ANTISEPTIC MAJID MOHIUDDIN

Antiseptic – are antimicrobial substances that are applied to living tissue/skin to reduce the possibility of infection, sepsis, or putrefaction. Antibacterial are antiseptics.

Antiseptic – are antimicrobial substances that are applied to living tissue/skin to reduce the possibility of infection, sepsis, or putrefaction.

Antibacterial are antiseptics.

Use in surgery: Antiseptic Principle of the Practice of Surgery in 1867 by Joseph Lister. (Carbolic acid) Inspired by Louis Pasteur’s germ theory of putrefaction. Dr. George H Tichenor – was working with use of alcohol on wounds (1861-1863) - Dr. Tichnenor’s Patent Medicine” Ignaz Semmelweis – published – “The cause, Concept and Prophylaxis of childbed Fever” in 1861. (observations since 1847) Florence Nightingale – “The Royal Commission on the Health of the Army (1856-1857)”. Oliver Wendell Holmes – “The Contagiousness of Puerperal Fever” – 1843.

Use in surgery:

Antiseptic Principle of the Practice of Surgery in 1867 by Joseph Lister. (Carbolic acid)

Inspired by Louis Pasteur’s germ theory of putrefaction.

Dr. George H Tichenor – was working with use of alcohol on wounds (1861-1863) - Dr. Tichnenor’s Patent Medicine”

Ignaz Semmelweis – published – “The cause, Concept and Prophylaxis of childbed Fever” in 1861. (observations since 1847)

Florence Nightingale – “The Royal Commission on the Health of the Army (1856-1857)”.

Oliver Wendell Holmes – “The Contagiousness of Puerperal Fever” – 1843.

COMMON ANTISEPTICS 1. ALCOHOLS: (surgical alcohol) Ethanol (60-90%) 1-Propanol (60-70%) 2- Propanol/isopropanol (70-80%)

COMMON ANTISEPTICS

1. ALCOHOLS: (surgical alcohol)

Ethanol (60-90%)

1-Propanol (60-70%)

2- Propanol/isopropanol (70-80%)

Alcohols referred as “Surgical alcohol” To disinfect the skin before injections cationic surfactants (benzalkonium chloride 0.05 – 0.5%, Chlorhexidine 0.2 – 4.0% or octenidine dihydrochloride 0.1 -2.0%)

Alcohols referred as “Surgical alcohol”

To disinfect the skin before injections

cationic surfactants (benzalkonium chloride 0.05 – 0.5%, Chlorhexidine 0.2 – 4.0% or octenidine dihydrochloride 0.1 -2.0%)

2. QUATERNARY AMMONIUM COMPOUNDS: (Quats or QAC’s) Benzalkonium chloride (BAC) Cetyl trimethylammonium bromide (CTMB) Cetylpyridinum chloride (Cetrim, CPC) Benzethonium chloride (BZT) (0.05 – 0.5% pre-operative skin disinfectants and antiseptic towels) Inactivated by anionic surfactant – soaps. Cationic surfactants.

2. QUATERNARY AMMONIUM COMPOUNDS: (Quats or QAC’s)

Benzalkonium chloride (BAC)

Cetyl trimethylammonium bromide (CTMB)

Cetylpyridinum chloride (Cetrim, CPC)

Benzethonium chloride (BZT) (0.05 – 0.5% pre-operative skin disinfectants and antiseptic towels)

Inactivated by anionic surfactant – soaps.

Cationic surfactants.

3. BORIC ACID For treatment of vagina, eyewashes and antiviral. used in creams for burns. present in eye contact solution.

3. BORIC ACID

For treatment of vagina, eyewashes and antiviral.

used in creams for burns.

present in eye contact solution.

4. CHLORHEXIDINE GLUCONATE Bignuanidine derivative – 0.5 – 4.0% Skin antiseptic To treat inflammation of the gums (gingivitis). Cationic surfactants.

4. CHLORHEXIDINE GLUCONATE

Bignuanidine derivative – 0.5 – 4.0%

Skin antiseptic

To treat inflammation of the gums (gingivitis).

Cationic surfactants.

5. HYDROGEN PEROXIDE 6% to clean and deodorize wounds and ulcers. 1% or 2% solutions for household first aid for scrapes, etc.

5. HYDROGEN PEROXIDE

6% to clean and deodorize wounds and ulcers.

1% or 2% solutions for household first aid for scrapes, etc.

6. IODINE Tincture of Iodine or Lugol’s iodine solution pre and post-operative antiseptic Disinfectants Antiseptics

6. IODINE

Tincture of Iodine or Lugol’s iodine solution

pre and post-operative antiseptic

Disinfectants

Antiseptics

7. OCTENIDINE DIHYDROCHLORIDE A Cationic surfactant and bis- (dihydropyridinyl)- decane derivative 0.1-2.0%. Mucosa and Wound antiseptic. Potentiated with addition of 2- phenoxyethanol.

7. OCTENIDINE DIHYDROCHLORIDE

A Cationic surfactant and bis- (dihydropyridinyl)- decane derivative

0.1-2.0%.

Mucosa and Wound antiseptic.

Potentiated with addition of 2- phenoxyethanol.

8. PHENOL (CARBOLIC ACID) COMPOUNDS. Germicide in strong solution inhibitory in weaker ones. used as Scrub powder – antiseptic baby powder Mouthwashes and throat lozenges

8. PHENOL (CARBOLIC ACID) COMPOUNDS.

Germicide in strong solution

inhibitory in weaker ones.

used as Scrub

powder – antiseptic baby powder

Mouthwashes and throat lozenges

9. SODIUM CHLORIDE General cleanser Mouthwash 10. SODIUM HYPOCHLORITE Diluted, neutralized and combined with potassium permanganate in the Daquin’s solution. Now only disinfectant.

9. SODIUM CHLORIDE

General cleanser

Mouthwash

10. SODIUM HYPOCHLORITE

Diluted, neutralized and combined with potassium permanganate in the Daquin’s solution.

Now only disinfectant.

Thanks MAJID MOHIUDDIN

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