KNOW THY LIVER - LOVE & CARE
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KNOW THY LIVER - LOVE & CARE

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WHAT IS LIVER AS AN ORGAN IN OUR BODY ?

WHAT IS LIVER AS AN ORGAN IN OUR BODY ?

HOW DOES IT HELP US ?

WHAT WE SHOULD DO TO PROTECT IT !

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    KNOW THY LIVER - LOVE & CARE KNOW THY LIVER - LOVE & CARE Presentation Transcript

    • P. K. MITRAP. K. MITRA EURODRUG LABORATORIESEURODRUG LABORATORIES KNOW THYKNOW THY LIVERLIVER LOVE & CARELOVE & CARE
    • Do you really love your liver ?Do you really love your liver ? How can you love your liverHow can you love your liver without knowing it ?without knowing it ? After knowing it how can you doAfter knowing it how can you do injustice to it ?injustice to it ?
    • Hi... I'm Your Liver !Hi... I'm Your Liver ! Let me tell you what I do forLet me tell you what I do for you…inyou…in 99 waysways
    • II store the ironstore the iron reserves youreserves you need, as well as a lot ofneed, as well as a lot of vitamins and other minerals.vitamins and other minerals. Without me, you wouldn'tWithout me, you wouldn't have the strength to carryhave the strength to carry on!on! 1. I am responsible for up to 500 separate functions, usually in combination with other systems and organs.
    • I makeI make bilebile to help digestto help digest your food,your food, without me,without me, you'd wasteyou'd waste away to nothingaway to nothing & dump me& dump me with poisonswith poisons.. 2. The bile produced by me is collected in bile canalliculi, which merge to form bile ducts.
    • II detoxify poisonousdetoxify poisonous chemicalschemicals you give me, andyou give me, and that includes alcohol, beer,that includes alcohol, beer, wine and drugswine and drugs (prescribed(prescribed and OTC)and OTC) as well as illegalas well as illegal substances.substances. 3 Without me, your "bad“ habits would kill you.
    • I storeI store energyenergy,, Like a battery, byLike a battery, by Stockpiling sugarStockpiling sugar (carbohydrates,(carbohydrates, glucose and fat)glucose and fat) Until you need it.Until you need it. 44 Without me, the sugar level in your blood could fall dramatically and you'd go into a coma.go into a coma.
    • You cann’t start your day in theYou cann’t start your day in the morning, if I am not on the job !morning, if I am not on the job !
    • II make the bloodmake the blood that gotthat got your system going evenyour system going even before you were born,before you were born, without me, you wouldn'twithout me, you wouldn't be here !be here ! 55
    • II manufacture new proteinsmanufacture new proteins that yourthat your body needs to stay healthy and grow.body needs to stay healthy and grow. Without me, you wouldn't grow properly!Without me, you wouldn't grow properly! 6
    • II remove poisonsremove poisons from thefrom the air, exhaust smoke andair, exhaust smoke and chemicals you breathe.chemicals you breathe. 7 Without me, you'd be poisoned by pollutants!
    • II make clotting factorsmake clotting factors thatthat stop the bleeding when youstop the bleeding when you accidentally prick yourself.accidentally prick yourself. 8 Without me, you'd bleed To death !
    • I helpI help defend youdefend you against the germs goingagainst the germs going into your body all the time. I take thoseinto your body all the time. I take those cold germs, flu bugs and other germs youcold germs, flu bugs and other germs you encounter, and knock them dead - or atencounter, and knock them dead - or at least weaken them.least weaken them. 9 Without me,Without me, you'd be ayou'd be a sitting ducksitting duck for everyfor every infectioninfection
    • I hope now you understandI hope now you understand how much I love you……..how much I love you……..
    • Let us understand the most commonLet us understand the most common diseases that affect me……diseases that affect me……
    • FATTY LIVER DISEASEFATTY LIVER DISEASE What is it?What is it? • Fatty liverFatty liver is the collection ofis the collection of excessiveexcessive amounts of fat inside liver cellsamounts of fat inside liver cells, also called, also called steatosis.steatosis. • Mostly triglycerides & CholesterolsMostly triglycerides & Cholesterols • Reversible condition.Reversible condition.
    • FATTY LIVER - CAUSESFATTY LIVER - CAUSES Fatty liver is commonly caused by AlcoholAlcohol  oror MetabolicMetabolic Syndrome (Diabetes, Hypertension, Obesity and Dysli demia), but can also be due to any one of many causes. 1.1. NUTRITIONAL (MALNUTRITION/WEIGHT LOSS)NUTRITIONAL (MALNUTRITION/WEIGHT LOSS) 2.2. DRUGS & TOXINSDRUGS & TOXINS 3.3. VIRAL HEPATITISVIRAL HEPATITIS 4.4. AUTOIMMUNE LIVER DISEASEAUTOIMMUNE LIVER DISEASE
    • FATTY LIVER - CAUSESFATTY LIVER - CAUSES • MetabolicMetabolic AbetalipoproteinemiaAbetalipoproteinemia, G, Glycogen storage diseaseslycogen storage diseases, , Weber-Christian diseaseWeber-Christian disease, A, A cute fatty liver of pregnancycute fatty liver of pregnancy, L, Lipodystrophyipodystrophy • NutritionalNutritional MalnutritionMalnutrition, T, Total parenteral nutritionotal parenteral nutrition, Severe , Severe weight lossweight loss, R, Refeedingefeeding syndromesyndrome, J, Jejunoileal bypassejunoileal bypass, G, Gastric bypassastric bypass, Jejunal, Jejunal diverticulosisdiverticulosis   with with bacterial overgrowthbacterial overgrowth.. • Drugs and toxinsDrugs and toxins AmiodaroneAmiodarone, M, Methotrexateethotrexate, D, Diltiazemiltiazem, Expired , Expired tetracyclinetetracycline, H, Highly activeighly active antiretroviral therapyantiretroviral therapy, G, Glucocorticoidslucocorticoids, T, Tamoxifenamoxifen, Environmental , Environmental hepatotoxinshepatotoxins   Inflammtory bowel disease, HIV, hepatitis C and alpha 1-antitrypsin deficiencyInflammtory bowel disease, HIV, hepatitis C and alpha 1-antitrypsin deficiency
    • Alcoholic FattyAlcoholic Fatty Liver orLiver or AlcoholicAlcoholic SteatosisSteatosis causedcaused By alcoholBy alcohol abuseabuse All body organs areAll body organs are affected,affected, with the liver and brainwith the liver and brain suffering most seriously.suffering most seriously.      Alcoholic liver disease does not usually cause any symptoms until the liver has been extensively damaged. When this happens, symptoms can include: • NauseaNausea • Weight lossWeight loss • AnnorexiaAnnorexia • Yellowing of the eyes and skin (Yellowing of the eyes and skin (jaundicejaundice)) • Swelling in the ankles and abdomenSwelling in the ankles and abdomen • Confusion or drowsinessConfusion or drowsiness
    • Non-Alcoholic Fatty Liver DiseaseNon-Alcoholic Fatty Liver Disease Affect people whoAffect people who drink little or nodrink little or no alcohol.alcohol. Simple fatty liver (steatosis),Simple fatty liver (steatosis), usually causes no liverusually causes no liver damage but may lead to NASHdamage but may lead to NASH Exact casue not knownExact casue not known but Obesity & Insulinbut Obesity & Insulin resistance lead toresistance lead to progress of NAFLDprogress of NAFLD Most patients have few or no symptoms,Most patients have few or no symptoms, may complain of fatigue, malaise, andmay complain of fatigue, malaise, and dull right-upper-quadrant abdominaldull right-upper-quadrant abdominal discomfort.discomfort.
    • NonalcoholicNonalcoholic steatohepatitis (NASH),steatohepatitis (NASH), aa more serious type.more serious type. Caused by hepatitisCaused by hepatitis infection, malnutrition,infection, malnutrition, obesity, diabetesobesity, diabetes mellitus,mellitus, andand Reye's syndromeReye's syndrome .. In some cases, this canIn some cases, this can progress either toprogress either to cirrhosis, which cancirrhosis, which can produce progressive,produce progressive, irreversible liver scarring,irreversible liver scarring, or to liver cancer.or to liver cancer. Fat in the liver, with inflammation and damage, can occur in children. Weight loss & weakness may begin once the disease is advanced or cirrhosis is present. Reduce body weight, eat a balanced diet, engage in physical activity, and avoid alcohol and unnecessary medications may help in treatment as no specific treatment available till date.
    • Reye's Syndrome:Reye's Syndrome: A deadly disease, attack any child or adult without warning. A deadly disease, attack any child or adult without warning.  All body organs are affected, with theAll body organs are affected, with the liver and brain suffering most seriously. liver and brain suffering most seriously.  Cause & cure remain unknown, research hasCause & cure remain unknown, research has established a link between Reye's Syndromeestablished a link between Reye's Syndrome And the use of aspirin and other salicylateAnd the use of aspirin and other salicylate containing medications. containing medications. 
    • Causes of NAFLD/NASH:Causes of NAFLD/NASH: Unclear but researchers believe the contributing factors are:Unclear but researchers believe the contributing factors are: • Obesity / Hypertension / Abnormal cholesterol levelsObesity / Hypertension / Abnormal cholesterol levels • Insulin Resistance / DiabetesInsulin Resistance / Diabetes • The fat may come from other parts of the body, or the liver mayThe fat may come from other parts of the body, or the liver may absorbabsorb anan increasedincreased amount of fat from the intestine.amount of fat from the intestine. • Another possible explanation is that the liver loses its ability toAnother possible explanation is that the liver loses its ability to change fat into a form that can be eliminated.change fat into a form that can be eliminated.
    • What are the symptoms ?What are the symptoms ? Fatty liver usually produces no symptoms butFatty liver usually produces no symptoms but few patients may show the following symptoms:few patients may show the following symptoms: • JaundiceJaundice • Right-side abdominal painRight-side abdominal pain • Abdominal swellingAbdominal swelling • Fever.Fever. • AnnorexiaAnnorexia • FatigueFatigue • Swollen LegsSwollen Legs
    • At more advanced stage, liverAt more advanced stage, liver becomesbecomes cirrhotic:cirrhotic: • Cirrhosis refers to scarring ofCirrhosis refers to scarring of the liver. It replaces healthythe liver. It replaces healthy tissue, cannot do what healthytissue, cannot do what healthy liver tissue does.liver tissue does. • Scar tissue also blocks theScar tissue also blocks the normal flow of blood throughnormal flow of blood through the liver, can be life-the liver, can be life- threatening.threatening.
    • A fatty liver is enlarged and has a greasy, pale yellow look.A fatty liver is enlarged and has a greasy, pale yellow look.
    • NAFLD / NASH: Diagnosis ?NAFLD / NASH: Diagnosis ? • The liver may be tender when the abdomen isThe liver may be tender when the abdomen is pressed.pressed. • Blood tests - for liver function (Enzymes)Blood tests - for liver function (Enzymes) • Ultrasound or abdominal CT scan.Ultrasound or abdominal CT scan. • Liver Biopsy (Grading of Steatosis)Liver Biopsy (Grading of Steatosis) • Fibro-ScanFibro-Scan • TSH Estimation (NASH-Marker)TSH Estimation (NASH-Marker)
    • NAFLD/NASH – Treatment ?NAFLD/NASH – Treatment ? • Treatment for fatty liver is aimed at eliminating or treatingTreatment for fatty liver is aimed at eliminating or treating the cause of the condition.the cause of the condition. • In some cases, fatty liver is reversible if caught early in itsIn some cases, fatty liver is reversible if caught early in its development.development. • Pregnancy-related fatty liver is treated by delivering thePregnancy-related fatty liver is treated by delivering the baby, if viable.baby, if viable. • In severe cases, the patient may eventually require a liverIn severe cases, the patient may eventually require a liver transplant.transplant. • Drugs like: UDCA, Pentoxifylline, Vitamin-E, Statins,Drugs like: UDCA, Pentoxifylline, Vitamin-E, Statins, Metformin, Pioglitazone, Metadoxine may help immensely.Metformin, Pioglitazone, Metadoxine may help immensely. • Nutritional counselling, Weight reduction also helpNutritional counselling, Weight reduction also help
    • AbnormalityAbnormality 2005 %2005 % 2006 %2006 % Fatty liver 17.52 24.12 Liver cyst 9.99 11.66 Renal cyst 7.04 7.77 Renal calculi 10.90 11.48 GB calculi 9.63 9.54 Prostatomegaly 4.39 6.18 ovarian cyst 4.58 4.77 uterine myoma 1.87 3.45 Total scan done 1661 1132 CholescintigraphyCholescintigraphy Statistics PGH – CT ScanStatistics PGH – CT Scan
    • Abnormality 2005 % 2006 % Fatty liver 9.82 18.82 Liver cyst 1.33 2.52 Renal cyst 1.60 3.45 Renal calculi 2.21 3.39 GB calculi 3.54 5.52 Prostatomegaly 1.48 2.83 ovarian cyst 5.10 8.58 uterine myoma 2.25 3.79 Total scan done 2627 3566 CholescintigraphyCholescintigraphy Statistics PGH – USGStatistics PGH – USG
    • Fatty liver % detection vs no of check-up 2006Fatty liver % detection vs no of check-up 2006 Modality 2005 total check-up 2005 % 2006- total check-up 2006 % Ct Scan 1661 17.52 1132 24.12 Ultrasound 2627 9.82 3566 18.82
    • I KNOW STILL SOME PEOPLEI KNOW STILL SOME PEOPLE DON’T LOVE ME ……DON’T LOVE ME ……
    • Let me tell you some easy waysLet me tell you some easy ways to love me, ….. your liverto love me, ….. your liver
    • • Don't drown me in beer, alcohol orDon't drown me in beer, alcohol or wine !wine ! • Even one drink is too much for someEven one drink is too much for some people and could scar me for life.people and could scar me for life. • Watch those drugs!Watch those drugs! All drugs are chemicals, and when youAll drugs are chemicals, and when you mix them up without a doctor's advicemix them up without a doctor's advice you could create something poisonousyou could create something poisonous
    • • I scar easily due to repeatedI scar easily due to repeated alcohol / drug abuse.. and thosealcohol / drug abuse.. and those scars, called "cirrhosis" arescars, called "cirrhosis" are permanent.permanent. • TTaking unnecessary medicine isaking unnecessary medicine is a bad habita bad habit. All those chemicals. All those chemicals can really hurt me (liver).can really hurt me (liver). • Sedentary life style or metabolicSedentary life style or metabolic syndrome damage me most …syndrome damage me most … please take careplease take care
    • Be careful withBe careful with aerosol spraysaerosol sprays !! Remember, I have to detoxify what you breathe in, too. SoRemember, I have to detoxify what you breathe in, too. So when you are cleaning with aerosol cleaners, make sure thewhen you are cleaning with aerosol cleaners, make sure the room is ventilated, or wear a mask.room is ventilated, or wear a mask. That goes double for bugThat goes double for bug sprays, mildew sprays,sprays, mildew sprays, Paint sprays and all thosePaint sprays and all those Other chemical spraysOther chemical sprays you use. Be careful whatyou use. Be careful what you breathe!you breathe!
    • Watch what gets on your skin!Watch what gets on your skin! Those insecticides you put onThose insecticides you put on trees and shrubs not only kill bugs they can get to me righttrees and shrubs not only kill bugs they can get to me right through your skin and destroy my cells, toothrough your skin and destroy my cells, too. Remember. Remember they're all chemicalsthey're all chemicals. Cover your skin with gloves, long. Cover your skin with gloves, long sleeves, a hat and mask every time insecticides are in thesleeves, a hat and mask every time insecticides are in the air or if you're handling them.air or if you're handling them.
    • Don't eat too muchDon't eat too much fattyfatty foodfood !! I make the cholesterol yourI make the cholesterol your body needs,body needs, and I try to makeand I try to make the right amount.the right amount. Give me a break.Give me a break. Eat a good,Eat a good, well balanced nourishing diet.well balanced nourishing diet. If you eat the right stuff forIf you eat the right stuff for me, I'll really do my stuff forme, I'll really do my stuff for you!you!
    • WARNING:WARNING: I can't and won't tell you I'm inI can't and won't tell you I'm in trouble until I'm almost at thetrouble until I'm almost at the end of my rope... and yours.end of my rope... and yours. Remember:Remember: I am a nonI am a non complainer.complainer. Overloading me with drugs, alcoholOverloading me with drugs, alcohol and other junk can destroy me !and other junk can destroy me ! This may be the only warning youThis may be the only warning you will ever getwill ever get..
    • Take My Advice, Please!Take My Advice, Please! • Check me out with your doctor regularly.Check me out with your doctor regularly. • Blood screening tests can identify some trouble.Blood screening tests can identify some trouble. If I'm soft and smooth, that's good. If I'm hard and bumpy, that could mean a trouble, take needful actions. If your doctor suspects trouble, USG and CT scans can look into it. My life, and yours, depends on how you treat me and love me.
    • Now you know how much I care forNow you know how much I care for you.you. Please treatPlease treat meme with tender loving care.with tender loving care. I am your silent partner in all vitalI am your silent partner in all vital Actions of life and …. Love youActions of life and …. Love you
    • THANK YOUTHANK YOU