Name: Songqing He
Job Title : postdoctoral fellow
Transplantation, Cancer, Immunology, Gene Therapy and Clinical Surgery.
1989.9 – 1994.6 M.D. Department of Medicine, Guilin Medical College, P. R. China
1997.8 – 1999. 6 M.Sc. Hepatic Surgery Center Affiliated Tongji Hospital,Tongji
Medical University, P. R. China (Advisor: Prof. Xiaoping Chen.)
2000.9 –2003. 6 Ph.D. Hepatic Surgery Center Affiliated Tongji Hospital Tongji
Medical College Huazhong University of Science and Technology,
P. R. of China (Advisor: Prof. Xiaoping Chen.)
1994- 1997 Resident, the affiliated hospital of Guilin Medical College, Guilin, P. R.
1999- 2000 Instructor, the affiliated hospital of Guilin Medical College, Guilin, P. R.
2003- 2005 Instructor, Hepatic Surgery Center, Affiliated Tongji Hospital, Tongji
Medical College, Huazhong University of Science and
Technology,wuhan, P. R. of China.
Sep.2005—Sept.2006 Post-Doctoral Research Fellow in the Department of
Medicine, Transplant Research Program, UC Davis
Oct.2006—May.2007 Post-Doctoral Research Fellow in Department of pharmaceutical
sciences, MUSC, Charleston, SC
June.2007-Now Post-Doctoral Research Fellow in Department of Microbiology and
Immunology, Children's Research Institute, Medical University of
South Carolina, Charleston, SC 29425, USA.
Awards and Honors:
1. 1990-1993 An award for top student from Guilin Medical College, Guilin P. R. China
2. 1993. An award for top student from Guangxi Province Government, P. R. of
3. 1994 Excellent Graduate Student Award from Guangxi Province Government, P.
R. of China
4. 2003 Ph.D. Thesis Award from the Huazhong University of Science and
Technology, Wuhan, P. R. China
5. 2005 An Award for A Progress of National Science and Technology from
Ministry Of Education focus on Liver Cancer Therapy.
Ι Animal Models:
Liver transplant model in Rat and mouse (small-for-size and full size)
Partial hepatectomy and ischemia/reperfusion model
Experimental nude mice In situ hepatocellular carcinoma model
Mouse heart transplantation (abdomen and neck)
Heart ischemia/reperfusion model
ΙΙ Molecular Biology
In situ hybridization
ΙV Cell culture technique
1.He SQ, Hasibur Rehman, Gong MG,et.al. Inhibiting survivin expression Enhances
TRAIL-induced tumoricidal activity in human hepatocellular carcinoma via cell cycle arrest.
Cancer Biol Ther 2007 May 16;6(8).
2.Zhang Y, Venugopal SK, He S, Liu P, Wu J, Zern MA. .Ethanol Induces Apoptosis in
Hepatocytes by a Pathway Involving Novel Protein Kinase C Isoforms. Cellular Signal
2007 Jul 27.
3. He SQ, Zhang YH, Venugopal SK, Dicus CW, Perez RV, Ramsamooj R, Nantz MH,
Zern MA, Wu J.Delivery of anti-oxidative enzyme genes protects against
ischemia/reperfusion liver injury in mice. Liver Transpl. 2006 Dec;12(12):1869-79.
4.Chen XP, Qiu FZ, Wu ZD, Zhang ZW, Huang ZY, Chen YF, Zhang BX, He SQ, Zhang
WG. Effects of Location and Extension of Portal Vein Tumor Thrombus on Long-Term
Outcomes of Surgical Treatment for Hepatocellular Carcinoma. Ann Surg Oncol. 2006
5.Chen XP, Zhang ZW, Zhang BX, Chen YF, Huang ZY, Zhang WG, He SQ, Qiu FZ.
Modified technique of hepatic vascular exclusion: effect on blood loss during complex
mesohepatectomy in hepatocellular carcinoma patients with cirrhosis. Langenbecks Arch
Surg. 2006 Jun;391(3):209-215.
6.Chen XP, He SQ, Zhao X, Huang ZY, Li CH. Chinese medicine Extractum trametes
robiniophila murr augment tumor necrosis factor related apoptosis-inducing ligand induced
apoptosis in human hepatic cancer cell lines. Chinese journal of surgery. 2005 Dec;
7.He SQ, Chen Y,Chen XP, et al. Antitumor effects of soluble TRAIL in human
hepatocellular carcinoma.J Huazhong Univ Sci Technolog Med Sci. 2005;25(1):51-4.
8.Huang ZY, He SQ, Xiao ZY, Wu CD, Li CH, Chen XP. Hepatic angiomyolipoma
demonstrating similar imaging characteristics as hepatocellular carcinoma: one case
report.J Huazhong Univ Sci Technolog Med Sci. 2005;25(5):615-6, 618.
9.Xiao ZY; Chen XP, He SQ, HUANG ZY, LI L. Expression of TRAIL and TRAILR in human
hepatocellular carcinoma and its therapeutic significance. Chinese Journal of General
10.Huang ZY, Chen XP, Wu ZD, He SQ. Nonresectable huge hepatocellular carcinomas
treated with cryosurgery in combination with intraoperative transarterial chemoembolization.
Journal of Abdominal Surgery 2005-06-013
11.Xiao ZY, Chen XP, He SQ, Huang ZY, LI L. ANTITUMOR EFFECT OF TRAIL IN
HUMAN HEPATOCELLULAR CARCINOMA. Journal of Hepatobiliary Surgery
12.Zhao X, Chen XP, He SQ, et al. THE THERAPEUTIC EFFECT OF TRAIL AND TRAILR
IN TREATMENT OF CHEMORESISTANT HEPATOCELLULAR CARCINOMA CELLS.
Journal of Hepatobiliary Surgery 2005
13.Zhao X, Chen XP, He SQ, et al. Apoptosis of chemoresistant hepatocellular carcinoma
cells synergisti cally induced by TRAIL and adriamycin. Digestive Surgery.2005
14.He SQ , Chen XP, Zhang WG, Wang HP, Wang Q.Tumor necrosis factor related
apoptosis-inducing ligand induces apoptosis and sensitizes resistant hepatic cancer cells to
chemotherapy. Chinese journal of Hepatology 2004 12(8):456-9.
15.Wang SF, Chen XP, Zhang WG, He SQ, Chen DF. Expression of peroxisome
proliferator-activated receptor alpha in human normal liver and hepatocellular carcinoma.
Chinese journal of Hepatology 2004 Jan; 12(1): 52-3.
16.Wang HP, Chen XP,Ding L,He SQ. Correlation between hypoxia-inducible factor-1α
and vascular endothelial growth factor expression in cirrhosis and hepatocellular
carcinoma. Chinese Journal of Experimental Surgery 2004-03-018.
17.Chen XP, He SQ , Wang HP, Zhao YZ, Zhang WG. Expression of TNF-related
apoptosis-inducing Ligand receptors and antitumor tumor effects of TNF-related apoptosis-
inducing Ligand in human hepatocellular carcinoma. World J Gastroenterol 2003 Nov;
18. Wang HP, Chen XP, Ding L, He SQ , Ali M, Li DH, Zhang WG. Hepatitis B x protein
activated vascular endothelial growth factor expression through hypoxia inducible factor-1
pathway. The Chinese Journal of Oncology 2003 Sep; 25(5): 433-6.
19. He SQ, Chen Y, Chen XP, Zhao YZ, et al . Effects of TRAIL gene therapy on human
hepatocellular carcinoma. Chinese journal of experimental surgery 2003, 8,708-710.
20.He SQ, Chen Y, Chen XP, Zhang WG, Wang HP, Zhang BX . Interleukin-12 enhanced
tumor necrosis factor related apoptosis-inducing ligand TRAIL-induced apoptosis in human
hepatocellular carcinoma by inhibiting expression of survivin. Chinese journal of surgery
2003 Jun; 41(6): 453-7.
21.Wang HP, Chen XP, He SQ, Ding L. Effects of regulatory endoplasmic HBX expression
on hepatic cell apoptosis. Chinese journal of Hepatology 2003 Jul; 11(7): 440.
22.He SQ , Chen Y, Chen XP, Zhang WG, Wang HP, Zhao YZ, Wang SF. Antitumor
effects of soluble TRAIL in humanhepatocellular carcinoma. The Chinese Journal of
Oncology 2003 Mar; 25(2): 116-9.
23. He SQ , Chen XP.Zhao YZ, et al. Expression Profiles of TRAIL Receptors and their
Clinical Significance in Human Hepatocellular Carcinoma. The Chinese-German Journal
of Clinical Oncology (English) 2003, 2, 25-29.
24. He SQ, Chen XP.The relationship of Interleukin-12 、 Interleukin-2 and soluble IL-2
receptor in human hepatocellular carcinoma. Chinese journal of general surgery 2002,4:
25.He SQ , Chen XP. Expression and clinical significance of soluble Interleukin-2 receptor in
human hepatocellular carcinoma. Chinese journal of Hepatobiliary surgery 2001 ， 3 ：
26.He SQ, Chen XP. Expression and clinical significance of Interleukin-12 in human
hepatocellular carcinoma. The journal of Hepatobiliary surgery 1999， 7：46-48.
1. He SQ, Chen XP.TRAIL 、TRAIL receptors and anticancer effect. Chinese journal
of surgery 2002, 4:311-313.
2. He SQ, Chen XP.Interleukin-12 and its antitumor effect. Chinese journal of
surgery 2000, 3:311-313.