This presentation was created by: Amelia Farber Sadie Shelton Amy Senestraro Zack Hartman Tanner Hebert This publication was made possible by Grant # 024094 from NIAID. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.
The immune system is designed to protect the body from harmful diseases.
The immune system begins to develop in the embryo and by the time the baby is born, it is a sophisticated collection of tissues that includes the blood, lymphatic system, thymus, spleen, skin, and mucosa.
Are different from B and NK cells because they have a special receptor on their surface called a T cell receptor (TRC) which are designed to recognize antigen. When a TRC comes in contact with an antigen, the T cell matures and changes into one of five things:
A Helper T cell – which divides rapidly and secretes tiny proteins (called cytokines), that help in the immune response.
A Cytotoxic T cell – which destroys virally infected cells and tumor cells
A Memory T cell – which remain active after an immune response, and help the body remember the specific antigen that attacked it.
A Regulatory T cell – which is responsible for shutting down the T cell reaction after an immune response is over.
A Natural Killer T cell – which is responsible for recognizing different types of antigens
Their primary role is to make antibodies to attack antigens. Once a B cell has come in contact with an antigen, it becomes a memory B cell, meaning it will remember that specific antigen if the body is every attacked by it again.
Basic diagram of flow cytometry Cells from a patient’s blood are injected, in a fluid stream, into the flow cytometer. As the cells pass the laser beam, the light refracts off the cells, causing a certain amount of forward and side scatter. By graphing and measuring the amount of scatter the cytometer reads, you can tell if the patient has a certain ailment or disease such as HIV/AIDS
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