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Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
Seminario: Biologia molecular
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Seminario: Biologia molecular

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  • 1. “THWARTING PROTEIN PRODUCTION SLOWS CANCER CELL´S MALIGNANT MARCH” AND “PROTEINS KEY IN STEM CELL PRODUCTION IDENTIFIED”   Manuela Rendón Díez Medicine Student III Semester Molecular Biology
  • 2. FOLDING
  • 3. FOLDING
  • 4. Introduction DNADNA RNARNA ProteinsProteins actions enzyme structural inmunological contractil homeostatic
  • 5. “THWARTING PROTEIN PRODUCTION SLOWS CANCER CELL´S MALIGNANT MARCH” Science Daily (July 18, 2013)
  • 6. “THWARTING PROTEIN PRODUCTION SLOWS CANCER CELL´S MALIGNANT MARCH” (July 18, 2013) Protein synthesis and cell proliferation is closely associated with the stress response. Inhibiting translation retards tumor growth
  • 7. “THWARTING PROTEIN PRODUCTION SLOWS CANCER CELL´S MALIGNANT MARCH” (July 18, 2013) Heat shock factor protein 1 (HSF1) Increases survival despite the efforts of natural defenses and therapeutic help them survive and thrive increases protein translation malignancy increases hyperactive response of cancer cells
  • 8. “THWARTING PROTEIN PRODUCTION SLOWS CANCER CELL´S MALIGNANT MARCH” (July 18, 2013) Rohinitib (RHT) Inhibits tumor growth Interrupts the translation and activity of HSF1 Suppresses glucose uptake
  • 9. Personal Observation I think that the discovery of new compounds that suppress the translational and proliferative activity of the cells has great importance for the treatment of different cancers, or as a therapeutic alternative to reduce the maximum pathogenesis.
  • 10. “PROTEINS KEY IN STEM CELL PRODUCTION IDENTIFIED” Science Daily (July 5, 2013)
  • 11. “PROTEINS KEY IN STEM CELL PRODUCTION IDENTIFIED” (July 5, 2013) Pluripotent stem cells (iPSCs) are transformed into many cell types Useful in therapeutics
  • 12. “PROTEINS KEY IN STEM CELL PRODUCTION IDENTIFIED” (July 5, 2013) Proteins play a critical role in pluripotency
  • 13. “PROTEINS KEY IN STEM CELL PRODUCTION IDENTIFIED” (July 5, 2013) Proteins identified by the splicing code Act as a switch Activate and deactivate the pluripotency of stem cells
  • 14. Personal Observation I think that the development of stem cells is of great importance to medical and scientific research, its use in regenerative medicine, immunotherapy, gene therapy, pain relief treatments, cancer, diabetes, cloning, set the standard in scientific development, but, for me, it leaves much to be desired in ethical issues.
  • 15. Medical Utility
  • 16. The medical importance of protein synthesis is mainly based on the large number of functions that these play a biological level, from hormones, neurotransmitters, antibodies, enzymes, transporters, etc.. Medical Utility
  • 17. Medical Utility The development of new methods for the treatment of diseases that are related to protein synthesis and cell proliferation will be the solution to future pathologies that were considered incurable.
  • 18. Medical Utility The production of stem cells will then be an alternative for survival.
  • 19. BIBLIOGRAPHY *Martínez Sánchez, Lina María. Biología Molecular. 7 Ed. Medellín. UPB. Facultad de Medicina 2012. 102-106 pp. *Proteins Key in Stem Cell Production Identified. Science Daily (online magazine). 2013 (July 5). Avaliable at: http://www.sciencedaily.com/releases/2013/07/130705113622.htm *Thwarting Protein Production Slows Cancer Cell´s Malignant March. Science Daily (online magazine). 2013 (July 18). Avaliable at: http://www.sciencedaily.com/releases/2013/07/130718142420.htm

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