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    CURRICULUM VITAE CURRICULUM VITAE Document Transcript

    • HARVARD MEDICAL SCHOOL CURRICULUM VITAE Part I: General Information Date Prepared: July 31, 2008 Name: Leslie Eric Silberstein, M.D. Office Address: Children’s Hospital, Boston Karp Family Research Building 10th floor, room 10217 1 Blackfan Circle Boston, Massachusetts 02115 Home Address: 500 Commercial Street Boston, Massachusetts 02109 E-mail: leslie.silberstein@childrens.harvard.edu Phone: (617) 919-2588 Fax: (617) 730-0765 Place of Birth: New York, NY Education: 1963 – 1969 B.A. Gymnasium-B Peter Stuyvesant Lyceum, Curacao, Netherlands Antilles 1969 - 1977 M.D. College and Medical School University of Leiden Leiden, The Netherlands Postdoctoral Training and Fellowship Appointments: 1977-1978 Intern Internal Medicine Georgetown University Medical Division D.C. General Hospital Washington, D.C. 20003 1978-1980 Resident Internal Medicine St. Francis Hospital and Medical Center Hartford, CT 06105
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 2 1980-1981 Clin. Fellow Hematology/Oncology Tufts-New England Medical Center Hospital Department of Medicine Boston, MA 02111 1981-1983 Fellow Blood Bank Tufts-New England Hematology/Oncology Medical Center Hospital Boston, MA 02111 Licensure and Certification: 1980 American Board of Internal Medicine – Member #77204 1980 Board of Registration in Medicine, Massachusetts 1982 American Board of Internal Medicine, subspecialty in Hematology Member #77204 1984 American Board of Pathology, subspecialty in Blood Banking Academic Appointments: 1983-1987 Assistant Professor 1988-1994 Associate Professor 1994-2000 Professor Departments of Pathology, Laboratory Medicine, and Medicine University of Pennsylvania Philadelphia, PA 19104 2000-present Professor Harvard Medical School Department of Pathology Brigham and Women’s Hospital, Children’s Hospital, Dana-Farber Cancer Institute. Boston, MA 02115 Hospital or Affiliated Institution Appointments: 1983-1985 Assistant Director, Blood Bank Hospital of the University of Pennsylvania 1985.2000 Director, Blood Bank and Hospital of the University of Transfusion Medicine Section Pennsylvania 1992.2000 Associate Director, Bone Marrow University of Pennsylvania Transplant Program Cancer Center 2000-present Director, Joint Program in Children's Hospital, Boston Transfusion Medicine Brigham and Women’s Hospital Dana-Farber Cancer Institute 2005-present Director, Center for Human Cell Therapy CBR Institute for Biomedical Research Awards, Honors and Membership in Honorary Societies:
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 3 1980-1982 American Cancer Society Fellowship Award 1992- American Society of Clinical Investigation 2000 Henry Kunkel Society, Rockefeller University. Membership in Professional and Scientific Societies: 1983-present American Society of Hematology Member 1983-present American Association for the Member Advancement of Science 1983-present Pennsylvania Association of Blood Banks Member 1984-present American Red Cross, Penn Jersey Region Member, Medical Advisory Board 1984-present American Federation for Clinical Research Member 1985-present American Association of Pathologists Member 1985-1988 American Association of Blood Banks Member, Committee on Self-Testing and Review 1986-1989 Philadelphia Society of Hematology/ Secretary/Treasurer Oncology 1986-1993 American Association of Blood Banks Chairman, Committee on Transfusion Practices 1986-1990 American Association of Blood Banks Elected by Membership, Scientific Section Coordinating Committee 1987-1990 American Association of Blood Banks Liaison Member, Molecular and Cellular Biotechnology 1988-present American Association of Immunologists Member 1988-present Greater Philadelphia Hospitals Member, Board of Directors Blood Bank Association 1990 Greater Philadelphia Hospitals Vice President Blood Bank Association 1991-1994 American Association of Blood Banks Member, Scientific Program Committee 1992-1998 American Society of Hematology Member, Subcommittee on Transfusion Medicine 1993-present American Society of Clinical Investigation Member 1993-present American Association of Blood Banks Member, Transfusion Medicine Research Strategies Committee 1994-1997 American Association of Blood Banks Chairman, Scientific Program Committee 1994-2002 National Blood Foundation Member 1995-present Lymphoma Research Foundation of Member, Scientific Review America, Inc. Committee 1995-1996 American Society of Hematology Chairman, Subcommittee on Transfusion Medicine 1996 Philadelphia Immunology Conference Co-Chairman 1996-2002 American Board of Internal Medicine Member, Subspecialty Board on Hematology
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 4 1996 American Society of Hematology Coordinating Reviewer of Abstracts, Annual Meeting 1998-present American Association of Blood Banks Member, Leukocyte Reduction Committee 2000 National Blood Foundation Chair, Grants Review Committee 2000-present National Blood Foundation Board Member 2000-present American Association of Blood Banks Member, Nominating Committee 2001-present American Society of Hematology Scientific Committee on Transfusion Medicine 2001-present Blood Research Institute, Milwaukee, WI Member, Scientific Advisory Board 2003 American Society of Hematology Co-Chair of 2003 Scientific Program 2005 Harvard Stem Cell Institute Program Head of Translational Research 2006-present K-12 Program in Non-Malignant Member, Advisory Committee Hematology Program, HMS 2006 American Association of Blood Banks Standards Program Committee 2007 Committee in Immunology, HMS Membership Subcommittee Editorial Boards: Reviewer for Journals, Publishers, and Abstracts: • Anesthesia and Analgesia • Annals of Internal Medicine • Acta Haematologica • Blood • Journal of Clinical Apheresis • Journal of Clinical Investigation • Journal of Immunology • New England Journal of Medicine • Transfusion • Williams and Wilkins Publishers • Internal Immunology • International Blood Group Reference Laboratory, Bristol, UK • Canadian Red Cross Society, Research and Development Program 1990-present Member Journal: Pathobiology 1992-present Editor Textbook: “Hematology: Basic Principles and Practice.” Churchill Livingstone. R. Hoffman, E. Benz, S. Shattil, B. Furie, H. Cohen, L.E. Silberstein eds. 1993-present Member Journal: Laboratory and Clinical Immunology 1995-2001 Assoc. Editor Journal of Immunology 1995 Editor Textbook: “Immunoglobin Gene Expression in Development and Disease.” Annals of the New York Academy of Sciences. P. Casali and L.E. Silberstein eds.
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 5 1996-2001 Assoc. Editor Transfusion 1996 Member Nouvelle Revue Francaise d’Hematologie (Hematology and Cell Therapy) 2001 Member Journal of Autoimmunity 2001 Member Blood 2002-present Editor Textbook: “Blood Banking and Transfusion Medicine: Basic Principles and Practice.” Christopher Hillyer, P. Ness, K. Anderson, L.E. Silberstein eds. Committees for the National Institutes of Health: 1994 Ad Hoc Reviewer for N.I.H. Study Section for RFA on Immunobiology of AIDS-related lymphoma. 1996- Reviewer, Special Emphasis Panel for N.I.H. study section to review program projects on transfusion biology. 1997-2001 Member of Program Project Review Committee, National Heart, Lung, and Blood Institute; Four-year appointment. 1997 - Invited member of Special Emphasis Panel, National Heart, Lung, Blood Institute, Bethesda, MD. 1997 - Reviewer, Centers for AIDS Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD. 1998- Immunobiology Study Section, (Ad Hoc member, 10/98) 1998Chair, Immunology, “Topics in Transfusion Medicine Research”, sponsored by the National Heart, Lung and Blood Institute, Bethesda, MD. September 14 and 15, 1998. 1998- ASH Academic Awards Committee/Reviewer for Year 2000 Awards. 1999- Invited member of National Cancer Institute Research Evaluation and Decision Panel of the AIDS Specimen Bank. 2000- Chair, Review Committee of REDS Program, NHLBI 2001- Special emphasis panel. National Heart, Lung and Blood Institute. “Research on stem cell therapies” 2004-Chair, Review Committee of REDS Program, NHLBI 2004- Reviewer, Tumor Microenvironment (TME) Program, NIH 2005- Scientific Committee Chairs Meeting, ASH, Washington, DC 2005Chair, Review Committee, Special Emphasis Panel, Review of PPG Applications (PO1s), February 23, 2005 2005 Reviewer, NHLBI Loan Repayment Program Review of Applications, Online Review, March 7-26, 2005 2005 Consultant, NHLBI Special Emphasis Panel, SCCOR in Transfusion Biology and Medicine, March, 29, 2005 2006 NIH P01 Review – Division of Extramural Affairs, Review Branch, April 25-26, 2006 2006 NHLBI – Strategic Planning Meeting, “Research in Global Blood Safety and Availability (Domestic and International)” May 9, 2006 2007 NIH TME Study Section, Bethesda, MD February 12-13, 2007
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 6 2007 NIH Operational Review of the Department of Transfusion Medicine. Bethesda, MD. March 5-7, 2007. 2007 NIH Grantees’ Meeting for SCCOR in Transfusion Biology and Medicine and Working Group on Immune Consequences of Allogeneic Exposures. Bethesda, MD. May 9, 2007. Principal Investigator of Grants: 1987 - 1988 Purification and Characterization of Monoclonal Red Blood Cell Autoantibodies Derived from B-Cell Lines. Biomedical Research Support, University of Pennsylvania School of Medicine $10,000 ADC 1987 - 1988 A Double-Blind, Placebo - Controlled Study to Determine Whether R- HuEPO Can Facilitate Presurgical Autologous Blood Donations and Determine its Safety for this Purpose. Ortho Pharmaceutical Corporation $25,000 5/88 - 4/93 The Human B-Cell Repertoire of Erythrocyte Autoantibodies. National Institute of Diabetes/Digestive/Kidney Diseases National Institutes of Health, Bethesda, MD; R29DK39065-01 $70,000 ADC 9/89 - 9/94 Analyses of Methods of Lymphocyte Separation for Sterile Culture and Flow Cytometry. Becton-Dickinson, Mountain View, CA $55,000 ADC 12/89 - 12/92 Harvest of Enriched Human Monocyte Preparations for the Characterization of Interleukin-1 Merck, Sharp & Dohme, Rahway, NJ $20,500 ADC 1/90 - 1/91 Variable Region Gene Alterations in Human B-Cell Neoplasia With Autoreactive Specificity Research Foundation, University of Pennsylvania, School of Medicine $4,500 10/89 - 10/95 5% effort on Transfusion Medicine Academic Award Grant Award to Dr. Urs Giger/University of Pennsylvania, School of Veterinary Medicine $4,000 per year 3/90 - 3/91 Molecular Characterization of the Rhesus (Rh) Blood Group Antigen Complex Biomedical Research Support, University of Pennsylvania School of Medicine $5,900 6/91 - 6/93 Cold Agglutinins in Relation to Autoimmunity, Autoimmune Disease, and Neoplasia NATO Collaborative Research Grants Program $10,000 7/91 - 6/96 15% effort on Transfusion Medicine Academic Award Grant Award to Dr. Leigh Jefferies.
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 7 University of Pennsylvania, School of Medicine; National Heart, Lung and Blood Institute; National Institutes of Health, Bethesda MD; # 1 K07 HL02673 - 01 $460,387 TDC 9/91 - 9/96 National Heart, Lung, and Blood Institutes of Health, Bethesda MD; #1 T35 HL07719-01; Short-Term Training for Minority Students Program; 5% effort $119,475 TDC 7/94 - 7/99 National Heart, Lung, and Blood Institutes of Health, Bethesda MD; Academic Transfusion Medicine Training Program; 1T322HL07775-01; 5% effort $343,980 TDC 1/94 - 1/95 Lupus Foundation of Philadelphia, "Pathogenesis of autoimmune hemolysis in SLE" $15,000 TDC 8/94 - 8/99 National Cancer Institute, "HIV associated B cell activation and lymphoma development"; RO1CA65394 - 20% effort $748,702 TDC 12/94 -12/98 National Institute of Diabetes, Digestive and Kidney Diseases. RO1DK39065-06-20% effort: “Pathogenesis of Autoimmune Hemolytic Anemia” $785,617 TDC 1/96 - 1/98 National Institute of Child Health and Human Development R44 HD31812-02-Consultant “Prenatal Blood Group Analysis in High Risk Pregnancy” (ATGC) $323,493 TDC 2/96 - 2/01 National Heart, Lung and Blood Institute, Bethesda, MD; #1P50HL54516-01 - 37.5% effort "Cellular & Humoral Aspects of Immunomodulation" $9,299,732 TDC 9/96 - 9/01 National Heart, Lung, and Blood Institute of Health, Bethesda, MD; #2T35 HL07719-06; Short-Term Training for Minority Students Program; 5% effort $108,750 TDC 7/99-7/04 National Heart, Lung, and Blood Institute of Health, Bethesda, MD; Academic Transfusion Medicine Training Program; 2T32HL07775; $634,722 TDC 7/01-7/11 National Heart, Lung, and Blood Institute of Health, Bethesda, MD; Academic Transfusion Medicine Training Program; 2T32HL66987; $1,653,057 TDC 09/01-08/06 National Heart, Lung, and Blood Institute of Health, Bethesda, MD P01 HL056949; (PI: Denisa Wagner): Adhesion Molecules in Transfusion Biology. Project Leader, “Role of Chemokine-Mediated Adhesion in B Lymphopoiesis.” $234,069 9/02-8/07 National Heart, Lung, and Blood Institute of Health, Bethesda, MD; “Transfusion Medicine/Hemostasis Clinical Research” Co-PI; 1U01HL72291 – 5% effort $252,587 8/02-2/04 Baxter Healthcare Corporation, “S-303 Treated Red Blood Cell Use in
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 8 Patients Requiring Chronic Transfusion Support” Investigator; RBC3B01 - 4% effort $120,586 7/04-6/09 National Institutes of Health; “Center for Human Cell Therapy”; Principal Investigator; 1 R24 HL074355-01 $12,600,000 Regional, national, or international contributions: Invited Presentations 1/31/91 "B-cell Origin of Cold Agglutinins" - Symposium on Autoimmunity and Immunology, Tufts University, Boston, Massachusetts 2/6/91 "The Role of Autoreactivity in Human B-cell Neoplasia" - Medical Biology Institute, La Jolla, California 3/26/91 "The Role of Autoreactivity in Human B-cell Neoplasia" - University of California, San Diego, Department of Medicine, CA 9/10/91 "The Relationship Between Autoreactivity and Human B-Cell Neoplasia" - Blood Center of Southeastern Wisconsin 6/6/92 "Autoreactive B-cell Neoplasms" - Tenovus Research Institute; Molecular Immunology Group, Southampton, United Kingdom 7/15/92 "The Relationship Between Self Reactive B-cells and Lymphomagenesis", GenPharm International Corp., Mountainview, CA. 10/5/92 "B-cell Origin of Cold Agglutinins", International Symposium on Immunology of Proteins and Peptides, Banff, Canada. 12/5/92 "Pathologic Cold Agglutinins Recognize i, I and PR2 Determinants on Both Murine and Human Lymphocyte Subsets", American Society of Hematology Annual Meeting, Anaheim, CA. 12/5-7/92 Reviewer of abstracts and Moderator for the session on "Lymphocytes and Immunology" at the American Society of Hematology Annual Meeting, Anaheim, CA. 4/13/93 "The Role of Self Reactivity in Lymphomagenesis" Departments of Pediatrics and Medicine, University of Rochester, Rochester, NY. 4/23-24/93 "The Origin of Red Cell Autoantibodies" at Harvard-Yale Update in Transfusion Medicine, Boston, MA. 5/20/93 "Origin of Naturally Occurring Versus Pathogenic Cold Agglutinins. Fundamental Aspects of Autoimmunity" - NATO conference, Acqua Fredda Di Maratea, Italy. 10/12/93 "B-cell Responses to Antigens", Hoxworth Blood Center, Cincinnati, OH. 10/25/93 "The Antibody Response to Antigen" at the American Association of Blood Banks Annual Meeting, Miami, FL. 2/22/94 "Role of Self-reactivity in Lymphomagenesis", Department of Laboratory Medicine, Yale University, New Haven, CT. 5/16/94 "Role of Self-reactivity in Lymphomagenesis", North Shore University Hospital, Manhasset, N.Y. 7/3-17/94 Chair: New York Academy of Sciences sponsored conference entitled: "Immunoglobulin Gene Expression in Development and Disease", Montreal, Canada.
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 9 12/3/94 American Society of Hematology, National Meeting, Nashville, TN; Educational Session: Peripheral Stem Cell Collection and Processing. 2/9/95 New Jersey Medical School, Newark, NJ, Department of Pathology, “Autoreactivity and Lymphomagenesis”. 6/5/95 Blood Center of Southeastern Wisconsin, Milwaukee, WI, “Origin of Autoimmune and Neoplastic B-Cells”. 6/9/95 New York University, New York, NY, Department of Hematology Oncology, “Immunoglobulin Gene Analysis in Normal, Autoimmune and Neoplastic B Cells”. 6/24/95 Oxford Forum, Oxford, UK, “Perspectives of Idiotypic Vaccines in B CLL”. 10/10/95 Institut Pasteur, Division of Immunology, Paris, France. "Is Immunoglobulin Gene Expression in Humans a Stochastic Process?". 10/15/95 NATO Conference on B-cells in Development and Disease, Luteren, The Netherlands, "Expression of the VH4-34 Gene in Normal, Autoimmune and Neoplastic Repertoires". 11/12/95 Chair, Annual Seminar: "Functional and Molecular Aspects of Blood Group Antigens". American Association of Blood Banks, New Orleans, LA. 11/13/95 Moderator, Plenary Session, American Association of Blood Banks, New Orleans, LA. 12/3/95 Chairman, Scientific Subcommittee on Transfusion Medicine, American Society of Hematology, Seattle, WA. 2/26/96 NIH Scientific Review Panel, “Adhesion Molecules in Transfusion Medicine”, Bethesda, MD. 3/7/96 Blood Research Institute, Blood Center of Southeastern Wisconsin, “Ig Gene Expression in Human B-cell Development”, Milwaukee, WI. 5/16/96 NIH, Heart, Lung and Blood Program Project Review Committee, “Cellular Therapies in Transfusion Medicine”, Bethesda, MD. 6/17/96 Blood Center Research Foundation External Review, Blood Center Research Institute, Milwaukee, WI. 11/15/96 St. Christopher’s Hospital for Children, “Pathophysiology of Autoimmune Hemolytic Anemia”, Philadelphia, PA. 1/9/97 Temple University School of Medicine, Clinical Pathology Conference, Department of Medicine. 3/8/97 National Cancer Institute, “HIV Induced B Cell Activation and Lymphomagenesis”, Rockville MD. 3/10/97 Emory University Hospital, “AIDS Related Lymphoma: B-cell Activation Preceding Lymphomagenesis”, Atlanta, GA. Visiting Professor, Dept. of Pathology and Laboratory Medicine. 3/15/97 National Blood Foundation Grants Review Committee, Bethesda, MD 9/17/97 The Johns Hopkins University, “HIV Induced B Cell Activation and Lymphomagenesis”, Baltimore, MD. Visiting Professor, Dept. of Pathology and Laboratory Medicine.
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 10 9/21/97 Harvard Medical School, Cancer Medicine and Hematology, “Autoimmune Hemolytic Anemias”, Boston, MA. 9/29/97 National Institutes of Health, National Heart, Lung and Blood Institute, Special Emphasis Panel Meeting, Research Priorities in Blood Diseases and Resources, Bethesda, MD. 10/19/97 Chair, Short topic seminar: “Novel Cellular Therapies”, American Association of Blood Banks Annual Meeting, Denver, Co. 11/25/97 Children’s Hospital of Pennsylvania, “Immunoglobulin Mediated Mechanisms in B-Cell Development: Implications for Autoimmunity and Lymphomagenesis”, Philadelphia, Pa. 12/8/97 Moderator, “Transfusion Medicine Session”, ASH Conference, American Society of Hematology, San Diego, CA 4/2/98 University of Miami School of Medicine, Department of Pathology, “HIV induced B-cell activation and lymphoma development”, Miami, FL. 4/19/98 “Role of Superantigen in Lymphomagenesis and Clonal evolution”, B- Cell Lymphoproliferative Disorders Conference, Imidex USA, Inc., New York, NY. 6/1/98 University of California, Los Angeles, Department of Pathology and Laboratory Medicine, Grand Rounds, “HIV induced B-cell activation and lymphoma development”, Los Angeles, CA. Visiting Professor, Dept. of Pathology and Laboratory Medicine. 6/13/98 “ Role of human VH genes in normal and neoplastic B cell development”, ACPLS Conference, Boston MA 9/16-17/98 National Heart Lung and Blood Institute, Chair, “Research in Transfusion Medicine”, Bethesda, MD October 12, 1998. Workshop: B Cell Regulation, “Chemokine Receptors and B-cell Activation”, European Research Conferences, Research Conference of B Cells in Health and Disease: B Cells and Autoimmunity, Maratea, Italy 12/5-6/98 "Immunomodulation in Leukoreduced Blood Components"; Transfusion Medicine Educational Symposium, American Society of Hematology, Miami Beach, Florida 1/19/99 Keystone Symposia, “Role of Chemokines in Human B Cell Development,” Silverthorne, CO. 5/22-29/99 Visiting Professor, Department of Pathology and Laboratory Medicine at Albert Einstein Medical Center, New York, NY. 9/22-23/99 Coordinator and Chair for Alloimmunization Panel at AABB Scientific Think Tank: “Setting the Research Agenda for Immunolobiology in Transfusion Medicine,” Ellicott City, MD. 10/12/99 “Role of Chemokines in Human B Lymphopoieses,” The Richard and Nancy Leeds Seminars in Experimental Immunology, North Shore University Hospital, Manhasset, NY. 11/8/99 “Role of Chemokines in Human B Cell Development,” Children’s Hospital Oakland Research Institute (CHORI), Oakland, CA.
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 11 11/5/00 American Association of Blood Banks Annual Meeting, Meet the Expert Session, Transfusion Medicine Expert 12/3/00 American Society of Hematology Annual Meeting, Meet the Expert Session, Transfusion Medicine Expert 5/9/01 Bay State Medical Center, Update in Diagnostic Pathology and Medicine Series 2000-2001 6/01 Cancer Research Institute, “Chemokine Mediated Adhesion in B Lymphopoiesis”, Genoa, Italy 10/13-14/01 American Society of Blood Banks 54th Annual Meeting, “NBF Grants in the Spotlight”, San Antonio Texas 10/16-22/01 Amsterdam Zoo 3rd Annual Meeting, “Sustained Versus Transient SDF-1 Induced Adhesion During B Call Development”, Amsterdam, Netherlands 4/2-7/02 Centro Nacional de Biotecnoloie (CNB), “B Linage Stage Determines Prolonged Versus Transient Adhesion through Distinct Chemokine Signaling Pathways”, Madrid, Spain 12/17-18/02 “Sustained Activation of Cell Adhesion in a Differentially Regulated Process in B Lymphopoiesis,” University of Illinois, Chicago, IL. 2/11/03 “Sustained Chemokine-Induced Cell Adhesion is a Differentially Regulated Process in B Lymphopoiesis,” University of Louisville, Louisville, KY 3/13/03 “Sustained Activation of Cell Adhesion is a Differentially Regulated Process in B Lymphopoiesis,” New York Blood Center, NY 3/24/03 “Chemokine Induced Adhesion in B Cell Development,” Yale Cancer Center Grand Rounds, Yale University, CT 3/9/04 “Biology of Chemokine Mediated Adhesion During B Lymphopoiesis“ College of Physicians and Surgeons of Columbia University, New York 4/14/05 “The Role of Chemokines in the Bone Marrow Compartment” Montefiore Medical Center, The University Hospital for the Albert Einstein College of Medicine, New York 6/24/05 American Society of Hematology (ASH) Representative at the International Society for Cellular Therapy (ISCT) Liaison Meeting, Bethesda, MD 1/6/06 “Lymphocyte Activation and Signaling” Keystone Symposia, Steamboat Springs, CO 5/07/06 “Targets and Delivery for Immunotherapy”- International Society for Cellular Therapy, Berlin, Germany 12/10/06 Meet the Experts Session – American Society of Hematology Annual Meeting, Orlando, FL 8/22/07 CELLutions Summit – Presentation: “Challenges of Translational Cell Therapy.” World Trade Center, Boston, MA
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 12 10/20/07 American Association of Blood Banks (AABB) Annual Meeting. Director/Moderator of session 5122-S-CT, Molecular Mechanisms in Stem Cell Therapy. Anaheim, CA Bibliography: Original Papers 1. Schoenfeld, Y.S., Hsu-Lin, S.C., Gabriels, J.E., Silberstein, L.E., Furie, B. C., Furie, B., Stollar, B.D., Schwartz, R.S. Production of autoantibodies by human-human hybridomas. Journal Clinical Investigation, 70(2):205-208, 1982. 2. Silberstein, L.E., Berkman, E.M., Fanburg, B.L. Serum angiotensin-1-converting enzyme after plasma exchange. Proceedings Society Experimental Medicine,173:222,1983. 3. Silberstein, L.E. and Berkman, E.M. Plasma exchange in autoimmune hemolytic anemia. Journal Clinical Apheresis, 1 (4):238, 1984. 4. Sherman, L.A., Silberstein, L.E., Berkman, E.M. Altered expression and thrombocytopenia responsive to plasma infusion in a patient with congenital rubella. Transfusion, 24:267-270, 1984. 5. Silberstein, L.E., Schoenfeld, Y., Schwartz, R.S., Berkman, E.M. A Combination of IgG and IgM autoantibodies in chronic cold agglutinin disease: immunologic studies and response to splenectomy. Vox Sanguinis, 48:105-109, 1985. 6. Silberstein, L.E., Duggan, D., Berkman, E.M. Plasma exchange in osteosclerotic myeloma associated with the POEMS syndrome. Journal Clinical Apheresis, 2:253,1985. 7. Silberstein, L.E. and Shaw, L. The effect of plasma exchange on phenytoin plasma concentration. Therapeutic Drug Monitor, 8:172-176, 1986. 8. Levine, S.B., Kimmelman, C.P., Zwillenberg, S., Silberstein, L. Blood transfusions in surgery of the larynx and neck. Laryngoscope, 96(10):1095, 1986. 9. Silberstein, L.E., Naryshkin, S., Haddad, J., Strauss, J.F. III. Calcium homeostasis during plasma exchange. Transfusion, 26:151, 1986. 10. Silberstein, L.E., Robertson, G.A., Hannam-Harris, A.C., Moreau, L., Besa, E., Nowell, P.C. Etiologic aspects of cold agglutinin disease: evidence for cytogenetically defined clones of lymphoid cells and the demonstration that an anti Pr cold autoantibody is derived from a chromosomally aberrant B-cell clone. Blood, 67(6):1705-1709, 1986. 11. Cameron, P., Limjuco, G., Chin, Y., Silberstein, L.E., Schmidt, J.A. Purification of the pI 5.1 and pI 5.4 species of human IL-1. Journal Experimental Medicine, 164:237-250, 1986. 12. Lichtin, A.E., Silberstein, L.E., Schreiber, A.D. Thrombotic thrombocytopenic purpura with colitis in an elderly woman. JAMA, 255:11, 1986. 13. Silberstein, L.E., Berkman, E.M., Schreiber, A.D. Cold hemagglutinin disease associated with IgG cold reactive antibody. Annals of Internal Medicine, 106:238-242, 1987. 14. Silberstein, L.E., Abrahm, J., Shattil, S.J. Intensive plasma exchange is an effective therapeutic modality in acquired von Willebrand's disease. Transfusion, 27:234-237, 1987.
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 13 15. Silberstein, L.E. and Spitalnik, S. Autoantibodies to erythrocytes. Clinical Immunology Newsletter, 8(12) 177-188, 1987. 16. Lichtin, A.E., Schreiber, A.D., Hurwitz, S., and Silberstein, L.E. Efficacy of intensive plasmapheresis in thrombotic thrombocytopenic purpura. Archives of Internal Medicine, 147:2122-2126, 1987. 17. Silberstein, L.E., Williams, L., Magee, D., Hughlett, M., and Weisman, R. An autologous fibrinogen based adhesive for use in otologic surgery. Transfusion, 28:319-321, 1988. 18. Andrzejewski, C., Gault, E., Briggs, M., and Silberstein, L.E. The benefit of a 37oC extracorporeal circuit in plasma exchange therapy for selected cases with cold agglutinin disease. Journal of Clinical Apheresis, 4:13-17, 1988. 19. Kruskall, M.S., Mintz, P.D., Bergin, J.J., Johnston, M.F.M., Klein, H., Miller, J.D., Rutman, R., Silberstein, L. Transfusion therapy in emergency medicine. Annals of Emergency Medicine, 17:327-335, 1988. 20. Silberstein, L.E., Goldman, J., Kant, J.A., Spitalnik, S.L. Comparative biochemical and genetic characterization of clonally related human B-cell lines secreting pathogenic anti Pr2 cold agglutinins. Archives Biochemistry Biophysics, 264:244-252, 1988. 21. Andrzejewski, C., Young, P., Goldman, J., Spitalnik, S., Silberstein, L.E. Production of human warm reacting anti-erythrocyte monoclonal autoantibodies by Epstein-Barr virus transformation. Transfusion, 29:196-200, 1989. 22. Silberstein, L.E., Litwin, S., Carmack, C. Relationship of V genes expressed by a human B-cell lymphoma secreting pathologic anti-Pr2 erythrocyte autoantibodies. Journal Experimental Medicine, 169:1631-1643, 1989. 23. Silberstein, L.E., Kruskall, M.S., Stehling, L.C., et al., Strategies for the review of transfusion practices. JAMA, 262:1993-1997, 1989. 24. Goodnough, L.T., Rudnick, S., Price, T.H., Ballas, S., Collins, M., Crowley, J., Kosmin, M., Kruskall, M., Lenes, B., Menitove, J., Silberstein, L.E., Smith, K., Wallas, C., Von Tress, M. Increased preoperative collection of autologous blood with recombinant human erythropoietin therapy. New England Journal of Medicine, 321:1163-1168, 1989. 25. Silberstein, L.E., Jefferies, L.C., Goldman, J., Spitalnik, S.L. Production of carbohydrate-specific human monoclonal antibodies in vitro. Methods in Enzymology, 179:299-304, 1989. 26. Judd, W.J., Luban, N.L.C., Ness, P.M., Silberstein, L.E., Stroup, M., Widmann, F.K. Prenatal and perinatal immunohematology: recommendations for serologic management of the fetus, newborn infant, and obstetric patient. Transfusion, 30:175-183, 1990. 27. Gordon, J., Silberstein, L.E., Moreau, L., Nowell, P.C. Trisomy 3 in cold agglutinin disease. Cancer Genetics and Cytogenetics, 46:89-92, 1990. 28. Jefferies, L.C., Goldman, J., Bennett, I.M., Spitalnik, S.L., Silberstein, L.E. Anti- idiotypic antibodies specific for a pathologic anti-Pr2 cold agglutinin. Transfusion, 30:495-502, 1990.
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 14 29. Goodnough, L. T., Johnston, M. F., Ramsey, G., Sayers, M.H., Eisenstadt, R.S., Anderson, K.C., Rutman, R.C., and Silberstein, L.E. Guidelines for transfusion support in patients undergoing coronary artery bypass grafting. Annals of Thoracic Surgery, 50:675-683, 1990. 30. Andrzejewski, C., Young, P.J., Cines, D.B., Silberstein, L.E. Heterogeneity of Human Anti-Erythrocyte autoantibodies assesed by isoelectric focusing. Transfusion, 31:236-244, 1991. 31. Anderson, K.C., Goodnough, L.T., Sayers, M., Pisciotto, P.T., Kurtz, S.R., Lane, T.A., Anderson, C.S., Silberstein, L.E. Variation in blood component irradiation practice: Implications for prevention of transfusion-associated graft-vs-host-disease. Blood, 77:2096-2102, 1991. 32. Friedman, D.F., Cho, E.A., Goldman, J., Carmack, C.E., Besa, E.C., Hardy, R.R., Silberstein, L.E. The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma. Journal of Experimental Medicine, 174:525-537, 1991. 33. Silberstein, L.E., Jefferies, L.C., Goldman, J., Friedman, D., Moore, J.S., Nowell, P.C., Roelcke, D., Pruzanski, W., Roudier, J., Silverman, G.J. Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens. Blood, 78(9):2372-2386, 1991. 34. Reidl, L.S., Friedman, D.F., Goldman, J., Hardy, R.R., Jefferies, L.C., Silberstein, L.E. Structural basis of a conserved idiotope expressed by an autoreactive human B-cell lymphoma: Evidence that a VH CDR3 mutation alters idiotypy and specificity. Journal of Immunology, 147(10):3623-3631, 1991. 35. Sayers, M.H., Anderson, K.C., Goodnough, L.T., Kurtz, S.R., Lane, T.A., Pisciotto, P., and Silberstein, L.E. Reducing the risk for transfusion-transmitted cytomegalovirus infection. Annals of Internal Medicine, 116:1, 1992. 36. Grillot-Courvalin, C., Brouet, J.C., Piller, F., Rassenti, L.Z., Labaume, S., Silverman, G.J., Silberstein, L.E., Kipps, T.J. An anti-B cell autoantibody from Wiskott-Aldrich syndrome which recognizes i blood group specificity on normal human B cells. European Journal of Immunology, 22:1781, 1992. 37. Lane, T.A., Anderson, K.C., Goodnough, L.T., Kurtz, S., Moroff, G., Pisciotto, P.T., Sayers, M., Silberstein, L.E. Leukocyte reduction in blood component therapy. Annals of Internal Medicine, 117:2, 1992. 38. Stadtmauer, E.A., Edelstein, M., Lin, E., Spitalnik, S., Silberstein, L., Cassileth, P.A. Autologous bone marrow transplantation with in vitro chemotherapy purge in first remission chemotherapy of acute myeloid leukemia. Progress in Clinical and Biological Research, 377:274-279, 1992. 39. Jefferies, L.C., Silverman, G.J., Carchidi, C.M., Silberstein, L.E. Idiotypic heterogeneity of Vo III autoantibodies to the related i and I red blood cell antigens. Clinical Immunology and Immunopathology, 65(2):119-128, 1992. 40. Friedman, D.F., Moore, J.S., Erikson, J., Manz, J., Goldman, J., Nowell, P.C., Silberstein, L.E. Variable region gene analysis of an isotype switched (IgA) variant of chronic lymphocytic leukemia. Blood, 80:2287-2297, 1992.
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 15 41. Konrad, R.J., Krica, L.J., Goodman, D.B.P., Goldman, J, Silberstein, L.E. A myeloma- associated paraprotein in an HIV-1 seropositive patient directed against the HIV-1 p24 antigen. New England Journal of Medicine, 328:1817-1819, 1993. 42. Stevenson, F.K., Spellerberg, M.B., Treasure, J., Chapman, C.J., Silberstein, L.E., Hamblin, T.J., Jones, D.B. Differential usage of an Ig heavy chain variable region gene by human B-cell tumors. Blood, 82:224-231, 1993. 43. Schutte, M.E.M., van Es, J.H., Silberstein, L.E., Logtenberg, T. VH4.21-encoded autoantibodies with anti-i specificity mirror those associated with cold haemagglutinin disease. Journal of Immunology, 151:6569-6576, 1993. 44. Goodnough, L.T., Anderson, K.C., Hurtz, S., Lane, T.A., Pisciotto, P.T., Sayers, M.H., Silberstein, L.E. Indications and guidelines for the use of hematopoietic growth factors. Transfusion, 33:944-959, 1993. 45. Jefferies, L.C., Carchidi C.M., Silberstein, L.E. Naturally occurring anti-i/I cold agglutinins may be encoded by different VH3 genes as well as the VH4.21 gene segment. Journal of Clinical Investigation, 92:2821-2833, 1993. 46. Siegel, D.L., Silberstein, L.E. Expression and characterization of recombinant anti- Rh(D) antibodies on filamentous phage: A model system for isolating human red cell antibodies by repertoire cloning. Blood, 83:2334-2344, 1994. 47. Biggs, D.D., Stadtmauer, E., Mangan, P., Edelstein, M., Powlis, W., Buzby, G., Magee, D., Sachs, B, Silberstein, L. 4-Hydroperoxycyclophosphamide purged autologous bone marrow transplantation of relapsed, responding Non-Hodgkin's Lymphoma with granulocyte colony stimulating factor support results in reliable hematopoietic recovery. Progress in Clinical and Biological Research, in press, 1994. 48. Stadtmauer, E.A., Hodi, F.S., Sickles, C., Biggs, D.D., Mangan, P., Buzby, G., Zaleta, E., Silberstein, L.E. High-dose therapy and growth factor mobilized peripheral blood progenitor cell support for responding patients with metastatic breast cancer. Advances in Bone Marrow Purging and Processing: Fourth International Symposium, 487-495, 1994. 49. Biggs, D.D., Kraj, P., Goldman, J., Jefferies, L., Carchidi, C., Anderson, K. and Silberstein, L.E. Immunoglobulin gene sequence analysis to further assess B-cell origin of multiple myeloma. Clinical Diagnostic Immunology, 2:44-52, 1995. 50. Parr, T.B., Johnson, T.A., Silberstein, L.E., Kipps, T.J. Anti-B cell autoantibodies encoded by VH4-21 genes in human fetal spleen do not require in vivo somatic selection. European Journal of Immunology, 24:2941-2949, 1995. 51. Kraj, P., Friedman, D.F., Stevenson, F., Silberstein, L.E. Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire. Journal of Immunology, 154:6406-6420, 1995. 52. Stadtmauer, E.A., Schneider, C.J., Silberstein, L.E. Peripheral blood progenitor cell generation and harvesting. Seminars in Oncology, 22:291-300, 1995. 53. Stoerker, J., Hurwitz, C., Rose, N.C., Silberstein, L.E., Highsmith, W.W. Heteroduplex generator in analysis of Rh blood group alleles. Clinical Chemistry, 42:356-360, 1996. 54. Przybylski, G.K., Goldman, J., Ng, V.L., McGrath, M.S., Herndier, B.G., Schenkein, D.P., Monroe, J.G., Silberstein, L.E. Evidence for early B-cell activation preceding the development of EBV-negative AIDS-related lymphoma. Blood, 88:4620-4629, 1996.
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 16 55. Silberstein, L.E., George, A., Durdik, J.M., Kipps, T.J. The V4-34 encoded anti-i autoantibodies recognize a large subset of human and mouse B-cells. Blood Cells, Molecules, and Diseases, 22:126-138, 1996. 56. Dighiero, G., Kipps, T., Schroeder, H.W., Chiorazzi, N., Stevenson, F., Silberstein, L.E., Caligaris-Cappio, F., Ferrarini, M. What is the CLL B-lymphocyte? Leukemia and Lymphoma, 22:13-39, 1996. 57. Rose, N.C., Hurwitz, C., Silberstein, L., Andovalu, R., Stoerker, J. Prenatal analysis of rhesus CcDEe blood groups by heteroduplex generator. American Journal Obstetrics and Gynecology, 176:1084-1089, 1997. 58. Kraj, P., Rao, S.P., Glas, A.M., Hardy, R.R., Milner, E.C.B., Silberstein, L.E. The human heavy chain immunoglobulin variable region gene repertoire is biased at all stages of B cell ontogeny including early pre-B cell. Journal of Immunology, 158:5824-5832, 1998. 59. Shan, H., Goldman, J., Cunto, G., Manuppello, J., Chaiken, I., Cines, D.B., and Silberstein, L.E. Heterogenity of Anti-Phospholipid and Anti-Endothelial Cell Antibodies. Journal of Autoimmunity, 11:651-660, 1998. 60. Westhoff, C.M., Schultze, A., From, A., Wylie, D., Silberstein, L.E. Characterization of the Mouse Rh Blood Group Gene. Genomics, 57: 451-454, 1999. 61. Moore, H.C., Mick, R., Solin, L. J., Sickles, C., Mangan, P.A., Luger, S.M., Fox, K.R., Schuchter, L.M., Loh, E., Porter, D.L., Schuster, S., Buzby, G.P., Glatstein, E., Silberstein, L.E. and Stadtmauer, E.A. Autologous stem-cell transplant after conventional dose adjuvant chemotherapy for high-risk breast cancer: impact on the delivery of local-regional radiation therapy. Annals of Oncology, 10: 929-936, 1999. 62. Rao, S.P., Riggs, J.M., Friedman, D.F., Scully, M., LeBien, T.W., Silberstein, L.E. Biased VH gene usage in early lineage human B cells: Evidence for preferential rearrangement in the absence of selection. Journal of Immunology, 163: 2732-40, 1999. 63. Honczarenko, M., Douglas, R.S., Mathias, C., Lee, B., Ratajczak, M.Z., and Silberstein, L.E. SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells. Blood, 94:2990-2998, 1999. 64. Majka, M., Rozmyslowicz, T., Lee, B., Murphy, S.L., Pietrzkowski, Z., Gaulton, G.N., Silberstein, L.E., Ratajczak. M.Z. Bone Marrow CD34+ Cells and Megakaryoblasts secrete e -chemokines that block infection of hematopoietic cells by M-tropic R5 HIV. Journal of Clinical Investigation, 104:1739-1749, 1999. 65. Cunto, G., Honczarenko, M., Przybilski, G., Monroe, J. and Silberstein, L..E. Evidence that immunoglobulin specificities of AIDS-related lymphoma are not directed to HIV- related antigens. Blood, 95:1393-1399, 2000. 66. Majka, M., Ratajczak, J., Lee, B., Honczarenko, M., Douglas, R., Kowalska, M.A., Silberstein, L.E., Gewirtz, A.M., Ratajczak, M.Z. The role of HIV related Chemokine Receptors and Chemokines in Human Erythropoiesis in Vitro. Stem Cells, 18: 2000. 67. Silberstein, L.E., Toy P Research Opportunities in Transfusion Medicine. The Journal of the American Medical Association, 285:5, 577-580, 2001. 68. Honczarenko, Marek, Le, Y., Glodek, A.M., Majka, M., Campbell, J.J., Ratajczak, M.Z., Silberstein, L.E. CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 17 responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor. Blood, 100:2321-2329, 2002. 69. Zubair, A., Silberstein, L.E., Ritz, J. Adult hematopoietic stem cell plasticity. Transfusion. 42:1096-1101. 2002. 70. Glodek, Aleksandra M., Honczarenko, M., Le, Y., Campbell, J.J., Silberstein, L.E. Sustained Activation of Cell Adhesion is a Differentially Regulated Process in B Lymphopoiesis. Journal of Experimental Medicine, 197:4, 1-14, 2003. 71. Burger, M., Glodek, A., Hartmann, T., Schmitt-Graff, A., Silberstein, L.E., Fujii, N., Kipps, T., Burger, J. Functional Expression of CXCR4 (CD184) on Small-Cell Lung Cancer Cells Mediates Migration, Integrin Activation, and Adhesion to Stromal Cells. Oncogene, 22, 8093-8101, 2003. 72. Le, Y., Honczarenko, M., Glodek, A.M., Ho, D., Silberstein, L.E. CXC Chemokine Ligand 12-Induced Focal Adhesion Kinase Activation and Segregation into Membrane Domain is Modulated by Regulator of G Protein Signaling 1 in Pro-B Cells. Journal of Immunology, 2582-2590, 2005. 73. Mazo, I.B., Honczarenko, M., Leung, H., Cavanagh, L.L., Bonasio, R., Weninger, W., Engelke, K., Xia, L., McEver, R.P., Koni, P.A., Silberstein, L.E., von Andrian, U.H. Bone Marrow Is a Major Reservoir and Site of Recruitment for Central Memory CD8+ T Cells. Immunity, 22(2):259-270, 2005. 74. Honczarenko, M., Lu, B., Nicholson-Weller, A., Gerard, N.P., Silberstein, L.E., Gerard, C. C5L2 receptor is not involved in C3a/C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12. Leukemia. 2005; 19: 1682-1683. 75. Honczarenko, M., Ratajczak, M.Z., Nicholson-Weller, A., Silberstein, L.E. Complement C3a Enhances CXCL12 (SDF-1)-Mediated Chemotaxis of Bone Marrow Hematopoietic Cells Independently of C3a Receptor (C3aR). J. Immunology. 2005; 195:3698-3706. 76. Honczarenko, M., Le, Y., Swierkowski, M., Ghiran, I., Glodek, A., Silberstein, L.E. Human Bone Marrow Stromal Cells Express a Distinct Set of Biologically Functional Chemokine Receptors. Stem Cells. 2006. Apr. 24(4):1030-41. Epub Oct. 2005. 77. Honczarenko M, Glodek AM, Swierkowski M, Na IK, Silberstein LE. Developmental stage-specific shift in responsiveness to chemokines during human B-cell development. Exp. Hematol. 2006 Aug;34(8):1093-1100. 78. Zhu D, Hattori H, Jo H, Jia Y, Subramanian K, Loison F, You J, Le Y, Honczarenko M, Silberstein L, Luo H. Deactivation of phosphatidylinositol 3,4,5-triphosphate/Akt signaling mediates neutrophil spontaneous death. Proc Natl Acad Sci USA. 2006 Oct 3;103(40):14836-14841. 79. Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE, Stossel TP, Hartwig JH, Hoffmeister KM. In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration. Transfusion. 2007 Mar;47(3):442-451. 80. Yang J, Chai L, Liu F, Fink LM, Lin P, Silberstein LE, Amin HM, Ward DC, Ma Y. Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells. Proc Natl Acad Sci USA 2007 Jun 19;104(25):10494-9. 81. Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE. Focal adhesion kinase is required for
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 18 CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells. Leukemia. 2007 Aug;21(8):1723-32. 82. Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen L, Silberstein LE. SOCS3 Protein Developmentally Regulates the Chemokine Receptor CXCR4-FAK Signaling Pathway During B Lymphopoiesis. Immunity. 2007 Nov;27(5):811-23. Editorials, Reviews, Chapters: 1. Berkman, E.M. and Silberstein, L.E. Hemodynamics of plasma exchange and its clinical effects. Proc. Fourth Annual Apheresis Symposium "Current Concepts and Future Trends," 1982. 2. Silberstein, L.E and Cines, D.B. Autoimmune hemolytic anemia, IN: Conn's Current Therapy, R.E. Rakel, ed., W.B. Saunders, 1985. 3. Silberstein, L.E. Cold hemagglutinin disease, IN: Current Therapy in Hematology/Oncology, eds. M.D. Brain & P.P Carbone; C.V. Mosby Co., Toronto, 1985. 4. Silberstein, L.E., and Cines, D.B. Autoimmune hemolytic anemia, IN: Conn's Current Therapy, R.E. Rakel, ed. W.B. Saunders, 1986. 5. Ellison, N., Silberstein, L.E. Hemostasis in the perioperative period. IN: Advances in Anesthesia, ed. Stoelting, R.K. Vol. 3, 1986. 6. White, K.W., and Silberstein, L.E. Quality Control in the Blood Bank, IN: Clinics in Laboratory Medicine. 7. Spitalnik, S.L., Andrzejewski, C., Goldman, J., Williams, L.J., Silberstein, L.E. Biochemical and molecular studies of human autoantibodies to erythrocytes. IN: The First International Workshop. Monoclonal Antibodies Against Human Red Blood Cells and Related Antigens, eds. Peter Rouger, D. Anstee, and C. Salmon, Paris, 1988. 8. Silberstein, L.E. and Rutman, R. Out-of-Hospital Transfusions. American Association of Blood Banks, Arlington, VA 1989. 9. Silberstein, L.E. Quality Assurance for Out-of-Hospital Transfusion Programs, IN: Improving Transfusion Practice: The Role of Quality Assurance, eds. SS.R. Kurtz, S. Summers, Kruskall, M.S.; American Association of Blood Banks, 1989. 10. Ellison, N. and Silberstein, L.E. A Commentary on Three Consensus Development Conferences on Transfusion Medicine, IN: Anesthesiology Clinics of North America, Bruce D. Spiess, M.D., Guest Editor, W. B. Saunders, 1990. 11. Silberstein, L.E., and Spitalnik, S.L. Blood Group Antigens and Antibodies, IN: Principles of Transfusion Medicine, eds. Rossi, E.C., Simon, T.L., Moss, G S., Williams and Wilkins, 1991. 12. Silberstein, L.E., and Spitalnik, S.L. Human Blood Group Antigens and Antibodies, IN: Hematology Basic Principles and Practice, eds. Hoffman, R., Benz, Jr., E.J., Shattil, S.J., Furie, B., and Cohen, H.J., Churchill Livingstone, 1991. 13. Schwartz, R.S., Berkman, E.M., Silberstein, L.E. The Autoimmune Hemolytic Anemias, IN: Hematology Basic Principles and Practice, eds. Hoffman, R., Benz, Jr., E.J., Shattil, S.J., Furie, B., and Cohen, H.J., Churchill Livingstone, 1991. 14. Siegel, D.L., Silberstein, L.E. Acquired Hemolytic Anemia. IN: Conn's Current Therapy, R.B. Conn, ed. W.B. Saunders, 1991.
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 19 15. Eshleman, J.R., and Silberstein, L.E. The Development of Selective Plasmapheresis as a Means for Specific Therapeutic Intervention. Transfusion 31:96, 1991 16. Stevenson, F.K., Spellerberg, M.B., Jefferies, L.C., Goldman, J., Hamblin, T.J., Pascual, V., Capra, J.D., and Silberstein, L.E. Monoclonal gammopathies and autoimmunity. IN: Topics in aging research in Europe, eds. J. Radkl and B. vanCamp. Eurage, 14, 1991. 17. Siegel, D.L. and Silberstein, L.E. Red Cell Antigen Specificities and Autoimmune Hemolytic Anemias. IN: Protein Blood Group Antigens of the Human Red Cell, Structure, Function and Clinical Significance. eds. Peter C. Agre and Jean-Pierre Cartron; The Johns Hopkins University Press, Baltimore, MD, 1992. 18. Lane, T.A., Anderson, K.C., Goodnough, L.T., Kurtz, S., Moroff, G., Pisciotto, P.T., Sayers, M., Silberstein, L.E. Leukocyte Reduction in Blood Component Therapy. Annals of Internal Medicine, 117:151-162, 1992. 19. Sayers, M.H., Anderson, K.C., Goodnough, L.T., Kurtz, S.R., Lane, T.A., Pisciotto, P. Silberstein, L.E. Reducing the Risk for Transfusion-transmitted Cytomegalovirus Infection. Annals of Internal Medicine, 116:55-62, 1992. 20. Siegel, D.L. and Silberstein, L.E. Structural Analyses of Red Blood Cell Antibodies. IN: Immunobiology of Transfusion Medicine. eds. George Garratty; Marcel Dekker, New York, NY, 1993. 21. Silberstein, L.E. Natural and Pathologic Human Autoimmune Responses to Carbohydrate Antigens on Red Blood Cells. IN: Springer Seminars in Immunopathology. eds. Peter A. Miescher and Hans L. Spiegelberg, Springer-Verlag, Heidelberg, Germany. 1993. 22. Pisciotto, P.T., Anderson, K.C., Goodnough, L.T., Kurtz, S.R., Lane, T.A., Sayers, M.H., Silberstein, L.E. Current Trends: Evolving Concepts in Transfusion Medicine. The Need for Standardization of Cryoprecipitate-derived Fibrin Adhesive. Transfusion Science 14:291-294, 1993. 23. Silberstein, L.E. The Antibody Response to Antigen. IN: Nance ST, ed. Alloimmunity: 1993 and Beyond Bethesda, MD: American Association of Blood Banks, 2:25-47, 1993. 24. Silberstein, L.E., Jefferies, L.E. Complications of Transfusion in Surgical Patients. IN: Perioperative Medicine, eds. David R. Goldman, Frank H. Brown, David M. Guarnieri. McGraw-Hill, New York, NY, 1994. 25. Siegel, D.L. and Silberstein, L.E. Red Blood Cell Autoantibodies. IN: Scientific Basis of Transfusion Medicine. Implications for Clinical Practice. eds. Kenneth C. Anderson and Paul M. Ness. W.B Saunders, Philadelphia, PA, 1994. 26. Silberstein, L.E. B-Cell Origin of Cold Agglutinins. Advances in Experimental Medicine and Biology. 347:193-205, 1994. 27. Biggs, D.D., Silberstein, L.E. Laboratory Aspects of Bone Marrow Transplantation: Collection, Processing, and Storage of Hematopoietic Stem Cells. eds. Ronald S. Weinstein, Anna R. Graham, Robert E. Anderson, et al; Advances in Pathology and Laboratory Medicine. 7:389-407, 1994. 28. Schwartz, R.S., Berkman, E.M., Silberstein, L.E. The Autoimmune Hemolytic Anemias, IN: Hematology Basic Principles and Practice, eds. Hoffman, R., Benz, Jr., E.J., Shattil, S.J., Furie, B., and Cohen, H.J. and Silberstein, L.E., 2nd edition Churchill Livingstone, 1994.
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 20 29. Monroe, J.G., Silberstein, L.E. HIV-Mediated B-Lymphocyte Activation and Lymphomagenesis. Journal of Clinical Immunology. 15:61-68, 1995. 30. Moore, J.S., Friedman, D.F., Silberstein, L.E., Besa, E.C., Nowell, P.C. Clinical Heterogeneity Reflects Biologic Diversity in Chronic Lymphocytic Leukemia, Critical Reviews in Oncology/Hematology, 20:141-164, 1995. 31. Silberstein, L.E. Molecular and Functional Aspects of Blood Group Antigens, editor, American Association of Blood Banks, 1995. 32. Casali, P. and Silberstein, L.E. Immunoglobulin Gene Expression in Development and Disease, editors, Annals of the New York Academy of Sciences, New York, NY, 1995. 33. Friedman, D.F., Kraj, P., Silberstein, L.E. VH4.21 Expression in the Normal Human B- Cell Repertoire. IN: Immunoglobulin Gene Expression in Development and Disease. eds. Casali, P. and Silberstein, L.E. Annals of the New York Academy of Sciences, New York, NY, 1995. 34. Jefferies, L.C., Carchidi, C.M., Silberstein, L.E. Immunoglobulin Gene Use by Naturally Occurring Cold Agglutinins. IN: Immunoglobulin Gene Expression in Development and Disease. eds. Casali, P. and Silberstein, L.E. Annals of the New York Academy of Sciences, New York, NY, 1995. 35. Stadtmauer, E.A., Schneider, C.J., Silberstein, L.E. Peripheral Blood Progenitor Cell Generation and Harvesting. Seminars in Oncology, 22:291-300, 1995. 36. Silberstein, L.E., Jefferies, L.C. Placental Blood Banking - A New Frontier in Transfusion Medicine. New England Journal of Medicine, 335:199-201, 1996. 37. Frattali, A.L., Silberstein, L.E., Spitalnik, S.L. Human Blood Group Antigens and Antibodies. In Principles of Transfusion Medicine (Rossi, E.C., Simon, T.L., Moss, G.S., eds.). Second Edition. Williams & Wilkins, Baltimore, 67-87, 1996. 38. Silberstein, L.E. Autoimmune Disorders of Blood, editor, American Association of Blood Banks, 1996. 39. Sloan, S. R. and Silberstein, L.E. Transfusion in the Face of Autoantibodies. IN: Red Cell Transfusions, A Practical Guide, eds. Reid, M.E., and Nance, S.J., Humana Press, 1998. 40. Eder, A.F. and Silberstein, L.E. Placental Blood: Immunology, Transplantation and Gene Therapy, In: Molecular Biology of B-cell and T-cell Development. John G. Monroe and Ellen V. Rothenberg, eds. Humana Press.1998. 41. Klein HG, Dzik WH, Slichter SJ, Hillyer CD, Silberstein LE: Leukocyte-reduced blood components: current status, in McArthur JR, Schecter GP, Schrier SL (eds). Hematology 1998: American Society of Hematology Education Program Book. The American Society of Hematology, Washington, DC, pp 154-77, 1998. 42. Hillyer, C.D., Lankford, K.V., Roback, J.D., Gillespie, T.W. and Silberstein, L.E. Transfusion of the HIV-seropositive patient: immunomodulation, viral reactivation, and limiting exposure to EBV (HHV-4), CMV (HHV-5), and HHV-6, 7, and 8. Transfusion Medicine Reviews, 13: 1-17, 1999. 43. Silberstein, L.E., Berkman, E.M., Schwartz, R.S. The Autoimmune Hemolytic Anemias, IN: Hematology Basic Principles and Practice, eds. Hoffman, R., Benz, Jr., E.J., Shattil, S.J., Furie, B., and Cohen, H.J. and Silberstein, L.E., 3rd edition Churchill Livingstone, 1999.
    • Leslie Eric Silberstein, M.D. Curriculum Vitae Page 21 44. Hug, B. and Silberstein, L.E. Red Blood Cell Autoantibodies. IN: Scientific Basis of Transfusion Medicine. Implications for Clinical Practice. 2nd edition, eds. Kenneth C. Anderson and Paul M. Ness. W.B Saunders, Philadelphia, PA, 2000. 45. Ninos, J.M., and Silberstein, L.E. Therapeutic Use of Blood Components. IN: Conn’s Current Therapy 2000. Ed. Robert E. Rakel. W.B. Saunders, Philadelphia, PA, 2000. 46. Honczarenko, M. and Silberstein, L.E. Chemokines, Chemokine Receptor and their Role in B Cell Development. Clinical Immunology, Second Edition. Edited by R. Rich, T. Fleisher, B. Kotzin, W. Shearer and H. Schroeder. Mosby, pp 13.1-13.14, 2001. 47. Hillyer, C.D., Hillyer, K.L., Srobl, F. J., Jefferies, L.C., and Silberstein, L.E., eds Handbook of Transfusion Medicine. Academic Press, San Diego, CA, 2001. 48. Silberstein, L.E., Cunningham, M.J. Autoimmune Hemolytic Anemias, In: Blood Banking and Transfusion Medicine, Basic Principles & Practice, eds Hillyer, C.D., Silberstein, L.E., Ness, P.M., Anderson, K.C., Churchill Livingstone, 2003. 49. Benjamin, R.J., Friedman, D.F., Silberstein, L.E., Sloan, S.R., Webb, I. Transfusion Medicine, In: Nathan and Oski’s Hematology of Infancy and Childhood, eds Nathan, D.G., Orkin, S.H., Look, A.T., Ginsberg, D., W.B. Saunders, Philadelphia, PA. 2003. 50. Sloan, S.R. and Silberstein, L.E. Transfusion Medicine. In: Clinical Hematology and Oncology, Presentation, Diagnosis, and Treatment, eds. Furie, B., Cassileth, P. A., Atkins, M. B., Mayer, R. J., Churchill Livingstone, 2003. 51. Campbell, J., Sloan, S., Silberstein, L.E., “Leukocyte Trafficking,” In: Hematology: Basic Principles and Practice, 4th Edition. Eds. Hoffman et al., Elsevier, Churchill Livingstone, Philadelphia, PA. 2005. 52. Cunningham, M., Silberstein, L.E., “Autoimmune Hemolytic Anemias,” In: Hematology: Basic Principles and Practice, 4th Edition. Eds. Hoffman et al., Elsevier, Churchill Livingstone, Philadelphia, PA. 2005. 53. Silberstein, L.E., Cunningham, M. “Autoimmune Hemolytic Anemias,” In: Blood Banking and Transfusion Medicine: Basic Principles and Practice. 2nd Edition. Eds. Hillyer et al. Elsevier, Churchill Livingstone, Philadelphia, PA. 2006.