Richard S. Blumberg, M.D.
                              CURRICULUM VITAE

PART I:                       General Informatio...
Richard S. Blumberg, M.D.
      1986-1987             Clinical Fellow in Medicine, Harvard Medical School, Boston,
       ...
Richard S. Blumberg, M.D.
Hospital and Health Care Organization Service Responsibilities:

      1989-                 Gas...
Richard S. Blumberg, M.D.
                            Affiliated Institutions:

      1993                  Thorn Research...
Richard S. Blumberg, M.D.
      1997                                  Special Emphasis Panel, Chronic Intestinal
         ...
Richard S. Blumberg, M.D.

       Other

       1999                 Ad Hoc Reviewer, Wellcome Trust, United Kingdom
     ...
Richard S. Blumberg, M.D.
                            of the AGA
      1993                                 Chair,        ...
Richard S. Blumberg, M.D.
                            2002                 Member,        International    Scientific
    ...
Richard S. Blumberg, M.D.
                            2003               Symposium Chair, 36th Annual Meeting of
         ...
Richard S. Blumberg, M.D.
      2003-                 Editorial Board, Drug Discovery Today: Disease Models

Awards and Ho...
Richard S. Blumberg, M.D.
PART II:     Research, Teaching, and Clinical Contributions

A.    Narrative Report:

      Rese...
Richard S. Blumberg, M.D.
      of Immunology. In the latter capacity, I have served as a Ph.D. thesis advisor on two
    ...
Richard S. Blumberg, M.D.
                                    Intestinal Transcytosis of IgG in Adult Life

              ...
Richard S. Blumberg, M.D.
                    1999-2004             NIH/K08 Mentor to Hyun Sil Kim, M.D.
                 ...
Richard S. Blumberg, M.D.
                            12 graduate students
                            15 hours/year

    ...
Richard S. Blumberg, M.D.
                            15 hours/year

             1989           Morbidity and Mortality W...
Richard S. Blumberg, M.D.
             2003-                 Housestaff Mentoring Program
                                ...
Richard S. Blumberg, M.D.
                            Dr. Daniel Podolsky (MGH) and Dr. Thomas Lamont (BIDMC).
           ...
Richard S. Blumberg, M.D.
             1996-1998      K. Somnay-                  Asst. Prof. of Medicine, SUNY
          ...
Richard S. Blumberg, M.D.
             2003-          Flavio Rocha, M.D.        Research Fellow, BWH
             2004-   ...
Richard S. Blumberg, M.D.

      1993          Invited lecture; "Molecular characterization of IEL - T cell interactions";...
Richard S. Blumberg, M.D.
                    enterocyte interactions"; Keystone Symposium Conference on Mucosal
         ...
Richard S. Blumberg, M.D.
                    Invited speaker; "Characterization of T cell receptor repertoire in
        ...
Richard S. Blumberg, M.D.
                    Invited  speaker;   "Lympho-epithelial    cross-talk in mucosal
            ...
Richard S. Blumberg, M.D.
                    lymphocytes (iIEL)”; Digestive Diseases Week and the 98th Annual
           ...
Richard S. Blumberg, M.D.
                    Invited speaker; “Intestinal epithelial cell-T cell interactions”; Annual
  ...
Richard S. Blumberg, M.D.

                    Invited speaker; “The multiple roles of MHC class I-like molecules in
     ...
Richard S. Blumberg, M.D.
                    present glycolipid antigens to natural killer (NK)-T cells in a CD1d-
      ...
Richard S. Blumberg, M.D.
                    Invited speaker; “Impaired function of NK-T cells in EBI3-deficient
        ...
Richard S. Blumberg, M.D.
                    Invited speaker; “T cell regulatory functions of CEACAM1”; Division of
     ...
Richard S. Blumberg, M.D.
                    antibody complexes across epithelial barriers”; Jackson Laboratory, Bar
    ...
Richard S. Blumberg, M.D.
                    School of Molecular Medicine, Rotterdam, The Netherlands

                  ...
Richard S. Blumberg, M.D.
                    Invited speaker; “CD1d-microsomal triglyceride transfer protein
            ...
Richard S. Blumberg, M.D.
      3.             Description of Teaching Awards

      1995           Nominee, Harvard Medic...
CURRICULUM VITAE.doc
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  1. 1. Richard S. Blumberg, M.D. CURRICULUM VITAE PART I: General Information DATE PREPARED: MAY 9, 2005 Name: Richard Steven Blumberg Office Address: Brigham and Women’s Hospital 75 Francis Street Boston, MA 02115 Home Address: 34 LaGrange Street Chestnut Hill, MA 02467 E-Mail: rblumberg@partners.org Fax: (617) 264-5185 Place of Birth: Philadelphia, PA Education: 1974 B.S. Carnegie-Mellon University, Pittsburgh, PA 1979 M.D. Jefferson Medical College of the Thomas Jefferson University, Philadelphia, PA 1993 M.B.A. Graduate School of Business Administration, Northeastern University, Boston, MA Postdoctoral Training: Internships and Residencies: 1979-1981 Internship and Residency in Internal Medicine, The New York Hospital, Cornell Medical Center, New York, NY 1981-1982 Assistant Chief Medical Resident in Internal Medicine, The New York Hospital, Cornell Medical Center, New York, NY Clinical and Research Fellowships: 1982-1983 Clinical Fellow in Medicine, Infectious Diseases, Massachusetts General Hospital, Boston, MA 1982.1986 Research Fellow in Medicine, Harvard Medical School, Boston, MA 1983-1986 Research Fellow in Medicine (Mentor: Robert T. Schooley, M.D.), Infectious Diseases, Massachusetts General Hospital, Boston, MA 1986-1987 Clinical Fellow in Medicine, Gastroenterology, Brigham and Women's Hospital, Boston, MA 1
  2. 2. Richard S. Blumberg, M.D. 1986-1987 Clinical Fellow in Medicine, Harvard Medical School, Boston, MA 1987-1989 Research Fellow in Medicine, Harvard Medical School, Boston, MA 1987.1989 Research/Clinical Fellow in Medicine, Gastroenterology, Brigham and Women's Hospital, Boston, MA 1987.1990 Research Fellow in Medicine, Laboratory of Molecular Immunology (Mentor: Cox P. Terhorst, Ph.D.), Dana-Farber Cancer Institute, Boston, MA Licensure and Certification: 1979-1982 New York Medical License 1980 Diplomate, National Board of Medical Examiners 1982 Diplomate, American Board of Internal Medicine 1983- Massachusetts Medical License 1986 Diplomate, American Board of Internal Medicine, Infectious Diseases 1989 Diplomate, American Board of Internal Medicine, Gastroenterology Academic Appointments: 1990.1991 Instructor in Medicine, Harvard Medical School, Boston, MA 1991.1996 Assistant Professor of Medicine, Harvard Medical School, Boston, MA 1996-2005 Associate Professor of Medicine, Harvard Medical School, Boston, MA 2005- Professor of Medicine, Harvard Medical School, Boston, MA Hospital or Affiliated Institution Appointments: 1989.1996 Associate Physician, Brigham and Women's Hospital, Gastroenterology Division, Boston, MA 1990- Consultant Staff, VA Boston HealthCare System, Boston, MA 1996- Physician, Brigham and Women's Hospital, Gastroenterology Division, Boston, MA 1996- Consultant Staff, Dana-Farber Cancer Institute, Boston, MA Other Professional Positions and Major Visiting Appointments: 1983.1986 Consultant in Medicine, Massachusetts Eye & Ear Infirmary, Boston, MA 1999- Scientific Founder, Syntonix Pharmaceuticals, Waltham, MA 2000- Scientific Advisory Board, GenPat77, Berlin, Germany 2
  3. 3. Richard S. Blumberg, M.D. Hospital and Health Care Organization Service Responsibilities: 1989- Gastroenterology Consult Service Attending, Brigham and Women's Hospital, Boston, MA 1989- Gastroenterology Endoscopy Service Attending, Brigham and Women's Hospital, Boston, MA 1990- Medicine Consult Service Attending, Brigham and Women's Hospital, Boston, MA Major Administrative Responsibilities: 1990- Director, Laboratory of Mucosal Immunology, Brigham and Women's Hospital, Boston, MA 1996.1998 Director of Gastroenterology Research, Brigham and Women's Hospital, Boston, MA 1997.1998 Acting Chief, Gastroenterology Division, Brigham and Women’s Hospital, Boston, MA 1998- Program Director, Categorical Fellowship Program in Gastroenterology, Brigham and Women’s Hospital, Boston, MA 1998- Chief, Gastroenterology Division, Brigham and Women’s Hospital, Boston, MA 1999.2000 Acting Chief, Gastroenterology Division, VA Boston HealthCare System, Boston, MA 1999- Training Grant Director, Gastroenterology Division, Brigham and Women’s Hospital, Boston, MA 2002-2005 Chairperson, National Scientific Advisory Committee, Crohn’s & Colitis Foundation of America Major Committee Assignments: Medical School: 1993- Member, Committee on Immunology, Harvard Medical School, Boston, MA 1995-1997 Member, Committee for Qualifying Examinations in Immunology, Harvard Medical School, Boston, MA 1996- Member, Harvard Skin Disease Research Center, Harvard Medical School, Boston, MA 1996.1997 Member, Executive Committee, Harvard Digestive Diseases Center, Harvard Medical School 1996- Co-Director, Harvard Digestive Diseases Center, Harvard Medical School 2001-2006 Xenotransplantation Advisory Committee, Harvard Medical School 3
  4. 4. Richard S. Blumberg, M.D. Affiliated Institutions: 1993 Thorn Research Committee, Brigham and Women's Hospital, Boston, MA 1994-1998 Gastroenterology Training Program Advisory Committee, Brigham and Women's Hospital 1996-1998 Member, Research Council, Brigham and Women's Hospital 1997.1998 Member, Practice Infrastructure Committee, Brigham and Women's Hospital 1997-1998 Member, Translational Research Committee, Brigham and Women's Hospital 1997- Advisory Board, Research Enhancement and Award Program, Research and Training in Swallowing and Motility Disorders (REAP), West Roxbury Veterans Administration Medical Center 1998 Internal Residency Review Committee, Neuropathology Residency Training Program, Brigham and Women’s Hospital 1999- Affiliate Member, Membrane Biology Program, Brigham and Women’s Hospital 2000 Internal Residency Review Committee, Obstetrics and Gynecology Residency Training Program, Brigham and Women’s Hospital 2000-2002 Advisory Committee, DNA Microarray Biotechnology Center, Brigham and Women’s Hospital 2002-2003 Member, Search Committee for Chief of Gastroenterology, Children’s Hospital Medical Center, Boston, MA 2003-2004 Junior Staff Appointment and Promotion Committee, Brigham and Women’s Hospital 2004 Ad hoc member, Partners Internal Technical Assessment Committee (ITAC) International, National and Regional: National Institutes of Health 1993 Special Emphasis Panel, Pathogenesis of Inflammatory Bowel Disease and Celiac Disease, National Institute of Health 1994 Special Emphasis Panel, Chronic Intestinal Inflammation- Mechanisms and Effects, National Institutes of Health 1994 Special Emphasis Panel, The Pathogenesis of Wasting and AIDS, National Institutes of Health 1995 Special Emphasis Panel, IBD: Genetic and Immunopathologic Mechanisms, National Institutes of Health 1995 GMA-2 Study Section (ad hoc), National Institutes of Health, (NIIDDK) 1996 Special Emphasis Panel, Mucosal and Synovial Gene Transfer, National Institutes of Health 1996-2000 Member, Immunological Sciences Study Section, National Institutes of Health (NIAID) 4
  5. 5. Richard S. Blumberg, M.D. 1997 Special Emphasis Panel, Chronic Intestinal Inflammation -- Mechanisms and Effects, National Institutes of Health 1998 Special Emphasis Panel, AIDS Biliary Disease, Prevalence, Etiology and Therapy, National Institutes of Health 1999 Special Emphasis Panel, Chronic Intestinal Inflammation – Mechanism & Effects, National Institutes of Health 1999 Special Emphasis Panel, Mucosal Immunology, National Institutes of Health 1999 Special Emphasis Panel, Immunogenetic Mechanisms of Experimental Colitis, National Institutes of Health, Site Visit, Charlottesville, VA 1999 Special Emphasis Panel, AIDS and Related Research Review Group, National Institutes of Health 2000 Special Emphasis Panel, IBD: Genetics and Immunopathology, National Institutes of Health 2000 Special Emphasis Panel, GMA-2 Study Section, National Institutes of Health 2002 Special Emphasis Panel, “Growth Hormone and Crohn’s Disease: Multicenter Study”, National Institutes of Health 2002 Special Emphasis Panel, GMA-2 Study Section, National Institutes of Health 2002 Ad Hoc Member, Scientific Review Committee, Immune Tolerance Network, National Institutes of Health 2003 Special Emphasis Panel, GMA-2 Study Section, National Institutes of Health 2003 Ad Hoc Member, Allergy and Immunology Study Section, National Institutes of Health 2004 Special Emphasis Panel, Innate and Adaptive Microbial Immunity in IBD, National Institutes of Health Crohn’s & Colitis Foundation of America 1993-1996 Research Chairman, Boston Chapter, Crohn's & Colitis Foundation of America 1993.1996 Member, Grants Review Committee, Crohn's & Colitis Foundation of America 1996 Committee Chair, "Challenges in IBD Research-Immune Regulation: Response to Pathogen", Crohn's & Colitis Foundation of America 1997-2000 Co-chairman, Grants Review Committee, Crohn's & Colitis Foundation of America 1999-2002 Chairman, Grants Council, National Scientific Advisory Committee, Crohn’s & Colitis Foundation of America 2000-2002 Research Initiatives Committee, Crohn’s & Colitis Foundation of America 2002 Committee Chair, Strategic Plan: Bacterial-Host Interactions, Crohn’s & Colitis Foundation of America 5
  6. 6. Richard S. Blumberg, M.D. Other 1999 Ad Hoc Reviewer, Wellcome Trust, United Kingdom 1999 Ad Hoc Reviewer, The Israel Science Foundation, The Israel Academy of Sciences and Humanities 1999 Organizing Committee, New Frontiers in Oral Immunological Diseases, Lillehammer, Norway. 2001-2002 Main Scientific Organizing Committee, Falk Symposium, Mechanisms of Intestinal Inflammation: Implications for Therapeutic Interventions in IBD, Berlin, Germany 2001 Ad Hoc Review Committee, Crohn’s in Childhood Research Association, Surrey, United Kingdom 2001- Clinical Immunology Society, Vice-Chair, Mucosal Immunology Interest Group 2002 Ad Hoc Review Committee, GRASP Digestive Diseases Research Center, Tufts/New England Medical Center 2002 Ad Hoc Reviewer, John Sealy Memorial Endowment Fund for Biomedical Research, University of Texas Medical Branch at Galveston, TX 2002 Main Organizer, Keystone Meeting, Microbial- Epithelial-Lymphocyte Interactions in Mucosal Immunology, Breckenridge, CO 2003- Ad Hoc Reviewer, Broad Medical Research Program 2003- Chair, Scientific Advisory Committee, Genetic and Immunopathologic Mechanisms Program Project Grant, University of California, Los Angeles 2003- Internal Advisory Board, Center for Experimental Therapeutics & Reperfusion Injury, Brigham and Women’s Hospital, Boston 2003- Member, Scientific Advisory Committee, Program Project Grant “Cellular and Molecular Mechanisms of Autoimmunity,” Mt. Sinai Hospital, New York 2003-2004 Organizing Scientific Committee, European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), “Gut inflammation: impact on GI and systemic diseases”, Capri, Italy 2003-2005 Organizing Scientific Committee, Falk Symposium, “Gut- Liver Interactions in Immunology,” Innsbruck, Austria 2004 Ad Hoc Reviewer, Science Foundation Ireland Professional Societies: American Gastroenterological Association (AGA) 1989- Member, AGA 1992 Chair, Immunology/Microbiology/Inflammatory Disorders Session, Annual Meeting of the AGA 1992-1998 Member, Abstract Selection Committee, Annual Meeting 6
  7. 7. Richard S. Blumberg, M.D. of the AGA 1993 Chair, T cells - Differentiation/Activation/Interactions Session, Annual Meeting of the AGA 1993- Chair, Gastrointestinal T cells Session, Annual Meeting, AGA 1993-1996 Member, Publications Committee, AGA 1995 Chair, Epithelial Cell Function in Immunity and Inflammation Session, Annual Meeting of the AGA 1995 Member, AGA Core Curriculum Task Force 1996 Chair, Abstract Selection Committee on Mucosal Immunity, AGA 1996 Chair, Epithelial Cell Function in Immunity and Inflammation Session, Annual Meeting of the AGA 1997 Chair, T Cells: Immunology and Inflammatory Bowel Disease Session, Annual Meeting of the AGA 1998 Chair, Inflammatory Bowel Disease: Basic Mechanisms Session, Annual Meeting of the AGA 1998-2000 Vice-Chair Elect, Immunology, Microbiology and Inflammatory Bowel Disease Section, AGA 2000-2002 Vice-Chair, Immunology, Microbiology and Inflammatory Bowel Disease Section, AGA 2000 Chair, Plenary Session; Immunology, Microbiology and Inflammatory Bowel Disease Section, Annual Meeting, AGA 2000 Co-Chair, Distinguished Abstract Plenary Session: Immunology, Microbiology and Inflammatory Bowel Disease Section, AGA 2001 Member, AGA Distinguished Achievement Award Selection Committee 2002-2003 Chair, Immunology, Microbiology and Inflammatory Bowel Diseases Section, AGA 2002 Co-Chair, Distinguished Abstract Plenary Session: Immunology, Microbiology and Inflammatory Bowel Disease Section, AGA 2003-2004 Member, Nominating Committee, AGA 2003 Co-Chair, Distinguished Abstract Plenary Session: Immunology, Microbiology and Inflammatory Bowel Disease Section, AGA 2004 Co-Chair, Distinguished Abstract Plenary Session: Immunology, Microbiology and Inflammatory Bowel Disease Section, AGA 2004 Chair, Abstract Review Section on Epithelial-Immune Interactions, Immunology, Microbiology and Inflammatory Bowel Diseases Section, AGA Society of Mucosal Immunology (SMI) 1991- Member, SMI 1994 Member, Organizing Committee, 8th International Congress of Mucosal Immunology, SMI 1995-1998 Member, Nominations Committee, SMI 1996 Member, Organizing Committee, 9th International Congress of Mucosal Immunology, SMI 7
  8. 8. Richard S. Blumberg, M.D. 2002 Member, International Scientific Committee, 11th International Congress of Mucosal Immunology, SMI 2002- Member, Governing Board, SMI 2002-2005 Main Organizer, 12th International Congress of Mucosal Immunology, SMI, Boston, MA Gastroenterology Research Group (GRG) of the American Gastroenterological Association 1993- Member, GRG 1998 Organizer and Chair, GRG Annual Symposium: Immuno- pathogenesis, Therapy and Prevention of Hepatitis C Virus Infection. 1998-2001 Member, GRG Steering Committee 2000 Organizer and Chair, GRG Symposium, Animal Models of Inflammatory Bowel Diseases Federation of Clinical Immunology Societies (FOCIS) 1993- Member, Clinical Immunology Society 2000 Member, Organizing Committee, FOCIS First Annual Meeting, Boston 2001 Chair, Mucosal Immunology, FOCIS Meeting 2002 Member, Organizing Committee, FOCIS Second Annual Meeting, San Francisco 2002- Member, Steering Committee, FOCIS 2002-2005 Councilor, Clinical Immunology Society 2003 Member, Program Committee, FOCIS Third Annual Meeting, Paris, France 2004 Member, Program Committee, FOCIS Fourth Annual Meeting, Montreal, Canada 2004-2005 Program Co-Chair, FOCIS Fifth Annual Meeting, Boston American Association of Immunologists (AAI) 1991- Member, AAI 2003Co-Organizer and Chair, Major Symposium on Mucosal Immunity, Annual Meeting, AAI 2004Organizer and Chair, Guest Symposium on Mucosal Immunity, Annual Meeting, AAI Other 1982-1989 Member, American College of Physicians 1989- Fellow, American College of Physicians 2000-2003 Member, National Intercollaborative Research Effort (N.I.C.E.) Foundation 8
  9. 9. Richard S. Blumberg, M.D. 2003 Symposium Chair, 36th Annual Meeting of the Society of Leukocyte Biology, “Cellular Mechanisms in Inflammation (Lymphocytes/NK Cells),” Philadelphia, PA Community Service Related to Professional Work: 1994.1995 Organizer, New England Symposium on Inflammatory Bowel Disease, Crohn’s & Colitis Foundation of America 1998- Board of Directors, New England Chapter, Crohn’s & Colitis Foundation of America 2002- Board of Trustees, Crohn’s & Colitis Foundation of America 2003- Founding Board of Scientists, International Autoimmune Disease Research Foundation (IADRF) Editorial Boards: 1990- Ad hoc reviewer for: Gastroenterology Journal of Immunology Journal of Clinical Investigation Journal of Experimental Medicine Digestive Diseases and Sciences New England Journal of Medicine Clinical and Experimental Immunology Infection and Immunity Journal of Biological Chemistry Molecular Immunology Science American Journal of Pathology Journal of Clinical Microbiology Hepatology DNA Nature Medicine Biochemica et Biophysica Acta Tissue Antigens Biochemistry Journal of Allergy and Clinical Immunology International Immunology Proceedings of the National Academy of Sciences, USA Nature 1994- Member, Editorial Board, Inflammatory Bowel Disease 1995 Member, Editorial Board, Gastroenterology 1995 Guest Associate Editor, Gastroenterology 1996-2001 Associate Editor, Gastroenterology 1997-2003 Member, Editorial Board, American Journal of Physiology: Gastrointestinal and Liver Physiology 1998-2003 Associate Editor, Journal of Immunology 2002- Guest Associate Editor, Gastroenterology 2002- Section Editor, Basic Sciences Section, Inflammatory Bowel Disease 9
  10. 10. Richard S. Blumberg, M.D. 2003- Editorial Board, Drug Discovery Today: Disease Models Awards and Honors: 1978 Selected Member, Alpha Omega Alpha Honor Medical Society 1978 Selected Member, Hobart Amory Hare Honor Medical Society 1979 Cum Laude, Jefferson Medical College of the Thomas Jefferson University 1979 Alexander and Lotte Katzman Award in Gastroenterology 1979 Lange Medical Publications Award 1985 Research Fellowship from Aid for Cancer Research 1988 American Gastroenterological Association Senior Research Fellow Award 1993 Selected Member, Beta Gamma Sigma Honor Society 1995 Elected Member, American Society of Clinical Investigation 1995 Nominee, Harvard Medical School Award for Excellence in Mentoring 1995 American Digestive Health Foundation/American Gastroenterological Association Basic Research Award 2001 Elected Member, Association of American Physicians 2002 Humanitarian Man of the Year, Crohn’s & Colitis Foundation of America 10
  11. 11. Richard S. Blumberg, M.D. PART II: Research, Teaching, and Clinical Contributions A. Narrative Report: Research: I am the Co-Director of the Harvard Digestive Diseases Center and I direct a laboratory that focuses on a number of issues related to mucosal immunity. My laboratory has made major contributions in the following areas that are highly relevant to inflammatory bowel disease (IBD), mucosal infections and vaccinology. Characterization of mucosal T cell receptor (TCR) repertoire. My laboratory has shown that human intestinal intraepithelial lymphocytes (IEL), as well as a subpopulation of lamina propria lymphocytes (LPL) and IEL associated with the human biliary epithelium, express a limited number of TCR-α and β chains. This indicates that IELs and LPLs are oligoclonally expanded despite their contiguity with the gut lumen and thus recognize an extremely limited number of antigens, which places significant constraints on their function. We extended these studies to human IBD through the use of TCR repertoire analysis to provide evidence for the existence of private and public TCR motifs in this disease. These latter studies support the existence of disease-related T-cell responses in human IBD. Delineation of Carcinoembyronic Antigen Cell Adhesion Molecule 1 (CEACAM1) as a T cell regulatory molecule. A major goal of my laboratory has been to characterize molecules involved in intestinal epithelial cell (IEC)- IEL interactions. We have shown that CEACAM1 is an activation antigen on T cells, which functions in the negative-regulation of mouse and human IELs and T cells, in general. This regulation by CEACAM1 occurs through homophilic interactions with CEACAM1 on target cells such as IECs leading to recruitment of SHP-1 and the inhibition of MAPK pathways and consequently T cell cytokine secretion. As a result, ligation of CEACAM1 in vivo results in inhibition of colitis in animal models of IBD. Characterization of the nonclassical major histocompatibility complex (MHC) class 1- related molecule, CD1. The oligoclonality of mucosal T cells led my laboratory to investigate nonpolymorphic MHC class I-related molecules such as CD1d and FcRn (see below) in mucosal tissues. We demonstrated that human and mouse CD1d is constitutively expressed by IECs with a unique biochemical structure and that CD1d on IECs functions in the polarized presentation of glycolipid antigens to T cells and is regulated in a novel manner by heat shock proteins. We showed such expression of CD1d and CD1d-restricted T cells in mucosal tissues to be regulated by Epstein Barr-Virus induced gene 3 and directly linked to the development of colitis and inhibition of mucosal colonization by bacteria in a variety of animal models in vivo. Characterization of the neonatal MHC class I-related Fc receptor (FcRn) for IgG. My laboratory challenged the dogma prevalent in the field that FcRn is expressed developmentally only during the neonatal period of life by showing that human FcRn is expressed in adults within IECs, dendritic cells and intestinal macrophages. We demonstrated that this expression is associated with the bidrectional transport of IgG across IECs, established some of the essential elements of the cell biologic itinerary associated with this transcytosis of IgG and proved that this pathway allows for the transport of antigen-IgG complexes into mucosal dendritic cells in vivo. Teaching: I have been active in the training and mentoring of numerous residents and fellows in multiple clinical departments at the Brigham and Women’s Hospital and, as a Principal Investigator, I have directly mentored 39 undergraduate students, graduate students and post-doctoral fellows, many of whom have gone on to academic careers. At Harvard Medical School, I have been an active lecturer in many courses and serve on the Committee 11
  12. 12. Richard S. Blumberg, M.D. of Immunology. In the latter capacity, I have served as a Ph.D. thesis advisor on two occasions. I have also had numerous leadership roles in education including that as a course organizer for three major course offerings in Gastroenterology and Mucosal Immunology. I am the Principal Investigator of an Institutional Training Grant from the NIH, and I have served as the Program Director in Gastroenterology at BWH. In the latter capacity, I contributed to the restructuring of this program leading to full accreditation by the ACGME. Clinical: As a clinician Board certified in Internal Medicine, Infectious Diseases and Gastroenterology, I have served over the years as consultant to the BWH, DFCI, BVAMC and MEEI. As a clinical leader, I briefly served as Acting Chief of the BVAMC and, since 1998, as the Chief of the Division of Gastroenterology, Hepatology and Endoscopy at the BWH. In the latter capacity, I was responsible for restructuring the Division leading to its recognition among the top ten Divisions in the nation by the U.S. News & World Report. B. Research Funding Information: NIH - Past: 1989-1992 NIH/Clinical Investigator Award PI Assembly and Function of the T cell receptor/CD3 complex 1990-1992 NIH/P30 PI (pilot study) Molecular Characterization of Intraepithelial Lymphocytes 1994-1996 NIH/P30 PI (pilot study) Molecular Characterization of the 34B1 Antigenic System 1996-1997 NIH/P30 PI (pilot study) Receptor-Mediated Transcytosis of IgG in Adult Life 1996-1997 NIH/P30 PI (pilot study) Antigen Recognition of T cells in IBD 1997-2002 NIH/RO1 Co-PI Function of Human Intestinal Lymphocytes 1999-2004 NIH/U39 Co-PI Autoimmunity: Treatment by Costimulatory Blockade NIH Current: 1992-2005 NIH/RO1 PI Molecular Characterization of Mucosal Lymphocytes 1997-2006 NIH/RO1 PI Regulation of Mucosal Lymphocytes 1997-2006 NIH/R01 PI 12
  13. 13. Richard S. Blumberg, M.D. Intestinal Transcytosis of IgG in Adult Life 1999-2005 NIH/Center Grant Co-Director of Microbiology and Immunology Core, Harvard Digestive Diseases Center Other Past: 1991-1993 Crohn's & Colitis Foundation of America PI (The Carroll and Milton Petrie Research Award of Excellence) Molecular Characterization of Human Intraepithelial Lymphocytes Associated with Inflammatory Bowel Disease 1995 Crohn's & Colitis Foundation of America PI Characterization of T Cell Clonal Restriction in Inflammatory Bowel Disease 1997-1999 Crohn's & Colitis Foundation of America Characterization of CD1d Function 1992-1993 Milton Fund PI Molecular Characterization of Intestinal Lymphocytes in Inflammatory Bowel Disease 1992-1994 Glaxo Research Institute PI Characterization of Intestinal Lymphocytes in Inflammatory Bowel Disease Other Present: 2005-2009 United States Israel Binational Science Foundation Co-PI The Molecular Mechanism Controlling the Interactions between Members of the CEACAM family and Immune Cells Mentoring Grants - Past 2000-2003 Crohn’s & Colitis Foundation of America Career Development Award Mentor to Xiaoping Zhu, D.V.M., Ph.D. 13
  14. 14. Richard S. Blumberg, M.D. 1999-2004 NIH/K08 Mentor to Hyun Sil Kim, M.D. Characterization of CD1d interacting proteins 1999-2004 NIH/K08 Mentor to Lawrence Saubermann, M.D. Characterization of T cell receptor repertoire Mentoring Grants – Current: 1996- NIH/T32 Preceptor Institutional Training Grant, Combined Program in Pediatric Gastroenterology, Massachusetts General Hospital 1999-2005 NIH/T32 PI (Training Director) Institutional Training Grant, Gastroenterology Division, Brigham & Women's Hospital 1998-2008 NIH/T32 Preceptor Institutional Training Grant, Department of Surgery, Brigham and Women’s Hospital C. Report of Current Research Activities: Characterization of CD1d function in mucosal inflammation PI and intestinal epithelial cell-T cell interactions Characterization of the cell biology and immunological function PI Of the neonatal Fc receptor (FcRn) in epithelia and macrophages Characterization of the regulatory function of CEACAM1 in PI T cell biology and relationship to mucosal inflammation D. Report of Teaching: 1. Local Contributions a. Harvard Medical School, Boston, MA 1983-1986 Microbiology (Traditional Pathway) Laboratory instructor 25-30 medical students 60 hours/year 1990 Introduction to Clinical Medicine (HST program) Preceptor in physical examination 2 medical students 50 hours/year 1994-1996 Markey Biomedical Scientist Training Program Lecturer, "Mucosal Immunology" 14
  15. 15. Richard S. Blumberg, M.D. 12 graduate students 15 hours/year 1996- Gastrointestinal Pathophysiology (HST program) Lecturer, "Mucosal Immunology" 30 medical students 15 hours/year 2001 Immunology and Microbiology (New Pathway) Group Leader for Case Presentation 80 medical students 5 hours/year b. Graduate Medical Course 1997-1998 Developmental/Regional Immunology (IMM213) Lecturer, "Significance of Limited T Cell Repertoire at Mucosal Surfaces" 15 graduate students 15 hours/year 2000-2002 Introduction to Immunology (IMM201) Preceptor 4-6 Graduate Students in Immunology Ph.D. Program 20 hours/year 2001 Introduction to Immunology (IMM201) Discussion leader 9 graduate students 8 hours/year 2002 Immunology Seminar (IMM300) Discussion Leader 10 graduate students 12 hours/year 2004 Introduction to Immunology (IMM202) Lecturer, “Host Defense I and II” 15 graduate students 10 hours/year 2004 Critical Reading for Immunology (IMM204) Discussion Leader 10 graduate students 10 hours/year c. Local Invited Teaching Presentations 1992, 1996 Enteric Biology Course Lecturer, "Mucosal Immunology" 80 fellows 15
  16. 16. Richard S. Blumberg, M.D. 15 hours/year 1989 Morbidity and Mortality Weekly Conference Discussant, "Gastric Outlet Obstruction" 50 medical students, interns, residents and fellows 10 hours/year 1996 Medical Grand Rounds, Department of Medicine Lecturer, "Update on Inflammatory Bowel Disease: Pathogenesis and its Relevance to Disease Therapy" 10 hours/year 1999- Professors Rounds, General Medicine Service 10 medical residents 6 hours/year 2000 Medical Grand Rounds, Department of Medicine (VA Boston HealthCare System, West Roxbury Campus) Lecturer, “Update on Inflammatory Bowel Disease” 10 hours/year d. Continuing Medical Education Course 1989 Intensive Review of Internal Medicine, Department of Medicine Lecturer, "The Gastrointestinal Manifestations of AIDS", "Infectious Enteritis", "Enteric Fever" 100-400 CME students 20 hours/year 1989-2002 Comprehensive Review of Gastroenterology, Lecturer, "The Gastrointestinal Manifestations of AIDS" and “The Hepatic Manifestations of AIDS” 100-400 CME students 12 hours/year 2002 Comprehensive Review of Gastroenterology, Lecturer, “How IBD Evolves – New Insights” 100-400 CME students 12 hours/year 16
  17. 17. Richard S. Blumberg, M.D. 2003- Housestaff Mentoring Program Physician-Scientist in Internal Medicine training 24 hours/year e. Advisory and Supervisory Responsibilities in Clinical or Laboratory Setting 1990- Research laboratory advisor for predoctoral and postdoctoral (MD, PhD and MD/PhD college and graduate students) 250 hours/year 1990- Attending Gastroenterology and Medicine for medical students, residents and fellows 80 hours/year 1994 External Reviewer, Doctoral Thesis Committee, Department of Microbiology and Immunology, Mt. Sinai Medical School 20 hours/year 1997- Ph.D. Thesis Advisory Committee (Lisa Steele), Graduate Program in Immunology, Harvard Medical School 10 hours/year 2000-2002 Ph.D. Thesis Advisory Committee, Edward Nieuwenhuis, University of Utrecht, The Netherlands 100 hours/year 1998-2003 Thesis Advisor for Steven Claypool, PhD Candidate in Immunology, Harvard Medical School 100 hours/year 2004- Thesis Advisor for Stephanie Betz, Candidate in Immunology, Harvard Medical School 100 years/year f. Teaching Leadership Role 1998- Director of Fellowship Program in Gastroenterology, Brigham and Women’s Hospital Function as program director for all administrative and educational activities related to ACGME-approved program for 15 fellows in Gastroenterology. Responsible for complete reorganization of program and full accreditation by residency review committee of the ACGME. 1999- Comprehensive Review of Gastroenterology Course Co-Director Function as Co-organizer of a CME course for 200-400 gastroenterologists together with Dr. Stephen Goldfinger (MGH), 17
  18. 18. Richard S. Blumberg, M.D. Dr. Daniel Podolsky (MGH) and Dr. Thomas Lamont (BIDMC). Together, we establish the curriculum and select the speakers. 2003 Gastroenterology for the Primary Care Physician Course Director Functioned as Co-organizer of a CME course for 100 primary care physicians with Dr. Sarath Reddy (BWH). Together, we chose all of the speakers and set the curriculum. 2003 Frontiers in Mucosal Immunology Course Director Established a new course in Mucosal Immunity for active investigators in New England through the Harvard Digestive Diseases Center together with Dr. Nicholas Mantis (CHMC). We chose a steering committee, set the topics for discussion, picked the speakers and moderated the sessions. g. Names of Advisees or Trainees Years Name Present Position 1991-1992 Steven Burke, MD Sr. Vice President for Medical and Regulatory Affairs, Geltex, Inc., Waltham, MA 1990-1993 Stephen Landau, MD Clinical Director, Millenium Pharmaceuticals 1993 Amal Al-Gawari, Ph.D. Sr. Research Associate, Millenium Pharmaceuticals 1993-1995 Wilfredo Canchis, MD Assistant Professor, Cornell 1994-1995 Tamara Koss Postdoctoral Research Fellow, Boston Dermatology and Laser Center 1994-2001 Victor Morales, Ph.D. Postdoctoral Research Fellow, Boston University Medical Center 1994-1996 Andreas Christ, MD Asst. Prof. of Medicine, University Hospital, Zurich 1994-1996 Christopher Probert, MD Assoc. Prof. of Medicine, Bristol Royal Infirmary, UK 1994-1996 Hyun Sil Kim, MD Asst. Prof. Medicine, UCSD 1995 Jeffrey Encinas, PhD Sr. Scientist, Chugai Pharmaceuticals 1995-1996 Michael Teitell, MD, PhD Assoc. Prof. of Pathology, UCLA 1995-1998 Lawrence Saubermann, M.D. Asst. Prof. of Medicine, Boston University Medical Center 18
  19. 19. Richard S. Blumberg, M.D. 1996-1998 K. Somnay- Asst. Prof. of Medicine, SUNY Wadgoankar, MD Downstate 1997 Lisa Steele Investigator, Center for Disease Control 1997 Margot Furman Patent Attorney 1997-1998 Relin Yang Medical Student, Univ. of Miami 1997-2003 Xiaoping Zhu, DVM, PhD Assistant Professor, University of Maryland 1997-1999 Fumio Omata, MD Asst. Prof. of Medicine, Tokai Medical College, Japan 1998-2000 A. Nakajima, MD, PhD Associate Professor and Chief of Gastroenterology, Yokohama City University Hospital, Japan 1998.2000 Sara Russell, MD Instructor in Surgery, BWH 1998-2003 Steven Claypool, PhD Postdoctoral Fellow, University of California, Los Angeles 1999-2000 Mark Ryan, PhD Senior Scientist, Nanomat, Ireland 1999-2001 Richard Pitman, PhD Patent Attorney, London, UK 2000-2001 Yvonne van de Wal, PhD Director, Clinical Laboratory, Utrecht, The Netherlands 2000-2002 Hideki Iijima, MD, PhD Assistant Professor, Osaka University, Japan 2000-2002 Edward Nieuwenhuis, MD Assistant Professor, University of Rotterdam, The Netherlands 2000-2002 R. Raychowdhury, PhD Instructor in Medicine, HMS 2000-2002 Nadia Corazza, PhD Research Fellow, University of Bern 2000- T. Nagaishi, MD, PhD Research Fellow, BWH 2001- Masaru Yoshida, MD, PhD Research Fellow, BWH 2001 Markus Neurath, MD Professor, University of Mainz, Germany 2002 JinYong Kim, MD Assistant Professor, University of Korea 2002-2004 Daohong Chen, MD, PhD Research Associate, BWH 2002-2003 Suzana Sistig, DMD, Research Associate, University of MD, PhD Louisville 2003- Stephanie Betz PhD Program in Immunology, HMS 2003 Ewa Micewicz Research Fellow, DFCI 2003-2004 Alicia Little Medical Student, Yale 2003- Arthur Kaser, M.D., Ph.D. Research Fellow, BWH 2003-2004 Azucena Salas, Ph.D. Assistant Professor, University of Barcelona 2003- Timothy Kuo, M.D. Research Fellow, BWH 19
  20. 20. Richard S. Blumberg, M.D. 2003- Flavio Rocha, M.D. Research Fellow, BWH 2004- Wael Haddad, M.D., Ph.D. Research Fellow, BWH 2005 Bryan Vander Lugt PhD Program in Immunology, HMS 2005 Feilin Zhu Senior Research Thesis, Harvard University 2. Regional, National, and International Contributions 1989 Invited speaker; "T cell receptor/CD3 complex structure and function"; Massachusetts General Hospital, Gastrointestinal Unit; Boston, MA 1991 Invited speaker; "Molecular characterization of intestinal intraepithelial lymphocytes"; Division of Gastroenterology, Boston University School of Medicine; Boston, MA Invited speaker; “Expression of CD1d by human gastrointestinal epithelial cells”; Digestive Diseases Week and the 92nd Annual Meeting of the American Gastroenterological Association; New Orleans, LA Invited speaker; “T cell receptor (TCR-α) expression and recognition of CD1 by a human jejunal intraepithelial lymphocyte (IEL) line”; Digestive Diseases Week and the 92nd Annual Meeting of the American Gastroenterological Association; New Orleans, LA 1992 Invited speaker; "Molecular characterization of mucosal T cell receptor/CD1 interactions"; The Molecular and Cellular Basis of Inflammatory Bowel Disease Symposium, The Center for Gastrointestinal Biology and Disease; Chapel Hill, NC Invited speaker; "CD1: a novel class I related molecule involved in intestinal epithelial cell - T cell interactions"; Conference on Intestinal Inflammation: Mechanisms and Modulation; Florence, Italy Invited speaker; "Role of CD1 in human IEL-epithelial cell interactions"; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Workshop on Intraepithelial Lymphocytes Boston, MA Invited speaker; “Oligoclonal expansion of human lamina propria lymphocytes”; Digestive Diseases Week and the 93rd Annual Meeting of the American Gastroenterological Association; San Francisco, CA Invited speaker; “Alternations of Vδ usage in intraepithelial lymphocytes in inflammatory bowel disease”; Digestive Diseases Week and the 93rd Annual Meeting of the American Gastroenterological Association; San Francisco, CA Invited lecture; "Structure of CD1 on human intestinal epithelial cells"; Inflammatory Bowel Disease Center, University of Chicago Medical School; Chicago, IL 20
  21. 21. Richard S. Blumberg, M.D. 1993 Invited lecture; "Molecular characterization of IEL - T cell interactions"; Graduate Program of Immunology, Tufts-New England Medical Center; Boston, MA Invited speaker; "Role of CD1 in human IEL-epithelial cell interactions"; FASEB Minisymposium on Antigen Presentation and Signal Transduction in the Mucosal Immune System; Denver, CO Invited speaker; “Structure of CD1d on intestinal epithelial cells”; Digestive Diseases Week and the 94th Annual Meeting of the American Gastroenterological Association; Boston, MA Invited speaker; “Expression of CD1a by altered human intestinal epithelium”; Digestive Diseases Week and the 94th Annual Meeting of the American Gastroenterological Association; Boston, MA Invited lecture; "Role of CD1 in human IEL-epithelial cell interactions"; The Picower Institute for Medical Research, Cornell University Medical College; Manhasset, NY Visiting Professor; "Role of CD1 in human IEL-epithelial cell interactions"; Gastroenterology Division, The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School; New Brunswick, NJ 1994 Invited speaker; "Role of nonclassical MHC class I molecules in intestinal epithelial cell-T cell interactions"; Digestive Diseases Week and the 94th Annual Meeting of the American Gastroenterological Association Annual Meeting, Minisymposium on Antigen Presentation in Intestine; New Orleans, LA Invited speaker; “Cloning and characterization of a novel MHC class I associated ligand for T cells on human intestinal epithelial cells”; Digestive Diseases Week and the 94th Annual Meeting of the American Gastroenterological Association; Boston, MA Invited speaker; "The new age of research in inflammatory bowel diseases: The role of non-classical MHC molecules in IEL function"; University of Chicago Inflammatory Bowel Disease Center; Chicago, IL Invited speaker; "Novel MHC-like and associated molecules on intestinal epithelial cells"; Massachusetts General Hospital Immunology Seminar Series, Boston, MA Invited speaker; "Epithelial - T cell interactions in the intestine"; Division of Microbiol/Immunol; Mt. Sinai School of Medicine; New York, NY Invited speaker; "Lymphoepithelial interactions in the human intestine"; Division of Immunology, Beth Israel Hospital; Boston, MA 1995 Invited speaker; "Receptors and ligands involved in lymphocyte- 21
  22. 22. Richard S. Blumberg, M.D. enterocyte interactions"; Keystone Symposium Conference on Mucosal Immunity: New Strategies for Protection Against Viral and Bacterial Pathogens; Keystone, CO Plenary speaker; "Mucosal Immunology in IBD: The role of epithelial cells"; Falk International Symposium on Inflammatory Bowel Disease, Den Haag, Netherlands Plenary speaker; "Novel MHC-like molecules on intestinal epithelial cells"; 8th International Conference on Mucosal Immunology; San Diego, CA Invited speaker; "Intestinal epithelial - T cell interactions"; Department of Pathology, University of Connecticut Health Center; Farmington, CT Invited speaker; “Biliary duct lymphocytes in primary sclerosing cholangitis (PSC) complicating ulcerative colitis are oligoclonal, T-cell receptor-αβ+ cells”; Digestive Diseases Week and the 95th Annual Meeting of the American Gastroenterological Association; San Diego, CA Invited speaker; “Chronic T cell clonal expansion in inflammatory bowel disease”; Digestive Diseases Week and the 95th Annual Meeting of the American Gastroenterological Association; San Diego, CA Invited speaker; "Intestinal epithelial cell - T cell interactions"; Department of Gastroenterology, University of Texas Medical Branch at Galveston; Galveston, TX Invited speaker; GRASP Center, New England Medical Center; "T cell receptor αβ repertoire in inflammatory bowel disease"; Boston, MA 1996 Invited speaker; "Characterization of T cell receptor αβ repertoire in IBD"; Department of Gastroenterology, University of Colorado; Denver, CO Invited speaker; "Characterization of T cell Receptor-αβ Repertoire in IBD"; Department of Microbiology, Mount Sinai School of Medicine; New York, NY Invited speaker; "CD1 and other non classical HLA-molecules"; German Society for Immunogenetics; Leipzig, Germany Visiting Professor; “Characterization of MHC class I-like molecules in mucosal immune function” and “Characterization of T-cell receptor repertoire in inflammatory bowel disease”; Gastroenterology Division, University of Virginia, School of Medicine; Charlottesville, VA 22
  23. 23. Richard S. Blumberg, M.D. Invited speaker; "Characterization of T cell receptor repertoire in Inflammatory Bowel Disease"; Gastrointestinal Unit, Massachusetts General Hospital; Boston, MA Invited speaker; “Functional major histocompatibility complex (MHC) class I-related Fc receptor expression in human adult enterocytes and intestinal epithelial cell (IEC) line”; Digestive Diseases Week and the 96th Annual Meeting of the American Gastroenterological Association; San Francisco, CA Invited speaker; “Evidence for a T cell receptor β chain motif in intestinal epithelium in ulcerative colitis (UC): a marker of severe disease?”; Digestive Diseases Week and the 96th Annual Meeting of the American Gastroenterological Association; San Francisco, CA 1997 Invited speaker; "The role of nonclassical MHC class I molecules in immune function"; Keystone Symposium on Mucosal Immunity: Cellular and Molecular Cross-Talk at Mucosal Surfaces; Santa Fe, NM Visiting Professor; Gastroenterology Division, Northwestern University; Chicago, IL Invited speaker; "Future approaches in the treatment of ulcerative colitis and Crohn's disease"; Boehringer-Ingelheim Pharmaceuticals, Inc.; Minisymposium; Ridgefield, CT Invited speaker; “Transcellular transport of IgG across model human intestinal epithelial cells (IEC): potential role of the IgG-receptor, FcRn”; Digestive Diseases Week and the 97th Annual Meeting of the American Gastroenterological Association; Washington, DC Invited speaker; “The pathogenesis of inflammatory bowel disease: the role of genetics, environment and inflammatory responses”; Indiana University, Indianapolis, IN Invited speaker; "Diverse immunoglobulin superfamily members"; Annual Congress, British Society for Immunology; Brighton, UK Invited speaker; "The pathogenesis of inflammatory bowel disease: the role of genetics, environment and inflammatory responses"; Ohio State University, Columbus, OH Invited speaker; "MHC class I-related molecules on epithelial cells"; Center for the Study of Inflammatory Bowel Disease, Workshop on Intestinal Epithelium: Immune and Inflammatory Responses, Boston, MA 23
  24. 24. Richard S. Blumberg, M.D. Invited speaker; "Lympho-epithelial cross-talk in mucosal immunobiology"; First Annual Immunology Retreat, Committee on Immunology, Harvard Medical School; Chatham, MA 1998 Invited teacher; Master Class on Mucosal Immunology; Utrecht, Holland. Invited speaker; "Antigen uptake, presentation and epithelial cell biology"; Falk Symposium on Induction and Modulation of Gastrointestinal Inflammation, Saarbrücken, Germany Invited speaker; "Antigen Presentation"; Falk Symposium on Inflammatory Bowel Disease; Rostock, Germany Visiting Professor; “Opportunistic infections of the GI tract” and “MHC- related Fc receptor in adult epithelia: characterization of a new paradigm”; Gastroenterology Division, University of Pennsylvania, Philadelphia, PA Invited speaker; “The pathogenesis of inflammatory bowel disease: the role of genetics, environment and inflammatory responses”; University of Colorado, Denver, CO Invited speaker; “Characterization of FcRn function in adult life”; University of Texas Southwestern Medical Center, Department of Microbiology and Immunology, Dallas, TX Invited speaker; “Biliary glycoprotein (C-CAM) functions as a killer inhibitory receptor for human intestinal intraepithelial lymphocytes”; Immunology Seminar Series, Beth Israel Deaconess Medical Center, Boston, MA Invited speaker; “Involvement of human FcRn in adult intestinal epithelial cell transcytosis--a new paradigm?”; University of Florida, Gainesville, FL Invited speaker; “Lymphocyte-epithelial cell cross-talk in the human intestine”; Center for Neurological Diseases, Brigham and Women’s Hospital, Boston, MA Invited speaker; “Lymphocyte-epithelial cell interactions in the intestine”; Gastroenterology Unit, Massachusetts General Hospital, Boston, MA Invited speaker; “CD1d biosynthetic pathway in a transfected T84 cell line”; Digestive Diseases Week and the 98th Annual Meeting of the American Gastroenterological Association; New Orleans, LA Invited speaker; “Biliary glycoprotein (BGP; CD66a) functions as an inhibitory co-receptor for activation of human intestinal intraepithelial 24
  25. 25. Richard S. Blumberg, M.D. lymphocytes (iIEL)”; Digestive Diseases Week and the 98th Annual Meeting of the American Gastroenterological Association; New Orleans, LA Invited speaker; “Characterization of intestinal lymphocyte-epithelial cell interactions” and “Characterization of MHC class I-like molecules in intestinal epithelium”; International Meeting on Vaccines, Brazilian Society of Immunology, Salvador, Bahia, Brazil Discussion leader; “Lymphocytes and IBD: current paradigms of disease mechanism and treatment”; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 1999 Invited speaker; “T cell-intestinal epithelial cell interactions”; Molecular Medicine of the Gut, Embo Workshop; Arolla, Switzerland. Invited speaker; “BGP, a novel immunoregulatory molecule in the intestine”; New Strategies in IBD Therapy, Northwestern University, Chicago, IL Invited speaker; “Characterization of CD1d in human intestinal epithelial cells”; Workshop on NK T cells and CD1 mediated antigen presentation; San Diego, CA Invited speaker; “FcRn mediated transcytosis of IgG by human intestinal epithelial cells”; Membrane Biology Program, Brigham and Women’s Hospital, Boston, MA Invited plenary speaker; “Antigen presentation by intestinal epithelial cells”; 10th International Congress of Mucosal Immunology (ICMI); Amsterdam, NL. Invited speaker; “The pathogenesis of inflammatory bowel disease: the role of genetics, environment and inflammatory response”; University of Arizona, Phoenix, AZ. Invited speaker; “Functional CD1d-mediated responses in intestinal epithelial cells; critical role of the cytoplasmic tail”; Digestive Diseases Week and the 99th Annual Meeting of the American Gastroenterological Association; New Orleans, LA Invited speaker; “The pathogenesis of inflammatory bowel disease: the role of genetics, environment and inflammatory response”; St. Louis Chapter of the Crohn’s & Colitis Foundation of America, St. Louis, MO. 25
  26. 26. Richard S. Blumberg, M.D. Invited speaker; “Intestinal epithelial cell-T cell interactions”; Annual Meeting of the Chicago Chapter of the Crohn’s & Colitis Foundation of America, Chicago, IL. 2000 Invited speaker; “Role of CD1d in intestinal epithelial cell-lymphocyte interactions”; Keystone Symposia, Taos, NM. Invited speaker; “One size fits all: the multiple roles of MHC class I-like molecules in epithelial cell function”; Department of Microbiology, Dartmouth Medical School, Hanover, NH Invited speaker; “Immunologic functions of epithelial cells”; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA. Invited speaker; “The pathogenesis of inflammatory bowel disease: the role of genetics, environment and inflammatory responses”; Rochester, NY Invited speaker; “Lymphocyte-epithelial interactions in the intestine”; Department of Immunology, New York University, New York, NY Invited speaker; “The utility of structure—the multiple roles of MHC class I-like molecules in epithelial cell function”; 12th Annual Symposium of the Japanese K-Club, San Diego, CA Plenary speaker; “Natural killer (NK)-T cell activation by α- Galactosylceramide in the presence of CD1d provides protection against colitis”; Digestive Diseases Week and the 100th Annual Meeting of the American Gastroenterological Association; San Diego, CA Invited speaker; : “IBD immunology made easy”; Special Clinical Symposium on Inflammatory Bowel Disease, Digestive Diseases Week and the 100th Annual Meeting of the American Association of Gastroenterology, San Diego, CA. Invited speaker; “Characterization of CD1d and NK-T cells in mucosal immunobiology”; Special Symposium – Immune Deviation and Tolerance in Autoimmune and Allergic Diseases, American Academy of Allergy, Asthma and Immunology, San Diego, CA Invited speaker; “The pathogenesis of inflammatory bowel disease: The role of genetics, environment and inflammatory responses”; Oklahoma Chapter of the Crohn’s & Colitis Foundation of America, Tulsa, OK Invited speaker; “Characterization of CD1d in mucosal immune Function: an immunotherapeutic target for inflammatory bowel disease?”; Department of Gastroenterology, Keio University, Tokyo, Japan Invited speaker; “Role of CD1d in intestinal epithelial cell-lymphocyte Interactions”; 4th US-Japan GI Meeting, Tokyo, Japan 26
  27. 27. Richard S. Blumberg, M.D. Invited speaker; “The multiple roles of MHC class I-like molecules in mucosal immune function”; Asahikawa GI and Hepatology Symposium, Satellite Symposium of 4th US-Japan GI Meeting, Otaru, Hokkaido, Japan Invited speaker; “Function of CD1d in Intestinal Inflammation”; Department of Microbiology and Immunology, University of San Antonio, San Antonio, TX Invited speaker; “Function of CD1d in Intestinal Inflammation”; Japanese Society of Immunology, Sendai, Japan 2001 Invited speaker; “The multiple roles of MHC class I-like molecules in mucosal immune function”; International Congress on Oral Immunology, Lillehammer, Norway. Invited speaker: “The role of FcRn in transepithelial transport of IgG In adult life”; University of Oslo, Oslo, Norway Invited speaker; “Function of CD1d in mucosal inflammation”; Experimental Biology 2001, The American Society of Immunologists, Orlando, FL Invited speaker; “Characterization of CD1d in the regulation of mucosal inflammation”; New England Medical Center, Boston, MA Invited speaker; “Regulation of T lymphocyte function by CEACAM1”; Seminar Series, Harvard Institutes of Medicine, Boston, MA Invited speaker; “Epithelial and T cell interactions in intestinal Inflammation”; 11th International Congress of Immunology, Stockholm, Sweden Invited speaker; “Beyond tissue morphogenesis—T cell regulatory functions of CEACAM1”; Syntonix Pharmaceuticals, Waltham, MA Invited speaker; “The immunoregulatory functions of CEACAM1 in Mouse T lymphocytes”; 12th Annual CEA Meeting, Providence, RI Invited speaker; “Dysregulation of mucosal immunity for disease development”; International Meeting on Mucosal Immunology in the 21st Century, Perdido Beach, Alabama Visiting Professor; “The neonatal receptor for IgG (FcRn): not so neonatal”; Gastroenterology Division, University of Pittsburgh, Pittsburgh, PA Invited speaker; “Immunological functions of the epithelium and its resident lymphoid cells”; Scuola Superiore d’Immunologia Ruggero Ceppellini School on Advances in Mucosal Immunity, Naples, Italy. Invited speaker; “Human and mouse intestinal epithelial cells (IEC) 27
  28. 28. Richard S. Blumberg, M.D. present glycolipid antigens to natural killer (NK)-T cells in a CD1d- restricted manner”; Digestive Diseases Week and the 101st Annual Meeting of the American Gastroenterological Association, Atlanta, GA Invited lecture; “From mystery to molecular: understanding the pathogenesis of Inflammatory Bowel Disease”; 15th Annual James A. Kangus Memorial Lecture, Pediatric Grand Rounds; Children’s Hospital of Pittsburgh, Pittsburgh, PA. Invited speaker; “Immunoregulatory function of CEACAM1 on T lymphocytes”; Gastrointestinal Unit Research Seminar Series, Massachusetts General Hospital, Boston, MA Invited Speaker; “Regulation of T lymphocyte function by CEACAM1”; Medical College of Ohio, Toledo, OH. 2002 Invited speaker: “Development of immunologic therapies directed at CEACAM1”; GenPat77, Berlin, Germany Plenary speaker; “Immunological functions of polarized epithelia and IgG transport”; 11th International Congress of Immunology, Orlando, FL Invited speaker; “Neonatal Fc-receptor for IgG – not so neonatal”; Gastroenterology Division, Beth Israel Deaconess Medical Center, Boston, MA Plenary speaker; “Epstein-Barr Virus-induced gene 3 deficiency disrupts T helper 2-mediated immune responses in experimental colitis”; Digestive Diseases Week and the 102nd Annual Meeting of the American Gastroenterological Association San Francisco, CA Invited speaker; “The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn’s disease”; Digestive Diseases Week and the 102nd Annual Meeting of the American Gastroenterological Association San Francisco, CA Invited speaker; “Regulation of T cell-mediated, Hapten-induced murine colitis by CEACAM1”; Digestive Diseases Week and the 102nd Annual Meeting of the American Gastroenterological Association San Francisco, CA 28
  29. 29. Richard S. Blumberg, M.D. Invited speaker; “Impaired function of NK-T cells in EBI3-deficient animals”; Digestive Diseases Week and the 102nd Annual Meeting of the American Gastroenterological Association San Francisco, CA Invited speaker; “Epstein-Barr Virus-induced gene 3 (EBI3) deficiency disrupts T helper 2-mediated immune responses”; Keystone Symposium on Microbial-Epithelial-Lymphocyte Interactions in Mucosal Immunity, Breckenridge, CO Invited speaker; “Regulation of T lymphocyte functions by CEACAM1”; Department of Microbiology and Immunology, University of Colorado Health Sciences Center, Denver, CO Invited speaker; “Epstein-Barr Virus-induced gene 3 (EBI3) deficiency disrupts T helper 2-mediated immune responses”; European Laboratory for the Investigation of Food-Induced Diseases, Naples, Italy. Invited speaker; “Epstein-Barr Virus-induced gene 3 (EBI3) deficiency disrupts T helper 2-mediated immune responses”; Immunex/Wyeth Ayerst Industry Symposium, Second Federation of Clinical Immunology Society Meeting, San Francisco, CA Invited speaker; “CD1d and microbial immunity”; Second International Workshop on CD1 and NKT Cells, Woods Hole, MA Invited speaker; “Immunomodulatory properties of CEACAM1”; Retreat of the Program in Immunology, Harvard Medical School, Waterville Valley, NH. 2003 Visiting Professor; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN Invited speaker; “FcRn-regulated transport of antibody and antibody- antigen immune complexes across intestinal epithelial cells”; Keystone Symposium on the Regulation of Mucosal Inflammation, Keystone, CO Invited speaker; “Modulation of Th1 and Th2 cytokines in the therapy of inflammatory bowel disease”; Inflammation Research Association, Seattle, WA Invited speaker; “Immunoregulatory functions of CD1d in mucosal tissues”; Major Symposium on “Mucosal Immunity: Guts and Glory” highlighting the top six investigators in mucosal immunology under the age of 50; American Association of Immunologists, Denver, CO Invited speaker; “Modulation of Th2-modulated immune responses by EBI3”; International Falk Symposium on the Mechanisms of Intestinal Inflammation: Implications for Therapeutic Intervention in IBD”; Berlin, Germany 29
  30. 30. Richard S. Blumberg, M.D. Invited speaker; “T cell regulatory functions of CEACAM1”; Division of Immunology, City of Hope, Duarte, CA Invited speaker; “T cell regulatory functions of CEACAM1”; Mucosal Immunity Section, National Institutes of Health, Bethesda, MD Invited speaker; “T cell regulatory functions of CEACAM1”; Boehringer- Ingelheim, Ridgefield, CT Invited speaker; “Regulation and function of CD1d in intestinal epithelia”; University of Virginia Third Annual IBD Symposium, Charlottesville, VA Invited speaker; “T cell regulatory functions of CEACAM1”; Symposium, Society of Mucosal Immunology, Paris, France Invited speaker; “Regulation of IgG transport across intestinal epithelia by FcRn”; FOCIS meeting, Paris, France Plenary speaker; “Specific regulation of T helper-1 mediated murine colitis by CEACAM1”; Annual meeting of the American Gastroenterological Association, Orlando, FL. Invited speaker; “SHP-1 dependent and independent suppression of colitis by CEACAM1 isoform expressing a long cytoplasmic tail”; Annual meeting of the American Gastroenterological Association, Orlando, FL. Invited speaker; “FcRn regulates transport of IgG and IgG/antigen complexes across mucosal epithelial barriers”; Annual meeting of the American Gastroenterological Association, Orlando, FL. Invited speaker; “Intestinal lumen-derived heat-shock protein 110 regulates expression of MHC class I-like molecule CD1d on intestinal epithelial cells”; Annual meeting of the American Gastroenterological Association, Orlando, FL. Key Note Address; “Mucosal T cells and their regulation in intestinal inflammation”; 30th Annual Meeting of the Japanese Society of Immunology, Tokyo, Japan Invited speaker: “Regulation of mucosal T cells by CEACAM1”; Kyoto University Hospital, Kyoto, Japan Invited speaker; “Regulation of T cell-mediated immune response by CEACAM1”; Society for Leukocyte Biology, Philadelphia, PA Invited speaker; “NKT cells in mucosal homeostasis”; New York Academy of Science, Second Workshop on Oral Tolerance, New York, NY Invited speaker: “Neonatal Fc receptor-mediated transport of antigen- 30
  31. 31. Richard S. Blumberg, M.D. antibody complexes across epithelial barriers”; Jackson Laboratory, Bar Harbor, ME Invited speaker: “NK T cells in mucosal homeostasis”; Mt. Sinai School of Medicine, New York, NY Invited speaker; “Specific regulation of T helper 1-mediated colitis by CEACAM1”; 14th Annual CEA Symposium, Munich, Germany Invited speaker; “Modulation of Th1 and Th2 cytokines in the therapy of inflammatory bowel disease”; Crohn’s & Colitis Foundation of America, Houston, TX Invited speaker; “Modulation of Th1 and Th2 cytokines in the therapy of inflammatory bowel disease”; Millenium Pharmaceuticals, Cambridge, MA Invited speaker; “Regulation of IgG Transport Across Mucosal Barriers by FcRn”; British Society of Immunology, Harrogate, UK Keynote speaker; “Research Advances in Human Inflammatory Bowel Disease”; Pediatric Inflammatory Bowel Disease Clinical Trials Workshop of the CCFA and NASPGHAN, Boston, MA Invited speaker; “Specific regulation of T helper 1-mediated colitis by CEACAM1”; New England Regional Symposium on Frontiers in Mucosal Immunology, Boston, MA Invited speaker; “Regulation of mucosal T cell-mediated immune responses by CEACAM1”; Section of Allergy and Clinical Immunology, Yale University, New Haven, CT Invited speaker; “Regulation of T cell mediated immune responses by CEACAM1”; Society for Leukocyte Biology, Philadelphia, PA Invited speaker; “Neonatal Fc receptor-mediated transport of antigen- antibody complexes across epithelial barriers”; Cedars Sinai Medical Center, Los Angeles, CA 2004 Invited speaker; “Regulation of CD1d function and CD1d-mediated inflammation by microsomal triglyceride transfer protein”; Bristol Myers Squibb, Princeton, NJ Plenary speaker; “Microsomal triglyceride transfer protein regulates CD1d function”; American Gastroenterological Association, New Orleans, LA Invited speaker; “Regulation of mucosal lymphocyte function by CEACAM1”; GI Unit, Massachusetts General Hospital, Boston, MA Keynote speaker; “Neonatal Fc receptor-dependent transcytosis of IgG and IgG/antigen complexes across mucosal epithelial barrier”; Erasmus 31
  32. 32. Richard S. Blumberg, M.D. School of Molecular Medicine, Rotterdam, The Netherlands Invited speaker; “Current concepts on the immunopathogenesis of IBD and their therapeutic implications”; St. Elizabeth’s Hospital, Boston, MA Invited speaker and chair; “FcRn mediated regulation of immune-complex transport to mucosal dendritic cells”; Symposium on the function of epithelial cells in host defense and immune regulation, American Association of Immunologists, Washington, D.C. Invited speaker and chair; “General overview of inflammatory mechanisms contributing to gut pathology”; 11th International Symposium on Coeliac Disease, Belfast, Ireland Invited speaker; “MTP regulation of CD1d function”; Center for Cardiovascular and Muscular Research, SUNY Downstate Medical Center, New York, NY Invited speaker; “Regulation of CD1d function by microsomal triglyceride transfer protein”; Mucosal HIV and Immunobiology Center, University of Alabama, Birmingham, AL Invited speaker; “The epithelial-lymphocyte-luminal interface”; European Society of Pediatric Gastroenterology, Hepatology and Nutrition, Capri, Italy Invited speaker; “CEACAM1 regulation of mucosal T cell function”; 12th International Congress of Immunology and 4th Annual Conference of FOCIS, Montreal, Quebec, Canada Invited speaker: “FcRn regulated transport of antigen-antibody complexes into mucosal dendritic cells”; Society of Mucosal Immunology Annual Meeting, Montreal, Quebec, Canada Invited speaker; “Regulation of T helper 1 pathways in mucosal inflammation”; American Gastroenterological Association/British Society of Gastroenterology, Oxford, UK 32
  33. 33. Richard S. Blumberg, M.D. Invited speaker; “CD1d-microsomal triglyceride transfer protein interactions in mucosal immunity”; Third International Workshop on NKT Cells and CD1 mediated Antigen Presentation, Heron Island, Australia Invited speaker; “Regulation of antigen transport across epithelial barriers mediated by neonatal Fc receptor”; Center for Immunology and Microbial Disease at the Albany Medical College, Albany, NY Invited speaker; “Pathogenesis and diagnosis of ulcerative colitis”; Medica Sur Clinic & Foundation, Mexico City Invited speaker; “Frontiers: inflammatory bowel disease: a blow to the gut”; Human Pathology Course, Harvard-MIT Division of Health Sciences and Technology, Boston, MA Keynote speaker; “Case study of academia launched bio-venture: Co- opting the neonatal Fc receptor for drug delivery and beyond”; International Association for Biological and Medical Research, The Forsyth Institute and Tufts University School of Dental Medicine, Boston, MA Invited speaker; “FcRn-mediated regulation of IgG antigen transport across mucosal barriers”; Mucosal Immunity Section, National Institutes of Health, Bethesda, MD 2005 Invited speaker; “Update on the pathogenesis of inflammatory bowel disease and therapeutic implications”; Medical Grand Rounds, VA Boston HealthCare System, West Roxbury, MA Invited speaker; “The role of microsomal triglyceride transfer protein in CD1-restricted antigen presentation”; Immunobiology Division, Yale University, New Haven, CT Invited speaker; “Regulation of colitis by carcinoembryonic antigen cell adhesion molecule 1”; Translational Medicine in Autoimmunity, Keystone Symposia, Big Sky, MT Invited speaker: “Regulation of CD1d function by microsomal triglyceride transfer protein”; Immunology Seminar Series, Massachusetts General Hospital, Boston, MA Invited speaker; “Lipids and IBD: Microsomal triglyceride transfer protein – the new dimension?”; Gut-Liver Interactions: Basic and Clinical Concepts, Falk Symposium, Innsbruck, Austria 33
  34. 34. Richard S. Blumberg, M.D. 3. Description of Teaching Awards 1995 Nominee, Harvard Medical School Award for Excellence in Mentoring 4. Major Curriculum Offerings 1998 Quarter Course in Immunology, Graduate Program in Immunology, Harvard Medical School Richard S. Blumberg (Organizer) Catherine Nagler-Anderson (Co-Organizer) E. Report of Clinical Activities: I have conducted clinical activities as Associate Physician and Physician at the Brigham and Women’s Hospital (BWH) since 1990, as an attending consultant in Gastroenterology and Internal Medicine. In these capacities, I am recognized for my expertise in inflammatory bowel diseases (IBD) and infectious diseases of the intestines and have provided consultation in these areas. As Division Chief since 1998, I have been responsible for significant growth in the Gastroenterology Division at the Brigham and Women’s Hospital. Specifically, I have been responsible for restructuring the Division with recruitment and appointment of 17 clinical and research faculty members at the BWH and 3 faculty members at the Boston Veteran’s Administration Medical Center (BVAMC), which included the recruitment of a Clinical Chief to the BWH and Chief of the Gastroenterology section at the BVAMC. I have also overseen the creation of a Digestive Health Center at the BWH. During this time, clinical activities of the Gastroenterology Division have grown significantly as manifest by an increase in ambulatory visits from 6,570 to 8,692 cases per year, an increase of colonoscopies as a metric of endoscopy activity from 1,296 to 3,498 cases per year and an increase of research activity from $1.7 million to $3.3 million per year. This has led to increased recognition of the Division nationally as indicated by the recent ranking of the Gastroenterology Division as 10th in the United States in the 2003 edition of the U.S. News & World Reports. My own basic research program has a strong translational component, which includes a total of nine issued and pending patents on the mucosal delivery of therapeutics and the treatment of a number of immunologically related diseases including IBD. In at least one case, my discoveries have been translated into human use through the successful completion of a clinical trial by a regional biotechnology company involving the utility of targeting the neonatal Fc receptor for IgG for the transport of erythropoietin across the epithelial barriers of the human lung. 34

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