Allergy and Clinical Immunology in the Czech RepublicPresentation Transcript
Allergy and Clinical Immunology in the Czech Republic Anna Šedivá, Institute of Immunology, Second Medical Faculty University Hospital Motol, Prague, Czech Republic „ Combating Allergy and Astma in Europe: Issues and Perspectives“, on 17th November in Brussels.
Allergy and Clinical Immunology
The field of allergy and clinical immunology is one of the fastest growing areas among medical sciences in the Czech Republic.
Both allergy and immunology are building up on the long time tradition in our countries.
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Allergic diseases in the Czech Republic Population 10 millions Current prevalence of allergy in general is almost 32% according to the latest available statistical data, with asthma 8% and atopic dermatitis 12%, with even higher number in the youngest age groups. Major problems and potential contribution to European research growing number of patients increasing problems in young age – genetic and pathogenetic studies environmental factors improved diagnostics and therapies % 1996 2001 2006 Alergy 16.9 24.7 31.8 Alergic Rhinitis 5.7 13.7 15.1 Asthma 3.8 6.7 8.2
Increasing number of patients
Contribution to international cohorts:
CIPA – Czech Initiative for Asthma
CARO – Czech Alliance for Chronic Respiratory Diseases
PRACTALL and ERS Task Force on childhood wheezing
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Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach.
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Genetic and pathogenetic studies Hum Immunol. 2008 Apr-May;69(4-5):306-13. Haplotype analysis of the endothelial nitric oxide synthase gene in asthma. J Hum Genet. 2007;52(2):152-8. Interleukin-18 and its three gene polymorphisms relating to allergic rhinitis. J Hum Genet. 2006;51(11):977-83. Polymorphisms of the CD14 gene and atopic phenotypes in Czech patients with IgE-mediated allergy. Holla LI et al.: Department of Pathophysiology, Medical Faculty, Masaryk University Brno, Brno, Czech Republic Severe form of atopic dermatitis in childhood: clinical outcome and cytokine gene polymorphisms - a prospective study . Pediatric Allergy adn Immunology, submitted. Kayserová J . , Šedivá A. et al.: Institute of Immunology, University Hospital Motol, Prague, Czech Republic
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Department of Immunology and Gnotobiology, Institute of Microbiology v.v.i, Czech Academy of Sciences, Prague, Czech Republic
Improved diagnostics and therapies
Application of global protocols
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DC in allergy The role of dendritic cells in allergic response Dendritic cells in allergic patients, morphology and function of moDCs in response to ligands and allergens Potential role of lectins as receptors for allergens Allergic patients have an increased expression of DC-SIGN on iDC, with subsequent significant decrease induced by OVA or birch allergen, associated, however, with increaded IL-6 production in patients compared to controls OVA binds C lectin receptor on DCs iDC + OVA: OVA (red),DC-SIGN (green)