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  • 1. British Society for Immunology and Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry 8th JOHN HUMPHREY ADVANCED SUMMER PROGRAMME IN IMMUNOLOGY IMMUNOLOGY AND VIRAL INFECTION PROGRAMME September 10-14, 2007 MOSCOW
  • 2. Vladimir Nesmeyanov With the utmost regret the Organizing Committee informs that Prof. Vladimir Nesmeyanov has died on July 13, 2007. The 8th John Humphrey Summer School in Immunology will be dedicated to his memory. 2
  • 3. Supported by : British Council British Society for Immunology efis-EJI European Federation of Immunological Societies - European Journal of Immunology International Union of Immunological Societies Russian Academy of Sciences Russian Foundation for Basic Research 3
  • 4. MONDAY SEPTEMBER 10 9.00-10.00 Registration 10.00-10.15 Opening of meeting: Chairperson Robert Bomford Vadim Ivanov A tribute to Prof. Vladimir Nesmeyanov BASIC IMMUNOLOGY Chairpersons: Eddy Liew and Chris Rudd 10.15-11.15 Rose Zamoyska Regulation of T cell activation and differentiation 11.15-11.45 Coffee break 11.45-12.45 Chris Rudd T cell signaling 12.45-13.45 Lunch 13.45-14.45 Kingston Mills Helper T cells subsets 15.15-15.45 Eddy Liew Novel cytokines in inflammatory disease 15.45-16.15 Coffee break 16.15-18.00 Workshop: T cell biology Chairpersons: Eddy Liew and Kingston Mills Introductory remarks by chairpersons and student contributions 18.30 Get-together party TUESDAY SEPTEMBER 11 LCMV AND HEPATITIS B AND C Chairpersons: Allan R. Thomsen and Mala Main 10.00-11.00 Allan R. Thomsen The interplay between host immune system and virus during murine infection with LCMV 11.00-11.30 Coffee break 11.30-12.15 Mala Maini The T cell response to HBV: control versus pathogenicity 12.15-13.30 Ellie Barnes Host response to hepatitis C and viral evasion mechanisms 13.30-14.30 Lunch 14.30-16.30 Workshop: LCMV and Hepatitis B and C Chairpersons: Mala Maini and Ellie Barnes Introductory remarks by chairpersons and student contributions 4
  • 5. 16.30-17.00 Coffee break 17.00-18.30 Poster session (A-R) WEDNESDAY SEPTEMBER 12 HIV AND HTLV Chairpersons: Yuri Sykulev and Charles Bangham 9.00-10.00 Sarah Rowland-Jones Immune control of HIV infection – Lessons from HIV-2 10.00-11.00 Yuri Sykulev Control of HIV by CTL: How to catch a virus by the tail (or finding a niddle in a haystack) 11.00-11.30 Coffee break 11.30-12.30 Andrei Kozlov Towards an HIV vaccine 12.30-13.30 Lunch 13.30-14.30 Charles Bangham Efficiency of the anti-viral CTL response: HTLV-1 14.30-15.00 Coffee break 15.00-17.00 Workshop: HIV and HTLV Chairpersons: Sarah Rowland-Jones and Yuri Sykulev Introductory remarks by chairpersons and student contributions 17.00-18.30 Poster session (S-Z) THURSDAY SEPTEMBER 13 INFLUENZA Chairpersons: Mikhail Matrosovitch and Nicolai Bovin 10.00-11.00 Mikhail Matrosovitch Role of influenza virus interactions with cellular receptor in interspecies transmission and emergence of pandemics 11.00-11.30 Coffee break 11.30-12.30 Nicolai Bovin Novel approaches to vaccination against influenza 12.30-13.00 Sarah Rowland-Jones Human T cell response to seasonal influenza A virus: Extent of cross-reactivity with H5N1 13.00-13.30 Mikhail Matrosovich Influenza virus interactions with sialic acid receptors on inflammatory and immunocompetent cells 14.00-15.30 Lunch 5
  • 6. HERPESVIRUSES Chairpersons: Alan Rickinson and Vladimir Gurtsevitch 14.30-15.15 Alan Rickinson The T cell response to EBV; resistance and pathogenicity 15.15-16.00 Vladimir Gurtsevitch LMP1 gene variants of Epstein-Barr virus in patients with lymphoproliferative diseases in Russia 16.00-16.30 Coffee break 16.30-18.00 Workshop – Influenza and Herperviruses Chairpersons: Mikhail Matrosovich and Alan Rickinson Introductory remarks by chairpersons and student contributions 19.00 Conference Banquet FRIDAY SEPTEMBER 14 10.00-11.00 Round table discussion Summary remarks by members of the faculty, and an opportunity for participants to discuss the future of their work with members of the faculty 11.00-11.30 Coffee break 11.30-12.30 Round table discussion continued 12.30-13.00 Robert Bomford Concluding remarks and end of programme 13.00-14.00 Lunch WORKSHOPS MONDAY SEPTEMBER 10 T CELL BIOLOGY Kingston Mills Regulatory T cell control of effector and pathogenic T cells Skewed V-alpha repertoire hardly affects the recognition of MHC molecules of bm-mutants Ekaterina Zvezdova, Grinenko T.S., Kadulin S.G. and Kazansky D.B. Antibiotic geldanamycin, an Hsp90-binding agent, affects the expression of signal proteins and heat shock proteins in normal mice lymphocytes Maxim Khrenov, Cherenkov D.A., Novoselova T.V., Lysenko E.M. Lunin S.M., Novoselova E.G. The role of VEGF in thymic involution during tumor growth Ekaterina Kisseleva, Krylov A.V., Lioudyno V.I. 6
  • 7. CD8+ responses to cancer/testis antigens can be detected in patients with haematological malignancies can be detected following allogeneic stem cell transplant Andrew McLarnon, Karen Piper, Oliver Goodyear, Paul Moss TUESDAY SEPTEMBER 11 LCMC AND HEPATITIS B AND C Allan R. Thomsen T-cell mediated inflammation of the virus-infected CNS Cytokine regulation parameters and their changes depending on therapy in patients with chronic viral hepatitis C Viktor Mitsura, Krasavtsev E.L., Zhavoronok S.V., Demchilo A.P. Clinical-Immunological Particularities and New Ways and Aspects in the Treatment of Chronic Hepatitis C and B+D Valentina Smesnoi, Gheorghe Cusnir CD8+ T cells from patients with chronic HBV infection display a ‘functionally exhausted’ phenotype associated with telomere shortening Abhishek Das, Vukmanovic-Stejic M., Fletcher J., Lopes A.R., Dunn C., Gilson R.J., Maini M.K. Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control hepatitis B virus infection Ross Lopes, Kellam P., Das A., Dunn C., Kiran A., Turner J., Gilson R.J., Bertoletti A., Maini M.K. WEDNESDAY SEPTEMBER 12 HIV AND HTLV Sarah Rowland-Jones Methods of measuring T cell responses to HIV Yuri Sykulev Understanding effective delivery of a position pill Evaluation of T-cell function in HIV-1 Bulgarian patients under HAART Yana Todorova, Markova R., Drenska R., Terzieva V., Elenkov I., Yankova M. The role of T-cell co-stimulatory molecule expression in Human T-Lymphotropic Virus Type-1 infection Tarek Kattan, Angelina AJ Mosley, Yuetsu Y Tanaka, Graham P Taylor, Charles RM Bangham Influence of HLA-B35 on HIV-2-specific cellular immunity Aleksandra Leligdowicz, Louis-Marie Yindom, Clayton Onyango, Matt Cotten, Assan Jaye, Tao Dong, Andrew McMichael, Hilton Whittle, Sarah Rowland-Jones 7
  • 8. Prediction of T-cell epitopes within protein antigens: theoretical analysis and software development Denis Antonets, Maksyutov A.Z. Formation of antibody response with different repertoire depends on the administration way of the combined DNA/protein HIV-1 vaccine Roman Uzhachenko, Karpenko L., Lebedev L., Ilychev A., Bazhan S. Analysis of the safety and the immunogenicity of the gag-env HIV1 recombinant protein-based vaccine VICHREPOL in healthy adults Svetlana Korobova, Nikolaeva I.A., Chevalier A.F., Gornostaeva Yu.A., Trubcheniniva L.P., Gorbunova Z.V., Gudima G.O., Pinegin B.V., Chernousov A.D., Petrova T.V., Trofimov D.Yu., Sidorovich I.G. THURSDAY SEPTEMBER 13 INFLUENZA AND HERPESVIRUS Broadly cross-reactive T-cell responses to avian influenza A (H5N1) in healthy individuals in the UK and Viet Nam Laurel Yong-Hwa Lee, Menno D. de Jong, Cameron Simmons, Lien Anh Ha, NguyenVan Vinh Chau, Yan Chun Peng, Brigitte A. Askonas, Jeremy Farrar, Andrew J. McMichael, Sarah Rowland-Jones and Tao Dong Analyze of TLR genes expression and cytokines production during prenatal herpes virus infection Oxana Gankovskaya, Koval’chuk L.V., Lavrov V.F. The macrophage functional activity correlates with susceptibility to genital HSV-2 infection in mice and success of vaccination Nagurskaya E., Zaitseva L., Natalia Kobets, Kireeva I., Alimbarova L., Samoilenko I., Barinskii I. EBV nuclear antigen processing and presentation for CD8+ and CD4+ T cell recognition: newly synthesised versus stable proteins Laura Mackay, Long H.M., Brooks J.M., Rickinson A.B. 8