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HPC in healthcare

HPC in healthcare






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  • Source : DataMonitor Report
  • Source : DataMonitor Report
  • Source : DataMonitor Report
  • Source : DataMonitor Report
  • Source : DataMonitor Report
  • Source : DataMonitor Report
  • Source : DataMonitor Report
  • Source : DataMonitor Report
  • Source : DataMonitor Report
  • Source : DataMonitor Report
  • Source : DataMonitor Report
  • Source : Ovum, IMS Health
  • http://www.mddionline.com/blog/devicetalk/will-merges-and-acquisitions-continue-boom-medical-device-industry http://www.mddionline.com/article/four-trends-2012-medical-design-excellence-awards
  • Source : Ovum, IMS Health
  • Source : DataMonitor Report
  • Source : Ovum, IMS Health
  • Source : DataMonitor Report
  • Source : DataMonitor Report
  • http://medienportal.univie.ac.at/presse/aktuelle-pressemeldungen/detailansicht/artikel/nano-machines-for-bionic-proteins/
  • http://www.csir.co.za/enews/2011_jun/14.html
  • http://www.efytimes.com/e1/fullnews.asp?edid=83639&magid=11
  • http://www.siemens.com/innovation/apps/pof_microsite/_pof-spring-2010/_html_en/identifying-invisible-invaders.html
  • http://www.siemens.com/innovation/apps/pof_microsite/_pof-spring-2010/_html_en/identifying-invisible-invaders.html
  • http://www.siemens.com/innovation/apps/pof_microsite/_pof-spring-2010/_html_en/identifying-invisible-invaders.html

HPC in healthcare HPC in healthcare Presentation Transcript

  • Application of HPC in Healthcare Industry 1 Confidential
  • HPC is being used to quickly diagnose Cancer (1/2) Pathwork Diagnostics uses cloud-based HPC to diagnose Cancer•Of the 1.4 million new cancer cases that occur each year in the United States, 90% arediagnosed rapidly; however, the remaining 10% are difficult to identify using the besttraditional means. This is because cancer tumors may have mutated and/or spread to Pathwork Diagnostics Genomic Testing For Cancermultiple regions in the body, making the origin, and thus the type of tumor (e.g., lung,pancreatic, skin, etc.) unknown Why does this matter ? According to recent studies, a patient’s response to treatment is significantly better when the tumor’s origin is known and patients can receive tumor-specific therapies •To address this crucial 10% of new cases, Pathwork Diagnostics has created its Tissue of Origin Laboratory Developed Test (LDT). •This unique application uses microarray technology to identify the unknown tumor by genomically comparing it to the DNA profiles of known tumors. •Once the sample has been analyzed, the physician receives a report with the profile Source: Pathwork Diagnostics and recommended treatment. Source: Forrester
  • HPC is being used to quickly diagnose Cancer (2/2) Pathwork Diagnostics uses cloud-based HPC to diagnose Cancer Specifically, it takes large amounts of loosely coupled compute resources to develop a model to analyze the data and generate a result. The larger the compute capacity, the faster this product can be built; on the Is a classic high- flipside, the more resources, the higher the cost to achieve the result. If you are a large research university or performance government agency that can spread this investment across multiple HPC projects or can justify the investment against one large project with a significant compute demand, you might be able to make the computing (HPC) upfront investment necessary to drive fast results. But for Pathwork, a small biotech firm without access to problem this type of capital, and without a clear picture of the demand or volume of analyses needed by the medical community, another answer was necessary…Under the above constraints, Pathwork would have needed years to develop this model with its Would take years tocurrent resources, preventing cancer patients from getting much-needed answers now. To meet complete with the market needs that it forecasts, Pathwork would need the compute capacity to develop this model in two to three months. Once the model has been developed, the company could then traditional HPC analyze hundreds of samples per day. models… With the capital to access compute resources of this magnitude out of reach, Pathwork turned to…but can be done infrastructure-as-a-service (IaaS) cloud computing, where it could leverage on-demand access to this on time and volume of resources but keep its operating costs low by not having to pay for these resources (not tocheaper with the mention the power, data center facility, and ongoing operating costs) when they’re not in use. Pathwork not only met its time-to-market objective, but the company said that the cost-avoidance of this model has cloud already saved Pathwork an estimated $160,000. Source: Forrester
  • Bringing the power of HPC to Drug Discovery (1/2) GNS Healthcare is using the power of HPC to accelerate drug discovery and treatment development process•In medieval times, leeches were used to “cure” arthritis and a number of other ailments. Today, while these rather repulsive little creatures are making a medicalcomeback of sorts, most people would rather treat creaky joints with less Draconian methods. Fortunately, there are companies like GNS Healthcare engaged inresearch to find new drug therapies to treat arthritis and many other common ailments. Challenges The National Institute of Health estimates that 20-30 percent of patients do •Accelerate the drug discovery and treatment development process not respond sufficiently to a given anti-TNF drug. Developing effective drugs •Find relief for disease sufferers that are not helped by standard that will benefit this population is a major research opportunity therapies •Match the right treatment(s) to the right patient Colin Hill, CEO and president of GNS •Help meet the increasingly complex health needs of an aging population. •Deal with overwhelming amounts of data derived from the clinical studies, such as the Cancer Genome Atlas Project and DNA testing Reverse Engineering/Forward Simulation (REFS) Approach •Apply the power of in-house and commercially available HPC resources to reverse-engineer data- driven models of human disease progression and drug response •Simulate these models to discover novel drug targets that can be used by GNS partners to develop new drug programs for patients suffering from diseases such as cancer, diabetes and rheumatoid arthritis. •Automate aspects of the scientific method from the creation of hypotheses through the stages of testing and validation Source: Council on Competitiveness High Performance Computing
  • Bringing the power of HPC to Drug Discovery (2/2) GNS Healthcare is using the power of HPC to accelerate drug discovery and treatment development process•As recently as eight years ago, the application of high performance computing (HPC) techniques to drug discovery efforts was problematic at best. Using the bestartificial intelligence platforms available at the time, even clusters composed of 40 or 50 processors could take up to 12 months to run through the DNA sequencedata and corresponding gene expression and clinical response data needed to identify the important genes in a tumor when compared to normal tissue. Today, due toadvances in supercomputing and software platforms from companies like GNS with its REFS computational environment, Wolfram Research with Mathematica, andThe MathWorks with MATLAB, results of this type can now be achieved in weeks—and, Hill adds, “much more comprehensively.” REFS (Reverse Engineering/Forward Simulation) Data Driven Process The REFS process begins with the creation of model building blocks, proceeds through the construction of an ensemble of models from the building blocks, and results in the simulation of the ensemble of models to extract quantitative outcome predictions accompanied by confidence levels
  • Improving Healthcare Delivery through HPC (1/6) Ohio Supercomputer Center (OSC) applies advanced computer technology for pioneering healthcare delivery 1 IMPROVING THE EPIDURAL• The epidural is a common anesthetic for childbirth, back and hip surgeries. Epidural Anesthesiology But in inexperienced hands it poses serious risks. Residents traditionally laern the delicate procedure on live patients. time-consuming and costly, multiple human trials, always in the presence of a supervising doctor are required.• Residents at the Ohio University College of Medicine and three other university medical centers soon will be learning to administer epidural blocks through virtual simulation techniques developed at the OSC-honing their skill on supercomputers before attempting to work on patients.• Three-dimensional graphics and force-reflecting "Cyberglove", which realistically simulate appropriate patient anatomy and provide instant feedback of errors, have been tested and approved for this purpose by anesthesiology experts. This research is funded by the US Air force Source: Coalition of Academic Supercomputing Centers (CASC)
  • Improving Healthcare Delivery through HPC (2/6) Ohio Supercomputer Center (OSC) applies advanced computer technology for pioneering healthcare delivery 2 REMOTE MEDICAL TRIAGE• Being able to provide sophisticated medical services to remote geographic areas is an unanticipated benefit of high speed computer networking. University-based supercomputer centers, credited with developing networking technology, are now pioneers in applying it to health care.• The Remote Medical Triage project is one example.• The University of Hawaii, OSC and the Georgetown University Medical center in Washington, D.C., are testing the feasibility of long distance radiation treatment planning. Patient data, such as an MRI, is sent by satellite from a medical site in Hawaii to Ohio for 3-D imaging, then to Washington for expert consultation and back to Hawaii for treatment. Each transmission takes only a few seconds.• The speed of NASAs COMSAT and funds from the Advanced Research Projects Agency make this project possible Source: Coalition of Academic Supercomputing Centers (CASC)
  • Improving Healthcare Delivery through HPC (3/6) Ohio Supercomputer Center (OSC) applies advanced computer technology for pioneering healthcare delivery 3 WHEELCHAIR DESIGN• Under a grant from the US Department of Education, OSC researchers are using virtually reality to test the efficiency of various wheelchair designs and to streamline architectural elements required for compliance with the Americans With Disabilities Act.• This research tracks power wheelchair users as they navigate through a simulated architectural environments. The technique also enables disabled individuals to gain the dexterity needed to operate power chairs, and allows health care providers to fine-tune wheelchair operations on the basis of high accuracy assessment of user proficiency.Source: Coalition of Academic Supercomputing Centers (CASC)
  • Improving Healthcare Delivery through HPC (4/6) University of Colorado School of Medicine Initiative 4 THE VISIBLE HUMAN PROJECT Cryosection through the head of a human male• Researchers at the University of Colorado School of Medicine, have been working with the National Center for Atmospheric Research (NCAR) to create the radiologic and photographic definition of a male cadaver in three-dimensions, with details as small as one millimeter resolved clearly• Funded by the National Library of Medicine, the project provides the most comprehensive computer image database of human anatomy ever available for teaching and research.• It consists of 1,878 full-color CT scans that define the entire human body at every location in space. But the work is far from done. Funding is being sought to finish segmenting and classifying this volume data into anatomical objects and to explore the potential for biomedical research that will open up once this is complete Discoveries By studying the data set, researchers at Columbia University found several errors in anatomy textbooks, related to the shape of a muscle in the pelvic region and the location of the urinary bladder and prostate Source: Coalition of Academic Supercomputing Centers (CASC)
  • Improving Healthcare Delivery through HPC (5/6) University of Texas Initiative 5 KINESIOLOGY• Researchers at the University of Texas at Austin Biomechanics Laboratory are using high performance computing to create full dynamic simulations of muscle interactions and multi-joint coordination of the human skeleton in action.• These simulations, involving complex mathematical models of muscle-joint dynamics and the forces induced by such everyday tasks as jumping, running, walking and rising from a chair, are leading to improved diagnosis and treatment of bone and joint disease.• This project is funded by NASAs Office of Space Science Applications.Source: Coalition of Academic Supercomputing Centers (CASC)
  • Improving Healthcare Delivery through HPC (6/6) University of Texas Initiative 6 BONE TRANSPLANT BIOENGINEERING• Researchers with the Department of Mechanical and Aerospace Engineering at Cornell University are using advanced computers at the Cornell Theory Center to study the efficacy of various bone-implant systems, with emphasis on the hip.• The models they produce of the stresses placed on normal bones and on the artificial components of hip joints are leading to customized prostheses and reducing the need for prosthesis replacement surgerySource: Coalition of Academic Supercomputing Centers (CASC)
  • HPC helps create new treatment for Stroke Victims(1/2) Medical devices and services provider Medrad uses HPC for advancement of catheter technology “The patented prototype device seemed•When someone has a stroke, the faster they can be brought to the hospital, the better. like a good fit with Medrads growth objectives, so we purchased the rights toDoctors have a very small window in which to introduce drugs into the patients the technology”circulatory system in order to break up the clot-any delay can lead to paralysis or death. -John Kalafut, Principal research scientist at Medrad But before commissioning expensive Go-or-no-go product development activity, Medrad Development work on Jell-O decision needed to test its feasibility About 5 years ago, two engineers developed a prototype device that would speed up •Not only did Medrad need to understand treatment by mechanically breaking up clots in the brain or elsewhere in the body. As the physics of how the device worked, it part of their research and development, they used Jell-O to simulate the physical properties of the brain. also wanted to explore different design and manufacturing approaches. •It felt that doing this computationally would be more efficient and faster than •This work on interventional catheter technology came to the attention of Medrad, Inc building lots of different physical Business Case for prototypes” HPC of Indianola, PA. Medrad is a leader in providing medical devices and services that enable and enhance diagnostics and therapeutic imaging procedures in the human However, the R&D groups high-end body. workstations lacked the horsepower to conduct the complex simulations. They also did not have the in-house expertise to •An affiliate of Bayer Schering Pharmaceutical AG, Germany, Medrads diagnostic develop the detailed CFD (Computational products have captured 70 to 80% market share. the company wanted to expand its Fluid Dynamics) codes. They needed access to HPC and software, and the expertise to business by moving into the interventional applications market Business Case for help them harness its full potential HPC Source: Council on Competitiveness High Performance Computing
  • HPC helps create new treatment for Stroke Victims(2/2) Busting Blood Clots with High Performance Computing Simulated flow field from the prototype device as computed by 3D CFD Software at PSC•Breaking with a long tradition of building numerous physical prototypes toresearch the potential of a new technology, Medrad turned to the NSF-fundedPittsburgh Supercomputing Center, experts at the Carnegie Mellon University foruse of complex numerical simulations running on high performance computers todetermine if the catheter technology was worth pursuing.•Medrad used HPC to simulate the process of the catheter destroying the clots,adjusting the parameters again and again to ensure that the phenomenon wasrepeatbale. This validated the science behind the patents theory was solid andthat the device would do what its inventors claimed.•Then HPC was used to mathematically refine the prototypes by simulating manydifferent combinations of cahnges -more than could be done physically in the Source: Medradtime frame or budget available - to arrive at the best designHPC allows us to tackle projects that were otherwise beyond our reach and has streamlined and optimized our production processes in new ways that translate into lower costs and higher productivity John Kalafut, Principal research scientist at Medrad
  • Breakthroughs in Brain Research with HPC (1/2) •Researchers at the Salt Lake Institute are using supercomputers at the nearby NSF-funded San Diego Supercomputer Center to investigate how the synapses of the brain work. Their research has the potential to help people suffering from mental disorders such as Alzheimers, schizophrenia and manic depressive disorders. •In addition, the use of supercomputers is helping to change the very nature of biology-from a science that has relied primarily on observation to a science that relies on high performance computing to achieve previously impossible in-depth quantitative results Researchers at the Salk Institute have been studying the ciliary ganglion of chickens with the help of high performance computing (HPC). The ciliary ganglion is a mass of neurons in the ciliary muscle-the muscle that opens and closes the iris in a human or animal eye. it acts like a circuit controlling the muscles functions. Within the ganglion is a synapse-the communication junction point where nerve cells communicate with target cells like those in a muscle or gland. By studying the ciliary ganglion of a chicken and how the synapse controls neural communication, researchers like Sejnowski and Bartol are gaining new insights into the neural Treatment of Neural Disorder communication pathways of the human brain that could lead to new treatments for serious mental disordersCompared to the tangled skin of synapses in the brain, the ciliary ganglion of a chicken is highly accessible,rather large and can be easily removed for study. The synapse within the ganglion has many communicationrelease sites and every intricate geometry, allowing researchers to conduct experiments that would not bepossible with the brain itself.Most drugs for neurological disorders are targeted at these synapses and, to some extent, are able torebalance these synapses Better Drugs for Better Living While the synapse that controls the eyes ciliary muscle has been under study for many years, the Salk Institute became involved when its researchers described the shape of the synapse in three dimensions-and a very strange shape it was. The researchers made an initial setting of the parameters, ran the model on in-house workstations and then looked to see what happened. “In a sense”, Bartol explains "we brought this little piece of tissue back to life Bringing tissue to Life inside the computer". Source: Council on Competitiveness High Performance Computing
  • Breakthroughs in Brain Research with HPC (2/2) Looking and Seeing with HPC Realistic computer simulation of neurotransmission in a chick ciliary ganglion synapse•The Salk Institute researchers did what is called a parameter sweep. Thisconsists of making numerous adjustments to the numerical parameters used toprovide an approximate model of reality. “So, I have nine different parameters, and now I want to know what will happen to my model when I vary all nine of these parameters, lets say using five different values, all independently of each other. Thats nine to the fifth power- and now we are in major supercomputing territory". -Bartol•The parameter sweeps and simulations executed on the SDSC high performancecomputer had some surprises in store for the Salk investigators. The classic viewof how synapses work, derived from laboratory investigation, is that neuraltransmissions occur primarily in dense protein rich areas called active zones. Butwhen the Salk team ran their models on the SDSC system, the results indicatedthat neural communication was not confined to just the synaptic active zones,but took place in peripheral areas as well outside of the synapses. this was highlyunexpected and exploded the traditional thinking of how synapses work. Source: Salk Institute for Bilogical Studies The high performance supercomputer gives us a scientific instrument like none other that has ever existed and will lead to discoveries thatw e cant even contemplate now. It is changing the way we think about the brain and the way we think about the brain, and the way we think about biology in general. We are entering a whole new era Terry Sejnowski, Professor and head of the Computational Neurolobilogy Laboratory, Salk Institute for Bilogical Studies
  • HPC helps create simulation of the Human Heart (1/2) Lawrence Livermore and IBM creates simulation that aims to realistically mimic a beating human heart•Developed by Laboratory scientists working with colleagues at the IBM T. J. Watson Research Center in New York, the code accurately simulates the activation ofeach heart muscle cell and the cell-to-cell electric coupling . The new simulations are made possible by a highly scalable code, called Cardioid, that replicates theelectrophysiology of the human heart. Without medical intervention, a serious arrhythmia can lead to sudden death and accounts for about 325,000 deaths every year in the U.S.•On every heartbeat, electric signals normally traverse the entire heart in an orderly manner, resulting in a coordinated contraction that efficiently pumps bloodthroughout the body. However, these signals can become disorganized and cause an arrhythmia, a dysfunctional mechanical response that disrupts the heart’spumping process and can reduce blood flow throughout the body. Cardioid Heart Simulations through HPC •The Cardioid code developed by a team of Livermore and IBM scientists divides the heart into a large number of manageable pieces, or subdomains. •The development team used two approaches, called Voronoi (left) and grid (right), to break the enormous computing challenge into much smaller individual tasks Source: Lawrence Livermore National Laboratory
  • HPC helps create simulation of the Human Heart (2/2) Extended cardiac simulations are critical when investigating how specific medications affect heart rate•Many drugs disrupt heart rhythm. In fact, even those designed to prevent Snapshots from a Cardioid simulation show how a drug might affect heart functionarrhythmias can be harmful to some patients. In most cases, however,researchers do not fully understand the exact mechanisms producing thesenegative side effects. With Cardioid, scientists can examine heart function as ananti-arrhythmia medication is absorbed into the bloodstream and itsconcentration changes “So, I have nine different territory". -Bartol•Operating on Sequoia, the Cardioid code can simulate hundreds of times asmany heartbeats as previous codes. One minute of Sequoia processing time isrequired to replicate nine human heartbeats at a nearly cellular spatialresolution. Simulating an hour of heart activity, or several thousand heartbeats,can be accomplished in seven hours when using the full Sequoia system. Lesssophisticated codes took up to 45 minutes to compute a single heartbeat,making it impossible to model the heart’s response to a drug or anelectrocardiogram trace for a particular heart problem. Source: Lawrence Livermore National Laboratory The Cardioid simulation has been named as a finalist in the 2012 Gordon Bell Prize competition, which annually recognizes the most important advances in HPC applications. The Livermore–IBM team hopes the code will grow into a product that is widely adopted by medical centers, pharmaceutical companies, and medical device firms, helping them better understand the mechanisms that can lead to heart ailments and the potential drug interactions that may occur during treatment
  • Improving Microscopy through HPC Confocal Microscopy uses High Performance Computing for processing and visualizing neuro-anatomical information • Confocal microscopy is an optical imaging technique used to increase optical resolution and contrast of a micrograph by using point illumination and a spatial pinhole to eliminate out-of-focus light in specimens •Depth-z-stacks generate 3D data that are thicker than the focal plane. •Time-time series of organelle migration • HPC has enabled better reconstruction of three- •Colour-differential fluorescence to dimensional structures from the obtained images. identify location of molecules • Paras Prasad, SUNY Distinguished Professor in the departments of Chemistry and Physics, and executive director of the Institute for Lasers, Photonics and Biophotonics, has used CCRs visualization resources Confocal Microscope to create a fully immersive, three-dimensional image High definition, of a human cell based on two-dimensional slicesMultidimensional image data obtained using confocal microscopySource: Cancer Research UK, University of Cambridge
  • HPC–assisted diagnosis tools to aid pathologists Histopathology yields higher throughput; quicker, more-consistent diagnoses Histopathology • Researchers are leveraging Ohio Supercomputer Center resources to develop Robotic Image Scanner computer-assisted diagnosis tools that will provide pathologists grading Follicular Lymphoma samples with quicker, more consistently accurate diagnoses. • The advent of digital whole-slide scanners in recent years has spurred a revolution in imaging technology for histopathology .• The large multi-gigapixel images produced by these scanners contain a wealth of information potentially useful for computer- assisted disease diagnosis, grading and prognosis Tissue microarrays – hundreds . of samples per slide Source: Cancer Research UK, University of Cambridge Each sample scanned at high resolution
  • HPC helps create Nano Machines for Bionic Proteins Bionic Proteins could play an important role in innovating pharmaceutical research Self-knotted structure of the bionic protein•Physicists of the University of Vienna together with researchers from theUniversity of Natural Resources and Life Sciences Vienna developed nano-machines which recreate principal activities of proteins. They present the firstversatile and modular example of a fully artificial protein-mimetic model system. “Imitating the astonishing bio-mechanical properties of proteins and transferring them to a fully artificial system is our long term objective”- Ivan Coluzza•Using computer simulations, they reverse engineered proteins by focusing onthe key elements that give them the ability to execute the program written in thegenetic code. The computationally very intensive simulations have been madepossible by access to the powerful Vienna Scientific Cluster (VSC), a highperformance computing infrastructure operated jointly by the University ofVienna, the Vienna University of Technology and the University of NaturalResources and Life Sciences Vienna. Source: University of Vienna The team now works on realizing such artificial proteins in the laboratory using specially functionalized nano-particles. The particleswill then be connected into chains following the sequence determined by the computer simulations, such that the artificial proteins fold into the desired shapes. Such knotted nanostructures could be used as new stable drug delivery vehicles and as enzyme-like, but more stable, catalysts.
  • Healthcare HPC in Developing Countries
  • Application/Trends in Developing Countries Supercomputing Telemedicine Platforms Live demonstration of endoscopy at the Prince of Wales Hospital in the Chinese Initiatives University of Hong Kong, connecting Xian and Shanghai in China, and Fukuoka, Japan •South Africa-India-Tanzania is involved ina tripartite collaboration on telemedicine initiative for high impact service delivery . •The Tanzanian HPC facility is a two teraflops machine developed through the India-Tanzania Centre of Excellence in ICT •Elsewhere, The Medical Informatics Group (MIG) of Centre for Development of Advanced Computing (C-DAC), Pune has successfully completed the rollout phase of Odisha Telemedicine Network (Phase-III) program Bio-molecular Simulation Screenshot of a sample Biomolecular simulation being conducted at South Africa’s CHPC using AMBER Software Initiatives •School of Computational & Integrative Sciences at JNU is working on application of computer simulation to biological phenomena using supercomputers •South Africa’s CHPC (Centre for High Performance Computing) , in partnership with the University of KwaZulu Natal (UKZN), is working on Biomolecular Simulations using AMBER Software Genome AnalysisScreenshot of a sample research on Denovo assembly of eukaryotic genomes from India’s CRL Laboratory Initiatives •Brazilian Supercomputer epigeal, purchased by Laboratory for Scientific Computing (LCC) is speeding up research on metabolism and genome analysis. •India’s own Computational Research Laboratories (CRL), have developed a tool for parallel Denovo assembly of eukaryotic genomes which makes the assembly process faster and cheaper. The laboratory provide an automated pipeline in its HPC Cloud for the analysis of next generation sequencing data covering De Novo assembly, resequencing, analysis and annotation
  • Application/Trends in Developing Countries Advanced Functional Visualization Sample Screenshots from Cura’s HPC-based Medical Imaging Devices Initiatives •Leading Developer of Supercomputing Functional Visualization Ziosoft has recently partnered with Advanced Medical Systems of APAC to address needs of rapidly Growing Healthcare Market in India, Malaysia and Singapore. The companys sophisticated, 3D-5D advanced visualization software provides a wide array of diagnostic tools at any chosen location. •Chennai-based Cura Healthcare is also working on high performance medical imaging equipment for the developing world. The company is currently also working on a collimator algorithm using HPC platform Cloud HPC based Hospital Information System Dr. Devi Shetty, Founder, Narayana Hrudayalaya signing the agreement on HPC with Harsh Chitale, CEO, HCL Infosystems Initiatives •Indias Narayana Hrudayalaya is using cloud-based HPC for its Hospital Information Systems (HIS) application. •It has tied up with HCL Infosystems for this unique initiative. •HCL blu Enterprise Clouds Infrastructure as a Service (IaaS) solution is being deployed across 22 NH hospitals and has been already rolled out in Bangalore, Ahmedabad, Jamshedpur and Jaipur. •The high performance cloud computing services are backed by a strong infrastructure backbone and HCLs national support network to ensure business continuity. The HCL IaaS includes components from Cisco, EMC, Net App and VMware.The tie up is the result of a rigorous evaluation and a painstaking proof of concept exercise which took almost a year to come to fruition.
  • Disruptive Innovation or Trend
  • Disruptive Innovation/Trend in Healthcare HPC 1 $100 Genome : Personalized Medicine Revolution DNA is the blue print of life, telling our cells what to become and when to become it. While even 5 years back, it cost roughly $60,000 to sequence a human genome, with advancement in technology, especially high performance computers, several companies are trying to create an inexpensive sequencing technology. it is widely believed that affordable and accurate reads of the entire genome will open the door to a whole new level of diagnostic and therapeutic discovery The Problem Learning to sequence DNA fast and cheap might be the most important challenge in health technology. Understanding each patients full genetic sequencing would give doctors X-Ray vision into their patients unique makeup and future diseases. Theres one big catch. Gene sequencing costs tens of thousands of dollars Two companies, Complete Genomics and BioNanomatrix, are collaborating to create a novel approach that would sequence our genome for less than the price of a nice pair of jeans–and the technology could read the complete genome in a single workday. IBM is also building a "DNA Transistor" that would be the worlds cheapest genetic reader The Idea This would work sort of like a DNA View-Master on the smallest conceivable level. Scientists drill a nano- sized hole -- 3,000 times slimmer than a human hair -- through a silicon computer chip and thread a DNA strands through it. As the molecule is passed through the nanopore, it is ratcheted one unit of DNA at a time. Click, click, click, and the long sequence of DNA would be sequenced. If doctors could know and use the full genetic sequence of every patient, the potential would be enormous. It would turn doctors into little prophets. Diseases and disorders could be caught and diagnosed early. Medicine could be radically personalized. Doctors would be working with a kind of super- X-Ray into the latent and not-so-latent illnesses of their patients.
  • Disruptive Innovation/Trend in Healthcare HPC 2 When Medicine and Machine meet Eye to Eye Recently, the USFDA approved a device that can restore sight to the blind. the bionic device, made by California-based Second Sight called Argus II, helps people with retinitis pigmentosa, a genetic condition that damages light sensitive cells and can lead to blindness. The project leveraged Livermore National Laboratories supercomputing facility to create simulations for the artificial retinal prosthesis One day, blind people fitted with artificial retinas will not only get sight, but like a smart phone, a range of apps will emerge that will allow recording, zooming and augmented reality. Eventually you reach the point where you can start doing things that normal people cant do -Dr Anders Sandberg, Future of Humanity Institute, University of Oxford
  • Disruptive Innovation/Trend in Healthcare HPC 3 Analysis of Human Rhinovirus St. Vincents Institute of Medical Research (AUSTRALIA) A cross-organizational team comprising researchers from St. Vincent’s Institute of Medical Why is it Disruptive ? Research, Victorian Infectious Disease Research Laboratories, IBM Research Collaboratory for Life Understanding how anti-viral drugs work on rhinoviruses and related viruses can potentially Sciences – Melbourne, and Victorian Life Sciences Computation Initiative developed a method to speed up the development of new treatments, simulate the 3D atomic motion of the complete human rhinovirus on Australia’s fastest and could produce savings in development costs. The research has the potential to produce savings supercomputer, paving the way for new drug development. This research is the first time that the in drug discovery and pre-clinical development of atomic motion of a complete human rhinovirus has been simulated on a computer up to $1,000,000 per year 4 Biomechanical Modeling ALYA RED (Barcelona) Barcelona Supercomputing Center developed a first of its kind, in-house, end-to-end biomechanical model including numerical methods, parallel implementation, mesh generation, and visualization. The Alya System is a computational mechanics code with two main features. First, it is specially Why is it Disruptive ? designed for running with high efficiency in large-scale supercomputing facilities. Secondly, it is The Alya Red biomechanical model can help bring drugs to market faster through HPC simulation capable of solving different physics tasks in a coupled way, each one with its own modeling driven testing. This could result in tens of millions characteristics: fluids, solids, electrical activity, species concentration, free surface, etc. The long of dollars in potential savings term vision of Alya Red Project is to create an IT infrastructure of hardware and software that can help medical doctors, clinical researchers, and the pharmacological industry to use HPC to positively impact healthcare Source: Both of them has been featured in the IDC HPC Innovation Excellence Awards declared on Nov, 2012
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