Applying for a Grant at the NIH


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Applying for a Grant at the NIH

  1. 1. Applying for a Grant at the NIH Helen Quill, Ph.D. Chief, Basic Immunology Branch Division of Allergy, Immunology & Transplantation NIAID, NIH
  2. 2. The Application Process
  3. 4. 2 Independent Assignments for Your Grant Application upon Receipt at NIH
  4. 6. Peer Review “ Before you criticize someone, you should walk a mile in their shoes. That way when you criticize them, you’re a mile away and you have their shoes.” -Steven Wright
  5. 7. CSR (Center for Scientific Review) <ul><li>Study Section </li></ul><ul><li>peer review panel </li></ul><ul><li>15-25 reviewers, mostly from academia </li></ul><ul><li>IRG (integrated review group) </li></ul><ul><li>group of study sections </li></ul>
  6. 8. New Immunology IRG <ul><li>New Study Sections: est. June 2004 </li></ul><ul><li>Innate Immunity & Inflammation (III) </li></ul><ul><li>Immunity & Host Defense (IHD) </li></ul><ul><li>Cellular & Molecular Immunology (CMI)-A </li></ul><ul><li>Cellular & Molecular Immunology (CMI)-B </li></ul><ul><li>Hypersensitivity, Autoimmune & Immune-Med. Dis. (HAI) </li></ul><ul><li>Transplantation, Tolerance & Tumor Immunology (TTT) </li></ul><ul><li>Vaccines Against Microbial Diseases (VMD) </li></ul><ul><li>F32 Postdoctoral Grants </li></ul>
  7. 10. Institute Program Officer <ul><li>Designated Federal official with overall </li></ul><ul><li>responsibility for the funding process </li></ul><ul><li>Scientist trained in area of coverage </li></ul><ul><li>Develops targeted research programs </li></ul><ul><li>Approves funding and oversees funded grants </li></ul><ul><li>Approves yearly progress reports </li></ul><ul><li>Assists PI with both administrative & scientific questions </li></ul><ul><li>Attends study section as observer </li></ul>
  8. 12. Review Process <ul><li>6-8 wks before study section meeting </li></ul><ul><li>SRA assigns and sends applications to primary, secondary, tertiary reviewers (mostly academics) for evaluation </li></ul><ul><li>At study section meeting </li></ul><ul><li>- These 3 reviewers give initial scores </li></ul><ul><li>- Primary presents research plan, discusses PI, etc. </li></ul><ul><li>- Secondary emphasizes points of agreement/disagreement </li></ul><ul><li>- Tertiary adds his/her 2 cents worth </li></ul><ul><li>- General discussion/questions among panel members </li></ul><ul><li>- All panel members vote a priority score </li></ul><ul><li>Less expected from new PI </li></ul>
  9. 13. Review Process <ul><li>1-2 months after review </li></ul><ul><li>- SRA prepares summary statement (written critique document) and calculates percentiles (R01s) </li></ul><ul><li>- CSR or Institute mails summary statement to PI </li></ul><ul><li>~ 5 months after review </li></ul><ul><li>Institute sends Notice-of-Grant Award by e-mail to PI’s business office </li></ul>
  10. 14. Paylines <ul><li>Payline is based on percentile (rank) </li></ul><ul><li>Percentile: your score percentiled against current scores in that study section plus the previous 2 rounds of review in that study section </li></ul><ul><li>Each Institute determines its own payline (e.g. in 2003, NIAID 22.0%; NCI 20.0%) </li></ul><ul><li>Payline may be different from prior fiscal year </li></ul><ul><li>For most Institutes, percentiles within the payline get funded automatically </li></ul><ul><li>Study sections may recommend budget/time cuts; Institutes usually follow these recommendations </li></ul>
  11. 16. Funding Mechanisms
  12. 18. K08 Mentored Clinical Scientist Development Award <ul><li>Clinical doctoral degree only </li></ul><ul><li>US citizenship or green card </li></ul><ul><li>3-5 yrs of support </li></ul><ul><li>Salary: up to $75K + FB/yr </li></ul><ul><li>Supplies: up to $20K/yr </li></ul><ul><li>75% effort required </li></ul>
  13. 19. K23 Mentored Patient-Oriented Research Career Development Award <ul><li>M.D. or Ph.D. working with patients </li></ul><ul><li>US citizen or green card </li></ul><ul><li>Candidates just out of specialty or sub-specialty training </li></ul><ul><li>Project must be patient-oriented research </li></ul><ul><li>3-5 yrs of support </li></ul><ul><li>Salary: up to $75K + FB/yr </li></ul><ul><li>Supplies: $25K/yr </li></ul><ul><li>75% effort required </li></ul>
  14. 20. K22 Research Scholar Development Award <ul><li>Postdoc moving to assistant professor </li></ul><ul><li>Eligibility </li></ul><ul><ul><li>Current NIAID intramural postdoc </li></ul></ul><ul><ul><li>Current postdoc on NIAID training grant/fellowship </li></ul></ul><ul><ul><li>US citizen or green card </li></ul></ul><ul><li>2 yrs non-renewable </li></ul><ul><li>Yr 1: $150K; yr 2: $100K </li></ul><ul><li>Can apply without a sponsoring institution </li></ul>
  15. 21. SUCCESS RATES FOR NIAID TRAINING AND CAREER DEVELOPMENT GRANTS <ul><li>Grant Type </li></ul><ul><li>F32 </li></ul><ul><li>K02 </li></ul><ul><li>K08 </li></ul><ul><li>K22 </li></ul><ul><li>K23 </li></ul><ul><li>K24 </li></ul><ul><li>T32 </li></ul><ul><li>OVERALL </li></ul><ul><li>2002 Success Rate (%) </li></ul><ul><li>25 </li></ul><ul><li>63 </li></ul><ul><li>66 </li></ul><ul><li>59 </li></ul><ul><li>39 </li></ul><ul><li>27 </li></ul><ul><li>60 </li></ul><ul><li>43 </li></ul>
  16. 23. R01 Success Rates (%) All PIs 30.9 27.2 27.2 30.2 32.8 NIDDK 32.0 34.4 33.3 34.6 30.7 NHLBI 25.9 26.0 26.9 29.8 30.2 NCI 30.8 34.2 30.8 30.9 35.5 NIAID N/A 31.3 31.4 31.6 30.9 NIH 2002 2001 2000 1999 1998
  17. 24. R01 Success Rates (%) New PIs NIH-wide 22.0 23.0 23.7 22.9 23.8 Success rate 1,596 1,640 1,670 1,596 1,539 Grants awarded 7,265 7,139 7,059 6,984 6,464 Applications reviewed 2002 2001 2000 1999 1998
  18. 25. Solicited Research Programs NIH Institutes
  19. 30. Help
  20. 31. How NIH Staff Can Help You <ul><li>CSR Scientific Review Administrator (SRA) </li></ul><ul><li>Before review </li></ul><ul><li>Advice on study section, amount of preliminary data, supplementary data, etc. </li></ul>
  21. 32. How NIH Staff Can Help You <ul><li>Institute Program Officer </li></ul><ul><li>Before review </li></ul><ul><li>Scientific advice on proposed Aims; on revised Aims; on study section, etc. </li></ul><ul><li>After review </li></ul><ul><ul><li>Discuss review, summary statement, revision </li></ul></ul><ul><ul><li>Provide information on payline, funding status </li></ul></ul><ul><ul><li>Rarely – help with funding outside the payline </li></ul></ul>
  22. 33. How NIH Staff Can Help You <ul><li> Use the Institute Program Officer </li></ul><ul><li>as your point person at NIH </li></ul>
  23. 35. Spend some time at the NIH and NIAID websites!
  24. 36. Websites <ul><li>NIH Home Page: </li></ul><ul><li>Training/Career Development: </li></ul><ul><li>Grant Guidelines/Forms: </li></ul><ul><li> </li></ul><ul><li>How to Write a Grant: </li></ul><ul><li> </li></ul><ul><li>NIH Guide: </li></ul><ul><li> </li></ul><ul><li>NIAID Solicited Biodefense Research Programs: </li></ul><ul><li> </li></ul>
  25. 37. New Immunology IRG <ul><li>New Study Sections: est. June 2004 </li></ul><ul><li>Innate Immunity & Inflammation (III) </li></ul><ul><li>Immunity & Host Defense (IHD) </li></ul><ul><li>Cellular & Molecular Immunology (CMI)-A </li></ul><ul><li>Cellular & Molecular Immunology (CMI)-B </li></ul><ul><li>Hypersensitivity, Autoimmune & Immune-Mediated Diseases (HAI) </li></ul><ul><li>Transplantation, Tolerance & Tumor Immunology (TTT) </li></ul><ul><li>Vaccines Against Microbial Diseases (VMD) </li></ul><ul><li>F32 Postdoctoral Grants </li></ul>
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