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Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
Curriculum Vitae.doc
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  • 1. Alan David Hutson Address Department of Biostatistics School of Public Health and Health Related Professions University at Buffalo Farber Hall, Rm. 249 3435 Main Street, Bldg. 26 Buffalo, New York 14214-3000 work: (716) 829-2975, home: (716) 689-9348 email: ahutson@buffalo.edu Education Ph.D. in statistics; 7/96, University of Rochester M.A. in statistics; 2/93, University of Rochester M.A. in statistics; 5/90, State University of New York at Buffalo B.A. in statistics; 5/88, State University of New York at Buffalo 2 years towards EE degree; 9/83-5/85, University of New Hampshire Experience State University of New York at Buffalo, Department of Biostatistics, June 2003 - present. Chair. Founding chair of the department. The Department has 15 faculty members and 2 staff members. Initiated MA and PhD program in Biostatistics. Roswell Park Cancer Institute, Department of Biostatistics August 2005- present. Chair. The Department works closely with UB’s Department of Biostatistics to support RPCI’s research mission. The Chair also serves as the Associate Director of the Biostatistics Resource. Roswell Park Cancer Institute, Department of Biostatistics August 2007- present. Professor of Oncology. State University of New York at Buffalo, Department of Biostatistics, August 2007 – present. Professor. State University of New York at Buffalo, Department of Biostatistics, June 2003 – August 2007. Associate Professor. State University of New York at Buffalo, Department of Pharmacy, April 2005 – present. Research Associate Professor. State University of New York at Buffalo, Department of Biostatistics, June 2003 – present. Director of Undergraduate Studies.
  • 2. State University of New York at Buffalo, Department of Social and Preventive Medicine, June 2002 – June 2003. Chief, Division of Biostatistics. State University of New York at Buffalo, Department of Social and Preventive Medicine, June 2002 – June 2003. Associate Professor. University of Florida, Department of Statistics, July 2001 - February 2002. Associate Director, Division of Biostatistics. The division consists of 12 faculty and over 20 staff members. Responsibilities include managing the division's budget and staff. University of Florida, Department of Statistics, July 1996 - May 2002. Director of the GCRC Informatics Core (responsible for the statistical components of approximately 50-70 active clinical trial protocols in a given year). Other duties include mentoring graduate statistics and medical students who intern on the GCRC and managing informatics staff. University of Florida, Department of Statistics, September 2001 - May 2002. Assistant Professor (awarded tenure and promotion to Associate Professor April 2002). Primary duties involve supporting clinical trials research. Teaching duties include graduate level biostatistics courses and short courses for medical researchers and students. University of Florida, Center for Biostatistics & Epidemiology, June 2000 - May 2002. Director. The work of the center includes directing data coordinating centers, developing software for internet data capture, and statistical support of clinical trials. University of Florida, Department of Statistics, March 1999 - May 2002. Director of the Biostatistics Coordinating Center for the DCA-MELAS phase III clinical trial. University of Florida, Department of Statistics, July 1996 - January 2002. Director of the Biostatistics Coordinating Center for the DCA-CLA phase III clinical trial. University of Florida, Department of Statistics, July 1996 - September 2001. Research Assistant Professor. University of Florida, Department of Statistics, May 2000 - July 2001. Interim Director, Division of Biostatistics. University of Florida, Department of Statistics, July 1996 - July 1999. Director of the Biostatistics Coordinating Center for the DCA-MALA phase III clinical trial. University of Rochester, Department of Statistics, Summer 1994 - Fall 1995. Instructor of “Applied Statistics for the Social Sciences” four times. Class sizes ranged from 130 to 170 students. University of Rochester, Department of Biostatistics, August 1992 - July 1996. Research trainee 2
  • 3. supported by NIH Environmental Health Science Training Grant. Consultant on various statistical projects. Also served as teaching assistant in courses for biomedical students and research fellows. University of Rochester, Department of Community and Preventative Medicine, Summer 1992. Worked with the department chair on simulation projects related to the investigation of ROC curves. The work resulted in one joint publication. Also developed Monte Carlo simulation programs for social economics study. University of Rochester, Department of Statistics, Fall and Spring 1991-1992. Teaching assistant for introductory statistics courses. Otsuka America Pharmaceuticals, Inc., Rockville, MD, June 1990 - August 1991. Biostatistician. Assisted in the development of phase I and phase II protocols for infectious diseases and psychopharmacology therapeutic groups. Performed statistical analysis in preparation of NDA for cardiology therapeutic group. Roswell Park Memorial Institute, Buffalo, NY, summer 1989. Research apprentice in the Biomathematics Department. Worked on customizing SAS and Fortran graphics routines in trying to better represent three dimensional dose response surfaces. Also worked on non- linear dose response curve fitting. State University of New York at Buffalo, Fall and Spring 1988-1990. Teaching assistant for SAS statistical computing course and introductory statistical courses (graduate and undergraduate). Awards 2004 School of Public Health and Health Profession Dean’s Award 2001 NYSTAR Distinguished Professor with recognized excellence in bioinformatics Who's Who in Health Sciences Education (WWHSE) Bonus Pay Award (1998-99), University of Florida Awarded UF CLAS Research Initiation Project (1997) Environmental Health Sciences Training Grant (4 years) NIH T32 E507271 Various tuition scholarships, Regents scholarship Scholar Athlete (SUNY Buffalo) Professional Affiliations 3
  • 4. Member American Statistical Association, Institute for Mathematical Statistics, American Public Health Association, Society for Controlled Clinical Trials President-elect 01-02 for the Association of GCRC Statisticians Editorial Boards Communication in Statistics, Associate Editor Journal of Surgical Oncology, Associate Editor Mathematical Reviews, Technical Reviewer Journal of Statistical Planning and Inference, Associate Editor for the S.N. Roy Centennial Volume Masters Project “New Measures of Process Capability for use in Statistical Quality Control.” The project resulted in a 30 page paper: White, D. B. and Hutson, A. D. (1990) Robust and Comprehensive Monetary Metrics for Process Capability, which was later presented as an ASA poster session. Ph.D. Thesis Title “Estimation of Quantile Functions and Applications.” Advisor: Govind S. Mudholkar Publications Book Reviews 1. Hutson, A. D. (2004) Book Review: Resampling Methods for Dependent Data, by S. N. Lahiri, New York, Springer-Verlag, 2003, ISBN 0-387-00928-0, xiv + 374 pp, $79.95. Technometrics. Encyclopedia Entries 1. Hutson, A. D.and Brady, M. (2010) “Clinical Trial”, Encyclopedia of Research Design. SAGE. Thousand Oaks, CA Book Chapters 1. Brady, M. F., Hutson, A.D. and Gaile, D. P. (2009) “Clinical Trials Methodology and Biostatistics”, Principles and Practice of Gynecology Oncology, 5th Edition. Wolters Kluwer and Lippincott Williams & Wilkins, New York. Invited Papers 4
  • 5. 1. Gaile, D. P., Hutson, A. D., Java, J., Conroy, J. M., McQuaid, D., Rossi, M. and Nowak, N. J. (2007) Errors in Centering of Array Data can Induce Biases in Correlation Estimates. Journal of Statistical Planning and Inference, 137 3208-3212. 2. Mudholkar, G. S., McDermott, M .P. and Hutson, A. D. (2007) Preface[Life and legacy of Samarendra Nath Roy 1906–1964]. Journal of Statistical Planning and Inference, 137 3207-3207. 3. Mudholkar, G. S., McDermott, M .P. and Hutson, A. D. (2007) Life and legacy of Samarendra Nath Roy 1906–1964. Journal of Statistical Planning and Inference, 137 3208-3212. 4. Ernst, M. D. and Hutson, A. D. (2003) Utilizing a Quantile Function Approach to Obtain “Exact” Bootstrap Solutions. Statistical Science, 18 231-240. Theory and Methods 1. Miecznikowski, J. C., Wang, D. and Hutson, A. D. (2010) Bootstrap MSE Estimators to obtain bandwidth for kernel density estimation. Communications in Statistics - Simulation and Computation. (in press) 2. Guogen, S., Vexler, A., Wilding, G. and Hutson, A. (2010) Simple and Exact Empirical Likelihood Ratio Tests for Normality Based on Moment Relationships. Communications in Statistics - Simulation and Computation. (in press) 3. Wang, D., Hutson, A. D. and Gaile, D. P. (2010) An exact bootstrap approach towards modification of the Harrell-Davis quantile function estimator for censored data. Journal of Nonparametric Statistics (in press). 4. Vexler A, Yu J, Hutson A. (2010) Likelihood testing populations modeled by autoregressive process subject to the limit of detection in applications to longitudinal biomedical data. Journal of Applied Statistics (in press) 5. Hutson, A. D. (2010) A Multi-Rater Nonparametric Test of Agreement and Corresponding Agreement Plot. Compuatational Statistics & Data Analysis. 54 109-119 6. Mashtare, T. L. and Hutson, A. D. (2009) Utilizing the flexibility of the Epsilon-skew- normal distribution for Tobit regression problems. Communications in Statistics-Theory and Methods (in press) 7. Mashtare, T. L. and Hutson, A. D. (2009) Log-Epsilon-Skew Normal Distribution and Applications. (submitted) 5
  • 6. 8. Yu, J., Vexler, A. and Hutson, A. (2009) A maximum likelihood approach to analyzing incomplete longitudinal data in mammary tumor development experiments with mice. Computational Statistics & Data Analysis. (in press) 9. Vexler, A., Liu, S., Kang, L. and Hutson, A. (2009) Modifications of the Empirical Likelihood Interval Estimation with Improved Coverage Probabilities Communications in Statistics - Simulation and Computation, 38 2171-2183 10. Cai, X., Wilding, G., Li, Y., Hutson, A. and Yu, Z. (2009) Testing the Equality of Conditional Correlations Across Numeric Variable(s) with Heteroscedastic Data. (submitted) 11. Wilding, G., Cai, X. and Hutson, A. (2009) A generalized linear model approach to estimating and testing the equality of conditional correlations. (submitted) 12. Wang, D. and Hutson, A. D. (2009) L-moment estimation for parametric survival models given censored data. (submitted) 13. Hutson, A.D. and Wang, D. (2009) An inversion theorem based kernel density estimator for a weighted average and difference of weighted averages with applications. (submitted) 14. Mashtare, T. L. and Hutson, A. D. (2009) SAS macro for estimating the standard error of area under the curve with an application to receiver operating curves. (submitted) 15. Mudholkar, G. S., Asubonteng, K. O. and Hutson, A. D. (2009) Transformation for Weibull model analysis of bathtub failure rate data in reliability analysis. Statistical Methodology 6 622-633 16. Hutson, A. D. (2009) Bootstrap Smoothing Strategies Based on Uniform Spacings. Journal of Statistics: Advances in Theory and Applications. (in press) 17. Hutson, A. D. (2009) A Concomitant Order Statistics Based Approach to Bivariate Density Estimation. Advances and Applications in Statistical Sciences, 1 107-132. 18. Hutson, A. D. (2009) Calculation of the Per Hypothesis Error Rate via Sums of Steck's Determinants. Advances and Applications in Mathematical Sciences, 1 31-38. 19. Hutson, A. D. (2009) A Distribution Function Estimator for the Difference of Order Statistics from Two Independent Samples. Statistical Papers, 50 203-208. 20. Hutson, A. D., Markman, M. and Brady, M. F. (2009) A Permutation Test Approach to Phase II Historical Control Trials with an Application to the Gynecologic Oncology Cooperative Group Setting. Journal of Applied Statistics, 36 589-599. 21. Hutson, A. D. (2008) Estimating the Relative Rank Correlation: Theory and Application. Statistical Methodology, 5 46-55. 6
  • 7. 22. Hutson, A. D. (2008) A Discrete-Continuous Mixture Quantile Function Estimator with a Practical Application to Phase II Cancer Clinical Trials. Statistics in Medicine, 27 2094-2109. 23. Hutson, A. D. (2007) An ``Exact'' Two-Group Median Test with an Extension to Censored Data. Journal of Nonparametric Statistics 19 103-112. 24. Hutson, A. D. (2006) Modifying the Exact Test for a Binomial Proportion and Comparisons with Other Approaches. Journal of Applied Statistics 33 679-690. 25. Hutson, A. D. (2005) Medical Diagnostic Testing Models for Multifactorial Disease Classifications. Statistics in Medicine, 24, 2649-57. 26. Hutson, A.D. (2004) Utilizing the Flexibility of the Epsilon-Skew-Normal Distribution for Common Regression Problems. Journal of Applied Statistical Science, 31 673-683. 27. Hutson, A. D. and Reid, M. A. (2004) The Utility of Partial Cross-Over Designs in Early Phase II Randomized Prevention Trials. Controlled Clinical Trials, 25 493-501. 28. Qureshi, A. I., Hutson, A., Harbaugh, R. E., Stieg, P. E., Hopkins, L. N. (2004) Methodologies and Design Considerations in Clinical Trials Evaluating Surgery or Endovascular Treatment in Cerebrovascular Diseases. Neurosurgery, 54 248-267. 29. Hutson , A. D. (2004) A General Alternative Approach to Tobit Analysis for Modelling Markers of Disease. Journal of Applied Sciences, 4 1-4. 30. Hutson, A. D. (2004) A Semiparametric bootstrap approach to correlated data analysis problems. Computer Methods and Programs in Biomedicine, 73 129-134. 31. Hutson, A. D. (2004) Exact Nonparametric Bootstrap Confidence Bands for the Quantile Function Given Censored Data. Communications in Statistics—Simulation and Computation, 33 729-746. 32. Hutson, A. D. (2003) Nonparametric Estimation of Quantiles and Normal Ranges Given Standard One-Way ANOVA Random Effects Assumptions. Statistics & Probability Letters, 64 415-424. 33. Hutson, A. D. (2003) A Sequential Test Procedure for Monitoring a Singular Safety and Efficacy Outcome. Tropical Journal of Pharmaceutical Research, 2 197-206. 34. Hutson, A. D. (2002) A Semiparametric Quantile Function Estimator for use in Bootstrap Estimation Procedures. Statistics and Computing, 12 331-338. 7
  • 8. 35. Hutson, A. D., Fishbein, L., O'Brien, P. and Stacpoole, P. W. (2002) Accounting for Plasma Levels Below Detection Limits in a One-Compartment Zero-Order Absorption Pharmacokinetics Model. Journal of Applied Statistics, 29 1181-1190. 36. Hutson, A. D. (2002) Quasi Medians are Robust and Relatively Efficient Estimators of a Common Mean Given Multivariate Normality. Statistics & Probability Letters, 57 403-408. 37. Hutson, A. D. (2002) “Exact” Bootstrap Confidence Bands for the Quantile Function via Steck's Determinant. Journal of Computational and Graphical Statistics, 11 471-482. 38. Hutson, A. D. (2002) Analytical Bootstrap Methods for Censored Data. Journal of Applied Mathematics and Decision Science, 6 129-141. 39. Hutson, A. D. (2001) Bootstrap-type Confidence Intervals for Quantiles of the Survival Distribution. Statistics and Medicine, 20 1693-1702. 40. Mudholkar, G. S., Hutson, A. D., and Marchetti, C. E. (2001) A Simple Hermitian Estimator of the Quantile Function. Journal of Nonparametric Statistics, 13 229-243. 41. Hutson, A. D. (2001) Rational Spline Estimators of the Quantile Function. Communications and Statistics--Simulation and Computation, 30 377-390. 42. Hutson, A. D. (2000) A Composite Quantile Function Estimator with Applications in Bootstrapping. Journal of Applied Statistics, 27 567-577. 43. Hutson, A. D. (2000) Estimating the Covariance of Bivariate Order Statistics with Applications. Statistics & Probability Letters, 48 195-203. 44. Hutson, A. D. and Ernst, M. D. (2000) The Exact Bootstrap Mean and Variance of an L- estimator. Journal of the Royal Statistical Society--Series B, 62 89-94. 45. Mudholkar, G. S. and Hutson, A. D. (2000) The Epsilon-Skew-Normal Distribution for Analyzing Near-Normal Data. Journal of Statistical Planning and Inference, 83 291-309. 46. Muller, S., Hutson, A., Arya, V. and Hochhaus, G. (1999) Assessment of complex peptide degradation pathways via structured multi-compartmental modeling approaches: the metabolism of Dynorphin A 1-13 and related fragments in human plasma. Journal of Pharmaceutical Science, 88 938-944. 47. Hutson, A. D. (1999) Calculating Nonparametric Confidence Intervals for Quantiles Using Fractional Order Statistics. Journal of Applied Statistics, 26 343-353. 48. Hutson, A. D. (1998) Direct Estimation of the Percentile “p-value” for the One-Sample Median Test. Journal of Applied Statistics, 25 525-533. 8
  • 9. 49. Mudholkar, G. S. and Hutson, A. D. (1998) LQ-moments: Analogs of L-moments. Journal of Statistical Planning and Inference, 71 191-208. 50. Mudholkar, G. S. and Hutson, A. D. (1998) Hermitian Quantile Curves as Statistical Plots. Communications in Statistics-Simulations and Computation, 27 783-805. 51. Hutson, A. D., Wilson, D. C. and Geiser, E. A. (1998) Measuring Relative Agreement: Echocardiographer Versus Computer. Journal of Agricultural, Biological, and Enviromental Statistics, 3 163-174. 52. Mudholkar, G. S. and Hutson, A. D. (1997) Improvements in the Bias and Precision of Sample Quartiles. Statistics. 30 239-257. 53. Mudholkar, G. S. and Hutson, A. D. (1997) Continuity Corrected Approximations for and “Exact” Inference with Pearson's X2. Journal of Statistical Planning and Inference, 59 61-78. 54. Mudholkar, G. S. and Hutson, A. D. (1997) Asymmetric Quasimedians: Remarks on an Anomaly. Statistics and Probability Letters, 32 261-268. 55. Mudholkar, G. S. and Hutson, A. D. (1997) Some Refinements of the Quasi-Quantiles. Statistics and Probability Letters, 32 67-74. 56. Mudholkar, G. S., Freimer, M., and Hutson, A. D. (1997) On the Efficiencies of Some Common Quick Estimators. Communications in Statistics-Theory and Methods, 26 1623-1647. 57. Mudholkar, G. S. and Hutson, A. D. (1996) A Study of the Exponentiated Weibull Family of Distributions. Communications in Statistics-Theory and Methods, 25 3059-3083. 58. Phelps, C. E. and Hutson, A. D. (1995) Estimating Diagnostic Test Accuracy Using a “Fuzzy Gold Standard”. Medical Decision Making, 14 44-57. Collaborative 1. Pauly, J. L., Smith, L. A., Rickert, M. H., Hutson, A. and Paszkiewicz, G. M. (2010) Is lung inflammation associated with microbes and microbial toxins in cigarette tobacco smoke? Immunologic Research, 46 127-136. 2. McCormack, R. and Hutson, A. (2010) In Reply to Commentary: "What Are the Unintended Consequences of Changing the Diagnostic Paradigm for Subarachnoid Hemorrhage After Brain Computed Tomography to Computed Topographic Angiography in Place of Lumbar Puncture?" Academic Emergency Medicine 17 996-997. 9
  • 10. 3. Quan, L., Hutson, A. and Demant, P. (2010) A locus on chromosome 8 controlling tumor regionality-a new type of tumor diversity in the mouse lung. Int J Cancer, 126 2603-2613. 4. Michalek, A.M., Hutson, A. D., Wicher, C. P. and Trump, D. L. (2010) The Costs of Research Misconduct - Underappreciated Consequences: A Case Study. PLOS Medicine, 7, e1000318. 5. McCormack, R. and Hutson, A. (2010) Can Computed Tomography Angiography of the Brain Replace Lumbar Puncture in the Evaluation of Acute Onset Headache after a Negative Non-Contrast Cranial Coputed Tomography Scan? Academic Emergency Medicine 17 444-451. 6. Smith, L. A., Paszkiewicz, G. M., Hutson, A. D. and Pauly, J. L. (2010) Inflammatory response of lung macrophages and epithelial cells to tobacco smoke: a literature review of ex vivo investigations. Immunologic Research, 46 127-136. 7. Nair, B., Kariapper, M., Lesniak, W., Tan, W., Hutson, A., Khan, M., Balogh, L. P. (2009) Toxicity Evaluation of Gold-Dendrimer Composite Nanodevices In Vitro - Difference Found Between Tumour and Proliferating Endothelial Cells. Nanotoxicology, 3 139-151. 8. Quan, L., Trtková, K., Grekov, I., Svobodová, M., Stassen, A. P., Hutson, A., Demant, P., and Lipoldová, M. (2009) Distinct Genetic Control of Parasite Elmination, Dissemination, and Disease after Leishmania major Infection. (in press) 9. Gibbs, J. F., Schlieman, M., Saxena, R., Martinick, M., Corasanti, J., Hutson, A. and Singh, P. (2009) A Pilot Study of Urokinase Type Plasminogen Activator (uPA) Overexpression in the Brush Cytology of Patients with Malignant Pancreatic or Biliary Strictures. HPB Surgery Epub 2009 Nov 30 10. Raghavendran, K., Davidson, B. A., Hutson, A. D., Helsinki, J. D., Nodzo, S. R., Notter, R. H. and Knight, P. R. (2009) Predictive Modeling and Inflammatory Biomarkers in Rats With Lung Contusion and Gastric Aspiration. Journal of Trauma-Injury Infection and Critical Care, 67, 1182-1190. 11. Kurey I, Kobets T, Havelková H, Slapničková M, Quan L, Trtková K, Grekov I, Svobodová M, Stassen AP, Hutson A, Demant P and Lipoldová M (2009) Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics, 61 619-633. 12. Raghavendran, K., Davidson, B.A., Huebschmann, J.C., Helinski, J.D., Hutson, A.D., Dayton, M.T., Notter, R.H. and Knight, P.R. (2009) Superimposed Gastric Aspiration Increases the Severity of Inflammation and Permeability Injury in a Rat Model of Lung Contusion. The Journal of Surgical Research, 155(2), 273-82 10
  • 11. 13. Markman, M., Brady, M., Hutson, A. and Berek, J.S. (2009) Survival After Second-Line Intraperitoneal Therapy for the Treatment of Epithelial Ovarian Cancer: The Gynecologic Oncology Group Experience. Int J Gynecol Cancer, 19(2), 223-229. 14. Jayaprakash, V., Sullivan, M., Merzianu, M., Rigual, N. R., Loree, T. R., Popat, S. R., Moysich, K. B., Ramananda, S., Johnson, T., Mang, T. S., Wilson, B. C., Gill, S. R., Marshall, J. R., Hutson, A. D., Frustino, J. and Reid, M. E. (2009) Autofluorescence Guided Surveillance for Oral Cancer. Cancer Prevention Research, 11 966-974. 15. Jewell, E. L., Darcy, K. M., Hutson, A., Lee, P. S., Havrilesky L.J., Grace, L.A., Berchuck, A., Alvarez-Secord, A. (2009) Association Between the N-Terminally Truncated (ΔN) p63α (ΔNp63α) Isoform and Debulking Status, VEGF Expression and Progression-Free Survival in Previously-Untreated, Advanced Stage Epithelial Ovarian Cancer: A Gynecologic Oncology Group Study. Gynecol Oncol., 115 424-429. 16. Rubatt, J.M., Darcy, K.M., Hutson, A, Bean, S.M., Havrilesky, L.J., Grace, L.A., Berchuck, A. and Secord, A.A. (2009) Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study. Gynecology Oncology, 112(3), 469-74. 17. Paszkiewicz, G. M., Timm, E. A., Mahoney, M. C., Wallace, P. K., Sullivan Nasca, M. A., Tammela, T. L., Hutson, A. and Pauly, J. L. (2008) Increased human buccal cell autoflourescence is a candidate biomarker of tobacco smoking. Cancer Epidemiology, Biomarkers and Prevention, 17, 239-244 18. Bharali DJ, Pradhan V, Elkin G, Qi W, Hutson A, Mousa SA, Thanavala Y. (2008) Novel nanoparticles for the delivery of recombinant hepatitis B vaccine. Nanomedicine, 4, 311-7 19. Quick, S. K., Shields, P. G., Nie, J., Platek, M. E., McCann, S. E., Hutson, A. D., Trevisan,M., Vito, D., Modali, R., Lehman, T. A., Seddon, M., Edge, S. B., Marian, C., Muti, P. and Freudenheim, J. L. (2008) Effect modification by catalase genotype suggests a role for oxidative stress in the relationship between hormone replacement therapy (HRT) use and breast cancer risk Cancer Epidemiology, Biomarkers and Prevention, 17, 1082-1087. 20. Ng PY, Donley M, Hausmann E, Hutson AD, Rossomando EF, Scannapieco FA (2007) Candidate salivary biomarkers associated with alveolar bone loss: cross-sectional and in vitro studies. Immunol Med Microbiol 49 252-60. 21. Guru KA, Seereiter PJ, Sfakianos JP, Hutson AD, Mohler JL. (2007) Is a cystogram necessary after robot-assisted radical prostatectomy? Urol Oncol. 25 465-467 22. Wei LH, Baumann H, Tracy E, Wang Y, Hutson A, Rose-John S, Henderson BW (2007) Interleukin-6 trans signalling enhances photodynamic therapy by modulating cell cycling. British Journal of Cancer 97 1513-1522 11
  • 12. 23. Balogh, L., Nigavekar, S. S., Nair, B. M., Lesniak, W., Zhang, C., Sung. L. Y., Kariapper, M. S., El-Jawahri, A., Llanes, M., Bolton, B., Mamou, F., Tan, W., Hutson, A., Minc. L. and Khan, M. K. (2007) Significant effect of size on the in vivo biodistribution of gold composite nanodevices in mouse tumor models. Nanomedicine. 3 281-296. 24. Secord AA, Darcy KM, Hutson A, Lee PS, Havrilesky LJ, Grace LA, Berchuck A. (2007) Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: A Gynecologic Oncology Group study. Gynecol Oncol. 106 221-232. 25. Weiss JR, Baer MR, Ambrosone CB, Blanco JG, Hutson A, Ford LA, Moysich KB (2007) Concordance of pharmacogenetic polymorphisms in tumor and germ line DNA in adult patients with acute myeloid leukemia. Cancer Epidemiol Biomarkers Prev 161038-1041. 26. Lesniak WG, Kariapper MS, Nair BM, Tan W, Hutson A, Balogh LP, Khan MK (2007) Synthesis and Characterization of PAMAM Dendrimer-Based Multifunctional Nanodevices for Targeting alpha(v)beta(3) Integrins. Bioconjug Chem 18(4):1148-54. 27. Sola-Visner, M. C., Christenson, R. C., Hutson, A. D. and Rimsza, L. D. (2007) Megakaryocyte Size and Concentration in the Bone Marrow of Thrombocytopenic and Nonthrombocytopenic Neonates. Pediatric Research 61 479-484. 28. Scannapieco FA, Ng P, Hovey K, Hausmann E, Hutson A, Wactawski-Wende J (2007) Salivary biomarkers associated with alveolar bone loss. Ann N Y Acad Sci 1098:496-7 29. Fakih MG, Trump DL, Muindi JR, Black JD, Bernardi RJ, Creaven PJ, Schwartz J, Brattain MG, Hutson A, French R, Johnson CS (2007) A phase I pharmacokinetic and pharmacodynamic study of intravenous calcitriol in combination with oral gefitinib in patients with advanced solid tumors. Clin Cancer Res. 13 1216-23 30. Segal, B. H., Davidson, B. A., Hutson, A. D., Russo, T. A., Holm, B. A., Mullan, B. A., Habitzruther, M., Holland, S. M. and Knight, P. R. (2007) Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. Am J Physiol Lung Cell Mol Physiol 292 760-8. 31. Stewart, S. H., Hutson, A. and Connors, G. J. (2006) Ethnicity and Gamma- Glutamyltransferase in Men and Women with Alcohol Use Disorders. Alcohol and Alcoholism 42 24-27 32. Stewart, S. H., Hutson, A., Connors, G. J. (2006) Exploration of the Relationship between Drinking Intensity and Quality of Life. American Journal on Addictions 15(5) 356-61. 33. Stacpoole, P. W., Kerr, D. S., Barnes, C., Bunch, S. T., Carney, P. R., Fennell, E. M., Felitsym, N. M., Gilmore, R. L., Greer, M., Henderson, G. N., Hutson, A. D., Neiberger, R. E., O’Brien, R. G., Perkins, L. A, Quisling, R. G., Shroads, A. L., Shuster, J. J., Silverstein, J. S., Theriaque, D. W. and Valenstein, E. (2006) Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children. Pediatrics, 117 1519-31 12
  • 13. 34. Fallavollita, J. A., Luisi, A., J., Michalek, S., Valverde, A. M.,deKemp, R., A., Haka, M. S., Hutson, A., and Canty, J., M. (2006) Prediction of ARrhythmic Events with Positron Emission Tomography: PAREPET Study Design and Methods. Contemporary Clinical Trials. 27 374-388. 35. Hutson, A. D., Davidson B. A., Raghavendran, K., Chess, P. R., Tait, A. R., Holm, B. A., Notter, R. H., and Knight, P. R. (2006) Statistical Prediction of the Type of Gastric Aspiration Lung Injury Based on Early Cytokine/Chemokine Profiles. Anesthesiology, 10 473-79 36. Raghavendran, K., Davidson, B. A. , Mullan, B. A., Hutson, A. D., Russo, T.A., Manderscheid, P. A., Woytash, J. A., Holm, B. A., Notter, R. H. and Knight, P. R. (2005) Acid and Particulate-induced Aspiration Lung Injury In Mice: Importance of MCP-1 (Macrophage Chemoattractant Protein-1). Am J Physiol Lung Cell Mol Physiol, 289 134-143. 37. Willer, B., Kroetsch, B., Darling, S., Hutson, A. and Leddy, J. (2005) Injury rates in House League, Select and Youth Ice Hockey. Med Sci Sports Exerc., 10 1658-1663 38. Davidson, B. A., Knight, P. R., Wang, Z., Chess, P. R., Holm, B. A., Russo, T. A., Hutson, A., and Notter, R. H. (2005) Surfactant Alterations in Acute Inflammatory Lung Injury from Aspiration of Acid and Gastric Particulates. Am J Physiol Lung Cell Mol Physiol. 288 699-708 39. Dolan, M. G., Graves, P., Nakazawa, C., Delano, T., Hutson, A. and Mendel, F. C. (2005) Ibuprofen and High-Voltage Electrical Stimulation Curbs Acute Edema Formation After Blunt Trauma to Limbs of Rats. Journal of Athletic Training, 40 111-115. (Kenneth L. Knight Award for Outstanding Research Manuscript) 40. Saxonhouse, M. A., Sola, M. C., Pastos, K. M., Ignatz, M. E., Hutson, A. D., Christenson, R. D. and Rimsza, L. M. (2004) Reticulated platelet percentages in term and preterm neonates. Journal of Pediatric Hematology Oncology, 26 797-802. 41. Knight, P. R., Davidson, B. A., Nader, N. D., Helinski, J., Marschke, C., Russo, T. A., Hutson, A. D., Notter, R. H. and Holm, B. A. (2004) Progressive, Severe Lung Injury Secondary to the Interaction of Insults following Gastric Aspiration. Experimental Lung Research, 30 535-557. 42. Odunsi, K., Wollman, R., Ambrosone, C., Hutson, A., McCann, S., Tammela, J., Gesler, J. P., Miller, G., Sellers, T., Cliby, W., Qian, F., Keitz, B., Intengan, M., Lele, S. and Alderfer, J. (2004) Detection of epithelial ovarian cancer using H-NMR-based metabonomics. International Journal of Cancer, 113, 782-788. 43. Saxonhouse, M. A., Christenson, R. D., Walker, D. M., Hutson, A. D. and Sola, M. C. (2004) The Concentration of Circulating Megakaryocyte Progenitors in Preterm Neonates as a Function of Post-Conceptional Age. Early Human Development 78 119-124. 13
  • 14. 44. Willer, B., Dumas, J., Hutson, A. and Leddy, J. (2004) A Population Based Investigation of Head Injuries and Symptoms of concussion of Children and Adolescents in Schools. Injury Prevention. 10 144-148. 45. Planche, T., Agbenyega, T., Bedu-Addo, G., Ansong, D., Owusu-Ofori, A., Micah, F., Anakwa, C., Asfo-Agyei, E., Hutson, A., Stacpoole, P., and Krishna, S. (2003) A Prospective Comparison of Malaria with Other Severe Diseases in African Children: Prognosis and Optimization of Management. Clinical Infectious Diseases 37 890-897. 46. Stacpoole, P. W., Nagaraja, N. V. and Hutson, A. D. (2003) Efficacy of Dicholoracetate as a Lactate-Lower Drug. A Meta Analysis. Journal of Clinical Pharmacology 43 683-691. 47. Litherland, S. A., She, J. X., Schatz, D., Fuller, K., Hutson, A. D., Peng, R. H., Li, Y., Grebe, K. M., Whittaker, D. S., Bahjat, K., Hopkins, D., Fang, Q., Spies, P. D., North, K. Wasserfall, C., Cook, R., Dennis, M. A., Crockett, S., Sleasman, J., Kocher, J., Muir, A., Silverstein, J., Atkinson, M., and Clare-Salzler, M. J. (2003) Abherrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset. Pediatric Diabetes 4 10-18. 48. Agbenyega, T., Planche, T., Bedo-Addo, G., Ansong, D., Owusu-Ofori, A., Bhattaram, V. A., Nagaraja, N. V., Shroads, A. L., Henderson, G. H., Hutson, A. D., Derendorf, H., Krishna, S., and Stacpoole, P. W. (2002) Population Kinetics, Efficacy and Safety of Dichloroacetate for Lactic Acidosis Due to Severe Malaria in Children. Journal of Clinical Pharmacology 43 386-396. 49. Saxonhouse, M. A., Rimsza, L. M., Stegner, J., Hutson, A. D., Christenson, R. D., and Sola, M. C. (2003) Effects of Anoxia on Megakaryocyte Progenitors Derived from Cord Blood CD34+ Cells. European Journal of Haematology, 71 359-365. 50. Duncan, G. E., Perri, M. G., Theriaque, D. W., Hutson, A. D., Eckel, R. H., and Stacpoole, P. W. (2003) Exercise Training, Without Weight Loss, Increases Insulin Sensitivity and Post- Heparin Plasma Lipase Activity in Previously Sedentary Adults. Diabetes Care 26 557-562. 51. Robles, L. D., Frost, A. R., Davila, M., Hutson, A. D., Grizzle, W. E., and Chakrabarti, R. (2002) Down regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer. Journal of Biological Chemistry 277 25431-25438. 52. Duncan, G. E., Hutson, A. D. and Stacpoole, P.W. (2002) QUICKI Is Not a Useful and Accurate Index of Insulin Sensitivity Following Exercise Training. Journal of Clinical Endocrinology & Metabolism 87 950-951. 53. Bailey, L. B., Duhaney, R., Maneval, D., Kauwell, G., Quinlivan, E., Cuadras, A., Hutson, A., and Gregory, J. F. (2002) Vitamin B12 Status is Inversely Associated with Plasma Homocysteine in Young Women and/or A1298C Methylene Tetrahyrdofolate Reductase Polymorphisms. Journal of Nutrition 132 1872-1878. 14
  • 15. 54. Neiberger, R. E., George, J. C., Perkins, L., Theriaque, D. W., Hutson, A. D., Stacpoole, P. W. (2002) Renal Manifestations of Congenital Lactic Acidosis. American Journal of Kidney Diseases 39 12-23. 55. Garcia, M. G., Duenas, E., Sola, M. C., Hutson, A. D., and Christenson, R. D. (2002) Epidemilogic and Outcome Studies in Patients who Received Platelet Transfusions in the Neonatal Intensive Care Unit. Journal of Perinatology 21 415-420. 56. Garcia, M. G., Hutson, A. D. and Christensen, R. D. (2002) Effect of recombinant erythropoietin on “late” transfusions in the neonatal intensive care unit: A meta-analysis. Journal of Perinatology 22 108-111. 57. Sullivan, S. E., Staba, S. L., Gersting, J. A., Hutson, A. D., Theriaque, D., Christensen, R. D. and Calhoun, D. A. (2002) Circulating Concentrations of Chemokines in Cord Blood, Neonates, and Adults. Pediatric Research 51 653-657. 58. Sherman, J., Patel, P., Hutson, A., Chesrown, S., and Hendeles, L. (2001) Adherence to Oral Montelukast and Inhaled Fluticasone in Children with Asthma. Pharmacotherapy 21 1464-1467. 59. Satoh, M., Behney, K. M., Mizutani, A., Richards, H. B., Hutson, A. and Reeves, W. H. (2001) Titration Emulation: A Computer-Assisted Technique that Simplifies the quantification of Anti-dsDNA Antibodies Using the Crithidia luciliae Assay. Lupus 10 632-636. 60. Sola, M. C., del Vecchio, A., Edwards, T. J., Suttner, D., Hutson, A. D. and Christenson, R. D. (2001) The relationship between hematocrit and bleeding time in very low birth weight infants during the first week of life. Journal of Perinatology 21 368-371. 61. del Vecchio, A., Sola, M. C., Theriaque, D. W., Hutson, A. D., Kao, K. J., Wright, D., Garcia, M. C., Pollock, B. H., Christenson, R. D. (2001) Platelet transfusions in the neonatal intensive care unit: Factors predicting patients who will require multiple transfusions. Transfusion 41 803-808. 62. Krishna, S., Nagaraja, R., Planche, T., Agbenyega, T., Bedo-Addo, G., Ansong, D., Owusa- Oforia, A., Shroads, A. L., Henderson, G., Hutson, A., Derendorf, H., Stacpoole, S. (2001) Population pharmacokinetics of intramuscular quinine in children with severe malaria. Antimicrob Agents Chemother 45 1803-1809. 63. Lossie, A. C., Whitney, M. M., Amidon, D., Dong, H.J., Chen, P., Theriaque, D., Hutson, A., Nicholls, R. D., Zori, R. T., Williams, C. A. and Driscoll, D. J. (2001) Distinct phenotypes distinguish the molecular classes of Angelman syndrome. Journal of Medical Genetics 38 834-845. 15
  • 16. 64. Duncan, G. E., Hutson, A. D. and Stacpoole, P.W. (2001) QUICKI Does not accurately reflect changes in insulin sensitivity with exercise training. Journal of Clinical Endocrinology & Metabolism 9 4115-4119. 65. Stacpoole, P. W., Fisher, W. R., Flotte, T., Geiser, E. A. Theriaque, D. W., and Hutson, A. D. (2001) A Paradigm for Teaching Hypothesis-Oriented Thinking in Medical Education. The University of Florida's Clinical Investigation Program. Academic Medicine 76 287-292. 66. Sola, M. C., del Vecchio, A., Edwards, T. J., Suttner, D., Hutson, A. D. and Christensen, R. D. (2001) The relationship between hematocrit and bleeding time in very low birth weight infants during the first week of life. Journal of Perinatology. 21 368-371. 67. Perez, E. E., Rose, S. L., Peyser, B., Lamers, S. L., Burkhardt, B., Dunn, B. M., Hutson, A. D., Sleasman, J. W. and Goodenow, M. M. (2001) Human immunodeficiency virus type 1 protease genotype predicts immune and viral responses to combination therapy with protease inhibitors (PIs) in PI-naive patients. Journal of Infectious Diseases. 183 579-588. 68. Fishbein L., O'Brien P., Hutson A., Theriaque D., Stacpoole P., Flotte T. (2000) Pharmacokinetics and pharmacodynamic effects of nicotine nasal spray devices on cardiovascular and pulmonary function. Journal of Investigative Medicine 48 435-440. 69. Kauwell, G. P. A., Wilsky, C. E., Cerda, J. J.,Herrlinger-Garcia, K., Hutson, A. D., Theriaque, D. W., Boddie, A., Rampersaud, G. C., and Bailey, L. B. (2000) Methylenetetrahydrofolate Reductase Mutation (677C → T) Negatively Influences Plasma Homocysteine Response to Marginal Folate Intake in Elderly Women. Metabolism 49 1440-1443. 70. Rampersaud, G. C., Kauwell, G. P. A., Hutson, A. D., Cerda, J. J. and Bailey, L. B. (2000) Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. American Journal of Clinical Nutrition 72 998-1003. 71. Juul, S. E., Zhao, Y., Dame, B., Hutson, A. D. and Christenson, R. D. (2000) Origin and Fate of Erythropoietin in Human Milk. Pediatric Research 48 660-667. 72. Sola, M. C., Du, Y., Hutson, A., and Christenson, R. D. (2000) Dose-response relationship of megakaryocyte progenitors from the bone marrow of thrombocytopenic and non- thrombocytopenic neonates to recombinant thrombopoietin. British Journal of Haematology 110 449-453. 73. Kauwell, G. P., Lippert, B. L., Wilsky, C. E., Herringer-Garcia, K., Hutson, A. D., Theriaque, D. W., Rampersaud, G. C., Cerda, J. J., and Bailey, L. B. (2000) Folate Status of Elderly Women following Moderate Folate Depletion Responds Only to a Higher Folate Intake. Journal of Nutrition 130 1584-1590. 16
  • 17. 74. Sherman, J., Hutson, A., Baumstein, S. and Hendeles, L. (2000) Telephoning the patient's pharmacy to assess adherence with asthma medications by measuring refill rate for prescriptions, Journal of Pediatrics, 136 532-536. 75. Sola, M. C., Christenson, R. D., Hutson, A. D. and Tarantal, A. F. (2000) Pharmacokinetics, Pharmacodynamics and Safety of Administering Pegylated Recombinant Megakaryocyte Growth and Development Factor to Newborn Rhesus Monkeys. Pediatric Research 47 208-214. 76. Calhoun, D. A., Lunoe, M., Du, Y., Hutson, A. D., Young, J, Veerman, M. and Christenson, R. D. (2000) Granulocyte colony-stimulating factor (G-CSF) serum and urine concentrations in neutropenic neonates before and following the intravenous administration of recombinant G-CSF. Pediatrics 105 392-397. 77. Baggs, J. G., Schmitt, M. H., Mushlin, A. I., Mitchell P., Eldredge, D. H., Oakes, D. and Hutson, A. D. (1999) Association Between Nurse-Physician Collaboration and Patient Outcomes in Three Intensive Care Units. Critical Care Medicine 27 1991-1998. 78. Litherland, S. A., Xie, X. T., Hutson, A. D., Wasserfall, C., Whittaker, D. S., She, J., Hofig, A., Dennis, M. A., Fuller, K., Cook, R., Schatz, D., Moldawer, L. L., and Clare-Salzler, M. J. (1999) Abherrant Prostoglandin Synthase 2 Expression Defines an Antigen Presenting Cell Defect in Humans at Risk for Insulin Dependent Diabetes Mellitus. Journal of Clinical Investigation 104 515-523. 79. Sleasman, J. W., Nelson, R. P., Goodenow, M. M., Wilfert, D., Hutson, A., Bassler, M., Zuckerman, J., Pizzo, P. A. and Mueller, B. U. (1999) Immunoreconstitution after ritonavir therapy in children with human immunodeficiency virus infection involves multiple lymphocyte lineages. The Journal of Pediatrics 134 597-606. 80. Sola, M. C., Calhoun, D. Hutson, A., and Christenson, R. D. (1999) Plasma Thrombopoietin Concentrations in Thrombocytopenic and Non-Thrombocytopenic Patients in a Neonatal Intensive Care Unit. British Journal of Haematology 104 90-92. 81. Stacpoole, P. W., Bunch, T., Neiberger, R. M., Perkins, L. A., Quisling, R., Hutson, A. D., and Greer, M. (1999) The Importance of Cerebrospinal Fluid Lactate in the Evaluation of Congenital Lactic Acidosis. The Journal of Pediatrics 134 99-102. 82. Bonnette, R. E., Caudill, M. A., Boddie, A. M., Hutson, A. D., Kauwell, G. P. and Bailey, L. B. (1998) Plasma homocycst(e)ine concentrations in pregnant and nonpregnant women fed a folate controlled diet. Obstetrics & Gynecology, 92(2) 167-170. 83. Geiser, E. A., Wilson, D. C., Wang, D. X., Conetta, D. A., Murphy, J. D. and Hutson, A. D. (1998) Autonomous Epicardial and Endocardial Boundary Detection in Echocardiographic Short-axis Images. Journal of the American Society of Echocardiography, 11 338-348. 17
  • 18. 84. Caudill, M. A., Gregory, J. F., Hutson, A. D., and Bailey, L. B. (1998) Folate Catabolism in Pregnant and Nonpregnant Women Consuming Controlled Folate Intakes. Journal of Nutrition, 128 204-208. 85. Katz, P. R., Karuza, J., Kolassa, J., Hutson, A. (1997) Medical practice with nursing home residents: results from the National Physician Professional Activities Census. Journal of the American Geriatric Society, 45 911-917. 86. Baggs, J. G., Schmitt, M. H., Mushlin, A. I., Eldredge, D. H., Oakes, D. and Hutson, A. D. (1997) Nurse-Physician Collaboration and Satisfaction with the Decision-Making Process in Three Critical Care Units. American Journal of Critical Care 6 393-399. 87. Caudill, M. A., Cruz, A. C., Hutson, A. D., Gregory, J. F., and Bailey, L. B. (1997) Folate Status Response to Controlled Folate Intake in Pregnant Women. The Journal of Nutrition, 127 2363-2370. 88. King, V. Constine, L., Clark, D., Schwartz, R. G., Muhs, A., Henzler, M., Hutson, A., and Rubin, P. (1996) Symptomatic Coronary Artery Disease After Mantle Irradiation for Hodgkin's Disease. International Journal of Radiation Oncology Biology Physics, 36 881-889. Conference Proceedings 1. Mudholkar, G. S., Hutson, A. E. and Marchetti, C. E. (2003). The Hermitian estimator of the quantile function: Implications for the M-estimation of location, In Statistical Methods and Practice: Recent Advances (Eds., N. Balakrishnan, N. Kannan and M.R. Srinivasan), pp. 203-229, Narosa Publishing House, New Delhi, India. Abstracts 1. Iyer R, Khushalani N, Tan W, et al A phase II study of erlotinib in patients (pts) with advanced pancreatic cancer (APC) who are refractory to gemcitabine (G) EJC SUPPLEMENTS Volume: 7 Issue: 2 Pages: 391-391 Published: SEP 2009 2. Title: New CT treatment response score for predicting survival in patients with metastatic colorectal carcinoma: A pilot study Author(s): Fora A, Fakih M, Scheib S, et al. Source: JOURNAL OF CLINICAL ONCOLOGY Volume: 27 Issue: 15 Supplement: Suppl. S Meeting Abstract: e15026 Published: MAY 3. Parkman HP, Hutson A, Katz L, et al. Relationship of body mass index (BMI) to gastric emptying of digestible and nondigestible solidsNEUROGASTROENTEROLOGY AND MOTILITY 19 (5): 430-430 33 MAY 2007 4. Parkman HP, Hutson A, Katz L, et al.Improving analysis of gastric emptying tests using patient's age, gender, and body mass index NEUROGASTROENTEROLOGY AND MOTILITY 19 (5): 430-431 34 MAY 2007 5. Sarosiek I, Parkman H, Kuo B, et al. SmartPill as a unique tool for an insight into the relationship between transit times within the upper and the lower alimentary tract in health and disease. NEUROGASTROENTEROLOGY AND MOTILITY 19 (5): 432-432 39 MAY 2007 18
  • 19. 6. Weiss JR, Baer MR, Arnbrosone CB, Blanco JG, Hutson A, Ford LA, Moysich KB High concordance between pharmacogenetic analysis of bone marrow and buccal cell samples in acute myeloid leukemia. BLOOD 108 (11): 670A-670A 2364 Part 1 NOV 16 2006 7. Seereiter PJ, Guru KA, Sfakianos J, Hutson A, Mohler JL Is a cystogram necessary after robot-assisted radical prostatectomy? JOURNAL OF ENDOUROLOGY 20: A221-A221 Suppl. 1 AUG 2006 8. Parkman HP, Hutson A, Sarosiek I, Kuo B, Chey WD, Katz L, Semler J, McCallum RW SmartPill capsule for assessment of gastric emptying - Comparison with simultaneous gastric emptying scintigraphy AMERICAN JOURNAL OF GASTROENTEROLOGY 101 (9): S99- S99 168 Suppl. S SEP 2006 9. Jaworowicz D, Nie J, Bonner M, Han D, Vito D, Hutson A, Trevisan M, Muti P, Freudenheim JL Assessment of early life exposures: Agreement between self-reported birth weight and birth certificate weight. AMERICAN JOURNAL OF EPIDEMIOLOGY 163 (11): S31-S31 Suppl. S JUN 1 2006 10. Meguerditchian A, Huang H, Pak Y, Sossey-Alaoui K, Watroba N, Hutson A, Kulkarni S, Edge SB, Geradts J, Coignet LJ CD24/FLJ 13639 expression ratio predicts worse outcome in invasive breast cancer ANNALS OF SURGICAL ONCOLOGY 14 (2): 35-35 Suppl. S FEB 2007 11. Scannapieco, FA, Ng, PBY, Hovey, K., Hausmann, E., Hutson, A. and Wactawski-Wende, J. (2006) Salivary Biomarkers Associated with Alveolar Bone Loss 12. Angeles Alvarez Secord MD, Kathleen M. Darcy PhD, Alan Hutson PhD, Paula S. Lee MD, Laura J. Havrilesky MD, Lisa Grace, Andrew Berchuck MD (2004) Co-expression and Prognostic Relevance of Angiogenic Markers in Advanced Epithelial Ovarian Cancer: A Gynecologic Oncology Group (GOG) Study. 13. Angeles Alvarez Secord, MD, Kathleen M. Darcy PhD, Alan Hutson PhD, Paula S. Lee, MD, Elizabeth L. Jewell, MD, Laura J. Havrilesky, MD, Lisa A. Grace, Susan K. Murphy, PhD, Andrew Berchuck, MD (2005) The Role of Methylation in the Regulation of Angiogenic Inhibitors in Advanced Epithelial Ovarian Cancer: A Gynecologic Oncology Group Study 14. Quick SK, Nie J, Ambrosone CB, Shields PG, Muti P, Smit E, Hutson AD, Trevisan M, Freudenheim JL (2005) Effect modification by catalase genotype suggests a role for oxidative stress in the relationship between hormone replacement therapy (HRT) use and breast cancer risk. American Journal of Epidemiology 161 (11): S22-S22 15. Odunsi K, Wollman R, Ambrosone C, Hutson A, McCann S, Tammela J, Geisler J, Qian F, Keitz B, Intengan M, Lele S, Alderfer J (2004) Use of 1H-NMR-based metabonomics for detecting epithelial ovarian cancer. Journal of the Society for Gynecological Investigation. 11 4. 16. Crans DC, Yang LQ, Alfano JA, Austin LT, Jin WZ, Elliott CM, Gaidamauskas E, Godzala ME, Hutson AD, Kostyniak PJ, Willsky GR (2004) Chemical and insulin-enhancing properties of chromium and vanadium compounds: Bis(2,6- dipyridinecarboxylato)chromium(III) and 2,6-dipyridinecarboxylatodioxovanadate(V). Abstracts of Papers of the American Chemical Society. 225 23. 17. Saxonhouse, M.A., Sola, M.C., Ignatz, M.E., Pastos, K.M., Hutson, A.D., Christensen, R.D. and Rimsza, L.M. (2003) Reticulated platelet percentage and mean platelet volume changes in preterm neonates. Pediatric Research 53 1661 19
  • 20. 18. Chevuru, S.C., Christensen, R.D., Rimsza, L.M., Hutson, A.D., Theriaque, D.W. and Kays, D.W. (2003) Plasma thrombopoietin (Tpo) concentrations, circulating megakaryocyte progenitors and reticulated platelet percentages in neonates on extracorporeal membrane oxygenation (ECMO). Pediatric Research 53 2661 19. Edstrom CS, McBride J, Hutson AD, Tarantal AE, Christensen RD (2002) Pharmacodynamics of low molecular weight heparin in preterm and juvenile rhesus monkeys. Pediatric Research 51 250A 20. Chevuru, S.C., Sola, M.C., Theriaque, D.W., Hutson, A.D., Leung, W.C.W., Perez. J.A., Nelson. R.M., Kays, D.W. and Christensen, R.D. (2002) Multicenter analysis of platelet transfusion usage among neonates on extracorporeal membrane oxygenation. Pediatrics 109 e89. 21. Miller, J., Morales, A., Valledares, A., Hutson, A., Rosenbloom, A., and Silverstein, J. (2002) Comparison of glargine(gn) and traditional insulin regimens in a diabetes camp setting. Pediatric Research, 51 726. 22. Sola, M. C., Christensen, R. D., Du, Y. Hutson, A. D., Rimsza, L. M. (2002) Neonates fail to increase their marrow megakaryocyte mass in response to thrombocytopenia. Pediatric Research, 51 1410. 23. Ignatz, M. E., Saxonhouse, M. A., Sola, M. C., Pastos, K. M., Hutson, A. D., Christensen, R. D., Rimsza, L. M. (2002) Reticulated platelet percentages in non-thrombocytopenic neonates of different post-conceptional ages. Pediatric Research, 51 1411. 24. Saxonhouse, M. A., Rimsza, L. M., Stegner, J. J., Hutson, A. D., Du, Y., Christensen, R. D., Sola, M. (2002) Effects of acute hypoxia on CD34+ progenitor cells from cord blood. Pediatric Research, 51 1470. 25. Garcia, M. G., Chevuru, S. C., Saxonhouse, M. A., Theriaque, D. W., Hutson, A. D., Christensen, R. D., Sola, M. C. (2002) Effect of implementing platelet transfusion guidelines in a neonatal intensive care unit. Pediatric Research, 51 1794. 26. Chevuru, S. C., Christensen, R. D., Du, Y., Hutson, A. D., Rimsza, L.M., Theriaque, D.W., Kays, D.W. and Sola, M.C. (2002) Plasma thrombopoietin (Tpo) concentrations and the effect of recombinant Tpo on circulating megakaryocyte (MK) progenitors in neonates on extracorporeal membrane oxygenation (ECMO). Pediatric Research, 51 2261. 27. Bailey, L.B., Duhaney, R., Kauwell G.P.A., Maneval, D., Hutson, A., Davis, S., Quinlivan, E.P., and Gregory, J.F. (2002) Plasma homocysteine association with vitamin B12 and folate status in young women with combined polymorphisms (C677T/A1298C) of the methylenetetrahydrofolate reductase (MTHFR) gene. Faseb Journal, 16 A268-A268. 28. Duncan, G. E., Hutson, A., Stacpoole, P. W. (2001) QUICKI does not predict changes in insulin sensitivity with exercise changes. Diabetes, 50, A222-A223. 29. Del Vecchio, A., Sullivan, S. E., Christensen, R. D., Schibler, K., Hutson, A. D., Chevuru, S. C., Bartoli, A. N., Gasparini, C. and Sola, M.C. (2002) Indomethacin prolongs the bleeding time in neonates significantly more than ibuprofen. Pediatric Research, 51 2718. 30. Lossie, A. C., Whitney, M., Amidon, D., Hutson, A., Theriaque, D., Zori, R.T., Nicholls, R.D., Williams, C. A., and Driscoll, D. J. (2000) Genotype/Phenotype Correlations Among the 5 Molecular Classes of Angelman Syndrome. American Journal of Human Genetics, 67 1958. 31. Patel, P., Hutson, A., Sherman, J., Chesrown, S., Hendeles, L. (2000) Do Children With Asthma take Motelukast More Consistently Than Fluticasone Proionate? American College of Clinical Pharmacy 20
  • 21. 32. Saxonhouse, M. A., Sola, M. C., Hutson, A. D., Du, Y. and Christenson, R. D. (2000) The Concentration of Circulating Megakaryocyte Progenitors is a Function of Post-Conceptional Age in Preterm Neonates, and Predicts the Concentration of Megakaryocyte Progenitors in the Bone Marrow. Pediatric Research, 47, 1981. 33. Sola, M. C., del Vecchio, A., Edwards, T. J., Suttner, D., Hutson, A. D. and Christenson, R. D. (2000) A Low Hematocrit Prolongs the Bleeding Time of Very Low Birth-Weight Infants in the First Week of Life. Pediatric Research, 47, 2557. 34. Wilsky C.E., Kauwell G.P.A., Cerda J., Herrlinger-Garcia K., Hutson A., Boddie A. and Bailey L.B. (1999) Methylenetetrahydrofolate reductase (MTHFR) mutation (677C → T) negatively influences plasma homocysteine response to marginal folate intake in elderly women. FASEB Journal, A228-A228. 35. Rampersaud, G., Kauwell, G., Hutson, A., Bailey, L. (1999) Effect of Controlled Folate Intake on DNA Methylation Status in Postmenopausal Women. FASEB Journal, 13 A700- A700. 36. Kauwell G., Lippert B., Cerda J., Hutson A., Bailey L. (1999) Folate status response to controlled dietary folate intake in elderly women. FASEB Journal, 13 A890-A890. 37. Fishbein L., O'Brien P., Hutson A., Theriaque D., Stacpoole P., Flotte T. (1999) Pharmacokinetics and pharmacodynamic effects of nicotine nasal spray devices on cardiovascular and pulmonary function. FASEB Journal, 13 A809-A809. 38. Sola, M. C., Christenson, R. D., Roskos, L., Reiber, C., Hutson, A. D. and Tarantal, A. F. (1999) Pharmacokinetics, Pharmacodynamics and Safety of Administering Pegylated Recombinant Megakaryocyte Growth and Development Factor to Newborn Rhesus Monkeys. Pediatric Research, 45 153A-153A. 39. Sola, M. C., Du, Y., Hutson, A. D. and Christenson, R. D. (1999) Dose-Response Relationship of Megakaryocyte Progenitors from Bone Marrow and Peripheral Blood of Thrombocytopenic Neonate to Recombinant Thrombopoietin. Pediatric Research, 45 1558. 40. Sola, M. C., Calhoun, D. A., Hutson, A. D. and Christenson, R. D. (1999) Do Plasma Thrombopoietin Concentrations Predict the Kinetic Mechanism Responsible for Thrombocytopenia in Neonates? Pediatric Research, 45 226A-226A. 41. Stacpoole, P. W., Fisher, W. R., Flotte, T. R., Geiser, E. A. and Hutson, A. D. (1999) A GCRC-Based Paradigm for Teaching Hypothesis-Oriented Thinking in Medical School. Association for Patient-Oriented Research. 42. Stacpoole, P. W., Fisher, W. R., Flotte, T. R., Geiser, E. A. and Hutson, A. D. (1999) Student Research at U.S. Medical Schools. Association for Patient-Oriented Research. 43. Fishbein L., O'Brien P., Hutson A., Theriaque D., Stacpoole P., Flotte T. (1999) Pharmacokinetics and pharmacodynamic effects of nicotine nasal spray devices on cardiovascular and pulmonary function. Journal of Investigative Medicine, 47 189A-189A. 44. Litherland, S. A., Xie, T. X., Whittaker, D. S., Hutson, A. D., Schatz, D., Moldawer, L. L., and Clare-Salzer, M. J. (1998) Abherrant Monocyte Prostoglandin Synthase-2 (PGS2) Expression; A novel cellular marker for IDD risk. Diabetes, 47 834. 45. Sleasman, J. W., Nelson, R. P., Goodenow, M. M., Wilfert, D., Hutson, A., Heath-Chiozzi, M., Bassler, M., Zuckerman, J., Pizzo, P. A. and Mueller, B. U. (1997) Immunoreconstitution of CD45RA and CD45RO CD4(+) cells occurs independent of virologic response in HIV-1 infected children treated with ritonavir. Journal of Investigative Medicine 46 62-62. 21
  • 22. 46. Shepard, T. M., Almond, B., Hevia, A., Hutson, A. D., Stacpoole, P. W. and Flotte, T. (1998) Pharmacokinetics and pharmacodynamics of a nicotine nasal spray. Journal of Investigative Medicine, 46, 18A. 47. Clark, D., Rubin, P., Hutson, A., McDermott, M., Constine, L., and Nelson, D. (1993) Increased Incidence of Second Malignant Neoplasms (SMN) in Hodgkin's Disease: 30 Year Follow-up. International Journal of Radiation Oncology Biology Physics 27 233-234. 48. Cowens, J. W., Greco, W., Hutson, A., Sewernyak, K., and Kanter, P. (1990) Pharmacokinetics of Liposome Encapsulated Doxorubicin in the Mouse. Proceedings of the American Association for Cancer Research 31 381. Technical Reports Hutson, A. D. (2004) Bootstrap Smoothing Strategies Based on Uniform Spacings with Practical Applications. Department of Biostatistics, University at Buffalo. Hutson, A. D. (2000) A Painless Method for Standard Repeated Measures Power Calculations. Technical Report, Department of Statistics, University of Florida. Hutson, A. D., Fishbein, L., O'Brien, P. and Stacpoole, P. W. (2000) Accounting for Plasma Levels Below Detection Limits in a One-Compartment Zero-Order Absorption Pharmacokinetics Model. Technical Report 2000-02, Department of Statistics, University of Florida. Hutson, A. D. and Ernst, M. D. (1998) An Exact Method For Calculating the Bootstrap Percentiles of a Functional of Order Statistics. Technical Report 582, Department of Statistics, University of Florida. Mudholkar, G. S., Hutson, A. D., and Marchetti, C. E. (1996) A Simple Hermitian Estimator of the Quantile Function with an application to M-Estimators of Location. Department of Statistics and Biostatistics Technical Report 96/02, Department of Biostatistics, University of Rochester. Conference Sessions Organized Conference Council Stochastic Models in Reliability Engineering, Life Sciences and Operations Management. February 2010, Beer Sheva, Israel. Chair for IMS Mini-Meeting on Imaging, Classification, and Clustering Analysis. January 2001, Gainesville, FL. Program committee for Mathematical Methods in Biomedical Imaging. August 2000, San Diego, CA. Session organizer and presenter for the International Conference On Order Statistics & Extreme Values -Theory & Applications December 18 -20, 2000 Mysore, India 22
  • 23. Invited Talks 2010 SMRLO’10, Beer Sheva, Israel. “An Inversion Theorem Based Kernel Density Estimator for a Weighted Average and Difference of Weighted Averages with Applications” 2008 University of Kentucky “Order Statistics, Quantile Functions and the Bootstrap” 2008 Lung Cancer Symposium. Invited Discussant to “Special Populations” session. 2008 Roswell Park Cancer Institute/CRS “Statistical Design Issues in Clinical Trials” 2008 Roswell Park Cancer Institute/CRS subcommittee “Statistical Design Issues in Clinical Trials” 2007 Ohio State “The Tail Extrapolation Quantile Function Estimator” 2007 Gynecologic Oncology Group National Meeting. “UB/RPCI/GOG Biostatistics Relationships” 2007 Cornell University “Order Statistics, Quantile Functions and the Bootstrap” 2007 University at Buffalo. Department of Surgery retreat. “Clinical Trials: Statistical Design Issues” 2006 McMaster University “Order Statistics, Quantile Functions and the Bootstrap” 2006 University of Castilla-La Mancha, International Conference on Mathematical and Statistical Modeling in Honor of Enrique Castillo “A Multivariate Concomitant Order Statistics Based Approach to Density Estimation” 2005 Gynecologic Oncology Group National Meeting. “What do you mean, it's not feasible?” 2005 University at Buffalo. College of Pharmacy. “A Permutation Test Approach to Phase II Historical Control Trials with an Application to the Gynecologic Oncology Cooperative Group Setting” 2003 University at Buffalo. College of Medicine. Clinical Trials Bootcamp. 2003 Buffalo-Niagara Chapter of ASA. Presented talk entitled “Bootstrap Smoothing Strategies Based on Uniform Spacings with Practical Applications.” 2003 University of New York at Buffalo. Presented talk entitled “A Sequential Test Procedure for Monitoring a Singular Safety and Efficacy Outcome” 2002 State University of New York at Buffalo. Presented talk entitled “Exact Bootstrap Methods for Censored Data.” 23
  • 24. 2001 Roswell Park Cancer Institute at Buffalo, NY. Presented talk entitled “Extending Tobit Analysis for Modelling Markers of Disease.” 2001 National meeting for the Association of GCRC Biostatisticians at Atlanta. Presented talk 8/01 entitled “Co-Authorship with GCRC Clinicians: The University of Florida Experience and the Yale University Experience.” 2001 Indianapolis University Purdue University at Indianapolis. Presented talk 2/01 entitled “Order Statistics, Quantile Functions and the Bootstrap.” 2000 Cleveland Clinic Foundation. Presented talk 10/00 entitled “Order Statistics, Quantile Functions and the Bootstrap.” 2000 Upstate Medical University of New York. Presented talk 10/00 entitled “Two Interesting Collaborative Modelling Problems.” 1998 SRCOS/ASA Summer Research Conference. Presented talk 6/98 entitled “Estimation of Quantile Functions and Applications.” 1998 IISA International Conference. Presented talk 10/98 entitled “Calculating the Exact Bootstrap Mean and Variance of an L-estimator.” Scientific Review Committees Reviewer Commision Nacional De Investigacion Centifica Y Tecnologica (CONICYT) 2010 (Chile) Member NIH SEP special Study Section 2009 Reviewer Austrian Science Fund 2009 National Institute of Dental and Craniofacial Research Special Emphasis Panel 2009 Reviewer German Research Foundation (The Clinical Trials Programme) 2008, 2009 Member Roswell Park Cancer Institute CRPC Committee 2007- Member Roswell Park Cancer Institute CCSG Steering Committee 2005- Member Alliance Foundation Scientific Review Committee 2005- Ex-officio member Roswell Park Cancer Institute CCSG Biostatistics Resource Steering Committee 2005- Member Roswell Park Cancer Institute CCSG Microarray Resource Steering Committee 2005- Member DSMB for NIH sponsored Oral Cleft prevention trial 2007-2010. Member DSMB for FDA sponsored CoQ10 formulation trial 2006- Member Health of the Population Fellowship Review NIH Special Emphasis Panel 2006 Member NIH Special Study Section 2006 (Secondary Chair) Member NIH KNOD Study Section 2005-2007 Member Roswell Park Cancer Institute Scientific Review Committee, 2002-2007. Member Gynecologic Oncology Group (GOG) Protocol Development Committee, 2006- . Member Gynecologic Oncology Group (GOG) Protocol Committee, 2004-2006 . 24
  • 25. Member Gynecologic Oncology Group (GOG) Committee on Experimental Medicine, 2004-2008 . Member Gynecologic Oncology Group (GOG) Tissue Utilization Subcommittee , 2004- 2008. Member Gynecologic Oncology Group (GOG) Protocol 210 Subcommittee , 2004-2008 . Member of the NIH/NIAID Data Safety Monitoring Board for the Inner City Asthma Consortium (ICAC), Consortium of Food Allergy Research (COFAR) and Asthma and Allergic Disease Cooperative Research Centers (AADCRC), 2003- . Member of UF College of Nursing's Biobehavioral Research Center Pilot Core, 2001-2002. Member of UF's GCRC Advisory Committee, 1996-2002. Reviewer for Lupus Research Institute, Clinical Methodologies Task Force, 2002. University Committees University at Buffalo. Chair for two Assistant Professor search committees in Biostatistics (2002) Chair for one Professor search committee in Biostatistics (2002) Chair for one Assistant Professor search committee in Biostatistics (2003) Member on the Ad hoc Committee on Promotions to Clinical Ranks (2003) Member Academic Affairs Committee (2003-2004 ) Member Dean of Public Health and Health Professions search committee (2003) Member Chair of Social and Preventive Medicine search committee (2003) IRCAF Review Committee (2003) Undergraduate Curriculum Committee (2004- 2005) Chair for Assistant Professor Search Committee (2004) Chair for Assistant Professor Search Committee (2005) Chair for Associate Professor Search Committee (2005) Chair for Rehabilitation Science Chair Search Committee (2005-2006) Member Chair for Health Behavior Search Committee (2005-2006) MSTP Steering Committee (2005-2007) Undergraduate Education Advisory Council (2006-2007) Gifted Math Program Advisory Council (2006-) UB2020 Extreme Events Guiding Team (2006-2007) UB2020 Bioinformatics Guiding Team (2006-2007) Strategic Strengths Faculty Advisory Council (2006-) TaskForce to identify the infrastructure needs for the “Health and Wellness Across the Life Span” Strategic Strength (2007) Center of Excellence Executive Committee (2007-2008) Informatics Task Force (2007-2008) Member SPHHP/Law School Joint Faculty Search Committee (2007-2008) Member Assistant Professor Search Committee (2008) SPHHP Core Curriculum Committee (2008) Member Department of Pediatrics Chair Search Committee (2009) Member CTSA Steering and Planning Committee (2010) Book Reviews 25
  • 26. Reviewed Warren Gilchrist's draft manuscript on quantile functions that was accepted for publication. Reviewed one draft manuscript for Springer-Verlag. Reviewed three draft manuscripts for Duxbury Press. Refereeing Journal Articles Reviewed one paper for Epidemiology Reviewed one paper for the Journal of Hydrology Reviewed one paper for Annals of the Institute of Statistical Mathematics Reviewed one paper for Annals of Statistics Reviewed one paper for Cancer Immunology Immunotherapy Reviewed one paper for Australian and New Zealand Journal of Statistics Reviewed one paper for Statistics Reviewed one paper for Clinical Trials Reviewed one paper for Annals of Epidemiology. Reviewed five papers for Communications in Statistics Reviewed seven papers for Statistics in Medicine. Reviewed four papers for Computational Statistics and Data Analysis. Reviewed two papers for Computer Methods and Programs in Biomedicine. Reviewed one paper for Journal of Statistical Computation and Simulation. Reviewed two papers for Journal of the American Statistical Association. Reviewed two papers for Journal of the Royal Statistical Society-Series B. Reviewed two papers for The Journal of Multivariate Analysis. Reviewed one paper for Lifetime Data Analysis. 26
  • 27. Reviewed one paper for JABES. Reviewed one paper for JASN. Reviewed four papers for Journal of Statistical Planning and Inference. Reviewed one paper for Biometrics Journal. Reviewed two papers for Biometrics. Reviewed one paper for Technometrics. Reviewed one paper for Journal of Computational and Applied Mathematics. Tenure and Promotion Reviews Letter for promotion to Full Professor at the University of Kansas Letter for promotion to Full Staff at St. Jude’s Children’s Hospital Letter for tenure and promotion to Associate Professor at the University of Pittsburgh Evaluation of Professor, Northwest University, South Africa Letter for promotion to Research Associate Professor at the University of Pittsburgh Teaching Activities Applied Statistics for the Social Sciences, University of Rochester (1994,1995) Introduction to Biostatistics, University of Florida (1997, 1998, 1999) Advanced Topics in Biostatistics, University of Florida (1999) Research Design and Biostatistics for Physician Assistants, University of Florida (1998) Science of Clinical Research, University of Florida (1996-2001) Special Topics (bootstrap methods), University at Buffalo (2004, 2008) Regression Analysis, University at Buffalo (2004, 2008) Survival Analysis, University at Buffalo (2005) Methods of Clinical Research (team taught), University at Buffalo/RPCI 2007 Special Topics (advanced bootstrap methods), University at Buffalo (2008) 27
  • 28. Grants and Contracts Active 2P30 CA16056 (Trump/Wilding, PI) 05/01/08-04/30/13 NIH/NCI-RPCI (subcontract) Cancer Center Support Grant The major goal of this project is to provide biostatistical support for cancer clinical trials. Role on Project: Biostatistics Core Resource Director 5U10CA037517-22 (Blessing-PI) 04/01/10-03/31/11 NIH/NCI Gynecologic Oncology Group Statistical andData Center (GOG SDC) The major goal of this project is to provide biostatistical support for cancer clinical trials. Role on Project: Biostatistician 5R01 CA 127162-02 (Demant-PI) 04/04/08-01/31/12 NIH Hosts Genes that Control Lymphocyte Infiltration of Tumors The first step toward studying function of Lynf genes and their molecular identification is establishment of their chromosomal location with a precision of 1-2 cM or less and generation of congenic lines carrying these short segments on O20 background. Role on Project: Biostatistician R01-CA116673-02 (Marshall-PI) 01/10/07-12/31/10 NIH Clinical Trial of Selenium and Prostate Biomarkers The goal of this study is to evaluate the short-term impact of selenium supplementation on androgen signaling among human subjects. Role on Project: Biostatistician (Johnson-PI) 07/01/09-06/30/14 NIH-RPCI (subcontract) Anti-Tumor Mechanisms and Therapeutic Effects of Vitamin D The overall goal of this study is to examine the mechanisms of vitamin D anti-tumor activity either alone or in combination with platinum agents and to determine whether these effects can be exploited for therapeutically. Role on the Project: Biostatistician 2R01 CA 095045-06 (Johnson-PI) 28
  • 29. NIH 09/15/08-07/31/13 Vitamin D in Prostate Cancer: Tumor Vasculature Brief description of project’s goals: The major goal of this study is to examine the effect of calcitriol both pre-clinically and clinically on tumor vasculature. Role: Statistician 1R01 CA137649-01-A1 (Pili-PI) HRI 04/01/09-03/31/11 Enhancing Renal Cell Carcinoma Response to IL-2 with the HDAC Inhibition The principal objective of the proposed research is to determine the therapeutic potential of modulating immune response with novel combination strategies involving HDAC inhibitors for the treatment of RCC. Our central hypotheses are that 1) targeting HDAC has shown preclinical and clinical activity in RCC;2) HDAC inhibitors have immunomodulatory properties by regulating specific subsets of T lymphocytes; and 3) there is a need to implement immunotherapies for RCC. NWU08-11-01 (Reid-PI) HRI 09/01/09-08/31/10 A Phase I Study of Eriotnib in Patients with Permalignant Lesions of the Lung The overall goal of this trial is to determine the optimal biological dose of erlotinib that can be given to patients who are a high risk of lung cancer that will maximize the efficacy of erlotinib on lung tissue and minimize the impact of toxicity on these patients. Previous Endogenous hormones and premenopausal breast cancer risk, NIH, Co-Inv Alan Hutson Oral Health and Ventilator-Associated Pneumonia, NIH, Co-Inv Alan Hutson Salivary Biomarkers to Predict Alveolar Bone Loss, NIH, Co-Inv Alan Hutson Hibernating Myocardium and Sudden Cardiac Death, NIH, Co-Inv Alan Hutson Genetic Markers of CHD in Men and Women, NIH, Co-Inv Alan Hutson Fasting glucose in long-term breast cancer survival , NIH, Co-Inv Alan Hutson NYSTAR Faculty Development grant. PI Alan Hutson The General Clinical Research Center National Institutes of Health/National Center for Research Resources, NIH and NCRR, Co-Inv Alan Hutson. Estimation of quantile functions and applications, CLAS Research Initiation Project, University 29
  • 30. of Florida, PI Alan Hutson. Velopharyngeal Function for Speech After Palatal Surgery, NIH, Biostatistician Alan Hutson Pathobiology and treatment of malaria in Africa, WHO and NIH, Co-PI Alan Hutson. HIV-1 variants within PBMC subpopulations in infants, NIH, Co-Inv Alan Hutson. Dose response to exercise and cardiovascular health, NIH, Co-Inv Alan Hutson. Folate requirements of pregnant human subjects, NIH, Co-Investigator Alan Hutson. Thrombocytopenia in patients in the neonatal intensive care unit, Co-Inv Alan Hutson. Pathogenesis and treatment of thrombocytopenias of neonates, Biostatistician Alan Hutson. Activity-dependent Plasticity after Spinal Cord Injury, Collaborator Alan Hutson. The Role of Alpha Defensins in Cystic Fibrosis Lung Disease, NIH, Consultant Alan Hutson. Mitochondrial Encephalomyopathies and Mental Retardation, NIH, Co-Inv Alan Hutson. Dichloracetate treatment of congenital lactic acidosis, FDA, Co-Inv Alan Hutson. The detection of early renal dysfunction in Type I Diabetes Mellitus (DM) by correlation of macrophage prostaglandins (PGs) production and renal hyperfiltration (RHF), NIH, Consultant Alan Hutson. Human kinetics and metabolism of disinfection by-products of water chlorination, EPA, (funding pending the result of another study) Statistical Consultant Alan Hutson. Folate requirements by MTHFR genotype for nonpregnant women, USDA, Biostatistician Alan Hutson. Evaluating the role of PGS2 expression in IDDM for use in risk assessment and therapeutic intervention,UF College of Medicine, Consultant Alan Hutson. Arginine & immune status in elderly with pressure ulcers, NIH, Statistician Alan Hutson. Development of mechanisms of fetal/neonatal cytopenias, NIH, Statistician Alan Hutson. Central nervous system modulation of visceral pain in Persian Gulf War Syndrome, VA, Consultant Alan Hutson. Novel urine markers of disease activity in SLE, NIH, Biostatistician Alan Hutson 30
  • 31. K Award Mentoring Scott Stewart (Co-Mentor) K23 Richard Blondell (Co-Mentor) K23 Krishnan Raghavendran (Co-Mentor) K23 Chukwumere Nwogu (Collaborator) K23 Graduate Students Outside Reader Abhijit Bhuyan, Tezpur University 2010 Committee Member Chukwumere Nwogu, Roswell Park Graduate Division (current) Committee Member David Cavanaugh, M.A. Biostatistics 2010 Committee Member Rameela Chandrasekhar, Ph.D. Biostatistics (current) Committee Member Wei Deng, Ph.D. Biostatistics (current) Chair, William Brady, Ph.D. Biostatistics (current) Committee Member Vijay Jayaprakash, Ph.D. Epidemiology (2009) Chair, Dongliang Wang, Ph.D. Biostatistics (2010) Chair, Terry Mashtare, Ph.D. Biostatistics (2009) Chair, Owusu Asubonteng, Ph.D. Biostatistics (2009) Committee Member, Chung Chun Lin, Ph.D., Industrial Engineering (current) Committee Member Xueya Cai, Ph.D. Biostatistics (2008) Committee Member Sylvia Quick, Ph.D. Biostatistics (2008) Committee Member Youngju Pak, Ph.D. Biostatistics (2007) Committee Member, Tania Das, MPH (emphasis in Biostatistics) (2006) Committee Member, Patricia Ng, M.S., Biomedical Sciences (2005) Project Advisor, Mark Legg, M. S. in Mathematics (2005) Committee Member, Jennifer Helferich, M.S. in Pharmacology And Toxicology 2004 Committee Member, Terry Mashtere, Ph.D. Biostatistics (current) 31
  • 32. Committee Member, Zena Hyman, Ph.D. Nursing (current) Committee Member, Silvia Quick, Ph.D. in Epidemiology (current) Chair, David Lawrence, Ph.D. in Statistics (2004) Co-Chair, Patrick Bradshaw, M.Stat. in statistics 2001 Co-Chair, Yongyi Min, Ph.D. in statistics 2001 Committee Member, Jeffrey Thompson, Ph. D. in statistics 2001 Committee Member, Ramona Greig, Ph.D. in nursing 2001 Committee Member, Carrie Chapman, M.S. in nutrition 2001 Committee Member, Judith Wolfe, M.S. in nutrition 2001 Committee Member, Robert Duhaney, M.S. in nutrition 2001 Committee Member, Dale Ostler, Ph. D. in audiology 2000 Committee Member, Susan Keesling, M.S. in nutrition 2000 Committee Member, Martin Ward, Ph.D. in clinical psychology 1996 32

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