Applying for a Grant at the NIH
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  • 1. Applying for a Grant at the NIH Helen Quill, Ph.D. Chief, Basic Immunology Branch Division of Allergy, Immunology & Transplantation NIAID, NIH
  • 2. The Application Process
  • 3.  
  • 4. 2 Independent Assignments for Your Grant Application upon Receipt at NIH
  • 5.  
  • 6. Peer Review “ Before you criticize someone, you should walk a mile in their shoes. That way when you criticize them, you’re a mile away and you have their shoes.” -Steven Wright
  • 7. CSR (Center for Scientific Review)
    • Study Section
    • peer review panel
    • 15-25 reviewers, mostly from academia
    • IRG (integrated review group)
    • group of study sections
  • 8. New Immunology IRG
    • New Study Sections: est. June 2004
    • Innate Immunity & Inflammation (III)
    • Immunity & Host Defense (IHD)
    • Cellular & Molecular Immunology (CMI)-A
    • Cellular & Molecular Immunology (CMI)-B
    • Hypersensitivity, Autoimmune & Immune-Med. Dis. (HAI)
    • Transplantation, Tolerance & Tumor Immunology (TTT)
    • Vaccines Against Microbial Diseases (VMD)
    • F32 Postdoctoral Grants
  • 9.  
  • 10. Institute Program Officer
    • Designated Federal official with overall
    • responsibility for the funding process
    • Scientist trained in area of coverage
    • Develops targeted research programs
    • Approves funding and oversees funded grants
    • Approves yearly progress reports
    • Assists PI with both administrative & scientific questions
    • Attends study section as observer
  • 11.  
  • 12. Review Process
    • 6-8 wks before study section meeting
    • SRA assigns and sends applications to primary, secondary, tertiary reviewers (mostly academics) for evaluation
    • At study section meeting
    • - These 3 reviewers give initial scores
    • - Primary presents research plan, discusses PI, etc.
    • - Secondary emphasizes points of agreement/disagreement
    • - Tertiary adds his/her 2 cents worth
    • - General discussion/questions among panel members
    • - All panel members vote a priority score
    • Less expected from new PI
  • 13. Review Process
    • 1-2 months after review
    • - SRA prepares summary statement (written critique document) and calculates percentiles (R01s)
    • - CSR or Institute mails summary statement to PI
    • ~ 5 months after review
    • Institute sends Notice-of-Grant Award by e-mail to PI’s business office
  • 14. Paylines
    • Payline is based on percentile (rank)
    • Percentile: your score percentiled against current scores in that study section plus the previous 2 rounds of review in that study section
    • Each Institute determines its own payline (e.g. in 2003, NIAID 22.0%; NCI 20.0%)
    • Payline may be different from prior fiscal year
    • For most Institutes, percentiles within the payline get funded automatically
    • Study sections may recommend budget/time cuts; Institutes usually follow these recommendations
  • 15.  
  • 16. Funding Mechanisms
  • 17.  
  • 18. K08 Mentored Clinical Scientist Development Award
    • Clinical doctoral degree only
    • US citizenship or green card
    • 3-5 yrs of support
    • Salary: up to $75K + FB/yr
    • Supplies: up to $20K/yr
    • 75% effort required
  • 19. K23 Mentored Patient-Oriented Research Career Development Award
    • M.D. or Ph.D. working with patients
    • US citizen or green card
    • Candidates just out of specialty or sub-specialty training
    • Project must be patient-oriented research
    • 3-5 yrs of support
    • Salary: up to $75K + FB/yr
    • Supplies: $25K/yr
    • 75% effort required
  • 20. K22 Research Scholar Development Award
    • Postdoc moving to assistant professor
    • Eligibility
      • Current NIAID intramural postdoc
      • Current postdoc on NIAID training grant/fellowship
      • US citizen or green card
    • 2 yrs non-renewable
    • Yr 1: $150K; yr 2: $100K
    • Can apply without a sponsoring institution
  • 21. SUCCESS RATES FOR NIAID TRAINING AND CAREER DEVELOPMENT GRANTS
    • Grant Type
    • F32
    • K02
    • K08
    • K22
    • K23
    • K24
    • T32
    • OVERALL
    • 2002 Success Rate (%)
    • 25
    • 63
    • 66
    • 59
    • 39
    • 27
    • 60
    • 43
  • 22.  
  • 23. R01 Success Rates (%) All PIs 30.9 27.2 27.2 30.2 32.8 NIDDK 32.0 34.4 33.3 34.6 30.7 NHLBI 25.9 26.0 26.9 29.8 30.2 NCI 30.8 34.2 30.8 30.9 35.5 NIAID N/A 31.3 31.4 31.6 30.9 NIH 2002 2001 2000 1999 1998
  • 24. R01 Success Rates (%) New PIs NIH-wide 22.0 23.0 23.7 22.9 23.8 Success rate 1,596 1,640 1,670 1,596 1,539 Grants awarded 7,265 7,139 7,059 6,984 6,464 Applications reviewed 2002 2001 2000 1999 1998
  • 25. Solicited Research Programs NIH Institutes
  • 26.  
  • 27.  
  • 28.  
  • 29.  
  • 30. Help
  • 31. How NIH Staff Can Help You
    • CSR Scientific Review Administrator (SRA)
    • Before review
    • Advice on study section, amount of preliminary data, supplementary data, etc.
  • 32. How NIH Staff Can Help You
    • Institute Program Officer
    • Before review
    • Scientific advice on proposed Aims; on revised Aims; on study section, etc.
    • After review
      • Discuss review, summary statement, revision
      • Provide information on payline, funding status
      • Rarely – help with funding outside the payline
  • 33. How NIH Staff Can Help You
    • Use the Institute Program Officer
    • as your point person at NIH
  • 34.  
  • 35. Spend some time at the NIH and NIAID websites!
  • 36. Websites
    • NIH Home Page: www.nih.gov
    • Training/Career Development: www.training.nih.gov
    • Grant Guidelines/Forms:
    • www.nih.gov/grants/documentindex.htm
    • How to Write a Grant:
    • www.niaid.nih.gov/ncn/grants/write/index.htm
    • NIH Guide:
    • http://grants.nih.gov/grants/guide/index.html
    • NIAID Solicited Biodefense Research Programs:
    • www.niaid.nih.gov/biodefense
  • 37. New Immunology IRG
    • New Study Sections: est. June 2004
    • Innate Immunity & Inflammation (III)
    • Immunity & Host Defense (IHD)
    • Cellular & Molecular Immunology (CMI)-A
    • Cellular & Molecular Immunology (CMI)-B
    • Hypersensitivity, Autoimmune & Immune-Mediated Diseases (HAI)
    • Transplantation, Tolerance & Tumor Immunology (TTT)
    • Vaccines Against Microbial Diseases (VMD)
    • F32 Postdoctoral Grants