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  • 1. Curriculum Vitae Name: John Joseph Ryan, Ph.D. Personal Information: Contact Information: Box 842012, VCU Department of Biology 1000 West Cary Street Richmond, VA 23284-2012 Telephone: (804) 828-0712 Fax: (804) 828-0503 E-mail: jjryan@vcu.edu Current Position: Professor in the Department of Biology, VCU Education and Former Positions: 2008-Present: Professor, Department of Biology, VCU 2003-2008: Associate Professor, Department of Biology, VCU 2003-2004: Visiting Scientist, NIAMS/NIH (Laboratory of Juan Rivera) 1997-2003: Assistant Professor, Department of Biology, VCU 1992 - 1997: LI/NIAID/NIH Postdoctoral Fellow Supervisor: William E. Paul, M.D. 1988-1992: Medical College of Virginia, Richmond, VA Graduate Student; Ph.D. (Immunology) Advisor: Thomas F. Huff, Ph.D. 1984-1988: University of Richmond, VA; B.A. (Biology) Awards/Honors • 1988 A.D. Williams Scholarship, Department of Microbiology, Virginia Commonwealth University • 1996 Miriam and Benedict Wolf Fellowship, Cancer Research Institute • 1999, 2001, 2003-2006: Outstanding Teacher Award, Immunology Course, School of Medicine, Virginia Commonwealth University.
  • 2. Funding (Total Funding awarded as a PI = $5.5M) Active Funding NIAID/NIH R01 Grant # 1RO1AI059638 PI: John Ryan 25% Effort Regulation of mast cell homeostasis by interleukin-10 Total Award: $1.8M; Direct costs $250k/year February 2007 - March, 2012. NIAID/NIH Allergy and Allergic Disease Cooperative Research Center U19 AI077435 PI: Larry Schwartz 25% Effort Cellular & Inflammatory Pathways in Ashtma & Allergic Diseases: From IgE to Cells Project Leader, Project 3: “The Effect of Lyn Deficiency on Mast Cell Activation and Inflammatory Disease Progression.” Total Award to my group: $1.25M; Direct Costs: $173,000/year March 2008-February 2013 NCI/NIH R01 Grant Number RO1CA78754 PI: Nicholas Farrell 5% Effort Mechanistic studies on new platinum clinical agents May 2008-Feb 2013 Previous Funding Jeffress Trust Fund January 2007-December 2007 Mast cell-Treg interactions. $25,000 National Cancer Institute/NIH R01 Grant # 1RO1CA91893-01 Stat5 function in proliferation and leukemogenesis Total Award: $1,100,000 July, 2001 - June, 2006. NIAID/NIH R56 Grant # 1RO1AI059638-01A2 Regulation of mast cell homeostasis by interleukin-10 Total Award: $334,298 August, 2005 - July, 2006. National Institute of Allergy and Infectious Diseases/NIH R01 Grant # 1R01AI43433-01 2
  • 3. Control of proliferation and differentiation by the human IL-4R- Total Award: $997,000 April 1, 1999 – March 31, 2004 National Institute on Drug Abuse Research Center Grant Sub-Award The effect of CB2 signaling on mast cell-mediated inflammatory responses Total award: $10,000 August, 2000-July, 2001 Horsley Cancer Research Fund/Virginia Academy of Science Grant # 99-0437-00 Determining the mechanism of Kit inhibition and apoptosis avoidance by mastocytomas Total Award: $6,000 January, 2000 – December, 2000 Jeffress Memorial Trust Fund Characterization of an allergic disease-linked mutation in the human IL-4 receptor alpha July, 1998-June, 1999 Total award: $20,000 American Cancer Society Institutional Grant Molecular Characterization of the Human IL-4 Receptor α: Separation of Proliferation and Differentiation January, 1998-December, 1999 Total Award: $13,500 Cancer Research Institute/Miriam and Benedict Wolf Fellowship Molecular Characterization of the Human IL-4 Receptor. 7/1/94 to 6/30/97 National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD. Total Award: $91,500 Individual Research and Training Award Molecular Characterization of the Human IL-4 Receptor. 7/1/94 to 6/30/97 National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD. Total Award: $11,160 Teaching Assistantship 9/1/89 to 9/30/92 Medical College of Virginia Total Award: $23,760 A.D. Williams Fellowship 9/1/88 to 8/31/89 Medical College of Virginia, Richmond, VA. Total award: Tuition plus stipend of $7,920 Funding Awarded to My Trainees 3
  • 4. NIH F30 Pre-Doctoral Fellowship The role of Stat5 in mast cell activation and inflammatory disease Awarded to Hoon Shim, under my direction Total Award: $141,048. (2008-2012) NIH Research Supplement for Underrepresented Minorities Supplement to NIH R01 grant #1R01AI43433-01 Molecular Characterization of Gene Regulation by IL-4 Receptor Alpha. Awarded to Carlos Ramirez, under my direction Total Award: $72,136. (2003, Declined) NIH Research Supplement for Underrepresented Minorities Supplement to NIH R01 grant #1R01AI43433-01 Molecular Characterization of Gene Regulation by IL-4 Receptor Alpha. Awarded to Carlos Ramirez, under my direction Total Award: $17,237 April, 2002-August 2002 VCU Center for the Study of Biological Complexity Graduate Scholarship Regulation of mast cell apoptosis by interleukin-4 and interleukin-10 Awarded to L. Andrew Bouton, under my direction Total Award: $10,000 January, 2002 – December, 2002 VCU Undergraduate Research Grant Regulation of cell cycle arrest by interleukin-4 and interleukin-10 Awarded to Joyce Yue, under my direction Total Award: $500 January, 2002 – May, 2002 A.D. Williams Summer Research Fellowship Regulation of FcεRI Beta by mast cell activation Awarded to Sheila Gillespie, under my direction Total Award: $2,000 May, 2001 – July, 2001 NIH Research Supplement for Underrepresented Minorities Supplement to NIH R01 grant #1R01AI43433-01 Control of mast cell development by interleukin-4 Awarded to Henrietta Collins, under my direction Total Award: $70,460 August, 2000 – July, 2002 American Association of Allergy Asthma and Immunology Summer Student Fellowship IL-4-mediated regulation of mast cell Fcn RII and Fcg RIII expression Awarded to Hey Jin Chong, under my direction Total Award: $2,500 June, 2000 – August, 2000 4
  • 5. VCU Undergraduate Research Grant IL-4-mediated regulation of mast cell Fc° RII and Fc RIII expression Awarded to Henrietta Collins, under my direction Total Award: $450 January, 2000 – May, 2000 Individual Research and Training Award Mapping of STAT-6 Binding Sites on the Human IL-4 Receptor 5/15/97-7/15/97 Awarded to Lisa McReynolds, under my supervision. National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD. Total Award: $2,000 Individual Research and Training Award Molecular Characterization of the Human IL-4 Receptor. 6/1/95-8/31/95 Awarded to Lisa McReynolds, under my supervision. National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD. Total Award: $2,250 Publications Peer-Reviewed Research Articles Manucripts Submitted 1. Carole A. Oskeritzian, Megan M. Price, John J. Ryan, Nitai C. Hait, Roger A. Sabbadini, Sheldon Milstien and Sarah Spiegel. Essential Role of Sphingosine-1-Phosphate Receptor 2 in Human Mast Cell Activation and Anaphylaxis. J. Exp. Med., submitted. 2. Matthew R. Macey, Jamie L. Sturgill, Johanna K. Morales, Sarah K. Norton, Nitin Yerram, Hoon Shim, Alasdair M. Gifillan, Gregorio Gomez, Lawrence Schwartz, Carole Oskeritzian, Sarah Spiegel, Daniel Conrad, and John J. Ryan. Interleukin-4 and TGFb Counterbalance One Another While Regulating Mast Cell Homeostasis. J. Immunol., submitted. 3. Geqiang Li, Kristy Miskimen, Zhengqi Wang, Xiu Yan Xie, Jennifer Brenzovich, John J. Ryan, William Tse, Richard Moriggl, and Kevin D. Bunting. STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease. Blood, submitted. 4. John J. Ryan, Benjamin Dows, Jeffrey Eastman, Michael V. Kirk, and Lemont Kier. A Systems Biology Approach Comparing Cancer Metastasis and Suburban Sprawl Development. BMC Cancer, submitted. 5. Kabolizadeh P., J. Stewart, P. Dent, J. Ryan, and N. Farrell. Platinum Based Drug Cytotoxicity is Enhanced by the Antidepressant Desipramine. Molec. Pharm., submitted. 5
  • 6. Manuscripts Published/In Press 6. Jennifer Brenzovich, Hey Jin Chong, Brian Barnstein, Paria Mirmonsef, Matthew Macey, Johanna K. Morales, Josephine Fernando, Tracey Dawson Cruz, and John J. Ryan. Mast Cell Genome Profiling Reveals FcεRIβ Regulation During IgE Signaling. J. Leuk. Biol., 2009, in press. 7. Nicolas Charles1, Wendy Watford2, Haydee Ramos2, Lars Hellman3, Hans Oettgen4, Gregorio Gomez5, John J. Ryan5, John J. O’Shea2, and Juan Rivera1Lyn kinase Governs th2 differentiation.* Immunity, 2009, in press. 8. Kelly Speiran*#, Daniel P. Bailey#, Josephine Fernando* #, Matthew Macey*#, Brian Barnstein*#, Motunrayo Kolawole*#, Dana Curley*#, Stephanie S. Watowich€, Peter J. Murray¥, Carole Oskeritzian*†, and John J. Ryan. Endogenous Suppression of Mast Cell Development by IL-4 and IL-10. J. Leuk. Biol. 2009, 85(5):826-36. 9. M Wei Zhao, Gregorio Gomez, John J. Ryan and Lawrence B. Schwartz. TGF-β1 Attenuates Mediator Release and De Novo Kit Expression by Human Skin Mast Cells through a Smad-dependent Pathway. J. Immunol. 2008. 181(10):7263-72. 10. Mohit Kashyap, Angela M. Thornton, Sarah Kennedy Norton, Ethan Shevach, Warren J. Leonard, and John J. Ryan. Cutting Edge: CD4 T cell-Mast Cell Interactions Alter IgE Receptor Expression and Signaling. J. Immunol., 2008. 180(4):2039-43. 11. Sarah Kennedy Norton, MS,* Brian Barnstein, BS,* Daniel P. Bailey, PhD,* Mohit Kashyap, PhD,* Kelly Speiran, MS *, Jill Ford, PhD,† Daniel Conrad, PhD,† Stephanie Watowich, PhD,€ Christopher L. Kepley, PhD, MBA § Peter J. Murray, PhD,¥ John J. Ryan, PhD* Interleukin-10 Suppresses Mast Cell IgE Receptor Expression and Signaling in vitro and in vivo. J. Immunol., 2008. 180(5):2848-54. 12. Yumi Yamashita, Nicolas Charles, Yasuko Furumoto, Sandra Odom1, Toshiyuki Yamashita, Alasdair M. Gilfillan, Stephanie Constant, Molly A. Bower, John J. Ryan and Juan Rivera. Cutting Edge: Genetic variation influences FcεRI-induced mast cell activation and allergic responses. J. Immunol, 2007, 179(2):740-3. 13. Clint Mitchell, Peyman Kabolizadeh, John Ryan, John D. Roberts, Adly Yacoub, David T. Curiel, Paul B. Fisher, Michael P. Hagan, Nicholas P. Farrell*, Steven Grant* and Paul Dent. Low dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of ERBB1-PI3K signaling. Molec. Pharm. 2007, 72(3):704-14. 14. Ryan JJ, Bateman HR, Stover A, Gomez G, Norton SK, Zhao W, Schwartz LB, Lenk R, Kepley CL. Fullerene Nanomaterials Inhibit the Allergic Response. J. Immunol, 2007, 179(1):665-72. 15. Sheena Aris, John Ryan, Nicholas Farrell, David Gewirtz, and Nicholas Farrell. Promotion of DNA strand breaks, interstrand crosslinks and apoptotic cell death in A2780 human ovarian cancer cells by transplatinum planar amine complexes. Biochem Pharm., 2007, 73(11):1749-57. 16. Peyman Kabolizadeh, John Ryan, Nicholas Farrell. Differences in the Cellular Response and Signaling Pathways of Cisplatin and BBR3464 ([{trans-PtCl(NH3)2}2µ-(trans- 6
  • 7. Pt(NH3)2(H2N(CH2)6-NH2)2)]4+ ) Influenced by Copper Homeostasis. Biochem. Pharm., 2007, 73(9):1270-9. 17. Harold Dickensheets, Faruk Sheikh, Nancy Vazquez, Sébastien Gingras, John J. Ryan and Raymond P. Donnelly. Suppressor of Cytokine Signaling (SOCS)-1 is an IL-4-inducible gene in macrophages that inhibits IL-4 signaling. Genes Immun., 2006, 8(1):21-7. 18. Qibing Zhou†*, Hang Xie‡, Lin Zhang†, Jennifer K. Stewart§, Xing-Xing Gu‡, and John J. Ryan§ cis-Terpenones as an Effective Chemopreventive Agent against Aflatoxin B1 Induced Cytotoxicity and TCDD-induced P450 1A/B activity in HepG2 Cells. Chem. Res. Toxic. 2006, 19(11):1415-9. 19. Brian O. Barnstein, Geqiang Li, Kevin D. Bunting, and, John J. Ryan. Stat5 expression is required for mast cell cytokine production. J. Immunol., 2006, 177(5):3421-6. 20. Daniel P. Bailey, Mohit Kashyap, L. Andrew Bouton, Peter J. Murray, and John J. Ryan. Interleukin-10 Induces Apoptosis in Developing Mast Cells via a Mitochondrial, STAT3- dependent Pathway. J. Leuk. Biol.., 2006, 80(3):581-9. 21. Farnaz Norozian, Mohit Kashyap, Carlos D. Ramirez, Neha Patel, Christopher L. Kepley, Brian O. Barnstein, John J. Ryan. TGFβ1 induces mast cell apoptosis. Exp. Hematol., 2006., 34(5):579-87. 22. Harry V. Wright, Daniel Bailey, Mohit Kashyap, Chris Kepley, Marina S. Drutskaya, Sergei A. Nedospasov, and John J. Ryan. IL-3-mediated TNFα production is necessary for mast cell development. J. Immunol., 2006, 176(4):2114-21. 23. Amanda L. Harris, John J. Ryan, and Nicholas Farrell. Biological Consequences of Trinuclear Platinum Complexes: Comparison of BBR 3464 to its Non-covalent Congeners. Mol. Pharm. 2005. 69(2):666-72. 24. A. Harris, X. Yang, A. Hegmans, L. Povirk, J. Ryan, and N. Farrell. Synthesis and characterization of the DNA binding and cytotoxicity of a novel trinuclear highly charged compound. Inorg. Chem., 2005, 44(26):9598-600. 25. Mohit Kashyap, Daniel P. Bailey, Gregorio Gomez2, Juan Rivera2, Thomas F. Huff, and John J. Ryan. TGFβ1 Inhibits Mast Cell Development. Exp. Hematol.., 2005, 33(11):1281-91. 26. Gregorio Gomez, Claudia Gonzales-Espinosa, Sandra Odom, Gabriela Baez, M. Eugenia Cid, John J. Ryan, Juan Rivera. Impaired FcεRI-dependent gene expression and defective eicosanoid and lymphokine production as a consequence of Fyn deficiency in mast cells. J. Immunol., 2005, 175(11):7602-10. 27. Meredith Mann-Chandler, Mohit Kashyap, Harry Wright, Brian Barnstein, Farnaz Norozian, Sebastien Gringas, Evan Parganas, and John Ryan. Interferon Gamma Induces Apoptosis in Developing Mast cells. J. Immunol. 2005, 175(5):3000-5. 28. Gregorio Gomez1, Carlos D. Ramirez3, Juan Rivera1, Manish Patel3, Farnaz Norozian 3, Harry V. Wright3, Mohit V. Kashyap 3, Brian O. Barnstein, Krista Fischer-Stenger, Lawrence 7
  • 8. B. Schwartz2, Christopher L. Kepley 2, John J. Ryan. TGFβ Inhibits Mast Cell FcεRI Expression. J. Immunol., 2005, 174(10):5987-93. 29. Kristie L. Engler, Meghan L. Rudd, John J. Ryan, Jennifer K. Stewart, and Krista Fischer- Stenger. Autocrine Actions of Macrophage-Derived Catecholamines on Interleukin-1β. J. Neuroimmunol., 2005, Mar;160(1-2):87-91. 30. John M. Coleman, Meredith Mann-Chandler, John Ryan, Leonard Shultz, and Hua Huang. Lack of IL-4 receptor alpha chain protein expression and IL-4-mediated functions in cells of SHP-1 deficient mice. Cytokine, 2004, 29(3):118-24. 31. L. Andrew Bouton, Carlos D. Ramirez, Daniel P. Bailey, C. Fitzhugh Yeatman, Joyce Yue, Jos Domen, Roberto R. Rosato, Steven Grant, Krista Fischer-Stenger and John J. Ryan. Co-stimulation with Interleukin-4 and Interleukin-10 Induces Mast Cell Apoptosis and Cell Cycle Arrest: The Role of p53 and the Mitochondrion. Experimental Hematology, 2004, 32(12):1137-45. 32. Christopher L. Kepley*, Sharven Taghavi*, Graham Mackayƒ, Daocheng Zhu§, Penelope A. Morel†, Ke Zhang§, John J. Ryan¶, Leslie S. Satin‡, Min Zhang ‡, Pier P. Pandolfi∗∗, and Andrew Saxon§. Co-Aggregation of FcγRII With FcεRI Inhibits Antigen-Induced Secretion and Involves SHIP-GRB2-Dok Complexes. J. Biol. Chem. 2004, 279(34):35139-49. 33. Sandra Odom, Gregorio Gomez, Yasuko Furumoto, John Ryan, Harry Wright, Margaret Hibbs, Kenneth Harder, and Juan Rivera. Negative regulation of FcεRI signaling by the Lyn tyrosine kinase. J. Exp. Med., 2004, 199(11):1491-502. 34. Daniel P. Baileya, M.S., Mohit Kashyapa, Paria Mirmonsefa M.S, L. Andrew Boutona,M.S., Jos Domenb, Ph.D., Jingfang Zhuc, Ph.D., William E. Paulc, M.D., Emmanuel Dessyprisd, M.D., and John J. Ryana, Ph.D. Interleukin-4 Elicits Bone Marrow Cell Apoptosis Via a Stat6-Dependent Mitochondrial Pathway. Experimental Hematology, 2004 Jan;32(1):52-9. 35. Sheila R. Gillespie, Hey-Jin Chong, Daniel P. Bailey, Christopher P. Shelburne, L. Andrew Bouton, Anita Gharse, Paria Mirmonsef, Randall DeMartina, Krista Fischer-Stenger and John. J. Ryan. Interleukin-4 and Interleukin-10 Regulate the Fc Epsilon Receptor I Beta Subunit: Homeostasis in the Inflammatory Response. The Journal of Immunology, 2004 Mar 1;172(5):3181-8. 36. Chong HJ, Andrew Bouton L, Bailey DP, Wright H, Ramirez C, Gharse A, Oskeritzian C, Xia HZ, Zhu J, Paul WE, Kepley C, Schwartz LB, Ryan JJ.. Differential Regulation of Mast cell FcγRII and FcγRIII by Interleukin-4 and Interleukin-10. Cellular Immunology, 2003. 224;65-73. 37. Christopher P. Shelburne, Margaret E. McCoy, Roland Piekorz, Veronica V. Sexl, Sheila R. Gillespie, Daniel P. Bailey, Anita Gharse, Paria Mirmonsef, Meredith N.Mann, Mohit Kashyap, Harry V. Wright, Hey Jin Chong, L. Andrew Bouton, Carlos D. Ramirez, Chris S. Lantz, and John J. Ryan. Stat5 expression is critical for mast cell development and survival. Blood, 2003. 102(4),1290-1297. 38. Scott W. Brown, Randall T. Meyers, Karen M. Brennan, Julie M. Rumble, Nedathur 8
  • 9. Narasimhachari, Edmund F. Perozzi, John J. Ryan, Jennifer K. Stewart, and Krista Fischer-Stenger. Catecholamines in a Macrophage Cell Line. J. Neuroimmunol., 2003. 135(1-2):47-55. 39. Sarah Helber, Daniel Bailey, John Ryan, Emmanuel Dessypris, Maurice Bondurant, Amittha Wickrema, Jing Chun Chin, D. Barber, Paul Dent,.and Steven Sawyer. Tumor necrosis factor-alpha expressed constitutively in erythroid cells or induced by erythropoietin has negative and stimulatory roles in normal erythropoiesis and erythroleukemia. Blood, 2003. 101(2):524-31. 40. Christopher P. Shelburne, Roland P. Piekorz, Andrew Bouton, Hey Jin Chong and John J. Ryan. Mast Cell-Restricted p70 Stat6 Isoform is a Product of Selective Proteolysis. Cytokine, 2002. 19(5):218-227. 41. Freeman, J., N. Narasimchari, Daniel P. Bailey, L. Andrew Bouton, C. Shelburne, P., Mirmonsef, J. Ryan, and J.K. Stewart. Catecholamines in murine bone marrow derived mast cells, Journal of Neuroimmunology, 2001. 119: 231-238. 42. Jacobs-Helber, SM, Ryan, JJ, and Sawyer, ST. EPO induces JNK and p38 activation in HCD57 cells. Blood, 2000. 96(3):933-40. 43. C. Fitzhugh Yeatman, Sarah Jacobs-Helber, Paria Mirmonsef, Andrew Bouton, Henrietta Collins, Christopher P. Shelburne, Steven Sawyer, and John J. Ryan. IL-4 and IL-10 induce apoptosis of murine bone marrow-derived mast cells. J. Exp. Med., 2000. 192(8):1093-1103. 44. Paria Mirmonsef, Hey Jin Chong, Christopher Shelburne, and John J. Ryan. IL-4 and IL-10 inhibit c-Kit expression on mouse mast cells: role of Stat6 and PI-3 kinase. Journal of Immunology, 1999. 163:2530-2539. 45. Helen Y. Wang, Christopher P. Shelburne, Jose Zamarano, Ann Kelly, John J. Ryan, and Achsah Keegan. Effects of an allergy-associated mutation in the human IL-4Ra (Q576R) on IL-4-induced signal transduction. Journal of Immunology, 1999. 162:4385-4389. 46. John J. Ryan, Shirley DeSimone, Gregory Klisch, Christopher P. Shelburne, Lisa J. McReynolds, Reka Kovacs, Paria Mirmonsef, and Thomas F. Huff. Interleukin-4 inhibits FcεRI expression on bone marrow-derived mast cells through a Stat6-dependent mechanism. Journal of Immunology, 1998. 161:6915-6923. 47. John J. Ryan, Lisa J. McReynolds, Hua Huang, Keats Nelms, and William E. Paul. Characterization of a Mobile Stat6 Activation Motif in the Human IL-4 Receptor. Journal of Immunology, 1998. 161:1811-1821. 48. John J. Ryan, Hua Huang, Lisa J. McReynolds, Chris Shelburne, Thomas F. Huff, and William E. Paul. Stem Cell Factor Activates STAT-5 DNA Binding Activity in Mouse Mast Cells. Experimental Hematology, 1997. 25:357-362. 49. Jane Hu-Li, Hua Huang, John Ryan, and William E. Paul. In Differentiated CD4+ T Cells, IL-4 Production is Cytokine Autonomous While IFNγ Production is Cytokine Dependent. 9
  • 10. Proceedings of the National Academies of Science USA, 1997. 94:3189-3194. 50. S. Oakes, F. Candotti, J. Johnston, Y.-Q. Chen, J. Ryan, N. Taylor, L. Hennighausen, L. Notarangelo, W. Paul, R. M. Blaese, and J. O’Shea. Signaling Via IL-2 and IL-4 in JAK3- Deficient Severe Combined Immunodeficiency Lymphocytes: JAK3-Dependent and -Independent Pathways. Immunity, 1996. 6:605-15. 51. John J. Ryan, Lisa J. McReynolds, Achsah Keegan, Lu-Hai Wang, Evan Garfein, Paul Rothman, Keats Nelms, and William E. Paul. Growth and Gene Expression are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor. Immunity, 1996. 4:123-132. 52. Scott Kauma, Thomas Huff, Geoff Krystal, John J. Ryan, Peter Takacs, and Thomas Turner. The Expression of Stem Cell Factor and its Receptor, c-kit in Human Endometrium and Placental Tissues During Pregnancy. Journal of Clinical Endocrinology and Metabolism, 1996. 81:1261-1266. 53. John J. Ryan, Carol A. Kinzer, and William E. Paul. Mast Cells Lacking the High Affinity Immunoglobulin E Receptor are Deficient in FcεRI Messenger RNA. Journal of Experimental Medicine, 1995. 182:567-574. 54. John J. Ryan, K.A. Klein, T. R. Neuberger, C.M. Morton, J. Fletcher, G.H. DeVries, and T.F. Huff. Role for the stem cell factor/KIT complex in Schwann cell neoplasia and mast cell proliferation associated with neurofibromatosis. Journal of Neurosciences Research , 1994. 37(3):415-32. Invited Review Articles and Book Chapters 55. John J. Ryan, Johanna K. Morales, Yves T. Falanga, Josephine F.A. Fernando, and Matthew R. Macey. Mast Cell Regulation of the Immune Response. World Allergy Organization Journal, in press. 56. John J. Ryan and Josephine Fernando. Mast Cell Modulation of the Immune Response. Current Allergy and Asthma 2009. Vol 9(5) 9(5):353-9. 57. J. Ryan and Sarah Spiegel. The role of sphingosine-1-phosphate and its receptors in asthma. Drug News and Perspectives. 2008, 21(2):89-96. 58. John J. Ryan, Mohit Kashyap, Daniel Bailey, Sarah Kennedy, Brian Barnstein, Carole Oskeritzian, and Gregorio Gomez. Mast Cell Homeostasis: A Fundamental Aspect of Allergic Disease. Crit. Rev. Immunol. 2007, 27(1):15-32. 59. Yasuko Furumoto1, Gregorio Gomez1, Claudia Gonzalez-Espinosa2, Martina Kovarova 1, Sandra Odom1, John J. Ryan3, and Juan Rivera. The role of Src Family Kinases in mast cell effector function. Novartis Fondation Symposium. In Derek J. Chadwick and Jamie Goode eds., "Mast cells and basophils: Development, activation and roles in allergic/autoimmune disease, No. 271" Novartis Foundation Symposium, Pgs. 39-47; 2005. 271:39-47. 60. Y. Furumoto, C. Gonzalez-Espinosa, G. Gomez, M. Kovarova, S. Odom, V. Parravicini, J.J. Ryan, 10
  • 11. and J. Rivera. Rethinking the role of Src family protein tyrosine kinases in the allergic response: New insights on the functional coupling of the high affinity IgE receptor. Immunologic Research, 2004. 30(2):241-53. 61. John Joseph Ryan and Thomas F. Huff. Biology of Mast Cells. In Middleton’s Allergy: Principles and Practice; 6th edition. N. Franklin Adkinson, editor. 2004. Chap. 20; p333-346. 62. Christopher P. Shelburne, Margaret E. McCoy, Roland Piekorz, Veronica V. Sexl, Sheila R. Gillespie, Daniel P. Bailey, Anita Gharse, Paria Mirmonsef, Meredith N.Mann, Mohit Kashyap, Harry V. Wright, Hey Jin Chong, L. Andrew Bouton, Carlos D. Ramirez, Chris S. Lantz, and John J. Ryan. Stat5: An Essential Regulator of Mast Cell Biology. Molecular Immunology, 2002. 38:1187-1191. 63. Christopher Shelburne and John Ryan (2001). The Role of Th2 Cytokines in Mast Cell Homeostasis. Immunological Reviews, 179:82-93. 64. Keats Nelms, Achsah Keegan, John Ryan, and William E. Paul (1999). The IL-4 Receptor: Signaling Mechanisms and Biologic Functions. Annual Reviews in Immunology, 17:701-738. 65. Nelms K, Huang H, Ryan J, Keegan A, Paul WE. (1998). Interleukin-4 receptor signalling mechanisms and their biological significance. Adv. Exp. Med. Biol., 452:37-43. 66. John J. Ryan (1997). Interleukin-4 and Its Receptor: Essential Mediators of the Allergic Response. Journal of Allergy and Clinical Immunology; 99(1):1-5. 67. Keegan, A.D., Ryan, J.J., and Paul, W.E. (1996). IL-4 regulates growth and differentiation by distinct mechanisms. The Immunologist, 4(6):194-198. 68. T.F. Huff, C.F. Lantz, J.J. Ryan, J.A. Leftwich (1995). Mast Cell Committed Progenitors, in Biological and Molecular Aspects of Mast Cells and Basophils in Differentiation and Function, Eds. Y. Kitamura, S. Yamamoto, S.J. Galli, M.W. Greaves, pp.105-118. Raven Press, New York. Patent Aplications: • Platinum Based Drug Cytotoxicity is Enhanced by the Antidepressant Desipramine. Submitted By Nicholas Farrell, Peyman Kabolizadeh, and John Ryan. Teaching and Mentoring Experience: Current Trainees and Employees • Brian Barnstein (Laboratory Manager) • Josephine Fernando (Postdoctoral trainee) • Yves Falanga (Ph.D. Candidate, ILS Program) • Matthew Macey (technician) • Sandeep Sharma (Undergraduate, HHMI student) • Katie Williams (Undergraduate) • Bretton Vance (Undergraduate) • Amina Abdul (High School student) Former Trainees 11
  • 12. Postdoctoral: • Christopher Shelburne, Ph.D. (1998-2000) Staff scientist at Duke University. Doctoral Trainees: • Sheena Aris (2008, co-mentored with Nicholas Farell): Postdoc at NIH • Peyman Kabolizadeh (M.D./Ph.D. 2007; co-mentored with Nicholas Farell) MD resident • Mohit Kashyap (Ph.D. 2006) Postdoctoral fellow at NIH. • Daniel Bailey (Ph.D., 2005). Scientific Analyst, SIAC Hazard Assessment Team. • Andrew Bouton (Ph.D. 2004). Staff scientist at PPDI, Inc. • Hey-Jin Chong (M.D./Ph.D. 2004) Asthma/Allergy fellow at Harvard University. Master’s Degree Trainees: • Matthew Macey (M.S. 2009) • Jennifer Brenzovich (M.S. 2008), Laboratory Director, University of Richmond • Kelly Speiran (M.S. 2007), PhD candidate at Univ. of South Carolina. • Sarah Kennedy (M.S., 2007) PhD candidate at VCU. • Farnaz Norozian (M.S. 2006) Medical student at Ross University • Harry Wright (M.S. 2004). Medical student at VCU. • Meredith Mann (M.S. 2004). Staff scientist at VA State Labs • Mohit Kashyap (M.S. 2003). Postdoctoral fellow at NIH. • Carlos Ramirez (M.S. 2004). Seeking MD residency program. • Daniel Bailey (M.S. 2002). Scientific Analyst, SIAC Hazard Assessment Team. • Sheila Gillespie (M.S. 2000). Practicing dentist in Virginia Beach, VA. • Fitzhugh Yeatman (M.S. 1999). Radiologist, Seattle, WA. • Paria Mirmonsef (M.S. 1999). Recent Ph.D. graduate of Johns-Hopkins University. Undergraduate Trainees: #Pubs submitted/published Name Years Later degrees with Ryan Lab as of 2008 Lisa McReynolds 1996-99 MD/PhD 4 Kathy Han 1997 PhD 1 1998-20 Hey Jin Chong 03 MD/PhD 7 Marlena Cain 1998 MD none Henrietta Collins 1999 BS 1 2000-20 Daniel Bailey 05 MS/PhD 13 2000-20 Carlos Ramirez 03 MS/MD 7 2000-20 Anita Gharse 01 3 Mahesh Datla 2000 MD none Joyce Yue 2002 MD 1 2003-20 Farah Norozian 05 Apply Med Sch 3 Neha Patel 2005 OD 1 Peter Ma 2006 Apply Med Sch none Dipal Pandya 2006 Apply Med Sch (in prep) Jeff Blair 2007 PharmD none 12
  • 13. Kevin Dholaria 2008 Med Sch (in prep) Nitin Yerram 2008 Med Sch (in prep) Yves Falanga 2008 Current PhD (in prep) Motunrayo Kolawole 2008 Applying to PhD (in prep) Bretton Vance Current Kathryn Williams Current Sandeep Sharma Current 13
  • 14. Courses Taught On average, I am in the classroom approximately 100 hours/year. I typically direct one 3 credit course each semester, and guest lecture in others. I have served as the course director, and frequently the sole teacher in 7 courses: • Course Director (and sole instructor), Biology 455: Immunology Department of Biology, Virginia Commonwealth University Average number of lecture hours presented in this course: 39/semester. Spring 2002; Spring 2006; Fall 2007. Enrollment = 50-85. • Course Director, Biology 450/451: Biology of Cancer Department of Biology, Virginia Commonwealth University Average number of lecture hours presented in this course: 10/semester. A two-semester tandem course. Taught in 2000-2001; 2002-2003; 2004-2005; 2006-2007. Enrollment = 40. • Course Director (and sole instructor), Biology 565: Advances in Signal Transduction Department of Biology, Virginia Commonwealth University Average number of lecture hours presented in this course: 20/semester. Fall, 1997; Spring 1999; Spring 2000; Fall 2001; Fall 2006; Spring 2008 Enrollment = 15-20. • Course Director, MICR 691: Molecular Biology Group Journal Club Department of Microbiology and Immunology, Virginia Commonwealth University Spring 2001. Enrollment = 15. • Course Director (and sole instructor), Biology 311: Animal Physiology Department of Biology, Virginia Commonwealth University Average number of lecture hours presented in this course: 39/semester. Spring 1998; Fall 1998; Fall 1999. Enrollment = 100. • Course Director, BIOL361: Biomedical Research Department of Biology, Virginia Commonwealth University Average number of lecture hours presented in this course: 4/semester. Spring 2005; Spring 2007; Spring 2008. Enrollment = 40. • Course Director, BIOL693: Graduate Seminar Department of Biology, Virginia Commonwealth University Average number of lecture hours presented in this course: 6/semester. Spring 2006. Enrollment = 8. • Additional courses in which I participate: • Advanced Immunology • BIOC/MICR 504 • MI Immunology • BIOL 300/Experimental Methods • LFSC101 Life Sciences 101 14
  • 15. Membership in Professional Societies: • American Association of Immunologists • American Association for the Advancement of Science • Virginia Academy of Science Professional Service and Affiliations • Associate Editor, The Journal of Immunology 2006-present • Ad Hoc Reviewer, National Institutes of Health study sections: Allergy and Immunology Study Section (ALY); Cellular and Molecular Immunology –A (CMI-A); Immunological Sciences Study Section (IMS); Immunobiology Study Section (IMB). I most recently served on CMI-A in June, 2007. • Ad Hoc Reviewer for other grant agencies in the past 5 years: Jeffress Trust Fund of Virginia; Maryland Industrial Partnership, (UK) Medical Research Council. • Co-chair of Mast Cell Biology mini-Symposium at Experimental Biology conference in 1999 and 2008. • Ad Hoc Reviewer for Journals in the past 5 years: The American Journal of Physiology, Experimental Hematology, The Journal of Experimental Medicine, Blood, Laboratory Investigations, European Journal of Immunology, Cellular Immunology, Cytokine, Clinical Laboratory Investigations, Clinical and Experimental Allergy, Journal of Leukocyte Biology, BMC Cancer, Immunological Investigations, Human Molecular Genetics, Experimental Cell Research, Biochemical Pharmacology, Journal of Allergy and Clinical Immunology, Thorax, International Journal of Cancer, Immunology Letters. Departmental Affiliations: • Faculty Member, Massey Cancer Center, Immune Mechanisms Interest Group (Fall, 1997 - present) • Affiliate Faculty, Department of Biochemistry (2003-present). • Affiliate Faculty, Department of Chemistry (2007-present). • Affiliate Faculty, VCU MD/PhD Program • Affiliate Faculty, Department of Microbiology and Immunology (Fall, 1997 - present) • Member, Molecular Biology and Genetics Group (Fall, 1997 - present) Service Committees: • Member HHMI Summer Internship Steering Committee (2006-present) • Member, Biology Department Graduate Academic Committee (Fall, 1997 - 2002) • Member, Biology Department Budget and Facilities Committee (2002-2005) • Chair, Biology Department Budget and Facilities Committee (2005-present) • Member, Flow Cytometry Oversight Committee • Member, Massey Cancer Center Review Panel for American Cancer Society Grant Awards. Non-Professional Services and Activities • Catholic Catechist (Sunday School Teacher). Redeemer Catholic Church, Mechanicsville, VA. 2000 - present. • Lector/Reader. Redeemer Catholic Church, Mechanicsville, VA. 2000, 2001, 2002. • Member, Knights of Columbus men’s service organization, Albert E. Chipman Chapter, Redeemer Catholic Church, Mechanicsville, VA. • Participant in Daily Planet/Freedom House services to the homeless through Redeemer 15
  • 16. Catholic Church, Mechanicsville, VA. This group of parishioners serves meals to the homeless at The Salvation Army center on Grace Street in Richmond. 16

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