Fayetteville State University
                                           Basic of Basic and Applied Sciences
<65                         F
                               Excessive Absences                EA
Student Behavior Expectations: The Code of the University of North Carolina (of which FSU is a constituent
  institution) ...
IX.   Teaching Strategies
      Power Point lectures will be delivered in the class and the same lectures will be posted o...
VIII. Course Content and Schedule       ----       Immunology (BTCH 310) - Fall 2010                MWF 10:00 to 10:50 AM
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1 Fayetteville State University

  1. 1. Fayetteville State University Basic of Basic and Applied Sciences Department of Natural Scienes BTCH 310 Immunology Fall 2010 I. Locator Information: Instructor: Muhammad Lodhi Office hours: MWF (11:00 – 12:00), T (1:00 – 2:00) & Course # and Name: BTCH 310 WF (8:00 – 10:00) OR by appointment Semester Credit Hours: 3-0-0 Office Phone: 910-672-1658 Day and Time Class Meets: MWF 10:00-10:50 AM Email address: mlodhi@uncfsu.edu Class Location: LSA 127 Webpage: http://faculty.uncfsu.edu/mlodhi Office Location: LSA 320; Lab - LS218 FSU Policy on Electronic Mail: Fayetteville State University provides to each student, free of charge, an electronic mail account (username@uncfsu.edu) that is easily accessible via the Internet. The university has established FSU email as the primary mode of correspondence between university officials and enrolled students. Inquiries and requests from students pertaining to academic records, grades, bills, financial aid, and other matters of a confidential nature must be submitted via FSU email. Inquiries or requests from personal email accounts are not assured a response. The university maintains open-use computer laboratories throughout the campus that can be used to access electronic mail. Rules and regulations governing the use of FSU email may be found at http://www.uncfsu.edu/PDFs/EmailPolicyFinal.pdf II. Course Description: Examines the components of the immune systems, immune responses, immune effectors, and immune diseases. Methods used in experimental studies of immunology are also introduced. III. Disabled Student Services: In accordance with Section 504 of the 1973 Rehabilitation Act and the Americans with Disabilities Act (ACA) of 1990, if you have a disability or think you have a disability to please contact the Center for Personal Development in the Spaulding Building, Room 155 (1 st Floor); 910-672-1203. IV. Textbook: Kuby Immunology, 6th edition, 2007. TJ Kindt, RA Goldsby and BA Osborne. V. Student Learning Outcomes: Upon completion of this course, students will be able to; Understand the basic concepts of immunology as evidenced through quizzes and exams Analyze the differences between innate and adaptive immune systems as assessed through quizzes, exam and assignments Differentiate various cell types involved in immunology as well as antigens and antibiotics as determined by online quizzes, exam and home assignments Communicate the complement system and its function in controlling pathogens as demonstrated by quizzes and exams Explain the nature and maturation process of B cells and T cells as established by quizzes and exam Recognize different types of cell-mediated cytotoxic responses as evidenced by quizzes, exam and assignments Communicate about different types of hypersensitivity reactions as determined by quizzes and exam Describe the role of active and passive immunization and their role in disease control in assessment done with quizzes, exams and assignments Discuss immune systems related to health and diseases such as AIDS and cancers evidenced by quizzes, exams and assignments VI. Course Requirements and Evaluation Criteria: Pre requisite is BIOL 200 a. Grading Scale – Following standard FSU grading scale will be used Percent of Points Grade 91 – 100 A 82 – 90 B 73 – 81 C 65 – 72 D 1
  2. 2. <65 F Excessive Absences EA Incomplete I No Show X b. Final grade will be based on the following evaluation components Item Number of Points/Item Total %age Items points 1 Class Exams 4 4@40/1@20 180 41 2 Research Paper 1 40 40 9 3 Assignments 3 15 45 10 4 Quizzes 15 10 150 34 5 Attendance /cell phone - 25 25 6 Total 440 100 1. Class Exams: Four exams will consist of the material covered in the lectures and any additional information provide till the day of the exam. These four exams will not contain any questions from the previous exam (s). Four exams will be comprehensive and will cover the topics and chapters covered in the entire semester. These exams will be given in the computer lab in LSA125. There will be no make- up exams except for medical emergency, that too with a doctor’s verification of your situation. 2. Research Paper: Topics for the research papers will be limited to the application of molecular biology or biotechnology to immunology. Topics will be distributed in the class. Length of the paper will be a minimum of 4 pages, 1.5 line spacing and not more than 12 font size. It will be due on or before November 25. More detail regarding the content of the paper will be covered in the class. However it should contain a good introduction, literature review, experimental strategies, results and bibliography. Papers submitted one week late will be considered only for 80% of the grade. Any paper submitted after a week of the due date will not be accepted. Rubrics will also be provided as a guide for writing and assessment. 3. Assignments: These will vary regarding the length and topics. Due dates for each assignment is mentioned in the schedule. Each assignment will be 2-3 pages long. No hand written assignments will be acceptable unless instructed otherwise. Assignments submitted one week late will be considered only for 80% grade of that assignment. Any assignment submitted after a week of the due date will not be accepted. 4. Quizzes: Each week one quiz will be given either in class or through Blackboard. Each quiz will cover material from the previous week (2-3 classes). Online quizzes will be uploaded by 5:00 PM on Sunday and be available till 5:00 PM on Tuesdays. All quizzes are open notes and open book but time limited. Best way to do well on quizzes is to read your notes and the book chapter before taking the quiz. 5. Attendance/Cell Phone: Grade for the class participation will be based on your attendance and participation in the class discussions and restraining from the use of cell phones. Each time I catch a person using cell phone during the class time, he/she will lose 3 points from the total. Similarly each unexcused absence will cost students 2.5 points. c. Attendance Requirements – Each student will be excused for missing 4 classes throughout the semester. If the student misses the 5th one, he/she will not be considered for an „A‟ grade. If the student misses 6th class he will not be qualified for a „B‟ grade and a 7th absence will disqualify him/her for the „C‟ grade. Absences due to medical or family emergencies will be excused. Routine medical or dental check-up is NOT considered a medical emergency. Please note: If these evaluation criteria must be revised because of extraordinary circumstances, the instructor will distribute a written amendment to the syllabus. 2
  3. 3. Student Behavior Expectations: The Code of the University of North Carolina (of which FSU is a constituent institution) and the FSU Code of Student Conduct affirm that all students have the right to receive instruction without interference from other students who disrupt classes. FSU Core Curriculum Learning Outcome under Ethics and Civic Engagement (6.03): All students will “prepare themselves for responsible citizenship by fulfilling roles and responsibilities associated with membership in various organizations.” Each classroom is a mini-community. Students learn and demonstrate responsible citizenship by abiding by the rules of classroom behavior and respecting the rights all members of the class. The FSU Policy on Disruptive Behavior (see FSU website for complete policy) identifies the following behaviors as disruptive: 1. Failure to respect the rights of other students to express their viewpoints by behaviors such as repeatedly interrupting others while they speak, using profanity and/or disrespectful names or labels for others, ridiculing others for their viewpoints, and other similar behaviors; 2. Excessive talking to other students while the faculty member or other students are presenting information or expressing their viewpoints. 3. Use of cell phones and other electronic devices 4. Overt inattentiveness (sleeping, reading newspapers) 5. Eating in class (except as permitted by the faculty member) 6. Threats or statements that jeopardize the safety of the student and others 7. Failure to follow reasonable requests of faculty members 8. Entering class late or leaving class early on regular basis 9. No cell phone or text messaging devices will be allowed to be used in the class. A student using cell phone/text message may be asked to leave the class. Consequences for Failing to Meet Behavioral Expectations: The instructor may take the following actions in response to disruptive behavior. Students should recognize that refusing to comply with reasonable requests from the faculty member is another incidence of disruptive behavior. 1. Direct student to cease disruptive behavior. 2. Direct student to change seating locations. 3. Require student to have individual conference with faculty member. At his meeting the faculty member will explain the consequences of continued disruptive behavior. 4. Dismiss class for the remainder of the period. (Must be reported to department chair.) 5. Lower the student‟s final exam by a maximum of one-letter grade. 6. File a complaint with the Dean of Students for more severe disciplinary action. Students who believe the faculty member has unfairly applied the policy to them may make an appeal with the faculty member‟s department chair. VII. Academic Support Resources – Students who are earning less than a “C” average will be encouraged to attend tutorial sessions provided free by various units and centers below. http://www.uncfsu.edu/univcoll/services.asp http://www.uncfsu.edu/learningcenter/ http://www.uncfsu.edu/sss/ http://www.uncfsu.edu/cpser/tutorialservices.htm Online tutoring is also available through Smartthinking: http://www.uncfsu.edu/fsuretention/smarthinkingflyer.pdf VIII. Course Outline and Assignment Schedule Provided separately as Course Schedule 3
  4. 4. IX. Teaching Strategies Power Point lectures will be delivered in the class and the same lectures will be posted on Blackboard. Internet resources will be utilized where appropriate to aid in the learning of new concepts. Students will be encouraged to ask questions and take part in discussions. Also, students will be given assignments and asked to write research a paper to independently learn or enhance their understanding of the subject. X. References 1. Publisher‟s Site (www.freeman.com/immunology6e) 2. Centers for Disease Control and Prevention (www.cdc.gov/) 3. National Institute for Allergyand Infectious Diseases (www3.niaid.nih.gov) 4. The American Academy of Allergy, Asthma and Immunology (www.aaaai.org) 5. (The American Association of Immunologists (www.aai.org) 6. Students should also go to the library and read articles in publications such as Nature Immunology, Nature Genetics, Science, American Scientific, the Journal of Immunology, Immunology journal and books. 7. http://immuno.bme.nwu.edu The Kabat Database of Sequences of Proteins of Immunological Interest: This site has the amino acid and DNA sequences of many antibodies and other proteins that play important roles in immunology. 8. http://www.biochem.ucl.ac.uk/~martin/abs Antibodies-Structure and Sequence: This web site summarizes useful information on antibody structure and sequence. It provides general information on antibodies and crystal structures and links to other antibody- related information. 9. http://www.ncbi.nlm.nih.gov National center for Biotechnology Information (NCBI): A unique and comprehensive resource of computerized databases of bibliographic information, nucleic acid sequences, protein sequences, and sequence analysis tools created and maintained by the National Library of Science. 10. http://www.ncbi.nlm.nih.gov/Structure/ The Molecular Modeling Database (MMDB) contains 3-dimensional structures determined by X-ray crystallography and NMR spectroscopy. The data for MMDB are obtained from the Protein Data Bank (PDB). The National Center for Biotechnology Information (NCBI) has cross-linked structural data to bibliographic information, to the databases of protein and nucleic acid sequences, and to the NCBI animal taxonomy database. The NCBI has developed a 3D structure viewer, Cn3D, for easy interactive visualization of molecular structures from within Entrez Med. 11. http://pathlabsofark.com/flowcyttests.html Pathology Laboratories of Arkansas is a place to see just what kinds of samples are taken from patients and what markers are used to evaluate lymphocyte populations by flow cytometry. 12. http://jcsmr.anu.edu.au/facslab/AFCG/standards.html At the highly informative Australian Flow Cytometry Group Web site, one can find a carefully detailed and illustrated guide to the interpretation of flow cytometric analyses of clinical samples. 13. http://www.kpl.com/support/immun/pds/50datasht/54-12-10.html, which allows one to follow a step-by-step procedure for using a chemiluminescent substrate in a sensitive immnoassay. 14. http://www.bioscience.org/knockout/b2micrgl.htm for beta-2 microglobulin KO 15. http://www.bioscience.org/knockout/mhci.htm for MHC class I KO 16. http://www.bioscience.org/knockout/mhcii.htm for KO of an MCH class II chain 17. http://www.bioscience.org/knockout/mhc2inva.htm for KO of the invariant chain This series of destinations in the Bioscience Web site provide updated information on studies of the consequences of targeted disruption of MCH molecules and other component molecules including b-2 microglobulin and the class II invariant chain. 18. http://www.ncbi.nlm.nih.gov/Omim/ The Online Mendelian Inheritance in Man Web site contains a sub-site that lists ten different inherited diseases that are associated with defects in the TCR complex or associated proteins. Any one of those listed may be studied in detail by following the links in this database. 19. http://www.ultranet.com/~jkimball/BiologyPages/A/Apoptosis.html http://www.ultranet.com/~jkimball/BiologyPages/B/B_and_Tcells.html These sub-sites of John Kimball's Biology Pages Web site provide a clear introduction to the bare fundamentals of T-cell biology and a good basic discussion of apoptosis. 20. http://www.bioscience.org/knockout/knochome.htm Within the Frontiers in Bioscience Database of Gene Knockouts, one can find information on the effects of knockouts of many genes of significance to the development and function of cells of the T lineage. 4
  5. 5. VIII. Course Content and Schedule ---- Immunology (BTCH 310) - Fall 2010 MWF 10:00 to 10:50 AM Content Class Date Chapters Tests Assignments Quizzes/closing date Class Presentations k1 W ee August 20, 2010 Introductions Pre-test - August 23, 2010 k2 August 25, 2010 Overview of Immune System. Quiz 1 (Chap 1&2), W ee August 27, 2010 Cells and Organs of Immune System Chapter 1 & 2 8/31 (Tues) August 30, 2010 k3 September 1, 2010 Innate Immunity Quiz 2 (Chap 3), W ee September 3, 2010 Chapter 3 9/7 (Tues) September 6, 2010 Labor Day (no class) k4 September 8, 2010 Antigens & Antibodies Quiz 3 (Chap 4), W ee September 10, 2010 Online Lecture Chapter 4 9/14 (Tues) September 13, 2010 Antigens & Antibodies Interactions k5 September 15, 2010 Exam 1: 9/17 Quiz 4 (Chap 6), W ee September 17, 2010 Chapter 6 (Chapters 1-4) 9/21 (Tues) September 20, 2010 The Complement System k6 September 22, 2010 Multiple Histocompat. Complex Quiz 5 (Chap 7&8), W ee September 24, 2010 Chapter 7 & 8 9/27 (Tues) T-Cell Maturation, Activation & September 27, 2010 Differentiation k7 September 29, 2010 Assign 1, Quiz 6 (Chap 10), W ee October 1, 2010 Chapter 10 Due: Oct 2 10/5 (Tues) B-Cell Generation, Activation & October 4, 2010 Differentiation Exam 2: 10/5 k8 October 6, 2010 (chapters 6,7,8 Quiz 7 (Chap 11), W ee October 8, 2010 Chapater 11 &10) 10/12 (Tues) October 11, 2010 Leukocyte Activation and Migration k9 October 13, 2010 Quiz 8 (Chap 13), W ee October 15, 2010 Fall Break (No class) Chapter 13 10/19 (Tues) October 18, 2010 Cell-Mediated Cytotoxic Responses 0 k1 October 20, 2010 Quiz 9 (Chap 14), W ee October 22, 2010 Chapter 14 10/26 (Tues) October 25, 2010 Hypersensitivity Reactions 1 k1 October 27, 2010 Quiz 10 (Chap 15), W ee October 29, 2010 Chapter 15 11/2 (Tues) Immune Response to Infectious November 1, 2010 Diseases Exam 3: 11/2 2 k1 November 3, 2010 (chapters Assign 2, Quiz 11 (Chap 18), W ee November 5, 2010 Chapter 18 11,13,14 &15) Due: Nov 2 11/9 (Tues) November 8, 2010 Vaccines 3 k1 November 10, 2010 Quiz 12 (Chap 19), W ee November 12, 2010 Chapter 19 11/16 (Tues) November 15, 2010 AIDS and other Immunodeficiencies 4 k1 November 17, 2010 Quiz 13 (Chap 20), W ee November 19, 2010 Chapter 20 11/23 (Tues) November 22, 2010 Cancer and Immune System 15 November 24, 2010 Research Paper Quiz 14 (Chap 21), ek We 11/26 No Class Thanksgiving (No class) Chapter 21 Due Nov 25 11/30 (Tues) November 29, 2010 Experimental System 6 k1 December 1, 2010 Assign 3, Quiz 15 (Chap 22), W ee December 3, 2010 Last day of classes Chapter 22 Due: Dec. 1 12/3 (Fri) a m Final Grades Available by Ex Exam 4: 12/6 (chapters 18,19,20,21 & 22) 10 AM in LSA125 Dec. 9 MLodhi 082408 BTCH310 Page 4