BAPP: Tecnología y Servicios Jornada de Presentaciones a Empresas Dra. Diana Navarro Madrid, 19 de septiembre de 2006
<ul><li>Who we are… </li></ul>We are members of the Biomedical Research Park of Barcelona (PRBB) Multidisciplinary  Servic...
Accreditations       <ul><li>Formed by two highly “Qualified Research grups” (according to the nomenclature of Government ...
<ul><li>Accredited as a Clinical Laboratory (Government of Catalonia) </li></ul><ul><li>Phase I Unit of Clinical Trials  (...
<ul><li>Member of ProteoRed </li></ul><ul><li>Member of the Red de  </li></ul><ul><li>Trastornos Adictivos </li></ul><ul><...
<ul><li>Our Areas of Expertise </li></ul><ul><li>Objectives </li></ul><ul><li>Perform basic and applied research in clinic...
<ul><li>Marketing Analysis </li></ul><ul><li>Clients   </li></ul><ul><li>Pharmaceutical companies </li></ul><ul><li>Univer...
Facilities We have modern facilities equipped with state-of-the-art instruments Analytical – Wide variety of analytical te...
<ul><li>Services offered </li></ul><ul><li>Clinical Assays and studies for new drug development </li></ul><ul><li>Analysis...
                                                        <ul><li>Proteomics </li></ul><ul><li>Protein separation by bidimen...
Peptide Synthesis <ul><li>Custom peptide synthesis (up to 30 residues), with 4 different levels of purity </li></ul><ul><l...
Clinical Assays and studies for new drug development <ul><li>Pharmacokinetic studies  </li></ul><ul><li>(determination of ...
<ul><li>Analysis of drugs of abuse </li></ul><ul><li>Determination and identification of drugs and metabolites in blood, u...
<ul><li>Evaluation of pharmacological and toxicological effects induced by drugs of abuse </li></ul><ul><li>pharmacodynami...
<ul><li>Antidoping control </li></ul>Major International Federations  International Doping Tests and Management (IDTM)  Na...
<ul><li>Psychopharmacology of  stimulants ,  psicotomimetic s,  anxiolytics  and anabolic agents </li></ul><ul><li>    </l...
Program for quality control of analysis of drugs of abuse in urine     Preparation of reference materials for standarizati...
<ul><li>Computer   assisted management of laboratories   </li></ul>Software for laboratori management IMLIMS  Software for...
<ul><li>Structure and interaction of glycoproteines </li></ul><ul><li>Structural studies (HPLC, IEF, MS, etc)  </li></ul><...
<ul><li>Diagnosis of alterations of steroidal metabolism   </li></ul>Congenital adrenal hyperplasia  Mineral/Glucocorticoi...
<ul><li>Neuroimaging Services </li></ul><ul><li>Genes, endophenotypes, and environmental vulnerability associated to subst...
<ul><li>Acknowledgements </li></ul><ul><li>Members of Pharmacology Research Unit </li></ul><ul><li>Members of Peptide and ...
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BAPP: Tecnología y Servicios

  1. 1. BAPP: Tecnología y Servicios Jornada de Presentaciones a Empresas Dra. Diana Navarro Madrid, 19 de septiembre de 2006
  2. 2. <ul><li>Who we are… </li></ul>We are members of the Biomedical Research Park of Barcelona (PRBB) Multidisciplinary Service-oriented group in applied health sciences The BAPP research group of IMIM-UPF focuses its activity on several areas of biological chemistry (bioanalysis, protein and peptide, proteomics), pharmacology, toxicology and new drug development.
  3. 3. Accreditations       <ul><li>Formed by two highly “Qualified Research grups” (according to the nomenclature of Government of Catalonia) </li></ul><ul><li>Anti-doping Laboratory accredited by </li></ul><ul><li>Olympic International Comitee </li></ul><ul><li>World Anti-doping Agency </li></ul><ul><li>Association of Oficial Racing Chemists </li></ul><ul><li>Consejo Superior de Deportes </li></ul>
  4. 4. <ul><li>Accredited as a Clinical Laboratory (Government of Catalonia) </li></ul><ul><li>Phase I Unit of Clinical Trials (Spanish Ministry of Health) </li></ul><ul><li>ISO-17025 acreditation by the Spanish National Acreditation Body ENAC for the performance of “Analysis of drugs in urine” </li></ul><ul><li>Acreditation by Government of Catalonia/Cidem, certifying the quality of services offered by its members to the industry </li></ul>
  5. 5. <ul><li>Member of ProteoRed </li></ul><ul><li>Member of the Red de </li></ul><ul><li>Trastornos Adictivos </li></ul><ul><li>Member of the Red de </li></ul><ul><li>Genotipación y Psiquiatría </li></ul><ul><li>Genética </li></ul><ul><li>Member of the Technological Innovation Net (Xarxa IT) </li></ul><ul><li>of the Government of Catalonia </li></ul>We are actively involved in ……
  6. 6. <ul><li>Our Areas of Expertise </li></ul><ul><li>Objectives </li></ul><ul><li>Perform basic and applied research in clinical assay and bio analysis, protein and peptide chemistry and proteomics </li></ul><ul><li>Provide analytical services to the pharmaceutical industry, public and private institutions </li></ul><ul><li>Provide Consultancy and assessment services in our expertise areas </li></ul><ul><li>Increase technology transfer in these areas </li></ul>The main expertise areas of our group are linked to the structural determination of biomolecules from both low and high molecular mass, as well as to the synthesis of peptides and related substances.
  7. 7. <ul><li>Marketing Analysis </li></ul><ul><li>Clients </li></ul><ul><li>Pharmaceutical companies </li></ul><ul><li>Universities </li></ul><ul><li>Official bodies </li></ul><ul><li>Regulation agencies </li></ul><ul><li>Anti-doping agencies </li></ul><ul><li>Hospitals </li></ul><ul><li>individuals </li></ul>La promoció de la recerca Diana Navarro Universitat Pompeu Fabra Our natural clients are pharmaceutical companies, research groups from universities and hospitals and public health institutions.
  8. 8. Facilities We have modern facilities equipped with state-of-the-art instruments Analytical – Wide variety of analytical techniques Clinical- Clinical Research Unit Instrumentation and Facilities Acces to LC/MS ( nanoES-Q-MS) MALDI/TOF/MS CE/UV/MS n multi-dimensional HPLC 2-Dimensional Electrophoresis LC coupled to: UV, DAD, EC LC/MS n (ion trap mass spectrometry) GC/MS GC/MS n (ion trap mass spectrometry) GC / Combustion / Isotope Ratio Mass Spectrometry GC coupled to: NPD, ECD or FID
  9. 9. <ul><li>Services offered </li></ul><ul><li>Clinical Assays and studies for new drug development </li></ul><ul><li>Analysis of drugs of abuse </li></ul><ul><li>Antidoping control </li></ul><ul><li>Contributions to analytical quality </li></ul><ul><li>Computer assisted management of laboratories </li></ul><ul><li>Structure and interaction of glycoproteines </li></ul><ul><li>Diagnosis of alterations of steroidal metabolism </li></ul><ul><li>Neuroimaging Services </li></ul><ul><li>Protein separation by bidimensional electrophoresis or multidimensional HPLC </li></ul><ul><li>Protein identification by mass spectrometry </li></ul><ul><li>Synthetic peptides </li></ul><ul><li>Selection and synthesis of peptide immunogens </li></ul>
  10. 10.                                                         <ul><li>Proteomics </li></ul><ul><li>Protein separation by bidimensional </li></ul><ul><li>electrophoresis </li></ul><ul><li>Protein separation by multidimensional </li></ul><ul><li>chromatography </li></ul><ul><li>Protein identification by MALDI-TOF mass </li></ul><ul><li>fingerprint and by tandem MS/MS </li></ul><ul><li>sequencing of protein digests. </li></ul><ul><li>Molecular weight determination </li></ul>
  11. 11. Peptide Synthesis <ul><li>Custom peptide synthesis (up to 30 residues), with 4 different levels of purity </li></ul><ul><li>(70, 90, 95 and 98 % content in target sequence by HPLC) </li></ul><ul><li>Synthesis of larger peptides, after feasibility study and price estimate </li></ul><ul><li>Site-specifically modified synthetic peptides: acetylation, lipidation, glycosylation, biotinylation, fluorophore labeling, other </li></ul><ul><li>Peptide nucleic acids (PNAs) </li></ul><ul><li>Expert assessment in sequence selection for synthesis of peptide immunogens </li></ul><ul><li>Conjugation of peptides to carrier proteins for immunization </li></ul>
  12. 12. Clinical Assays and studies for new drug development <ul><li>Pharmacokinetic studies </li></ul><ul><li>(determination of pharmacokinetic parameters; bioavailability including bioequivalences for generic medications; metabolism and metabolite identification) </li></ul><ul><li>Consulting on methodology for clinical trial protocols. </li></ul><ul><li>Phase I and phase II efficacy and tolerability trials. </li></ul><ul><li>Abuse liability evaluation of new medications </li></ul><ul><li>(psychopharmacological profile, studies of preference and discrimination) </li></ul>
  13. 13. <ul><li>Analysis of drugs of abuse </li></ul><ul><li>Determination and identification of drugs and metabolites in blood, urine and saliva </li></ul><ul><li>Confirmation analysis </li></ul><ul><li>Analysis of purity and richness of specimens </li></ul><ul><li>Analysis of drug confirmation in biologycal samples </li></ul><ul><li>Monitoring of drugs in urine for sick patients under treatment </li></ul><ul><li>Evaluation of new analytical development </li></ul>
  14. 14. <ul><li>Evaluation of pharmacological and toxicological effects induced by drugs of abuse </li></ul><ul><li>pharmacodynamics </li></ul><ul><li>pharmacokinetics </li></ul><ul><li>Neuroimaging </li></ul><ul><li>Genetics in recreational users with substance abuse disorders (polyconsumption) and others associated (psychopathology and neurocognitive performance). </li></ul><ul><li>Current studies are focused in </li></ul><ul><li>clubber drugs (MDMA, GHB) </li></ul><ul><li>cannabis and </li></ul><ul><li>&quot;smart drugs&quot; </li></ul>Clinical Assays and studies for new drug development
  15. 15. <ul><li>Antidoping control </li></ul>Major International Federations International Doping Tests and Management (IDTM) National Sports Governing Bodies Major International Events IOC Medical Commission World Anti-Doping Agency (WADA) Successful defensibility of Anti-Doping results in Court: - Court of Arbitration for Sport - International Federations Doping Panels Antidoping control analysis in athletes Antidoping control analysis in samples from animals Analysis of drugs in biological fluids
  16. 16. <ul><li>Psychopharmacology of stimulants , psicotomimetic s, anxiolytics and anabolic agents </li></ul><ul><li>   </li></ul><ul><li>Analysis of drugs with abuse liability in biological fluids </li></ul><ul><li>Screening and confirmation of stimulants , narcotics , anabolic agents (anabolic steroids, b-agonists), diuretics , b-blockers , peptide hormones (EPO, hGH, b-hCG), plasma expanders (HES) </li></ul><ul><li>Development of analytical methods for the detection of &quot;pseudoendogen&quot; compounds using isotope ratio mass spectrometry </li></ul><ul><li>Validation of methodology for the detection of direct and indirect biomarkers of the administration of recombinant hormones (EPO, hGH) </li></ul>
  17. 17. Program for quality control of analysis of drugs of abuse in urine    Preparation of reference materials for standarization of analytical techniques Training and assessment in immunological and chromatographic techniques Contributions to analytical quality
  18. 18. <ul><li>Computer assisted management of laboratories </li></ul>Software for laboratori management IMLIMS Software for management of Quality Control Programes ALADIN Advice in development of software for laboratori management
  19. 19. <ul><li>Structure and interaction of glycoproteines </li></ul><ul><li>Structural studies (HPLC, IEF, MS, etc) </li></ul><ul><li>Interactions with lectins and antibodies </li></ul><ul><li>Metabolic relevance of glycanes </li></ul>
  20. 20. <ul><li>Diagnosis of alterations of steroidal metabolism </li></ul>Congenital adrenal hyperplasia Mineral/Glucocorticoid disfuntions Male pseudohermaphroditism Aromatase and sulfatase deficiency Smith-Lemli-Opitz syndrome
  21. 21. <ul><li>Neuroimaging Services </li></ul><ul><li>Genes, endophenotypes, and environmental vulnerability associated to substance abuse and psychiatric disorders </li></ul><ul><li>Evaluation of genes (candidate genes), endophenotypes (clinical symptoms, cognitive traits, personality traits, biological markers) and environmental factors (drugs abuse, life events) implicated in the vulnerability of substance abuse and psychiatric disorders and comorbidity within them and pharmacological response </li></ul>
  22. 22. <ul><li>Acknowledgements </li></ul><ul><li>Members of Pharmacology Research Unit </li></ul><ul><li>Members of Peptide and Protein Chemistry group </li></ul><ul><li>Financial Support (GenCat, Cidem) </li></ul>Contact Information Diana Navarro Science Business Manager Biomedical Research Park of Barcelona, PRBB c/ Dr. Aiguader, 80 08003 Barcelona Spain Tel. (+34)-935421379 E-mail: bapp@upf.edu Web: http://www.upf.edu/bapp

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