Welcome
To our Presentation

ON
Stem cells……
Stem Cells
Stem Cell History
1998 - Researchers first extract stem cells from
human embryos
1999 - First Successful human transplant ...
Stem Cell – Definition
Stem Cell – Definition

A cell that has the ability to
continuously divide and
differentiate (devel...
Stem Cell Characteristics

•

‘Blank cells’ (unspecialized)

• Capable of dividing and renewing
themselves for long period...
Kinds of Stem Cells
Embryonic stem cells
five to six-day-old embryo
Tabula rasa
Embryonic germ cells
derived from the part...
Kinds of Stem Cells
Embryonic stem cells
five to six-day-old embryo
Tabula rasa
Embryonic germ cells
derived from the part...
Pluripotent Stem Cells –
more potential to become any type of cell
Multipotent stem cells
•Multipoten
t stem cells
– limited in
what the
cells can
become
Embryonic Stem Cells
Adult Stem Cells
An undifferentiated cells found
among specialized or differentiated
cells in a tissue or organ after birt...
Induced Pluripotent Stem Cells
Bone Marrow

• Found in spongy bone where blood cells form
• Used to replace damaged or destroyed bone
marrow with healthy...
Umbilical cord stem cells

•
•
•
•
•

Also Known as Wharton’s Jelly
Adult stem cells of infant origin
Less invasive than b...
Umbilical cord stem cells
Three important functions:
1. Plasticity: Potential to change into
other cell types like nerve c...
Stem Cell Applications
• Tissue repair
nerve, heart, muscle, organ,
skin
• Cancers
• Autoimmune diseases
- diabetes, rheum...
Tissue Repair

• Regenerate spinal
cord, heart tissue or any
other major tissue in the
body.
Heart Disease

• Adult bone marrow stem cells
injected into the hearts are believed
to improve cardiac function in victims...
Stem cells in the adult brain:
Problems with Adult Stem Cells
Stem cells in mature skeletal muscle:
Is there power still in our stem cells?
What is stem cell research?
•Understand more about
development, aging, disease
Experimental model systems
Prevent or treat...
Why is Stem Cell Research So Important
to All of Us?

• Stem cells can replace diseased or
damaged cells
• Stem cells allo...
Thank you for watching
BY:- MADHULA & MADHURI 2nd B.Sc(B.G.B)
Stem cells
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Stem cells

  1. 1. Welcome To our Presentation ON Stem cells……
  2. 2. Stem Cells
  3. 3. Stem Cell History 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful human transplant of insulin-making cells from cadavers 2001 - President Bush restricts federal funding for embryonic stem-cell research 2002 - Juvenile Diabetes Research Foundation International creates $20 million fund-raising effort to support stem-cell research 2002 - California ok stem cell research 2004 - Harvard researchers grow stem cells from embryos using private funding 2004 - Ballot measure for $3 Billion bond for stem cells
  4. 4. Stem Cell – Definition Stem Cell – Definition A cell that has the ability to continuously divide and differentiate (develop) into various other kind(s) of cells/tissues
  5. 5. Stem Cell Characteristics • ‘Blank cells’ (unspecialized) • Capable of dividing and renewing themselves for long periods of time (proliferation and renewal) • Have the potential to give rise to specialized cell types (differentiation)
  6. 6. Kinds of Stem Cells Embryonic stem cells five to six-day-old embryo Tabula rasa Embryonic germ cells derived from the part of a human embryo or fetus that will ultimately produce eggs or sperm (gametes). Adult stem cells undifferentiated cells found among specialized or differentiated cells in a tissue or organ after birth appear to have a more restricted ability to produce different cell types and to self-renew.
  7. 7. Kinds of Stem Cells Embryonic stem cells five to six-day-old embryo Tabula rasa Embryonic germ cells derived from the part of a human embryo or fetus that will ultimately produce eggs or sperm (gametes). Adult stem cells undifferentiated cells found among specialized or differentiated cells in a tissue or organ after birth appear to have a more restricted ability to produce different cell types and to self-renew.
  8. 8. Pluripotent Stem Cells – more potential to become any type of cell
  9. 9. Multipotent stem cells •Multipoten t stem cells – limited in what the cells can become
  10. 10. Embryonic Stem Cells
  11. 11. Adult Stem Cells An undifferentiated cells found among specialized or differentiated cells in a tissue or organ after birth Skin Fat Cells Bone marrow Brain Many other organs & tissues
  12. 12. Induced Pluripotent Stem Cells
  13. 13. Bone Marrow • Found in spongy bone where blood cells form • Used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. • treat patients diagnosed with leukemia, aplastic anemia, and lymphomas • Need a greater histological immunocompatibility
  14. 14. Umbilical cord stem cells • • • • • Also Known as Wharton’s Jelly Adult stem cells of infant origin Less invasive than bone marrow Greater compatibility Less expensive
  15. 15. Umbilical cord stem cells Three important functions: 1. Plasticity: Potential to change into other cell types like nerve cells 2. Homing: To travel to the site of tissue damage 3. Engraftment: To unite with other tissues
  16. 16. Stem Cell Applications • Tissue repair nerve, heart, muscle, organ, skin • Cancers • Autoimmune diseases - diabetes, rheumatoid arthritis, MS
  17. 17. Tissue Repair • Regenerate spinal cord, heart tissue or any other major tissue in the body.
  18. 18. Heart Disease • Adult bone marrow stem cells injected into the hearts are believed to improve cardiac function in victims of heart failure or heart attack
  19. 19. Stem cells in the adult brain:
  20. 20. Problems with Adult Stem Cells
  21. 21. Stem cells in mature skeletal muscle: Is there power still in our stem cells?
  22. 22. What is stem cell research? •Understand more about development, aging, disease Experimental model systems Prevent or treat diseases and injuries •Cell-based therapies Pharmaceutical development Includes testing and drug delivery
  23. 23. Why is Stem Cell Research So Important to All of Us? • Stem cells can replace diseased or damaged cells • Stem cells allow us to study development and genetics • Stem cells can be used to test different substances (drugs and chemicals)
  24. 24. Thank you for watching BY:- MADHULA & MADHURI 2nd B.Sc(B.G.B)
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