+ T cell responses. 97th Annual Meeting for American Association of Cancer Research (AACR). April 1-5, 2006. Washington, DC. ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 12
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae 10- Marcela Diaz-Montero, Andre Kadima, Sabry A. EL-Naggar, Narender Nath, David J. Cole, and Mohamed L. Salem. Sustained generation and survival of antigen-specific CD62Lhigh CD8+ T-cells though in vitro conditioning with interleukin-12: implications for anti-tumor adoptive immunotherapy. 97th Annual Meeting for American Association of Cancer Research (AACR). April 1-5, 2006. Washington, DC. 11- Mohamed L. Salem, Sabry A. EL-Naggar, Andre Kadima, Marcela Diaz-Montero, William E. Gillanders, and David J. Cole. Vaccination using Toll-like receptor ligand (TLRL)-primed dendritic cells and TLR3L poly I:C administration leads to an augmentation of antigen-specific memory CD8+ T cell responses. 5th Annual Research Retreat, Citadel, Charleston, SC, USA. November 18th, 2005. 12- Mohamed L. Salem, Sabry A. EL-Naggar, Andre Kadima, Marcela Diaz-Montero, William E. Gillanders, and David J. Cole. Cyclophosphamide preconditioning enhances the antigen-specific CD8+ T cell responses to peptide vaccination: evidence of enhanced innate immunity and induction of a beneficial cytokine milieu. 5th Annual Research Retreat, Citadel, Charleston, SC, USA. November 18th, 2005. 13- Mohamed L. Salem, Andre Kadima, Sabry EL-Naggar, and William E. Gillanders, David J. Cole. Temporal induction of a beneficial inflammatory cytokine milieu relative to peptide vaccination is crucial for the optimal adjuvanticity of the TLR3 agonist polyinosinic-polycytidylic acid (Poly I:C). 96th Annual Meeting for American Association of Cancer Research (AACR). Anaheim, California, USA, April 16-21, 2005. 14- Mohamed L. Salem, Andre Kadima, Sabry EL-Naggar, and William E. Gillanders, David J. Cole. Cyclophosphamide Preconditioning Enhances The Antigen-specific CD8 T Cell Responses to Peptide Vaccination: Evidence of Enhanced Innate Immunity and Induction of A Beneficial Cytokine Milieu. The American Association of Immunologists (AAI), April 2-6, 2005. San Diego, CA, USA. 15- Narender Nath, Shalinendra Giri, Ratna. Prasad, Mohamed L. Salem, Avtar K. Singh, and Inderjit Singh. 5-aminoimidazole-4-carboxymide ribonucleoside: a novel Immunomodulator in experimental autoimmune encephalomyelitis. The American Association of Immunologists (AAI), April 2-6, 2005. San Diego, CA, USA. 16- Mark P Rubinstein, Andre N Kadima, Mohamed L Salem, Christophe L Nguyen, William E Gillanders, David J Cole. Retrovirally-modified T cells persist after adoptive transfer but exhibit discordant gene expression associated with a lack of therapeutic ability. The American Association of Immunologists (AAI), April 2-6, 2005. San Diego, CA, USA. 17- Mohamed L. Salem, Andre Kadima, Sabry EL-Naggar, David J. Cole, and William E. Gillanders. Novel non-viral delivery system enhances the efficacy of DNA vaccines targeting cytotoxic T lymphocytes. 4th Annual Research Retreat, November 11th, 2004, Charleston, SC, USA. 18- Mohamed L Salem, Andre N Kadima, David J Cole, William E Gillanders. Double- stranded RNA (dsRNA) danger motif is potent adjuvant for accentuating peptide-based vaccine by bridging innate and adaptive immunity. Immunotherapy of Cancer X: Tumor Vaccine and Cell Therapy Working Group (TVACT). Orlando, Florida, USA, March 26, 2004. ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 13
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae 19- Mohamed L Salem, Andre N Kadima, David J Cole, William E Gillanders. Double- stranded RNA (dsRNA) danger motif is potent adjuvant to accentuate peptide-based cancer vaccine by bridging innate and adaptive immunity. 95th Annual Meeting for American Association of Cancer Research, March 27-31, 2004, Orange County Convention Center, Orlando, FL, USA. 20- Waild Osta, Mike Mitas, Yian Chen, Mohamed L. Salem, Kaidi Mikhitarian and Carlton Barnett. 3rd Annual Research Retreat, Wild Dunes, Charleston, SC, USA, December 23rd, 2003, PP. 67. 21- Mohamed L Salem, Yuehua Zhou, Andre N Kadima, David J Cole, William E Gillanders. Double-stranded RNA (dsRNA) Danger Motif Bridges Innate and Adaptive Immunity and Is Potent Adjuvant for Accentuating Peptide-Based Cancer Vaccine. 3rd Annual Research Retreat, December 23rd, 2003, Wild Dunes, Charleston, SC, USA. 22- Mohamed L Salem, Andre N Kadima, Yuehua Zhou, Christophe L Nguyen, Mark P Rubinstein, Marina Demcheva, John N Vournakis, David J Cole, William E Gillanders. Mechanisms of enhanced antigen-specific T cell response to a novel peptide-based cancer vaccine: paracrine release of interleukin-12 results in enhancement of antigen presentation and appears to be interferon-gamma dependent. 94th Annual Meeting for American Association of Cancer Research, July10-14, 2003, Washington Convention Center, Washington, DC, USA. 23- Mohamed L Salem, Andre N Kadima, Yuehua Zhou, David J Cole, William E Gillanders. Exploring the interplay between innate and adaptive immunity: polyinosine: cytosine (Poly I:C) enhances the antigen-specific T cell response to a peptide-based cancer vaccine. Basic Aspects of tumor immunotherapy (C5) Feb 17-23, 2003, Keystone, Colorado, Denver, USA. 24- Grab J. Dennis, R. Bucala and Mohamed L. Salem: A Role for Peripheral Blood Fibrocytes in African trypanosomiasis and Lyme disease. South African Veterinary Association. 74(3):87-101, 2003. 25- Mohamed L Salem, Andre Kadima, Mark P Rubinstein, Marina Demcheva, John N Vournakis, David J Cole, William E Gillanders: Paracrine release of IL-12 from a modular peptide-based cancer vaccine enhances the antigen-specific CD8 T cell response. 2nd Annual Research Retreat, August 23rd, 2002, Wild Dunes, Charleston, SC, USA Page:48. 26- Mohamed L Salem, Andre Kadima, Mark P Rubinstein, Marina Demcheva, John N Vournakis, David J Cole, William E Gillanders: Paracrine release of IL-12 from a modular peptide-based cancer vaccine enhances the antigen-specific CD8 T cell response. 93rd Annual Meeting for American Association of Cancer Research, April 6-10, 2002, San Francisco, CA, USA, Abstract#3002, page:606. 27- Mark P Rubinstein, Andre N Kadima, Mohamed L Salem, Christophe L Nguyen, William E Gillanders, David J Cole: Persistence and function of adoptively transferred retrovirally-transduced T cells in vivo. 93rd Annual Meeting for American Association of Cancer Research, April 6-10, 2002, San Francisco, CA, USA. Abstract#2193, page:441. 28- Mark P Rubinstein, Andre N Kadima, Ch ristophe L Nguyen, Mohamed L Salem, William E Gillanders, David J Cole: Systemic administration of IL-15 augments primary ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 14
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae T cell response to vaccination. 16th Annual Meeting for Society for Biological Therapy of Cancer, Bethesda, Maryland, USA 9 - 11 November 2001. 29- Mohamed L. Salem, Kenji Kishihara, Matsuzaki G. and Nomoto K. Subcutaneous treatment with linoleic acid suppresses the growth of EL4 thymoma in mice through augmentation of Cytolysis of CD8 and production of IFN- . The Autumn Conference of Immunology, 19-21 Nov., 2000, Abstract no. 48, Page: 25Chicago, USA. 30- Mohamed L. Salem, Matsuzaki G. and Nomoto K. Influence of -estradiol on Listeria monocytogenes infection. Japanese Soc. for Microbiol., March 28-31, 1994 Tokyo, Japan. 31- Mohamed L. Salem, Matsuzaki G. and Nomoto K. -estradiol-induce d inhibition of macrophages function during Listeria monocytogenes infection. The Winter Advanced Course for Immunology and Infectious Diseases (WACIID)'1994". Tokyo, Japan, Feb., 13-16, 1994. BIBLIOGRPAHY Review articles: 1. Mohamed L. Salem: Bridging scientific enterprise in developed and less developed countries: Ideas for improving Sciences in developing countries. The BioMed Scientist, Vol. 3, June 2007: 3-4. 2. Faris Q. AL-Enzi and Mohamed L. Salem. Career preference among university’s faculty: Literature review. Education Resources Information Center (ERIC), 2007. 3. Mohamed L. Salem, Mark P Rubinstein, and David J Cole. Tumours: Immunotherapy. Encyclopedia life Sciences. April 16, 2007 John Wiley & Sons, Ltd. 4. Mohamed L. Salem, Andre Kadima, Sabry EL-Naggar, and William E. Gillanders, David J. Cole. Novel non-viral delivery approaches for IL-12 protein and gene systems: curbing toxicity and enhancing adjuvant activity. J. Interferon & Cytokine Research, 2006, 26(9): 593-608. 5. Mohamed L. Salem, Immunomodulatory and immunotherapeutic properties of Nigella sativa L. seeds. Int. Immunopharmacology. Vol 5/13-14:1749-1770 6. Mohamed L. Salem. Estrogen, A Double-edged Sword: Modulation of TH1- and TH2- mediated Inflammations by Differential Regulation of TH1/TH2 Cytokine Production. Current Drug Targets-Inflammation & Allergy, 3: 95-102, 2004. 7. Grab J. Dennis, Mohamed L. Salem, J.Dumler, R. Bucala and N-H Lanners A role for the peripheral blood fibrocytes in leishmaniasis? Trends Parasitol., 20:12, 2003. 8. Grab J. Dennis, Mohamed L. Salem, J. Chesney, R. Bucala and N-H Lanners: A Role for Peripheral Blood Fibrocytes in Lyme disease? Med Hypotheses. 59:1-10, 2002. 9. Mark P Rubinstein, Mohamed L. Salem. The influence of primary antigen encounter on the generation of T-cell memory. Trends Immunol. (News and Comment), 23, 3: 123-124, 2002. ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 15
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae Original Peer Reviewed Articles 10. Alberto J Montero, Mohamed L. Salem, Elizabeth Garrett-Mayer, David Cole, Marcela Diaz Increased Levels of Circulating Myeloid-Derived Suppressor Cells in Solid Tumor Patients Correlate With Advanced Clinical Cancer Stage, Increased Tumor Burden, and Cyclophosphamide Containing Chemotherapy. 2007, Submitted, Journal of Clinical Oncology. 11. Mohamed L. Salem, Marcela Diaz, Amir A. AL-Khami, Sabry EL-Naggar, and David Cole. Immature dendritic cells expand after cyclophosphamide treatment and augment anti-tumor T cell adoptive immunotherapy upon their activation in vivo. 2007, Submitted, Journal of Experimental Medicine. 12. C. Marcela Díaz-Montero, Sabry El Naggar, Randa El Naggar, Amir Al Khami, Alberto J Montero., David J Cole., and Mohamed L Salem. Priming of naive cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity. Cancer Immunology & Immunotherapy, 2007 Aug 28; [Epub ahead of print]. 13. Mark P Rubinstein, Mohamed L. Salem, Andre N Kadima, Christophe L Nguyen, William E Gillanders, David J Cole Retrovirally-modified T cells persist after adoptive transfer but exhibit discordant gene expression associated with a lack of therapeutic ability. Cancer Gene Therapy, 2007 In Press. 14. Mohamed L. Salem, Andre Kadima, Sabry EL-Naggar, and William E. Gillanders, David J. Cole. Cyclophosphamide Preconditioning Enhances the Antigen-specific CD8 T Cell Responses to Peptide Vaccination: Evidence of Enhanced Innate Immunity and Induction of a Beneficial Cytokine Milieu. J Immunother. 2007 Jan;30(1):40-53. 15. Mohamed L. Salem, Provision of cytokines and cytokine-inducing adjuvants along with peptide-based vaccination accentuated intrahepatic retention of antigen-activated CD8+ T cells: opposing roles for natural killer and Kupffer cells. Egyptian Journal of Experimental Biology (Zoology). 2006, 2: 33 – 47. 16. Mohamed L. Salem, Andre Kadima, Sabry EL-Naggar, William E. Gillanders, and David J. Cole. The adjuvant effects of the toll-like receptor 3 ligand polyinosinic- cytidylic acid (poly I:C) on antigen-specific CD8 T cell responses are partially dependent on NK cells and macrophages with the induction of a beneficial cytokine milieu. Vaccine. 2006 12(24):5119-5132. 17. Mohamed L. Salem, Mohsen Zommara and K. Imaizumi. Dietary supplementation of tiger nut (Cyperus esculentus L) attenuates inflammatory cell responses in apolipoprotein E knockout mouse. American Journal of Immunology 1 (1): 60-67, 2005. 18. Narender Nath, Shalinendra Giri, Ratna. Prasad, Mohamed L. Salem, Avtar K. Singh, and Inderjit Singh. 5-aminoimidazole-4-carboxymide ribonucleoside: a novel Immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis (EAE). J Immunol. 2005 Jul 1;175(1):566-74. 19. Mohamed L. Salem, Andre N Kadima, David J Cole, William E Gillanders. Defining the Antigen-Specific T-Cell Response to Vaccination and Poly(I:C)/TLR3 Signaling: Evidence of Enhanced Primary and Memory CD8 T-Cell Responses and Antitumor Immunity. J Immunother. 2005 May-Jun;28(3):220-8. ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 16
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae 20. Mohamed L. Salem, Systemic treatment with n-6 polyunsaturated fatty acids attenuates EL4 thymoma growth and metastasis through enhancing specific and non- specific anti-tumor cytolytic activities and production of TH1 cytokines. Int. Immunopharmacology. 2005, Vol 5/6 pp 947-960. 21. Osta WA, Chen Y, Mikhitarian K, Mitas M, Mohamed L. Salem, Hannun YA, Cole DJ, Gillanders WE. EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res. 2004 Aug 15;64(16):5818-24. 22. Mohamed L. Salem, Andre N Kadima, Yuehua Zhou, Christophe L Nguyen, Mark P Rubinstein, Marina Demcheva, John N Vournakis, David J Cole, William E Gillander Paracrine release of interleukin-12 stimulates interferon-gamma production and dramatically enhances antigen-specific T-cell response after vaccination with a novel peptide-based cancer vaccine. J Immunol. 2004 May 1;172(9):5159-67. 23. Christophe L Nguyen, Mohamed L. Salem, Mark P Rubinstein, Marina Demcheva, John N Vournakis, David J Cole, William E Gillanders. Mechanisms of enhanced antigen-specific T cell response following vaccination with a novel peptide-based cancer vaccine and systemic interleukin-2 (IL-2). Vaccine 21:2318-2328, 2003 24. Mark P Rubinstein, Andre N Kadima, Mohamed L. Salem, Christophe L Nguyen, William E Gillanders, David J Cole. Transfer of TCR genes into mature T cells is accompanied by the maintenance of parental T cell avidity. J Immunol. 170:1209-17, 2003 25. Mark P Rubinstein, Andre N Kadima, Mohamed L. Salem, Christophe L Nguyen, William E Gillanders, David J Cole. Systemic administration of IL-15 augments the antigen-specific primary CD8+ T cell response following vaccination with peptide- pulsed dendritic cells. J Immunol. 169:4928-35, 2002. 26. Mohamed L. Salem, K. Kishihara and K. Nomoto. N-3 Polyunsaturated fatty acids accentuate B16 melanoma growth and metastasis through suppression of tumoricidal function of T cells and macrophages. Anticancer Research 20:3195-3204, 2000. 27. Mohamed L. Salem and Hossain M. Shorab. In vivo acute depletion of CD8+ T cells upregulates the anti-viral activity of NK cells against murine cytomegalovirus. Int. J. Immunopharmacology. 22:707-718, 2000. 28. Mohamed L. Salem and Hossain M. Shorab. Protective effect of the black seed oil from Nigella sativa against murine cytomegalovirus infection. Int. J. Immunopharmacology. 22:729-740, 2000. 29. Mohamed L. Salem, Matsuzaki G., Kishihara K., Madkour G. and Nomoto K. - estradiol suppresses the T cell-mediated delayed-type hypersensitivity through suppression of antigen presenting cell function and Th1 induction. International Archives of Allergy and Immunology 121:161-169, 2000. 30. Mohamed L. Salem, Hossain SM, and Nomoto K. Mediation of the immunomodulatory effects of beta-estradiol on inflammatory responses by inhibition of recruitment and activation of the inflammatory cells, and their gene expression of TNF-alpha and IFN-gamma. International Archives of Allergy and Immunology 121:235-245, 2000. 31. Mohamed L. Salem and W. El Shouny. Exopolysaccharides produced by Pseudomonas syringae pathovars suppress tumor cell proliferation and augment thymocyte proliferation in vitro. Az. J. Pharm Sci 25: 175-188, 2000. ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 17
    • SALEM, MOHAMED LABIB, PhD Curriculum Vitae 32. Mohamed L. Salem and Randa Ez Al Deen Al Nagar. Immunomodulatory and antitumor effects of simultaneous treatment of mice with n-3 and n-6 polyunsatrated fatty acids. J. Union Arab Biol, Vol. 14A:489-505, 2000. 33. Mohamed L. Salem and Wael Y Attia. Synergestic effect of beta-estradiol and progesterone on the distribution of the immune cells in the lymphoid tissues. J. Union Arab Biol, Vol 14A:293-307, 2000. 34. Mohamed L. Salem, Matsuzaki G., Gamal Madkour, and Nomoto K. -estradiol- induced suppression of macrophages functions in the course of Listeria monocytogenes infection is mediated by suppression of IL-12 and TNF-alpha expression. Int. J. Immunopharm 21;487-497, 1999. 35. Mohamed L. Salem. Increase of the bacteriostatic function against early infection of mice with Listeria monocytogenes after treatment with beta-estradiol. J. Egypt German Society of Zoology, Vol.23(A), Comp. Physiol, 347-378, Feb. 1997. 36. Wael Attia Y., Randa El-Naggar E., Mohamed L. Salem, and El-Bolkiny S. Influence of prolactin and prolactin antagonist, bromocriptine, on the regulation of the immune response. J. Egypt German Society of Zoology, Vol.23(A), Comp. Physiol., 325-346, Feb. 1997. 37. El-Bolkiny E., Mohamed L. Salem, Wael Attia Y., and AL-Sharkawy I. Toxicological study of Ammi majus as a plant mollusccicide on the hemolysis and hemolysis-related parameters. J. Egypt German Society of Zoology, Vol.23 (A), Comp. Physiol. 379- 3401, Feb. 1997. 38. Mohamed L. Salem, Wael Attia Y., Wageh Awara A., Al Mehallawy A. Immunotoxicity of cadmium chloride in mice. J. Union Arab Biology, Vol. 6 (A) Zoology, 531-554, Nov. 1996. 39. Fouad A. Abou-Zaid; Siham B. Salem and Mohamed L. Salem. Oesteology of Psammomys obesus I. The cranial region. Delta J. Sci. 13 (4): 2087-3002, 1989. 40. Fouad A. Abou-Zaid; Siham B. Salem and Mohamed L. Salem. Oesteology of Psammomys obesus. II. The post-cranial region. Delta J. Sci. 13 (4): 3003-3024, 1989. 41. Fouad A. Abou-Zaid; Siham B. Salem and Mohamed L. Salem. Histological studies on the digestive system of the fat sand rat Psammomys obesus. Delta J. Sci. 12 (2): 1141-1166, 1988. THESIS o MS: Anatomical studies on the rodent of the genus Psammomys found in Egypt deserts. Tanta University, Faculty of Science, Egypt, September 1989. o PhD: Influence of contraceptive hormones on the interrelationship between endocrine and immune systems. Tanta University, Faculty of Science, Egypt and Kyushu University-Fukuoka, Japan, December 1995. ___________________________________________________________________________________________ SALEM, MOHAMED LABIB, PhD October 2007 18