Curriculum Vitae

                        NAVNEET KAUR DHILLON, Ph.D.


Professional Address:

      Department of Molecul...
2007- 2007              Senior Research Scientist
                             Department of Molecular & Integrative Physi...
•    Awarded the Junior Scientist Award in Immunology (2005) by
            Association of Scientists of Indian Origin in ...
7.    Navneet K. Dhillon, Sukhbir Dhillon, Yahia Chebloune, David Pinson
      Francois Villinger and Shilpa Buch. 2006. T...
15.Navneet      K. Dhillon, S.Sharma, G.K.Khuller. 2003. Biochemical
             characterization of Ca2+/calmodulin depe...
6.       Navneet Dhillon, Sukhbir Dhillon, Yahia Chebloune, Istvan Adany,
      Zhuang Li, Opendra Narayan and Shilpa Buch...
Invited Oral presentations:
         “Therapy of SHIV-infected Macaques with Antisense DNA of Interleukin-4:
         Two ...
virus and opportunistic pathogens that invade and proliferate in the lungs and induce
host factors that promote replicatio...
Upcoming SlideShare
Loading in...5
×

Curriculum Vitae

1,273

Published on

Published in: Education, Health & Medicine
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
1,273
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
5
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Curriculum Vitae

  1. 1. Curriculum Vitae NAVNEET KAUR DHILLON, Ph.D. Professional Address: Department of Molecular & Integrative Physiology University of Kansas Medical Center 3901 Rainbow Boulevard Kansas City, KS-66160 Telephone: 913.588.5576 Email: ndhillon@kumc.edu Nationality: INDIAN (Permanent residence status in US-Approved) Education: Degree Institution Date BS Biochemistry Punjab University 1991-1993 (Honours program) Chandigarh, INDIA MS Biochemistry Punjab University 1993-1995 (Honours program) Chandigarh, INDIA Ph.D. Postgraduate Institute of 1997-2002 Thesis: "Molecular mechanism(s) Medical Education and of regulation of phospholipid synthesis Research,Chandigarh, by Ca2+/calmodulin dependent protein INDIA phosphorylation in Candida albicans" Professional Positions: 2007- Present Research Assistant Professor Department of Molecular & Integrative Physiology University of Kansas Medical Center Kansas City, KS
  2. 2. 2007- 2007 Senior Research Scientist Department of Molecular & Integrative Physiology University of Kansas Medical Center Kansas City, KS 2006- 2007 Senior Research Associate Department of Molecular & Integrative Physiology University of Kansas Medical Center Kansas City, KS 2005- 2006 Senior Research Associate Department of Microbiology University of Kansas Medical Center Kansas City, KS 2002- 2005 Postdoctoral Research Fellow Marion Merrell Dow Laboratory of Viral Pathogenesis, Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS Awards & Fellowships: • Punjab University Gold Medalist for standing first in B.Sc. (Hons.) Biochemistry. • Dr. Ramji Narain Omvati Gold Medalist for excelling in B.Sc. (Hons.) Biochemistry. • National Scholarship awarded in M.Sc (H.S.) for two years. • Punjab University Gold Medalist for standing first with distinction in M.Sc (Hons.) Biochemistry. • Dr. Ramji Narain Omvati Gold Medalist in M.Sc (Hons.) Biochemistry. • Qualified Graduate aptitude test of engineering (GATE),1995 (94.99 percentile) • Awarded Council of Scientific and Industrial Research fellowship (CSIR) at national level for five years during Ph.D program. • Offered Postgraduate Institute of Medical Education and Research (PGIMER) fellowship for Ph.D program (but opted for CSIR fellowship) • Travel Award to attend the 22nd Annual Symposium on Nonhuman Primate Models for AIDS,2004
  3. 3. • Awarded the Junior Scientist Award in Immunology (2005) by Association of Scientists of Indian Origin in America (ASIOA) • Awarded the Young Investigator Award to attend the 13th Conference on Retroviruses and Opportunistic Infections (CROI 2006) • Travel Award to attend the 12th Society of Neuroimmunology and Pharmacology Conference (SNIP,2006) Peer Reviewed Publications: 1. Navneet K. Dhillon, Fuwang Peng, Richard R. Ransohoff, Shilpa Buch. 2007, PDGF Synergistically Enhances IFN-γ Induced Expression of CXCL10 in Blood-Derived Macrophages: Implications for HIV-Dementia. J. Immunology (accepted). 2. Navneet K. Dhillon, Rachel Williams, Fuwang Peng, Yi-jou Tsai, Sukhbir Dhillon, Brandon Nicolay, Milind Gadgil and Shilpa J. Buch. 2007, Cocaine-mediated Enhancement of Virus Replication in Macrophages: Implications for HIV-Dementia. J Neurovirology (accepted) 3. Navneet K. Dhillon, Milind Gadgil, Andy Rahardja, Himanshu Kenjale, Alex Sidelnik, Duncan Renfrow, Amanda†, Sukhbir Dhillon, Anil Kumar and Shilpa J. Buch†. 2007. Cocaine: A Catalyst for Human Immunodeficiency Virus-Associated Dementia. Am. J. Infectious Diseases. (Review) 4. Navneet K. Dhillon, D Pinson, S Dhillon, O Tawfik, M Danley, M Davis, O Nemon, M Mayo, A Kumar, Y Tsai, A Kumar, and S Buch. 2007. Bleomycin Treatment causes Enhancement of Virus Replication in the Lungs of SHIV- infected Macaques. Am J Physiol Lung Cell Mol Physiol. May; 292(5):L1233-40. 5. Navneet K. Dhillon*,Yongjun Sui*, David Pinson, Shanping Li, Sukhbir Dhillon, Ossama Tawfik, Shannon Callen, Olga Nemon, Opendra Narayan, Shilpa Buch (*co first authors ).2007. Up-regulation of PDGF and its Receptor Expression in Simian-Human Immunodeficiency Virus- Associated Pneumonia in Macaques. AIDS. Jan 30; 21(3):307-316. 6. Abhik Datta, Uma Sinha-Datta, Navneet K. Dhillon, Shilpa Buch and Christophe Nicot. 2006. HTLV-I and innate immunity: Interference with TLR4 signaling by p30 modulates the release of pro-and anti- inflammatory cytokines from human macrophages. J Biol Chem. Aug 18;281(33):23414-24
  4. 4. 7. Navneet K. Dhillon, Sukhbir Dhillon, Yahia Chebloune, David Pinson Francois Villinger and Shilpa Buch. 2006. Therapy of SHIV Infected Macaques with Liposomes Delivering Antisense IL-4 DNA. AIDS. May 12;20(8):1125-30 8. Yongjun Sui, Lisa Stehno-Bittel, Shanping Li, Rajprasad Loganathan, Navneet K. Dhillon, David Pinson, Avindra Nath, Dennis Kolson, Opendra Narayan, Shilpa Buch.2006. CXCL10-induced Cell Death in Neurons: Role of Calcium Dysregulation. Eur J Neurosci. Feb;23(4):957-64. 9. Navneet K. Dhillon, Yongjun Sui, Raghava Potula, Sukhbir Dhillon, Istvan Adany, Zhuang Li, Francois Villinger, David Pinson, Opendra Narayan, and Shilpa Buch. 2005. Inhibition of Pathogenic SHIV Replication in Macaques Treated With Antisense DNA of Interleukin-4. Blood. April; 105(8):3094-3099. 10. Shilpa Buch, Yongjun Sui, Navneet Dhillon, Raghava Potula, Christopher Zien, David Pinson, Shanping Li, Sukhbir Dhillon,Brandon Nicolay, Alex Sidelnik, Cicy Li, Tara Villinger, Kunal Bisarriya and Opendra Narayan.2004. Cytokines and Chemokines as perpetrators of Simian Human Immunodeficiency Virus-Encephalitis. J Neuroimmunology Dec;157(1-2):71-80. Review. 11. Raghava Potula, Navneet Dhillon, Yongjun Sui, Christopher Zien, Keiko Funa, David Pinson, Opendra Narayan and Shilpa Buch.2004 Association of Platelet-derived Growth Factor-B chain with Simian Human Immunodeficiency Virus Encephalitis. American J Pathology 165(3) 12. Yongjun Sui, Raghava Potula, Navneet Dhillon , David Pinson, Shanping Li, Avindra Nath, Carol Anderson, Dennis Kolson, Opendra Narayan, and Shilpa Buch. 2004. Neuronal Apoptosis is mediated by CXCL 10 over-expression in Simian Human Immunodeficiency Virus- Encephalitis. American J Pathology 164(5):1557-1566 13. Buch S, Y Sui, R Potula, D Pinson, I Adany, Z Li, S Li, Navneet Dhillon, E major and O Narayan .2003. Role of interleukin-4 and monocyte chemoattractant protein-1 in the neuropathogenesis of X4- SHIV infection in macaques. J. Neurovirology 10 suppl 1:118-24 14.Navneet K. Dhillon, S.Sharma, G.K.Khuller. 2003. Signaling through protein kinases and transcriptional regulators in Candida albicans. Crit. Rev.Microbiol.29: 259-75.
  5. 5. 15.Navneet K. Dhillon, S.Sharma, G.K.Khuller. 2003. Biochemical characterization of Ca2+/calmodulin dependent protein kinase from Candida albicans. Mol.cell.Biochem. 252: 183-191. 16.Navneet K. Dhillon, S.Sharma, G.K.Khuller. 2003. Influence of W-7, a calmodulin antagonist on phospholipid biosynthesis in Candida albicans. Lett Appl Microbiol. 36(6): 382-6. 17.Navneet Kaur, Jyotdeep Kaur and Akhtar Mahmood. 2002. Studies on Harmaline interactions with brush border sucrase in rat intestine. Ind. J Biochem. Biophys. 39:119-123. Abstracts: 1. S.D. Bartolome, Sukhbir Dhillon, Navneet Dhillon, J. Vacek, R. Ferrell, S. Buch, A.R. O’Brein-Ladner. Peripheral Blood HIF-1α RNA Levels before and after Exercise. American Thoracic Society International Conference, May 18-23, 2007, San Francisco, California, US. 2. Navneet Dhillon, R. Williams, F. Peng, K. Kim and Shilpa Buch. HIV- gp120 & cocaine affect blood brain barrier permeability. 13th Annual Meeting of the Society on NeuroImmune Pharmocology, April 11-14, 2007, Salt Lake city, Utah, US. 3. Navneet Dhillon, Brandon Nicolay, Milind Gadgil, Yi-jou Tsai, Sukhbir Dhillon, Opendra Narayan and Shilpa J. Buch. Cocaine: A co-factor for HIV-Dementia. 1st USA-Caribbean Conference for HIV-AIDS and Drug Abuse, Dec 8-12, 2006, San Juan, Puerto Rico. 4. Shilpa Buch, Navneet Dhillon, Brandon Nicolay, Milind Gadgil, Yi-Jou Tsai, Cicy Li, Sukhbir Dhillon and David Pinson. Cocaine: A co-factor for HIV-Dementia. 7th International Symposium on NeuroVirology, May 31- June 3, 2006, Philadelphia, PA, US. 5. Navneet Dhillon, Brandon Nicolay, Milind Gadgil, Yi-Jou Tsai, Sukhbir Dhillon, Himanshu Kenjale, Cicy Li, Opendra Narayan and Shilpa Buch. Synergistic Effect of Cocaine and HIV on Factors Mediating HIV-Dementia. 12th Annual Meeting of the Society on NeuroImmune Pharmocology, April 5-9, 2006, Santa Fe, NM, US.
  6. 6. 6. Navneet Dhillon, Sukhbir Dhillon, Yahia Chebloune, Istvan Adany, Zhuang Li, Opendra Narayan and Shilpa Buch. Therapy of SHIV Infected Macaques with Antisense DNA of IL-4. 13th Conference on Retrovirus and Opportunistic Infections, February 5-8,2006, Denver, CO, US. 7. Navneet Dhillon, Sukhbir Dhillon, Istvan Adany, Zhuang Li, Opendra Narayan and Shilpa Buch. Therapy of SHIV Infected Macaques with Antisense DNA of IL-4. 23rd Annual symposium on Non Human primate models for AIDS, September21-24, 2005, Portland, OR, US. 8. Navneet Dhillon, Sukhbir Dhillon, Istvan Adany, Zhuang Li, Francois Villinger,Opendra Narayan and Shilpa Buch. Therapy of SHIV Infected Macaques with Antisense DNA of IL-4.3rd International AIDS Society Conference on HIV Pathogenesis and Treatment, - July 24 - 27, 2005 Rio de Janeiro, Brazil. 9. Navneet Dhillon, Sukhbir Dhillon, Istvan Adany, Zhuang Li, Opendra Narayan and Shilpa Buch. Inhibition of Pathogenic SHIV Replication in Macaques Treated with Antisense DNA of Interleukin-4. 22nd Annual symposium on Non Human primate models for AIDS, November3-6, 2004, San Antonio, TX, US. 10. Shilpa Buch, Raghava Potula, Yongjun Sui, Navneet Dhillon, Christopher Zien, Opendra Narayan. Role of Platelet-Derived Growth Factor in SHIV-Encephalitis. 22nd Annual symposium on Non Human primate models for AIDS, November3-6, 2004, San Antonio, TX, US 11. Christopher A. Zien, Shamping Li, Navneet Dhillon, Dinesh K. Singh, Opendra Narayan, Shilpa Buch. SHIV 89.6P Mediated Induction of MCP-1, IP-10, and IL-8 in Astrocytes. 22nd Annual symposium on Non Human primate models for AIDS, November3-6, 2004, San Antonio, TX, US. 12. Navneet Dhillon, Raghava Potula, Shilpa Buch and Opendra Narayan. Modulation of Simian Human Immunodeficiency Virus Replication by Antisense IL-4 Oligonulceotides. 21st annual symposium on Non Human primate models for AIDS, October 22-25, 2003, Seattle, WA US. 13. Navneet Dhillon, Raghava Potula, Shilpa Buch and Opendra Narayan. Inhibition of Simian Human Immunodeficiency Virus replication by Antisense IL-4 oligonucleotide. 5th International Symposium on Neurovirology, September 4-6, 2003, Baltimore, MD US.
  7. 7. Invited Oral presentations: “Therapy of SHIV-infected Macaques with Antisense DNA of Interleukin-4: Two possible Mechanisms,” Invited presentation in the Department of Microbiology, Molecular Genetics and Immunology Seminar series March 3, 2005 “Inhibition of Pathogenic SHIV Replication in Macaques Treated with Antisense DNA of Interleukin-4.” 22nd Annual symposium on Non Human primate models for AIDS, November3-6, 2004, San Antonio, TX, US. Teaching Experience: • Taught undegraduate students in Biochemistry. • Supervised graduate students: Crystal Bethel and Rachel Williams • Supervised summer students : 2003: Jane Segerbrecht 2004: Brandon Nicolay, Alex Sideliick, 2006: Cicy Li, Amanda Moradi, Ishweena Duggal, Duncan Symon, Andy Rahardja • Supervised research technician and post doctoral fellows Professional Affiliations: Member of American Association for the Advancement of Science Member of New York Academy of Sciences Member of Sigma Xi Funding: Project Title: “Nanoparticle-Based Gene Therapy for SHIV Pneumonia in Macaques” Funding Organization: Parker B. Francis Foundation (Fellowships in Pulmonary Research) Amount to be funded: $144,000 over 3 years (July 2007-2010) Role in the Project: Principal Investigator In this grant I will be comparing the efficiency of poly (DL-lactic-co-glycolic acid) (PLGA) nanoparticles with that of the cationic liposomes to deliver AS IL-4 to chronically infected macaques in attempts to curtail replication of the virus, thereby preventing the pneumopathy. Research Interests and Future plans: HIV-associated pneumonia is a late complication of the systemic infection and is a major cause of morbidity and mortality in more than 50% of infants and children infected with this virus. Current ideas on mechanisms of pathogenesis of the pneumopathy are that the syndrome results from a synergistic interaction between the
  8. 8. virus and opportunistic pathogens that invade and proliferate in the lungs and induce host factors that promote replication of the virus. Intervention strategies could therefore be aimed at attempts to curtail either replication of the virus with antiretroviral drugs, as is currently being done, or to curtail the exaggerated production of the host factors that promote virus replication. My studies have been aimed at intervention using gene therapy techniques to curtail the exaggerated production of host factors that promote virus replication. I plan to move the field of antisense delivery further by using nanoparticle-mediated gene delivery in infected macaques with the ultimate goal of abrogating virus replication in the lungs of infected macaques. Since many of the pneumopathies are chronic syndromes, any approach to therapy would have to involve multiple sequential administrations, spanning long periods of time. Although liposomal gene delivery vectors are attractive for their ability to deliver AS DNA, they are typically immunogenic, toxic and could not be considered for multi-administration. Therefore, there is a critical need to develop an alternative gene delivery vector(s) that can deliver AS DNA in vivo repeatedly. I received a fellowship from Parker B. Francis Foundation this year to compare the efficacy of liposomes with that of the biodegradable poly (DL-lactic-co-glycolic acid) (PLGA) nanoparticles, containing AS IL-4, as therapy for SHIV-infected macaques with pneumonia. The advantages of nanoparticle delivery system of being non-immunogenic, non-toxic and cost effective will provide an opportunity to evaluate efficacy of ASDNA containing nanoparticles for therapy of chronic pneumonia in HIV-infected individuals. This gene therapy has also a potential to be tested for other infectious or immune-mediated lung diseases such as asthma.

×