Radiopharmaceuticals: Positron Emmison Tomography

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PET is a growing diagnostic tools and radiopharmaceuticals are the essential part in diagnosing a disease.

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Radiopharmaceuticals: Positron Emmison Tomography

  1. 1. Prepared by: Madan Baral (8) Anish Shrestha (9) Krishna Ghimire (10) Rahul Rana Chhetri (11) RADIOPHARMACEUTICALS: POSITRON EMMISION TOMOGRAPHY (PET)
  2. 2. Introduction ET- Positron Emission Tomography mployed since 1970 on-invasive method for diagnosis and management of cancer ields high-quality images that characterize substrate metabolism, cellular proliferation, receptor density and other parameters used to identify cancer and evaluate its response to treatment llows the physician to to retain the cerebral physiology of patient through the low resolution “autoradiograph”
  3. 3. Methodology adiolabelled tracers injected in nonpharmacologic doses are used to construct three dimensional images by computer to demonstrate the location and concentration of the tracer of interest uantitative imaging of regional function and chemical reactions within various organs of the human body pplication in mapping regional blood flow, oxygen metabolism, regional blood volume, rates of use of metabolic substrates receptor-specific tracer binding, bone remodeling , tumor receptor density, and reporter gene expression
  4. 4. Operation
  5. 5. Types of Tracer Molecules arbon-11 itrogen-13 xygen-15
  6. 6. Carbon-11 ncorporated into a number of organic molecules like carboxylic acids, alcohols glucose alf life is 20 minutes almitic acid commonly used for myocardial metabolism pplication: Imaging of cerebral glucose metabolism
  7. 7. Nitrogen-13 3 N ammonia used for cerebral and myocardial blood flow alf life 10 minutes uperior than radioactive noble gases due to lower solubility in gases
  8. 8. Oxygen-15 5 O has too short half life for tracer synthesis alf life: 2.04 minutes vailable radiopharmaceuticals radiolabeled with 15 O are 5 Ooxygen gas(15 OO): Used for the studies of Oxygen metabolism, 5 O water ( H2 15 O): Used for the equilibrium studies of tissue water content
  9. 9. Fluorine-18 8 F has long half-life 110 minutes comparatively hows receptor-specific tracer binding DG(2-18 F-fluoro-deoxy-D-glucose) major application in imaging of cerebral, myocardial, and tumor metabolism, myocardial and tumor metabolism lso cancers of lung and colon and myelomas and lymphomas.
  10. 10. Gallium-68 apidly bound to iron-binding sites pplication: studies of regional plasma volume also in calculation of regional hematocrit
  11. 11. References oyd V. Allen Nicholas G. Popvich, Howard C. Ansel (2008), Ansel’s Pharmaceutical Dosage Forms and Drug delivery Systems (8th Ed),Walters Klewer ,New Delhi,pp 584-588

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