By Linda Guzman
Preview of Main Points• What it is?• Its history• Pathology – transmission• Symptoms• Preventative measures
What is the WNV?• Flaviviridae family• Icosahedral envelope – RNA• 40-60 nm in size
WNV History• 1937 – West Nile District of Uganda• Africa, Middle East, Eastern Europe, West  Asia• New York City 1999 – Fi...
WNV History• 1999 – 62 cases and 7 deaths
WNV 2004
WNV 2011• Every US state has reported a WNV case
WNV Global
Seasonal Disease• Active during mosquito breeding season• Spring till the end of August
Pathology• Zoonotic• Replicates in salivary glands• Culex pipiens mosquito - the common house  mosquito
Transmission Cycle
Interesting Fact• Europe – two types of Culex pipien population• America – mosquito population has evolved• Spread faster ...
Transmission• Dead end host• Per CDC – OK to breast feed• Infected mosquito bites a human
Pathology• Keratinocyte and dendritic  cell in basal layer• Dendritic cells travels to  lymph nodes – 1st virus  replicati...
Pathology• Viremia triggers production of proteins &  enzymes• Weaken tight junction of BBB
Pathology• Neurons and glial cells infected• Triggers cells narcosis = inflammation• Encephalitis – inflammation of brain•...
Who’s at Risk?• Children, elderly,  compromised immune  system• Over 50yo especially over  75yo – more at risk –  morbidit...
Symptoms• 3 to 14 days after infection• 80% show no symptoms• 20% show acute symptoms – mild, last couple of  days   – Fev...
Symptoms• Out of 20% only 1% show severe symptoms  – Tremors, stiff neck, high fever,    severe headache, paralysis,    mu...
Cure?• There is not cure for WNV• But there is one for horses• Best way to protect is prevention
Prevention• Stay indoors during dusk & dawn hours• Long sleeves and long pants• Insect repellent 10-30% DEET - mosquitoes ...
Prevention• Dispose stagnant water
Works CitedByron E. E. Martina, et al. "West Nile Virus: Immunity and Pathogenesis." Viruses (1999-4915) 3.6    (2011): 81...
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WNV

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Microbiology presentation on West Nile Virus

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WNV

  1. 1. By Linda Guzman
  2. 2. Preview of Main Points• What it is?• Its history• Pathology – transmission• Symptoms• Preventative measures
  3. 3. What is the WNV?• Flaviviridae family• Icosahedral envelope – RNA• 40-60 nm in size
  4. 4. WNV History• 1937 – West Nile District of Uganda• Africa, Middle East, Eastern Europe, West Asia• New York City 1999 – First case
  5. 5. WNV History• 1999 – 62 cases and 7 deaths
  6. 6. WNV 2004
  7. 7. WNV 2011• Every US state has reported a WNV case
  8. 8. WNV Global
  9. 9. Seasonal Disease• Active during mosquito breeding season• Spring till the end of August
  10. 10. Pathology• Zoonotic• Replicates in salivary glands• Culex pipiens mosquito - the common house mosquito
  11. 11. Transmission Cycle
  12. 12. Interesting Fact• Europe – two types of Culex pipien population• America – mosquito population has evolved• Spread faster in America
  13. 13. Transmission• Dead end host• Per CDC – OK to breast feed• Infected mosquito bites a human
  14. 14. Pathology• Keratinocyte and dendritic cell in basal layer• Dendritic cells travels to lymph nodes – 1st virus replication• Epithelial cells of visceral organs – 2nd virus replication
  15. 15. Pathology• Viremia triggers production of proteins & enzymes• Weaken tight junction of BBB
  16. 16. Pathology• Neurons and glial cells infected• Triggers cells narcosis = inflammation• Encephalitis – inflammation of brain• Meningitis – inflammation of meninges spinal cord
  17. 17. Who’s at Risk?• Children, elderly, compromised immune system• Over 50yo especially over 75yo – more at risk – morbidity and mortality
  18. 18. Symptoms• 3 to 14 days after infection• 80% show no symptoms• 20% show acute symptoms – mild, last couple of days – Fever, headache, body aches, nausea, vomiting, rash & swollen lymph glands
  19. 19. Symptoms• Out of 20% only 1% show severe symptoms – Tremors, stiff neck, high fever, severe headache, paralysis, muscle weakness, confusion, convulsion, coma, encephalitis or meningitis
  20. 20. Cure?• There is not cure for WNV• But there is one for horses• Best way to protect is prevention
  21. 21. Prevention• Stay indoors during dusk & dawn hours• Long sleeves and long pants• Insect repellent 10-30% DEET - mosquitoes can still bite thru thin material
  22. 22. Prevention• Dispose stagnant water
  23. 23. Works CitedByron E. E. Martina, et al. "West Nile Virus: Immunity and Pathogenesis." Viruses (1999-4915) 3.6 (2011): 811-828. Academic Search Complete. EBSCO. Web. 28 Sept. 2011.Gerardi, Michael H., and Melvin C. Zimmerman. Wastewater Pathogens. John Wiley & Sons, Inc. (US), 2005. eBook Collection (EBSCOhost). EBSCO. Web. 28 Sept. 2011.Hoyle, Brian. "West Nile." Infectious Diseases: In Context. Ed. Brenda Wilmoth Lerner and K. Lee Lerner. Vol. 2. Detroit: Gale, 2008. 899-905. Gale Virtual Reference Library. Web.Quick, Jennifer, and J. P. Saleeby. "The Mighty Mosquito-borne Killer." American Fitness 25.4 (2007): 26-29. Health Source - Consumer Edition. EBSCO. Web. 29 Sept. 2011."West Nile Virus." CRS - Pediatric Advisor (2010): 1. Health Source - Consumer Edition. EBSCO. Web. 29 Sept. 2011.
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