MSDS Clodrosome_Clodronate encapsulated liposome_ Encapsula Nanosciences_2012
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MSDS Clodrosome_Clodronate encapsulated liposome_ Encapsula Nanosciences_2012

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The document is the Material Safety Data Sheet (MSDS) for Clodronate Encapsulated liposomes (Clodrosome) Manufactured by Encapsula NanoSciences in United States of America ...

The document is the Material Safety Data Sheet (MSDS) for Clodronate Encapsulated liposomes (Clodrosome) Manufactured by Encapsula NanoSciences in United States of America

www.clodrosome.com

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MSDS Clodrosome_Clodronate encapsulated liposome_ Encapsula Nanosciences_2012 MSDS Clodrosome_Clodronate encapsulated liposome_ Encapsula Nanosciences_2012 Document Transcript

  • ENCAPSULA NANOSCIENCES LLC MATERIAL SAFETY DATA SHEET Date Printed: 12/18/2011 Date Updated: 02/04/2006 Version 1.4Section 1 - Product and Company InformationProduct Name: LIPOSOME ENCAPSULATED CLODRONATEProduct Number: CLDN-2Brand: CLODROSOME®Company Address: ENCAPSULA NANOSCIENCES LLC 441 DONELSON PIKE, SUITE 345 NASHVILLE, TN 37214, USATechnical Phone: 615-884-4442Fax: 615-250-8747Emergency Phone: 615-438-8553Section 2 - Composition/Information on IngredientSubstance Name CAS# SARA313CLODRONATE ENCAPSULATED LIPOSOMES NONE NoIngredient Name CAS # Percent SARA313WATER 7732-18-5 >90 NoSODIUM CHLORIDE 7647-14-5 <5 NoPOTASSIUM CHLORIDE 7447-40-7 <5 NoDISODIUM PHOSPHATE 7558-79-4 <5 NoPOTASSIUM PHOSPHATE 7758-11-4 <5 NoL-α-PHOSPHATIDYLCHOLINE 8002-43-5 <5 NoCHOLESTEROL 57-88-5 <5 NoCLODRONATE DISODIUM 22560-50-5 <5 NoSection 3- Hazards IdentificationEMERGENCY OVERVIEWOSHA HAZARDSTARGET ORGAN EFFECTTARGET ORGANSBONE, KIDNEYHMIS RATINGHEALTH: 0CHRONIC HEALTH HAZARD: *FLAMMABILITY: 0REACTIVITY: 0NFPA RATING 1HEALTH: 0 PageFLAMMABILITY: 0CLODROSOME® WWW.CLODROSOME.COM
  • ENCAPSULA NANOSCIENCES LLC MATERIAL SAFETY DATA SHEETREACTIVITY: 0Potential Health EffectsInhalation May be harmful if inhaled. May cause respiratory tractirritation.Skin May be harmful if absorbed through skin. May cause skin irritation.Eyes May cause eye irritation.Ingestion May be harmful if swallowed.For additional information on toxicity, please refer to Section 11.Section 4 - First Aid MeasuresORAL EXPOSURE If swallowed, wash out mouth with water provided person is conscious. Call a physician.INHALATION EXPOSURE If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.DERMAL EXPOSURE In case of contact, immediately wash skin with soap and copious amountsof water.EYE EXPOSURE In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.Section 5 - Fire Fighting MeasuresFLASH POINT N/AAUTOIGNITION TEMP N/AFLAMMABILITY N/AEXTINGUISHING MEDIA Suitable: Water spray. Carbon dioxide, dry chemical powder, or appropriate foam.FIREFIGHTING Protective Equipment: Wear self-contained breathing apparatus 2 and protective clothing to prevent contact with skin and eyes. Page Specific Hazard(s): Emits toxic fumes under fire conditions.CLODROSOME® WWW.CLODROSOME.COM
  • ENCAPSULA NANOSCIENCES LLC MATERIAL SAFETY DATA SHEETSection 6 - Accidental Release MeasuresMETHODS FOR CLEANING UP Absorb on sand or vermiculite and place in closed containers for disposal. Ventilate area and wash spill site after material pickup is complete.Section 7 - Handling and StorageHANDLING User Exposure: Do not breathe vapor. Do not get in eyes, on skin, on clothing.STORAGE Suitable: Keep tightly closed under an inert gas. Store in refrigeratorat 4 °C.Section 8 - Exposure Controls / Personal ProtectionENGINEERING CONTROLS Safety shower and eye bath. Mechanical exhaust required.PERSONAL PROTECTIVE EQUIPMENT Respiratory: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Respiratory protection is not required. Where protection is desired, use multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges. Hand: Compatible chemical-resistant gloves. Eye: Chemical safety goggles.GENERAL HYGIENE MEASURES Wash thoroughly after handling. Wash contaminated clothing before reuse.Section 9 - PHYSICAL AND CHEMICAL PROPERTIESAppearanceWhite liquid dispersionSafety datapH7.4Melting point 3N/A PageBoiling pointCLODROSOME® WWW.CLODROSOME.COM
  • ENCAPSULA NANOSCIENCES LLC MATERIAL SAFETY DATA SHEETN/AFlash pointN/AIgnition temperatureN/ALower explosion limitN/AUpper explosion limitN/AWater solubilityN/ASection 10 - STABILITY AND REACTIVITYStorage stabilityCan be stored for one month under nitrogen or argon at 4 °C.Materials to avoidStrong acids, Strong basesHazardous decomposition productsHazardous decomposition products formed under fire conditions. - Carbonoxides, Oxides of phosphorus, Hydrogen chloride gas, Sodium oxidesSection 11 - TOXICOLOGICAL INFORMATIONAcute toxicityN/ASkin Contact: May cause skin irritation.Skin Absorption: May be harmful if absorbed through the skin.Eye Contact: May cause eye irritation.Inhalation: Material may be irritating to mucous membranes andupper respiratory tract. May be harmful if inhaled.Ingestion: May be harmful if swallowed.Chronic exposureIARC: No component of this product present at levels greater than or equalto 0.1% is identified as probable, possible or confirmed human carcinogenby IARC. 4 PageCLODROSOME® WWW.CLODROSOME.COM
  • ENCAPSULA NANOSCIENCES LLC MATERIAL SAFETY DATA SHEETACGIH: No component of this product present at levels greater than orequal to 0.1% is identified as a carcinogen or potential carcinogen byACGIH.NTP: No component of this product present at levels greater than or equalto 0.1% is identified as a known or anticipated carcinogen by NTP.OSHA: No component of this product present at levels greater than or equalto 0.1% is identified as a carcinogen or potential carcinogen by OSHA.Signs and Symptoms of ExposureNausea, Vomiting, Diarrhoea, RashPotential Health EffectsInhalation May be harmful if inhaled. May cause respiratory tractirritation.Skin May be harmful if absorbed through skin. May cause skin irritation.Eyes May cause eye irritation.Ingestion May be harmful if swallowed.Target Organs Bone, Kidney,Additional InformationRTECS: SZ7640700Section 12 - ECOLOGICAL INFORMATIONElimination information (persistence and degradability)N/AEcotoxicity effectsN/AFurther information on ecologyN/ASection 13 - DISPOSAL CONSIDERATIONSProductObserve all federal, state, and local environmental regulations.Contaminated packagingDispose of as unused product.Section 14- TRANSPORT INFORMATION 5DOT (US) PageNot dangerous goodsCLODROSOME® WWW.CLODROSOME.COM
  • ENCAPSULA NANOSCIENCES LLC MATERIAL SAFETY DATA SHEETIMDGNot dangerous goodsIATANot dangerous goodsSection 15 - REGULATORY INFORMATIONOSHA HazardsTarget Organ EffectDSL StatusThis product contains the following components that are not on theCanadian DSL nor NDSL lists.Disodium dihydrogen (dichloromethylene)diphosphonateCAS-No.22560-50-5SARA 302 ComponentsSARA 302: No chemicals in this material are subject to the reportingrequirements of SARA Title III, Section 302.SARA 313 ComponentsSARA 313: This material does not contain any chemical components withknown CAS numbers that exceed the threshold (De Minimis) reporting levelsestablished by SARA Title III, Section 313.SARA 311/312 HazardsChronic Health HazardMassachusetts Right To Know ComponentsNo components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know ComponentsDisodium dihydrogen (dichloromethylene)diphosphonate AKA ClodronateCAS-No. 22560-50-5Revision Date:Lecithin AKA L-α-PhosphatidylcholineCAS-No. 8002-43-5Revision Date:CholesterolCAS-No. 55-88-5Revision Date:New Jersey Right To Know Components 6Disodium dihydrogen (dichloromethylene)diphosphonate AKA Clodronate PageCAS-No. 22560-50-5Revision Date:CLODROSOME® WWW.CLODROSOME.COM
  • ENCAPSULA NANOSCIENCES LLC MATERIAL SAFETY DATA SHEETLecithin AKA L-α-PhosphatidylcholineCAS-No. 8002-43-5CholesterolCAS-No. 55-88-5Revision Date:California Prop. 65 ComponentsThis product does not contain any chemicals known to State of Californiato cause cancer, birth, or any other reproductive defects.Section 16- OTHER INFORMATIONFurther informationCopyright 2009 Encapsula NanoSciences LLC license granted to makeunlimited paper copies for internal use only.The above information is believed to be correct but does not purport to beall inclusive and shall be used only as a guide. The information in thisdocument is based on the present state of our knowledge and is applicableto the product with regard to appropriate safety precautions. It does notrepresent any guarantee of the properties of the product. EncapsulaNanoSciences LLC shall not be held liable for any damage resulting fromhandling or from contact with the above product. 7 PageCLODROSOME® WWW.CLODROSOME.COM