ANTISEPTIC

4,170 views
4,007 views

Published on

Antiseptics (Chemical non-medicinal antimicrobials)

Published in: Education, Business, Technology
1 Comment
6 Likes
Statistics
Notes
No Downloads
Views
Total views
4,170
On SlideShare
0
From Embeds
0
Number of Embeds
7
Actions
Shares
0
Downloads
0
Comments
1
Likes
6
Embeds 0
No embeds

No notes for slide

ANTISEPTIC

  1. 1. ANTISEPTIC MAJID MOHIUDDIN
  2. 2. <ul><li>Antiseptic – are antimicrobial substances that are applied to living tissue/skin to reduce the possibility of infection, sepsis, or putrefaction. </li></ul><ul><li>Antibacterial are antiseptics. </li></ul>
  3. 3. <ul><li>Use in surgery: </li></ul><ul><li>Antiseptic Principle of the Practice of Surgery in 1867 by Joseph Lister. (Carbolic acid) </li></ul><ul><li>Inspired by Louis Pasteur’s germ theory of putrefaction. </li></ul><ul><li>Dr. George H Tichenor – was working with use of alcohol on wounds (1861-1863) - Dr. Tichnenor’s Patent Medicine” </li></ul><ul><li>Ignaz Semmelweis – published – “The cause, Concept and Prophylaxis of childbed Fever” in 1861. (observations since 1847) </li></ul><ul><li>Florence Nightingale – “The Royal Commission on the Health of the Army (1856-1857)”. </li></ul><ul><li>Oliver Wendell Holmes – “The Contagiousness of Puerperal Fever” – 1843. </li></ul>
  4. 4. <ul><li>COMMON ANTISEPTICS </li></ul><ul><li>1. ALCOHOLS: (surgical alcohol) </li></ul><ul><li>Ethanol (60-90%) </li></ul><ul><li>1-Propanol (60-70%) </li></ul><ul><li>2- Propanol/isopropanol (70-80%) </li></ul>
  5. 5. <ul><li>Alcohols referred as “Surgical alcohol” </li></ul><ul><li>To disinfect the skin before injections </li></ul><ul><li>cationic surfactants (benzalkonium chloride 0.05 – 0.5%, Chlorhexidine 0.2 – 4.0% or octenidine dihydrochloride 0.1 -2.0%) </li></ul>
  6. 6. <ul><li>2. QUATERNARY AMMONIUM COMPOUNDS: (Quats or QAC’s) </li></ul><ul><li>Benzalkonium chloride (BAC) </li></ul><ul><li>Cetyl trimethylammonium bromide (CTMB) </li></ul><ul><li>Cetylpyridinum chloride (Cetrim, CPC) </li></ul><ul><li>Benzethonium chloride (BZT) (0.05 – 0.5% pre-operative skin disinfectants and antiseptic towels) </li></ul><ul><li>Inactivated by anionic surfactant – soaps. </li></ul><ul><li>Cationic surfactants. </li></ul>
  7. 7. <ul><li>3. BORIC ACID </li></ul><ul><li>For treatment of vagina, eyewashes and antiviral. </li></ul><ul><li>used in creams for burns. </li></ul><ul><li>present in eye contact solution. </li></ul>
  8. 8. <ul><li>4. CHLORHEXIDINE GLUCONATE </li></ul><ul><li> Bignuanidine derivative – 0.5 – 4.0% </li></ul><ul><li> Skin antiseptic </li></ul><ul><li> To treat inflammation of the gums (gingivitis). </li></ul><ul><li> Cationic surfactants. </li></ul>
  9. 9. <ul><li>5. HYDROGEN PEROXIDE </li></ul><ul><li>6% to clean and deodorize wounds and ulcers. </li></ul><ul><li>1% or 2% solutions for household first aid for scrapes, etc. </li></ul>
  10. 10. <ul><li>6. IODINE </li></ul><ul><li> Tincture of Iodine or Lugol’s iodine solution </li></ul><ul><li>pre and post-operative antiseptic </li></ul><ul><li>Disinfectants </li></ul><ul><li>Antiseptics </li></ul>
  11. 11. <ul><li>7. OCTENIDINE DIHYDROCHLORIDE </li></ul><ul><li>A Cationic surfactant and bis- (dihydropyridinyl)- decane derivative </li></ul><ul><li>0.1-2.0%. </li></ul><ul><li>Mucosa and Wound antiseptic. </li></ul><ul><li>Potentiated with addition of 2- phenoxyethanol. </li></ul>
  12. 12. <ul><li>8. PHENOL (CARBOLIC ACID) COMPOUNDS. </li></ul><ul><li>Germicide in strong solution </li></ul><ul><li>inhibitory in weaker ones. </li></ul><ul><li>used as Scrub </li></ul><ul><li>powder – antiseptic baby powder </li></ul><ul><li>Mouthwashes and throat lozenges </li></ul>
  13. 13. <ul><li>9. SODIUM CHLORIDE </li></ul><ul><li> General cleanser </li></ul><ul><li> Mouthwash </li></ul><ul><li>10. SODIUM HYPOCHLORITE </li></ul><ul><li> Diluted, neutralized and combined with potassium permanganate in the Daquin’s solution. </li></ul><ul><li>Now only disinfectant. </li></ul>
  14. 14. <ul><li> Thanks </li></ul> MAJID MOHIUDDIN

×